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Macrophage Targeting for Therapy of Intraocular Diseases

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Macrophage Targeted Delivery Systems

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Abstract

The eye is a unique and intricate organ with a persisting challenge to uphold optical clarity and sustain satisfactory neural retina function. The immune defenses in the eye occur at varying microenvironments including the corneal and conjunctival epithelia, uveal pigmented connective tissue, and even the highly protected neural retina. Ocular macrophages have been implicated in homeostasis and number of pathological conditions. In this chapter, the present understanding of ocular immunology with the distribution, phenotype, and the physiological role of the various ocular immune cells is discussed with their implication on ocular pathologies. Various novel strategies for potential macrophage targeting of drug in intraocular diseases are also discussed.

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Acknowledgments

The authors are thankful to the Director, University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur. The authors extend special thanks to the Librarian, Pt. Sundarlal Sharma Library of the University for making e-resources available through UGC-INFLIBNET. The authors are thankful to the Chhattisgarh Council of Science and Technology for MRP (1863/CCOST/MRP/2014).

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  1. University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India

    Nagendra Bhuwane, Ishwari Choudhary, Shweta Ramkar, Narayan Hemnani & Preeti K. Suresh

  2. Department of Pharmacy, Shri Govindram Seksariya Institute of Technology & Science (SGSITS), Indore, Madhya Pradesh, India

    Abhishek K. Sah

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  1. Nagendra Bhuwane
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  1. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

    Swati Gupta

  2. University of South Florida, Taneja College of Pharmacy, Tampa, FL, USA

    Yashwant V. Pathak

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Bhuwane, N., Choudhary, I., Ramkar, S., Hemnani, N., Sah, A.K., Suresh, P.K. (2022). Macrophage Targeting for Therapy of Intraocular Diseases. In: Gupta, S., Pathak, Y.V. (eds) Macrophage Targeted Delivery Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-84164-5_19

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