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Stem Cell Technology in Medical Biotechnology

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Fundamentals and Advances in Medical Biotechnology

Abstract

Stem cells are small, unspecialized, and undifferentiated cells with a chromatin conformation that is not characteristic of any particular cell type and can be programmed, upon appropriate stimulation, into different cell types. These cells provide base material for formation of many different body cells for therapeutic and research applications. There has been a revolution in the therapeutic applications of stem cell technology during the past decade and the revolutionary introduction of CRISPR-Cas9 has further increased the possibilities of their use. This chapter describes stem cell technology, its types, applications in various established pathological conditions, and ethical concerns revolving their use. It also provides insightful details about the culture conditions required for propagating and differentiating stem cells, tissue engineering, establishment of organ cultures, and limitations in establishing stem cell cultures.

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Author notes

  1. Shahnawaz Wani and Tahir Dar contributed equally to this work and they are co-first authors.

Authors and Affiliations

  1. Department of Medicine, SKIMS, Srinagar, Jammu & Kashmir, India

    Shahnawaz Wani

  2. Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Tahir Dar

  3. Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA

    Swanand Koli

  4. Department Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Willayat Yousuf Wani

  5. Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Mumtaz Anwar & Zeenat Farooq

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  1. Shahnawaz Wani
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  1. Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Mumtaz Anwar

  2. Department of Biotechnology, Wachemo University, Hosaena, Ethiopia

    Riyaz Ahmad Rather

  3. Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Zeenat Farooq

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Wani, S., Dar, T., Koli, S., Wani, W.Y., Anwar, M., Farooq, Z. (2022). Stem Cell Technology in Medical Biotechnology. In: Anwar, M., Ahmad Rather, R., Farooq, Z. (eds) Fundamentals and Advances in Medical Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-98554-7_8

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