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The Immunogenetics of Photodermatoses

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The Immunogenetics of Dermatologic Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1367))

Abstract

Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Idiopathic photodermatoses, a spectrum of diseases with abnormal responses to ultraviolet radiation (UVR), include polymorphous light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis, and solar urticaria. Young people are more susceptible to most idiopathic photodermatoses except for chronic actinic dermatitis. Interestingly, idiopathic photodermatoses exhibit different characteristics between Caucasians and Asians. For example, the average age of Asian actinic prurigo patients is older than that of Caucasians in which genetic backgrounds or Fitzpatrick skin type might play a role. Drug-induced photodermatoses can be classified into phototoxic and photoallergic drug reactions. Certain drug-induced photodermatoses may mimic other dermatoses. For instance, drug-induced lupus erythematosus (LE) should be considered if an old man is diagnosed with LE but had a poor response to standard treatments.

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Authors and Affiliations

  1. Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan

    Chaw-Ning Lee, Tzu-Ying Chen & Tak-Wah Wong

  2. Department of Biochemistry & Molecular Biology, College of Medicine, Tainan, Taiwan

    Tak-Wah Wong

  3. Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan

    Tak-Wah Wong

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  1. Chaw-Ning Lee
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  2. Tzu-Ying Chen
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Correspondence to Tak-Wah Wong .

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Editors and Affiliations

  1. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  2. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

    Fateme Rajabi

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Lee, CN., Chen, TY., Wong, TW. (2022). The Immunogenetics of Photodermatoses. In: Rezaei, N., Rajabi, F. (eds) The Immunogenetics of Dermatologic Diseases. Advances in Experimental Medicine and Biology, vol 1367. Springer, Cham. https://doi.org/10.1007/978-3-030-92616-8_14

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