Abstract
Acute lung injury is a medical problem that causes a high mortality rate if it is not detected early and followed by appropriate treatment. The detection of acute lung injury is generally by clinical, radiological, and arterial blood gas analysis. This is a little late because when clinical symptoms appear, the cure rate will decrease. We need an early diagnosis of acute lung injury so that, as clinicians, we can anticipate further organ damage. One idea to detect acute lung injury is by examining the serum surfactant protein D. Although it still has to be combined with clinical examination and other examinations, at least there is a simple technique to increase the sensitivity and specificity of the overall diagnostic method if done holistically before more extensive organ damage occurs.
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Abbreviations
- ALI:
-
Acute lung injury
- Ang-2:
-
Angiopoietin-2
- ARDS:
-
Acute respiratory distress syndrome
- AT2:
-
Alveolar type II pneumocyte
- BAL:
-
Bronchoalveolar lavage
- BMI:
-
Body mass index
- CD4:
-
Cluster of differentiation 4
- CD91:
-
Cluster of differentiation 91
- CF:
-
Cystic fibrosis
- COPD:
-
Chronic obstructive pulmonary disease
- CRD:
-
Carbohydrate recognition domain
- ELISA:
-
Enzyme-linked immunosorbent assay
- IPF:
-
Interstitial pulmonary fibrosis
- KGF:
-
Keratinocyte growth factor
- KL-6:
-
Krebs von den Lungen 6
- LPS:
-
Lipopolysaccharides
- MAPK:
-
Mitogen-activated protein kinase
- MBL:
-
Mannose-binding lectin
- NF-κB:
-
Nuclear factor kappa light chain enhancer of activated B cells
- PAMPs:
-
Pathogen-associated molecular pattern molecules
- PARS:
-
Pediatric acute respiratory distress syndrome
- PTB:
-
Pulmonary tuberculosis
- RAGE:
-
Receptor for advanced glycation end products
- SARS:
-
Severe acute respiratory syndrome
- SNPs:
-
Single-nucleotide polymorphisms
- SP-A:
-
Surfactant protein A
- SP-B:
-
Surfactant protein B
- SP-C:
-
Surfactant protein C
- SP-D:
-
Surfactant protein D
- sRAGE:
-
Soluble receptor for advanced glycation end products
- Th1:
-
T helper 1 cells
- VEGF:
-
Vascular endothelial growth factor
- VWF:
-
von Willebrand factor
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Veterini, A.S. (2022). The Opportunity of Surfactant Protein D as a Potential Biomarker for Detecting Acute Lung Injury. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Biomarkers in Trauma, Injury and Critical Care. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-87302-8_20-1
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