Skip to main content
SpringerLink
Log in

Therapieresistente Otitis externa mit zusätzlicher Trommelfellperforation

Lokaltherapie mit N-Chlortaurin und Dexamethason

Therapy-resistant otitis externa with additional tympanic membrane perforation

Local therapy using N-chlorotaurine and dexamethasone

  • Kasuistiken
  • Published:
HNO Aims and scope Submit manuscript

Zusammenfassung

Insbesondere bei anbehandelten Gehörgangsentzündungen kann klinisch nicht immer zwischen einer bakteriellen Otitis externa, einer Otomykose oder einer Mischinfektion unterschieden werden. Zusätzlich bestehende Trommelfellperforationen sind häufig nicht sofort erkennbar. Die Verwendung eines Antiseptikums mit breitem Wirkspektrum und ohne innenohrtoxische Wirkung wäre daher von Vorteil. Wir berichten über eine Patientin, deren therapieresistente Otitis externa mit Trommelfellperforation durch eine lokale Behandlung mit einem Gemisch aus 1% N-Chlortaurin (NCT) und 0,1% Dexamethason erfolgreich therapiert wurde.

Abstract

Ear canal infections may not always be clinically distinguished between a bacterial otitis externa, an otomycosis or a mixed infection. In addition, tympanic membrane perforations are often not immediately apparent. The use of a broad-spectrum antiseptic agent without an inner ear toxic effect would therefore be beneficial. We report the case of a female patient suffering from intractable otitis externa with tympanic membrane perforation, who was successfully treated locally with a mixture of 1% NCT and 0.1% dexamethasone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Grisham MB, Jefferson MM, Melton DF, Thomas EL (1984) Chlorination of endogenous amines by isolated neutrophils. J Biol Chem 259:10404–10413

    CAS  PubMed  Google Scholar 

  2. Test ST, Lampert MB, Ossanna PJ et al (1984) Generation of nitrogen-chlorine oxidants by human phagocytes. J Clin Invest 74:1341–1349

    Article  CAS  PubMed  Google Scholar 

  3. Gottardi W, Nagl M (2002) Chemical properties of N-chlorotaurine sodium, a key compound in the human defence system. Arch Pharm Pharm Med Chem 335:411–421

    Article  CAS  Google Scholar 

  4. Nagl M, Nguyen VA, Gottardi W et al (2003) Tolerability and efficacy of N-chlorotaurine compared to chloramine T for treatment of chronic leg ulcers with purulent coating. Br J Dermatol 149:590–597

    Article  CAS  PubMed  Google Scholar 

  5. Neher A, Nagl M, Appenroth E et al (2004) Acute otitis externa: Efficacy and tolerability of N-chlorotaurine, a novel endogenous antiseptic agent. Laryngoscope 114:850–854

    Article  PubMed  Google Scholar 

  6. Neher A, Fischer H, Appenroth E et al (2005) Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter. Auris Nasus Larynx 32:359–364

    Article  PubMed  Google Scholar 

  7. Teuchner B, Nagl M, Schidlbauer A et al (2005) Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis – a double-blind randomized phase 2 clinical trial. J Ocular Pharmacol Ther 21:157–165

    Article  CAS  Google Scholar 

  8. Neher A, Arnitz R, Gstöttner M et al (2008) Antimicrobial activity of Dexamethasone and its combination with N-chlorotaurine. Arch Otolaryngol Head Neck Surg 134:615–620

    Article  PubMed  Google Scholar 

  9. Neher A, Gstöttner M, Scholtz AW, Nagl M (2008) Antibacterial activity of mometasone. Arch Otolaryngol Head Neck Surg 134:519–521

    Article  PubMed  Google Scholar 

  10. Dudani AK, Martyres A, Fliss H (2008) Short communication: rapid preparation of preventive and therapeutic whole-killed retroviral vaccines using the microbicide taurine chloramine. AIDS Res Hum Retroviruses 24:635–642

    Article  CAS  PubMed  Google Scholar 

  11. Fürnkranz U, Nagl M, Gottardi W et al (2008) Cytotoxic activities of N-chlorotaurine (NCT) on Acanthamoeba spp. Antimicrob Agents Chemother 52:470–476

    Article  PubMed  Google Scholar 

  12. Nagl M, Gottardi W (1996) Enhancement of the bactericidal efficacy of N-chlorotaurine by inflammation samples and selected N-H compounds. Hyg Med 21:597–605

    Google Scholar 

  13. Nagl M, Larcher C, Gottardi W (1998) Activity of N-chlorotaurine against herpes simplex- and adenoviruses. Antiviral Res 38:25–30

    Article  CAS  PubMed  Google Scholar 

  14. Nagl M, Lass-Floerl C, Neher A et al (2001) Enhanced fungicidal activity of N-chlorotaurine in nasal secretion. J Antimicrob Chemother 47:871–874

    Article  CAS  PubMed  Google Scholar 

  15. Yazdanbakhsh M, Eckmann CM, Roos D (1987) Killing of schistosomula by taurine chloramine and taurine bromamine. Am J Trop Med Hyg 37:106–110

    CAS  PubMed  Google Scholar 

  16. Neher A, Nagl M, Schrott-Fischer A et al (2001) N-chlorotaurine, a novel endogenous antimicrobial agent: tolerability tested in a mouse model. Arch Otolaryngol Head Neck Surg 127:530–533

    CAS  PubMed  Google Scholar 

  17. Neher A, Nagl M, Prieskorn D et al (2004) Tolerability of N-chlorotaurine in the guinea pig middle ear – a pilot study using an improved application system. Ann Otol Rhinol Laryngol 113:76–81

    PubMed  Google Scholar 

  18. Hofer E, Neher A, Gunkel AR, Nagl M (2003) In vitro study on the influence of N-chlorotaurine on the ciliary beat frequency of nasal mucosa. Am J Rhinol 17:149–152

    PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Anichstraße 35, 6020, Innsbruck, Österreich

    M. Lumassegger, C. Pototschnig &  A. Neher

  2. Department für Hygiene, Mikrobiologie und Sozialmedizin, Sektion für Hygiene und Medizinische Mikrobiologie, Medizinische Universität Innsbruck, Innsbruck, Österreich

    M. Nagl

Authors
  1. M. Lumassegger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Nagl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Pototschnig
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Neher
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Neher.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lumassegger, M., Nagl, M., Pototschnig, C. et al. Therapieresistente Otitis externa mit zusätzlicher Trommelfellperforation. HNO 58, 927–930 (2010). https://doi.org/10.1007/s00106-010-2082-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00106-010-2082-1

Schlüsselwörter

Keywords

Search

Navigation