Abstract
In the present study, we investigated the pharmacokinetics of oral ingested tauropine which is a natural taurine derivative found in marine invertebrates, such as abalone, and in mouse. To measure tauropine in the blood, it was derivatized with phenyl isothiocyanate (PITC), and PITC-tauropine was separated by reverse-phase high-performance liquid chromatography (HPLC) and detected by ultraviolet absorbance. Tauropine was detectable in the blood obtained from mice intraperitoneally injected with tauropine. However, it was not detectable in blood obtained from orally treated mice. In conclusion, oral ingested tauropine may be poorly absorbed by the gastrointestinal tract and transported into the blood.
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Acknowledgments
This work is supported by the grant for Scientific Research from Fukui Prefectural University and Lotte Foundation (to Takashi Ito).
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Ito, T., Nguyen, K.H., Maruyama, C., Hamano, Y., Murakami, S., Schaffer, S.W. (2022). Bioavailability of Tauropine After Oral Ingestion in Mouse. In: Schaffer, S.W., El Idrissi, A., Murakami, S. (eds) Taurine 12. Advances in Experimental Medicine and Biology, vol 1370. Springer, Cham. https://doi.org/10.1007/978-3-030-93337-1_13
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DOI: https://doi.org/10.1007/978-3-030-93337-1_13
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