Abstract
Transcranial Doppler ultrasonography represents a noninvasive method to evaluate flow velocities through the basal cerebral arteries. By evaluating the flow velocity spectrum of the cerebral arteries, transcranial Doppler ultrasound can provide information on the direction of flow, patency of vessels, focal stenosis, and cerebrovascular reactivity, and estimates of cerebral blood flow.
By comparing changes to flow velocity to changes in blood pressure, transcranial Doppler ultrasonography can be used to estimate cerebral blood flow and cerebral autoregulation in select circumstances. Similarly, increasing flow velocities after subarachnoid hemorrhage are often interpreted as worsening cerebral vasospasm and can be used to guide therapies. Transcranial Doppler ultrasound in the neurological intensive care unit has also been used in head trauma, intracerebral hemorrhage, and assessing sources of ischemic stroke. Transcranial Doppler ultrasound has also been used as a confirmatory test for brain death.
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References
Aaslid R, Markwalder T-M, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982;57:769–74.
Fick A. Ueber die Messung des Blutquantums in den Herzventrikeln. Sitz ber Physik-Med Ges Wurzburg. 1870;2:16–28.
Kety SS, Schmidt CF. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Phys. 1945;143:53–66.
Manno EM, Koroshetz WJ. Cerebral blood flow. Chapter 5. In: Babikian VL, Wechsler LR, editors. Transcranial Doppler ultrasonography. 2nd ed. Boston: Butterworth Heinmann; 1999. p. 67–87.
Aaslid R. Development of the principles of transcranial Doppler ultrasound. In: Aaslid R, Newell DE, editors. Transcranial Doppler. New York: Raven Press; 1992. p. 1–8.
Saver JL, Feldmann E. Basic transcranial Doppler examinations. In: Babikian VL, Wechsler LR, editors. Transcranial Doppler ultrasonography. Mosby-Year Book: St Louis; 1993. p. 11–28.
Manno EM. Transcranial Doppler ultrasonography in the neurocritical care unit. In: Diringer MN, editor. Critical care clinics, vol. 13. Philadelphia: W.B. Saunders; 1997. p. 79–104.
Sorteberg W. Cerebral artery blood velocity and cerebral blood flow. In: Newell DW, Aaslid R, editors. Transcranial Doppler. New York: Raven; 1992. p. 57–66.
Sorteberg W, Lindegaard KF, Rootwell K, et al. Blood velocity and regional blood flow in defined cerebral artery systems. Acta Neurochir. 1989;97:47–52.
Schoning M, Walter J, Scheel P. Estimation of cerebral blood flow through color duplex sonography of the carotid and vertebral arteries in healthy adults. Stroke. 1994;25:17–22.
Kirkham FJ, Padayachee TS, Parsons S, et al. Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow. Ultrasound Med Biol. 1986;12:15–21.
Dahl A, Russell D, Nyberg-Hansen R, et al. Simultaneous assessment of vasoreactivity using transcranial Doppler ultrasound and cerebral blood flow in healthy subjects. J Cereb Blood Flow Metab. 1994;14:974–81.
Sorteberg W, Lindegaard KF, Rootwell K, et al. Effect of acetazolamide on cerebral artery blood velocity and regional cerebral blood flow in normal subjects. Acta Neurochir. 1989;97:47–52.
Naylor AR, Merrick MV, Slattery JM, et al. Parametric imaging of cerebrovascular reserve. Eur J Nucl Med. 1991;18:259–64.
Kofke WA, Brauer P, Policare R, et al. Middle cerebral artery blood flow velocity and stable xenon-enhanced computed blood flow during test balloon occlusion of the internal carotid artery. Stroke. 1995;26:1603–6.
Hartmann A, Ries F, Tsuda Y, et al. Correlation of regional cerebral blood flow and blood flow velocity in normal volunteers and patients with cerebro-vascular disease. Neurochirgia (Stuttg). 1991;34:6–13.
Manno EM, Rabinstein AA. Central nervous system. Chapter 43. In: Gabriella A, Layton AJ, Yu M, editors. Civetta, Taylor, and Kirby’s critical care. 4th ed. Philadelphia: Wolters Kluver Lippincott Williams and Wilkins; 2009. p. 649–65.
Rose JC, Mayer SA. Optimizing blood pressure in neurological emergencies. Neurocrit Care. 2004;1:287–99.
Edvisson L. Neurogenic mechanisms in the cerebrovascular bed. Autonomic nerves, amine receptors, and their effects on cerebral blood flow. Acta Physiol Scand Suppl. 1975;427:1.
Kontos HA, Wei EP, Navari RM, et al. Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol Heart Circ Physiol. 1978;234:H371.
Folkow B. Description of the myogenic hypothesis. Circ Res. 1964;15:279–87.
Chillon JM, Baumbach JL. Autoregulation: arterial and intracranial pressure. In: Edvisson L, Krause DN, editors. Cerebral blood flow and metabolism. 2nd ed. Philadelphia: Lippincott Williams and Wilkens; 2002. p. 395–412.
Lou HC, Edvission L, MacKenzie ET. The concept of coupling blood flow to brain function: revision required? Ann Neurol. 1987;22:289.
Ginsberg MD. Cerebral circulation: its regulation, pharmacology, and pathophysiology. In: Asbury AK, McKhann GM, McDonald WI, editors. Diseases of the nervous system clinical neurobiology. Philadelphia: Saunders; 1992. p. 989–1001.
Harper AM, Glass HI. Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial pressures. J Neurol Neurosurg Psychiatry. 1965;28:449–52.
Ropper AH. Treatment of intracranial hypertension. In: Ropper AH, editor. Neurological and neurosurgical intensive care. 3rd ed. New York: Raven Press; 1993. p. 29–52.
Ringelstein EB, Otis SM. Physiological testing of vasomotor reserve. Chapter 8. In: Newell DW, Aaslid R, editors. Transcranial Doppler. New York: Raven; 1992. p. 83–100.
Aaslid R. Cerebral Hemodynamics chapter 5. In: Newell DW, Aaslid R, editors. Transcranial Doppler. New York: Raven; 1992. p. 49–55.
Tiecks FP, Lam AM, Aaslid R, Newell DW. Comparison of static and dynamic autoregulation measurements. Stroke. 1995;26:1014–9.
Manno EM, Gress DR, Schwamm LH, et al. Effects of induced hypertension on transcranial Doppler ultrasound velocities in patients after subarachnoid hemorrhage. Stroke. 1998;29:422–8.
Ringelstein EB, van Eyck S, Mertens I. Evaluation of cerebral vasomotor reactivity by various vasodilating stimuli: comparison of CO2 with acetazolamide. J Cereb Blood Flow Metab. 1992;12:162–8.
Tresser SJ, Selmon WR, Ratcheson RA. Pathophysiological alterations following aneurysm rupture. Concepts Neurosurg. 1994;6:23–45.
Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized on computed tomographic scanning. Neurosurgery. 1980;6:1–9.
Kistler JP, Crowell RM, Davis KR, et al. The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study. Neurology. 1983;33:424–36.
Seckhar LN, Wechsler LR, Yonas H, et al. Value of transcranial Doppler examination in the diagnosis of cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery. 1988;22:813–21.
Sloan MA, Rigamonti D, Rothman M, et al. Sensitivity and specificity of transcranial Doppler ultrasound in the diagnosis of vasospasm following subarachnoid hemorrhage. Neurology. 1989;39:1514–8.
Laumer R, Steinmeier R, Gonner F, et al. Cerebral hemodynamics in subarachnoid hemorrhage evaluated by transcranial Doppler ultrasonography. Part 1: reliability of flow velocities in clinical management. Neurosurgery. 1993;33:1–9.
Brass LM, Pavlakis SG, DeVivo D, et al. Transcranial Doppler measurements of the middle cerebral artery: effect of hematocrit. Stroke. 1988;19:1466–9.
Lindegaard KF, Nornes H, Bakke SJ, et al. Cerebral vasospasm after subarachnoid hemorrhage investigated by means of transcranial Doppler ultrasound. Acta Neurochir Suppl (Wien). 1988;42:81–4.
Soustiel JF, Shik V, Schreiber R, et al. Basilar vasospasm diagnosis: investigation of a modified “Lindegaard index” based on imaging studies and blood velocity measurements of the basilar artery. Stroke. 2002;33:72–7.
Hassler W, Chioffi F. CO2 reactivity of cerebral vasospasm after aneursysmal subarachnoid hemorrhage. Acta Neurochir. 1989;98:167–75.
Siuta M, Zuckerman SL, Mocco J. Nitric oxide in cerebral vasospasm. Theories measurement and treatment. Neurology Research International; 2013;2013:11. Article ID 972417.
Rabinstein AA, Weigand S, Atkinson JL, Wijdicks EF. Patterns of cerebral infarction in aneurysmal subarachnoid hemorrhage. Stroke. 2005;36:992–7.
MacDonald RL, Higashida RT, Keller E, et al. Clazosentan, an endothelian receptor antagonist in patients with subarachnoid hemorrhage undergoing surgical clipping: a randomized double blinded placebo controlled phase 3 trial (conscious −2). Lancet Neurol. 2011;10:618–25.
White H, Venkatesh B. Applications of transcranial Doppler in the ICU: a review. Intensive Care Med. 2006;32:981–94.
Hassler W, Steinmetz H, Gawloswski J. Transcranial Doppler ultrasongraphy in raised intracranial pressure and in circulatory arrest. J Neurosurg. 1988;68:745–51.
Klingelhofer J, Conrad B, Benecke R, et al. Evaluation of intracranial pressure from transcranial Doppler studies in cerebral disease. J Neurol. 1988;235:159–62.
Chan K-H, Miller JD, Dearden NM. Intracranial blood flow velocity after head injury: relationship to severity of injury, time, neurological status, and outcome. J Neurol Neurosurg Psychiatry. 1992;55:787–91.
Van Santbrink H, Schouten JW, Steyerberg EW, et al. Serial transcranial Doppler measurements in traumatic brain injury with special focus on the early posttraumatic period. Acta Neurochir. 2002;144:1141–9.
Vavilala MS, Lee LA, Boddu K, et al. Cerebral autoregulation in pediatric traumatic brain injury. Pediatr Crit Care Med. 2004;5:257–63.
Schmidt EA, Czosnyka M, Steiner LA, et al. Asymmetry of pressure autoregulation after traumatic brain injury. J Neurosurg. 2003;99:991–8.
Compton JS, Teddy PJ. Cerebral arterial vasospasm following severe head injury: a transcranial Doppler study. Br J Neurosurg. 1987;1:435–9.
Martin NA, Doberstein C, Zane C, et al. Posttraumatic cerebral arterial spasm: transcranial Doppler ultrasound, cerebral blood flow, and angiographic findings. J Neurosurg. 1992;77:575–83.
Azevedo E, Teixeira J, Neves JC, Vaz R. Transcranial Doppler and brain death. Transplant Proc. 2000;32:2579–81.
Dominguez-Roldan JM, Jimenez-Gonzalez PI, Garcia-Alfaro C, et al. Diagnosis of brain death by transcranial Doppler sonography: solutions for cases of difficult sonic windows. Transplant Proc. 2004;36:2896–7.
Chang JJ, Tsivgoulis G, Katsanos AH, et al. Diagnostic accuracy of transcranial Doppler for brain death confirmation: systemic review and meta-analysis. AJNR. 2016;37:408–14.
Ducrocq X, Hassler W, Moritake K, et al. Consensus opinion on diagnosis of cerebral circulatory arrest using Doppler-sonography: task force group on cerebral death of the neurosonology research group of the World Federation of Neurology. J Neurol Sci. 1998;159:145–50.
Young GB, Shemie SD, Doig J, Teitelbaum JT. Brief review: the role of ancillary tests in the neurological determination of death. Can J Anesth. 2006;53:620–7.
Klingelhofer J, Sander D. Doppler CO2 test as an indicator of cerebral vasoreactivity and prognosis in severe intracerebral hemorrhage. Stroke. 1992;23:962–6.
Kukulska-Pawluczul B, Ksiazkiewicz B, Nowaczewska M. Imaging of spontaneous intracerebralhemorrhages by means of transcranial colr-coded sonography. Europ J Radiol. 2012;81:1253–8.
Kiphuth IC, Huttmer HB, Breuer L, et al. Songraphic monitoring of midline shift predicts outcome after intracerebral hemorrhage. Cerebrovascular Dis. 2012;34:297–304.
Camps-Renom P, Granell JME, Prats-Sanchez L, et al. Transcranial duplex sonography predicts outcome following intracerebral hemorrhage. AJNR. 2017;38:1543–9.
Spencer MP, Thomas GI, Nicholls SC, Sauvage LR. Detection of middle cerebral emboli during carotid endarterectomy using transcranial doppler ultrasound. Stroke. 1990;21:415–23.
Merceron S, Geeraerts T, Montlahuc C, et al. Assessment of cerebral blood flow in nonconvulsive status epilepticus in comatose patients: a pathophysiological transcranial Doppler study. Seizure. 2014;23:284–9.
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Manno, E.M., Sorond, F. (2022). Transcranial Doppler (TCD/TCCS) and Cerebral Blood Flow: Applications in the Neurological Intensive Care Unit. In: Rodríguez, C.N., et al. Neurosonology in Critical Care . Springer, Cham. https://doi.org/10.1007/978-3-030-81419-9_8
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