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PKPD of PLGA-PEG-PLGA Copolymeric Micelles

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Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Abstract

Much research has been undertaken on stimuli-sensitive polymers and their applications in biochemistry, biomedicine, and a plethora of domains over the last decade. Stimuli-sensitive gelling polymers or in situ forming hydrogels, in particular, have drawn a lot of interest as prospective injectable implant systems with low invasiveness. Drugs or cells can be readily combined with the aqueous copolymer solution at low temperatures, and then injected into the body at a specific spot to form a semisolid matrix. Nanoparticles composed of amphiphilic block copolymers with biodegradable core-forming blocks are extremely appealing for the development of long-acting drug delivery systems. The FDA-approved PLGA-PEG-PLGA triblock copolymer possesses the capability to provide sustained release of various biologicals. Polymer solutions having an ability to convert from sol to gel at physiological temperatures can be used for in situ gel formation and injectability. Drug delivery systems with more complicated architectures are being developed as technology advances. As a result, the processes of drug absorption and disposition following the administration of these newer delivery systems have grown extremely complicated. Thus, knowledge of the pharmacokinetics and pharmacodynamics could be utilised to disentangle these complexities and increase our understanding of these drug delivery systems’ in vivo behaviour, hence guiding their preclinical-to-clinical translation and clinical development.

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Acknowledgments

The authors are thankful to MAHE for providing fellowship to Miss. Shirleen Miriam Marques. The authors acknowledge the support of Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India, for providing infrastructural facilities.

Conflict of Interest

The authors report no conflicts of interest in this work.

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Authors and Affiliations

  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India

    Shirleen Miriam Marques & Lalit Kumar

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  1. Shirleen Miriam Marques
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  2. Lalit Kumar
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Correspondence to Lalit Kumar .

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Editors and Affiliations

  1. Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida Health, Tampa, FL, USA

    Yashwant V. Pathak

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Marques, S.M., Kumar, L. (2022). PKPD of PLGA-PEG-PLGA Copolymeric Micelles. In: Patel, J.K., Pathak, Y.V. (eds) Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems . Springer, Cham. https://doi.org/10.1007/978-3-030-83395-4_15

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