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2-[18F]FDG PET Imaging of Infection and Inflammation

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Nuclear Medicine and Immunology

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Abstract

2-[18F]fluoro-2-deoxy-d-glucose (2-[18F]FDG) positron emission tomography (PET) has been used for the diagnosis and management of the malignancy, cardiac, and brain disorders. A significant linear correlation between 2-[18F]FDG uptake and inflammatory cell density was confirmed in both acute and chronic inflammation. These observations explain the superior accuracy of 2-[18F]FDG PET over traditional imaging techniques in the assessment of infection/inflammation. Currently, 2-[18F]FDG PET provides outstanding performance for the diagnosis of several infectious and inflammatory diseases and monitoring of response to therapy. 2-[18F]FDG PET can provide higher resolution images than conventional nuclear medicine examinations. Moreover, 2-[18F]FDG PET has the advantage of completing a whole-body scan in a short time. However, compared to malignancy, evidence for the usefulness of 2-[18F]FDG PET is still weak for assessing infections, inflammatory, and autoimmune diseases. This chapter introduces the utility and limitations of 2-[18F]FDG PET for the diagnosis and assessment of treatment in infections, inflammatory, and autoimmune diseases.

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  1. Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan

    Ryogo Minamimoto

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  1. Department of Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Sara Harsini

  2. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Abass Alavi

  3. Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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Minamimoto, R. (2022). 2-[18F]FDG PET Imaging of Infection and Inflammation. In: Harsini, S., Alavi, A., Rezaei, N. (eds) Nuclear Medicine and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-81261-4_7

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