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Surface Modification of Nanoparticles for Macrophage Targeting

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Macrophage Targeted Delivery Systems

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Abstract

Among various targeting techniques, macrophage targeting has achieved special consideration in the field of biomedicals. Macrophage targeting is facilitated through macrophages and is bestowed with several properties, such as greater payload at the desired site, minimum delivery to off-targets, and stability. Macrophage targeting can be achieved through various strategies such as receptor-mediated phagocytosis, cytoplasmic delivery with the help of endocytosis, and endocytic receptor-mediated active transport by proteins clathrin and caveolin. All the merits of macrophage targeting eventually prove it a suitable and potential target for numerous biomedical and therapeutic applications. In recent years, considerable literature has suggested macrophage targeting as important in various therapies such as cancer, tuberculosis, macular degeneration, and angiogenesis. Macrophage targeting is achieved through numerous nanodelivery systems such as niosomes, carbon nanotubes, liposomes, and dendrimers and has been explored for their drug delivery and therapeutic potential.

Further, these nanosystems are surface modified to improve the delivery of drugs and therapeutic efficacy of targeting. Surface modifiers include CD163, CD204, vascular endothelial growth factor (VEGF), cMAF, folic acid, mannose, etc. This chapter describes several strategies and their targeting potential based on macrophage targeting developed explicitly to deliver drugs and other therapeutic applications.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidyavihar, Lucknow, Uttar Pradesh, India

    Neelu Singh, Priyanka Maurya, Nidhi Mishra, Samipta Singh, Ravi Raj Pal, Priya Singh, Poonam Parashar, Alka Sonkar & Shubhini A. Saraf

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  1. Neelu Singh
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  2. Priyanka Maurya
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  3. Nidhi Mishra
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  4. Samipta Singh
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  5. Ravi Raj Pal
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  6. Priya Singh
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  7. Poonam Parashar
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  8. Alka Sonkar
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  9. Shubhini A. Saraf
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Editors and Affiliations

  1. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

    Swati Gupta

  2. University of South Florida, Taneja College of Pharmacy, Tampa, FL, USA

    Yashwant V. Pathak

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Singh, N. et al. (2022). Surface Modification of Nanoparticles for Macrophage Targeting. In: Gupta, S., Pathak, Y.V. (eds) Macrophage Targeted Delivery Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-84164-5_8

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