Abstract
Cyanobacteria, one of the least investigated microbes, may synthesize and generate a significant number of antimicribial secondary metabolites. As they are ubiquitous in distribution and present in all possible habitats, cyanobacteria have developed several mechanisms to survive in various extreme habitats. Also, they are compatible biocatalysts, and they can be used in the field of “white biotechnology” for increasing the sustainable manufacture of nutraceutical and pharmaceutical compounds as novel drugs and also as clean energy sources such as biodiesel and hydrogen. Cyanobacteria are known as a mother of wide categories of secondary metabolites with different biological activities, i.e., antibacterial, antitumoral, antiviral, antifungal, antialgal, antimalarial, anti-inflammatory, and anticancer properties. In this chapter, we try to uncover the application of various metabolites like phytols, free fatty acids, exopolysaccharides, phenolics, terpenoids, phytoene, sterols, carotenoids, MAAs, scytonemin, phytohormones, cyanotoxins, biocides (algicides, fungicides, bactericides, and insecticides), etc. and its various applications.
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References
Abarzua S, Jakubowski S, Eckert S, Fuchs P (1999) Biotechnological investigation for the prevention of biofouling II. Blue-green algae as potential producers of biogenic agents for the growth inhibition of microfouling organisms. Bot Mar 42:459–465
Andrianasolo E, Gross EH, Goeger D, Musafija G, McPhail M, Leal K (2005) Isolation of swinholide A and related glycosylated derivatives from two field collection of marine cyanobacteria. Org Lett 7:1375–1378
Asthana RK, Srivastava A, Kayastha AM, Nath G, Singh SP (2006) Antibacterial potential of γ-linolenic acid from Fischerella sp. colonizing neem bark. J Appl Phycol 22:443–448
Aziz M, Hashem MA (2003) Role of cyanobacteria in improving fertility of saline soil. Pak J Biol Sci 6:1751–1752
Bar-Yosef Y, Sukenik A, Hadas O (2010) Enslavement in the water body by toxic Aphanizomenon ovalisporum, inducing alkaline phosphatase in phytoplanktons. Curr Biol 20:1557–1561
Becher PG, Beuchat J, Gademann K, Juttner F (2005) Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A. J Nat Prod 68:1793–1795
Berg G (2009) Plant-microbe interactions promoting plant growth and health: perspectives for controlled use of microorganisms in agriculture. Appl Microbiol Biotechnol 84:11–18
Berry JP, Gantar M, Perez MH, Berry G, Noriega FG (2008) Cyanobacterial toxins as allelochemicals with potential applications as algaecides, herbicides and insecticides. Mar Drugs 6:117–146
Biondi N, Piccardi R, Margheri MC, Rodolfi L, Smith GD, Tredici MR (2004) Evaluation of Nostoc strain ATCC 53789 as a potential source of natural pesticides. Appl Environ Biotechnol 70:3313–3320
Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC, Turpin J, Watson K, Buckheit RW, Boyd MR (2003) A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry 42:2578–2584
Bonjouklian R, Smitka TA, Doolin LE, Molloy RM, Debono M, Shaffer SA (1991) Tjipanazoles, new antifungal agents from the blue–green alga Tolypothrix tjipanasensis. Tetrahedron 47:7739–7750
Boyd MR (1999) Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides form the sponges Theonella mirabilis and Theonella swinhoei collected in Papua New Guinea. J Am Chem Soc 121:5899–5909
Bui TN, Jansen R, Pham TL, Mundt S (2007) Carbamidocyclophanes A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the Vietnamese cyanobacterium. Nostoc sp. J Nat Prod 70:499–503
Burja AM, Banaigs B, Abou-Mansour E, Burgess JG, Wright PC (2001) Marine cyanobacteria—a prolific source of natural products. Tetrahedron 57:9347–9377
Chauhan A, Chauhan G, Gupta PC, Goyal P, Kaushik P (2010) In vitro antibacterial evaluation of Anabaena sp. against several clinically significant microflora and HPTL Canalysis of its active crude extracts. Indian J Pharmacol 42:105–107
Choi H, Engene N, Smith JE, Preskitt LB, Gerwick WH (2010) Crossbyanols A-D, toxic brominated polyphenyl ethers from the Hawaiian bloom-forming Cyanobacterium Leptolyngbya crossbyana. J Nat Prod 73:517–522
Clark BR (2008) Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J Nat Prod 71:1530–1537
Dahms HU, Xu Y, Pfeiffer C (2006) Anti fouling potential of cyanobacteria: a mini-review. Biofouling 22:317–327
Dhar DW, Prasanna R, Singh BV (2007) Comparative performance of three carrier based blue green algal biofertilizers for sustainable rice cultivation. J Sustain Agric 30(2):41–50
Doan NT, Rickards RW, Rothschild JM, Smith GD (2000) Allelopathic actions of the alkaloid 12-epi-Hapalindole E Isonitrile and Calothrixin A from cyanobacteria of the Genera Fischerella and Calothrix. J Appl Phycol 12:409–416
Edwards C, Graham D, Fowler N, Lawton LA (2008) Biodegradation of microcystins and nodularin in freshwaters. Chemosphere 73:1315–1321
Gademan K, Portman C (2008) Secondary metabolites from cyanobacteria: complex structures and powerful bioactivities. Curr Org Chem 12:326–341
Ganter M, Berry JP, Thomas S, Wang M, Perez R, Rein K (2008) Allelopathic activity among cyanobacteria and microalgae isolated from Florida freshwater habitats. FEMS Microbiol Lett 64:55–64
Gerwick WH, Coates RC, Engene N, Gerwick LG, Grindberg R, Jones A, Sorrels C (2008) Giant marine cyanobacteria produce exciting potential pharmaceuticals. Microbe 3:277–284
Gleason FK, Baxa CA (1986) Activity of the natural algicide, cyanobacterin, on eukaryotic microorganisms. FEMS Microbiol Lett 33:85–88
Goldin E (2012) Biologically active microalgae and cyanobacteria in nature and marine biotechnology. Turk J Fish Aquat Sci 12:423–442
Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ (2009) Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. J Nat Prod 73:459–462
Gupta V, Prasanna R, Srivastava AK, Sharma J (2012) Purification and characterization of a novel antifungal endo-type chitosanase from Anabaena fertilissima. Ann Microbiol 62:1089–1092
Gustafson KR, Cardellina JH, Fuller RW, Weislow OS, Kiser RF, Snader KM (1989) AIDS-antiviral sulfolipids from cyanobacteria (blue-green algae). J Natl Cancer Inst 81:1254–1258
Haggog WM, Abouziena HF, AbdEM MSA, Hoballa E, Islam AE (2015) Application of blue-green algae for integrated disease management of barley against foliar pathogens. J Chem Pharm Res 7(10):266–272
Harrigan GG, Yoshida WY, Moore RE (1998) Isolation, structure determination, and biological activity of dolastatin 12 and lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages. J Nat Prod 61:1221–1225
Hartmann T (2007) From waste products to ecochemicals: fifty years research of plant secondary metabolism. Phytochemistry 68:2831–2846
Hayashi K, Hayashi T, Kojima IA (1996) Natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS Res Hum Retrovir 12:1463–1471
Healey FP (1982) Phosphte. In: Carr NG, Whitton BA (eds) The biology of the cyanobacteria. Blackwell, Oxford, p 105
Hirata K, Nakagami H, Takashina J, Mahmud T, Kobayashi M, In Y, Ishida T, Miyamoto K (1996) Novel violet pigment, nostocine A, an extracellular metabolite from cyanobacterium Nostoc spongiaeforme. Heterocycles 7(43):1513–1519
Hoffmann D, Hevel JM, Moore RE, Moore BS (2003) Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. Gene 311:171–180
Iwasaki A, Ohno O, Sumimoto S, Ogawa H, Nguyen KA, Suenaga K (2015) Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp. Org Lett 17:652–655
Jaiswal P, Singh PK, Prasanna R (2008) Cyanobacterial bioactive molecules—an overview of their toxic properties. Can J Microbiol 54(9):701–717
Jang MH, Ha K, Takamura N (2007) Reciprocal allelopathic responses between toxic cyanobacteria (Microcystis aeruginosa) and duckweed (Lemna japonica). Toxicon 49:727–733
Jones AC, Gu LC, Sorrels CM, Sherman DH, Gerwick WH (2009) New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol 13:216–223
Juttner F, Todorova AK, Walch N, von Philipsborn W (2001) Nostocyclamide M: a cyanobacterial cyclic peptide with allelopathic activity from Nostoc 31. Phytochemistry 57:613–619
Kajiyama SI, Kanzaki H, Kawazu K, Kobayashi A (1998) Nostofungicidine, an antifungal lipopeptide from the field grown terrestrial blue-green alga Nostoc commune. Tetrahedron Lett 39:3737–3740
Katircioglu H, Beyatli Y, Aslim B, Yüksekdag Z, Atici T (2006) Screening for antimicrobial agent production of some microalgae in freshwater. Int J Microbiol 2
Kehr JC, Picchi DG, Dittmann E (2011) Natural product biosyntheses in cyanobacteria: a treasure trove of unique enzymes. Beilstein J Org Chem 7:1622–1635
Kodani S, Ishida K, Murakami M (1998) Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis. J Nat Prod 61:1046–1048
Koehn FE, Longley RE, Reed JK (1992) Microcolins A and B, new immunosuppressive peptides from the blue-green alga Lyngbya majuscula. J Nat Prod 55:613–619
Koníčková R, Vaňková K, Vaníková J, Váňová K, Muchová L (2014) Anti-cancer effects of blue green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds. Ann Hepatol 13:273–283
Kulik MM (1995) The potential for using cyanobacteria (blue green algae) and algae in the cyanobacterial control of plant pathogenic bacteria and fungi. Eur J Plant Pathol 101:585–599
Kumar J, Singh D, Tyagi MB, Kumar A (2019) Cyanobacteria: applications in biotechnology. https://doi.org/10.1016/B978-0-12-814667-5.00016-7
Larsen LK, Moore RE, Patterson GM (1994) Beta-carbolines from the blue–green alga Dichothrix baueriana. J Nat Prod 57:419–421
Lee JB, Hayashi K, Hirata M, Kuroda E, Suzuki E, Kubo Y, Hayashi T (2006) Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay. Biol Pharm Bull 29:2135–2139
Li WI, Berman FW, Okino T, Yokokawa F, Shioiri T, Gerwick WH, Murray TF (2001) Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proc Natl Acad Sci USA 98:7599–7604
Manjunath M, Prasanna R, Lata PD, Singh R, Kumar A, Jaggi S, Kaushik BD (2010) Bio control potential of cyanobacterial metabolites against damping off disease caused by Pythium aphanidermatum in solanaceous vegetables. Arch Phytopathol Plant Prot 43:666–677
Mason CP, Edwards KR, Carlson RE, Pignatello J, Gleason FK, Wood JM (1982) Isolation of chlorine-containing antibiotic from the freshwater cyanobacterium Scytonema hofmanni. Science 215:400–402
McCarty MF (2015) Hypothesis: Spirulina may slow the growth and spread of ovarian cancer by interfering with growth factor activity of lysophosphatidic acid. J Mol Genet Med 9:184
Moore RE, Banarjee V, Bornemann V, Caplyn FR, Chen JL, Corley DJ, Larsen LK, Moore BS, Patterson GML (1989) Novel cytotoxins and fungicides from blue-green algae and marine animals possessing algal symbionts. Pure Appl Chem 61:521–524
Morliere P, Maziere JC, Santus R (1998) Tolyporphin: a natural product from cyanobacteria with potent photosensitizing activity against tumor cells in vitro and in vivo. Cancer Res 58:3571–3578
Mukund S, Sivasubramanian V (2014) Anticancer activity of Oscillatoria terebriformis cyanobacteria in human lung cancer cell line a:549. Int J Appl Biol Pharm 5:2
Mundt S, Kreitlow S, Jansen R (2003) Fatty acids with antibacterial activity from the cyanobacterium Oscillatoria redekei HUB051. J Appl Phycol 15:263–267
Muniaraj S, Subramanian V, Srinivasan P, Palani M (2018) In silico and in vitro studies on Lyngbya majuscula using against lung cancer cell line (A549). Pharmacogn J 10
Nagarajan M, Maruthanayagam V, Sundararaman M (2012) A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites. J Appl Toxicol 32:153–185
Namikoshi M, Rinehart KL (1996) Bioactive compounds produced by cyanobacteria. J Ind Microbiol 17:373–384
Natarajan C, Prasanna R, Gupta V, Dureja P, Nain L (2012) Dissecting the fungicidal activity of Calothrix elenkinii using chemical analyses and microscopy. Appl Biochem Microbiol 48:51–57
Oku N, Yonejima K, Sugawa T, Igarashi Y (2014) Identification of the n-1 fatty acid as an antibacterial constituent from the edible freshwater cyanobacterium Nostoc verrucosum. Biosci Biotechnol Biochem 78(7):1147–1150
Ouellette AJA, Wilhelm SW (2003) Toxic cyanobacteria: the evolving molecular toolbox. Front Ecol Environ 1:359–366
Paerl HW, Fulton RS III, Moisander PH, Dyble J (2001) Harmful freshwater algal blooms, with an emphasis on cyanobacteria. Sci World 1:76–113
Panda D, Ananthnarayan V, Larson G, Shi C, Jordan MA, Wilson L (2000) Interaction of the antitumor compound cryptophycin-52 with tubulin. Biochemistry 39:14121–14127
Papke U, Gross EM, Francke W (1997) Isolation, identification and determination of the absolute configuration of fischerellin B. A new algicide from the freshwater cyanobacterium Fischerella muscicola (Thuret.). Tetrahedron Lett 38:379–382
Patterson GM, Larsen LK, Moore RE (1994) Beta-carbolines from the blue–green alga Dichothrix baueriana. J Nat Prod 57:419–421
Prasanna R, Chaudhary V, Gupta V, Babu S, Kumar A, Singh R, Shivay YS, Nain L (2013) Cyanobacteria mediated plant growth promotion and bioprotection against Fusarium wilt in tomato. Eur J Plant Pathol 136:337–353
Rastogi RP, Sinha RP (2009) Biotechnological and industrial significance of cyanobacterial secondary metabolites. Biotechnol Adv 27:521–539
Reinert R, Donald EL, Rosi FX, Watal C, Dowzicky M (2007) Antimicrobial susceptibility among organisms from the Asia/Pacific rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline. J Antimicrob Chemother 60:1018–1029
Reshef V, Mizrachi E, Maretzki T, Silberstein C, Loya S, Hizi A (1997) New acetylated known glycolipids from cyanobacteria with potential to inhibit the reverse transcriptase of HIV-1. J Nat Prod 60:1251–1260
Rickards RW, Rothschild JM, Willis AC et al (1999) Calothrixins-a and B, novel pentacyclic metabolites from Calothrix sp. cyanobacteria with potent activity against malaria parasites and human cancer cells. Tetrahedron 55:13513–13520
Sangthongpitag K, Delaney SF, Rogers PL (1996) Evaluation of four fresh-water unicellular cyanobacteria as potential hosts for mosquitocidal toxins. Biotechnol Lett 18:175–180
Saxena S, Pandey AK (2001) Microbial metabolites as ecofriendly agrochemicals for the next millennium. Appl Microbiol Biotechnol 55:395–403
Sharma NK, Tiwari SP, Tripathi K, Rai AK (2011) Sustainability and cyanobacteria (blue-green algae): facts and challenges. J Appl Phycol 23(6):1059–1081
Shishido TK, Humisto A, Jokela J, Liu L, Wahlsten M, Tamrakar A, Fewer DP, Permi P, Andreote APD, Fiore MF (2015) Antifungal compounds from cyanobacteria. Mar Drugs 13:2124–2140
Singh A, Shukla N, Kabadwal BC, Tewari AK, Kumar J (2018) Review on plant-Trichoderma-pathogen interaction. Int J Curr Microbiol Appl Sci 7:2382–2397
Singh BK (2009) Organophosphorus-degrading bacteria: ecology and industrial applications. Nat Rev Microbiol 7:156–164
Singh T, Basu P, Singh TA, Boudh S, Shukla P (2020) Cyanobacteria as source of novel antimicrobials: a boon to mankind. Microorganisms Sustain Environ Health. https://doi.org/10.1016/B978-0-12-819001-2.00011-5
Soltani N, Khavari-Nejad RA, Tabatabaei Yazdi M, Shokravi S, Fernandez-Valiente E (2005) Screening of soil cyanobacteria for antifungal and antibacterial activity. Pharm Biol 43:455–459
Stevenson CS, Capper EA, Roshak AK, Marquez B, Eichman C, Jackson JR (2002) The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther 303:858–866
Sukenik A, Eskhol R, Livne A, Hadas O, Rom M (2002) Inhibition of growth and photosynthesis of the dinoflagellate Peridinium gatunense by Microcystis sp. (cyanobacteria): a novel Allelopathic mechanism. Limnol Oceanogr 47(6):1656–1663
Syed S, Arasu A, Ponnuswamy I (2015) The uses of Chlorella vulgaris as antimicrobial agent and as a diet: the presence of bio-active compounds which caters the vitamins, minerals in general. Int J Biosci Biotechnol 7:185–190
Tyagi R, Kaushik DB, Rastogi J (2014) Antimicrobial activity of some cyanobacteria. Mic Div Biot Food Sec:463–470
Vijayakumar S, Menakha M (2015) Pharmaceutical applications of cyanobacteria. J Acute Med 5:15–23
Volk RB (2005) Screening of microalgal culture media for the presence of algicidal compounds and isolation and identification of two bioactive metabolites, excreted by the cyanobacteria Nostoc insulare and Nodularia harveyana. J Appl Phycol 17(4):339–347
Volk RB, Furkert FH (2006) Antialgal, antibacterial and antifungal activity of two metabolites produced and excreted by cyanobacteria during growth. Microbiol Res 161:180–186
Welker M, Dohren HV (2006) Cyanobacterial peptides-nature’s own combinatorial biosynthesis. FEMS Microbiol Rev 30:530–563
Wiederhold NP (2017) Antifungal resistance: current trends and future strategies to combat. Infect Drug Resist 10:249
Wink M (1988) Plant breeding: importance of plant secondary metabolites for protection against pathogens and herbivores. Theor Appl Genet 75:225–233
Wu JT, Kuo-Huang LL, Lee J (1998) Algicidal effect of Peridinium bipes on Microcystis aeruginosa. Curr Microbiol 37:257–261
Xiong C, O'Keefe BR, Byrd RA, McMohan JB (2006) Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides 27:1668–1675
Yadav S, Rai R, Shrivastava AK, Singh PK, Sen S, Chatterjee A, Rai S, Singh S, Rai LC (2018) Cyanobacterial biodiversity and biotechnology: a promising approach for crop improvement. Crop Improv Through Microbial Biotechnol:195–219
Yanni YG, Abdallah FE (1990) Role of algalization in rice growth, yield and incidence of infestation with the stem borer Chilo Agamemnon Bles and the leaf miner Hydrellia prosternalis deeming in the Nile Delta. World J Microbiol Biotechnol 6:383–389
Yingying S, Changhai W, Jing C (2008) Growth inhibition of the eight species of microalgae by growth inhibitor from the culture of Isochrysis galbana and its isolation and identification. J Appl Phycol 20:315–321
Zainuddin EN, Mentel R, Wray V, Jansen R, Nimtz M, LalkM (2007) Cyclic depsipeptides, ichthyopeptins a and B, from Microcystis ichthyoblabe. J Nat Prod 70:1084–1088
Zulpa G, Zaccaro MC, Boccazzi F, Parada JL, Storni M (2003) Bioactivity of intra and extracellular substances from cyanobacteria and lactic acid bacteria on wood blue stain fungi. Biol Control 27:345–348
Acknowledgments
The authors thank the Head of the Department of Botany, Banaras Hindu University, for providing infrastructure facility and the CSIR-UGC, New Delhi for providing financial support in the form of fellowship.
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Yadav, P., Singh, R.P., Patel, A.K., Pandey, K.D., Gupta, R.K. (2022). Cyanobacteria as a Biocontrol Agent. In: Kumar, A. (eds) Microbial Biocontrol: Food Security and Post Harvest Management. Springer, Cham. https://doi.org/10.1007/978-3-030-87289-2_6
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