Blood and Urinary Flavonoids

Almanza-Aguilera, Enrique; Bars-Cortina, David; Llaha, Fjorida; Zamora-Ros, Raul

doi:10.1007/978-3-030-81304-8_6-1

Enrique Almanza-Aguilera⁵,
David Bars-Cortina⁶,
Fjorida Llaha⁵ &
…
Raul Zamora-Ros⁵

Part of the book series: Biomarkers in Disease: Methods, Discoveries and Applications ((BDMDA))

41 Accesses

Abstract

Flavonoids are a large and complex group of phenolic compounds present in plant origin foods that may promote health and prevent diseases in humans. Traditional methods to estimate flavonoids intake are based on self-reported questionnaires and food composition databases. These instruments not only are fast, cheap, and practical, but also have certain limitations when estimating the real dietary exposure to flavonoids. However, measurement of flavonoids and their metabolites in biological fluids such as blood and urine may overcome these limitations. Although there are different analytical methods and instruments that can identify and quantify the different flavonoid subclasses, both liquid and gas chromatography coupled or not to mass spectrometry are, currently, the most commonly used methodologies. This chapter summarizes the current literature on these and other innovative technologies for the analysis of flavonoids in human biospecimens, as well as their application in nutritional studies evaluating the exposure to these compounds and their relationships with diseases.

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Abbreviations

APCI:: Atmospheric Pressure Chemical Ionization Source
APPI:: Atmospheric Pressure Photoionization
BHT:: Butylated hydroxytoluene
CE:: Capillary electrophoresis
CEC:: Capillary electrochromatography
CVD:: Cardiovascular disease
DBS:: Dried blood spot cards
DELFIA:: Dissociation-enhanced lanthanide fluorescence immunoassay
DP:: Degree of polymerization
EDTA:: Ethylenediaminetetraacetic acid
EKC:: Electrokinetic chromatography
ESI:: Electrospray Ionization Source
FFQ:: Food frequency questionnaire
GC:: Gas Chromatography
HPLC:: High-performance liquid chromatography
LC:: Liquid chromatography
LLE:: Liquid-liquid extraction
MEKC:: Micellar electrokinetic chromatography
MS:: Mass spectrometry
NMR:: Nuclear magnetic resonance
QDF:: Quantitative dietary fingerprinting
SPE:: Solid-phase extraction
T2D:: Type 2 diabetes
TR-FIA:: Time-resolved fluorescence immunoassay
UHPLC:: Ultra-high-performance liquid chromatography
USDA:: United States Department of Agriculture

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Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
Enrique Almanza-Aguilera, Fjorida Llaha & Raul Zamora-Ros
Colorectal Cancer Group, ONCOBELL Programme, Oncology Data Analytics Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
David Bars-Cortina

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Enrique Almanza-Aguilera
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Fjorida Llaha
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Vinood B. Patel
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Victor R. Preedy

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Almanza-Aguilera, E., Bars-Cortina, D., Llaha, F., Zamora-Ros, R. (2022). Blood and Urinary Flavonoids. In: Patel, V.B., Preedy, V.R. (eds) Biomarkers in Nutrition . Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-81304-8_6-1

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DOI: https://doi.org/10.1007/978-3-030-81304-8_6-1
Received: 03 March 2022
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Published: 03 August 2022
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