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Hesperidin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

  • Living reference work entry
  • First Online:
Handbook of Dietary Flavonoids

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Abstract

The dietary flavonoid hesperidin is the most vital phytochemical in orange peel and other citrus species and is of great general interest due to their diverse bioactivity. Very little information is included in reviews about hesperidin as it is specific to its ameliorating effect in certain disease or toxicity. This chapter summarizes advances on resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of hesperidin. Due to its low water solubility, weak intestinal absorption, disposition via phase II enzymes, and efflux by the enterocytes, HPD’s oral bioavailability is less than 20%, and it is quickly altered by environmental conditions such as temperature, pH, and light. Therefore, a viable strategy for improving hesperidin oral bioavailability is the development of nanoscale drug carriers. Hesperidin exhibited significant antioxidant, anti-inflammatory, anticancer, and hepatoprotective activities as well as anti-diabetes, antiadipogenic, antihypertensive, and antimicrobial activities and other biological effects which are confirmed well in in vitro and in vivo studies. However, there is a lack of clinical data on the biological benefits of flavonoid hesperidin. It is necessary to clinically investigate more on this phytochemical mechanism in different diseases especially cancer and neurodegenerative diseases.

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Authors and Affiliations

  1. Molecular Cell Biology Unit, Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt

    Thoria Donia

  2. Pharmacist and Independent Researcher, Alexandria, Egypt

    Nelly M. Dabbour

  3. Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt

    Samah A. Loutfy

  4. Nanotechnology Research Center, British University, Cairo, Egypt

    Samah A. Loutfy

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  1. Thoria Donia
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  2. Nelly M. Dabbour
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  3. Samah A. Loutfy
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Correspondence to Thoria Donia or Samah A. Loutfy .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Donia, T., Dabbour, N.M., Loutfy, S.A. (2023). Hesperidin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_28-1

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