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Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases

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Taurine 12

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1370))

Abstract

Taurine haloamines, N-chlorotaurine (NCT, TauCl), and N-bromotaurine (NBT, TauBr) are formed by a reaction between taurine and hypohalous acids, HOCl and HOBr, respectively. The major source of endogenous taurine haloamines is neutrophils. Both NCT and NBT share strong anti-inflammatory and microbicidal activities supported by an absence of microbial resistance. In the light of these properties, a number of clinical studies have been performed to document their effectiveness in treatment of bacterial, fungal, and viral infections. The administration of NCT and NBT has been limited to topical application, as they are decomposed upon systemic delivery. This review summarizes current knowledge concerning the therapeutic use of NCT and NBT mainly in various skin disorders such as non-healing wounds, acne vulgaris, herpes zoster, and psoriasis. Moreover, the beneficial effect of NCT inhalation in early stages of COVID-19 and other viral respiratory infections is discussed. And finally, we would like to suggest that NCT might be used to inhibit the development of the cytokine storm through its capacity to suppress the production of IL-6.

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Abbreviations

ARDS:

acute respiratory distress syndrome

ASM:

artificial sputum medium

CFU:

colony-forming unit

EKC:

epidemic keratoconjunctivitis

HOBr:

hypobromous acid

HOCl:

hypochlorous acid

MIC:

minimum inhibitory concentration

MPO:

myeloperoxidase

NBT:

N-bromotaurine

NCT:

N-chlorotaurine

ROS:

reactive oxygen species

RSV:

respiratory syncytial virus

Tau:

taurine

TauBr:

taurine bromamine

TauCl:

taurine chloramine

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Acknowledgments

This paper was supported by the Jagiellonian University Medical College grant No (N41/DBS/000190).

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Authors and Affiliations

  1. Department of Immunology, Jagiellonian University Medical College, Krakow, Poland

    Janusz Marcinkiewicz, Maria Walczewska & Paulina Skalska

  2. Department of Hygiene, Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

    Markus Nagl

  3. Nasco AD Biotechnology Laboratory, Piraeus, Greece

    Anthony Kyriakopoulos

  4. Department of Infection Control and Mycology Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland

    Magdalena Skóra

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  1. Janusz Marcinkiewicz
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  2. Markus Nagl
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  3. Anthony Kyriakopoulos
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  4. Maria Walczewska
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  5. Magdalena Skóra
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  6. Paulina Skalska
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Correspondence to Janusz Marcinkiewicz .

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  1. Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, USA

    Stephen W. Schaffer

  2. Department of Biology, College of Staten Island, New York, NY, USA

    Abdeslem El Idrissi

  3. Faculty of Bioscience and Biotechnology, Fukui Prefectural University, Eiheiji-cho, Fukui, Japan

    Shigeru Murakami

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Marcinkiewicz, J., Nagl, M., Kyriakopoulos, A., Walczewska, M., Skóra, M., Skalska, P. (2022). Current Opinion on the Therapeutic Capacity of Taurine-Containing Halogen Derivatives in Infectious and Inflammatory Diseases. In: Schaffer, S.W., El Idrissi, A., Murakami, S. (eds) Taurine 12. Advances in Experimental Medicine and Biology, vol 1370. Springer, Cham. https://doi.org/10.1007/978-3-030-93337-1_8

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