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Frequency and Causes of Primary and Secondary Hyperparathyroidism in Patients Treated with Surgery at the University Clinical Hospital Mostar

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CMBEBIH 2021 (CMBEBIH 2021)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 84))

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Abstract

Background. The aim of this study was to investigate the causes of hyperparathyroidism and whether there is a difference between the sexes. An additional goal was to determine the incidence of primary and secondary hyperparathyroidism and the most common surgical method of treatment.

Subjects and methods: 56 subjects were included in the study, of which 49 were women and 7 were men with diagnosed hyperparathyroidism. Subjects were patients who were treated endocrinologically and had elevated serum PTH (>7 pmol/L) as well as elevated Ca values (>2.6 mmol/L). The parameters considered are: age, sex, primary or secondary hyperparathyroidism, the most common surgical method of treatment.

The results: The study included 56 respondents, of whom 49 women and 7 men. All respondents had a diagnosis of hyperparathyroidism. Statistically, a significantly higher proportion of female sex than men with primary hyperparathyroidism was diagnosed (χ2 = 8.64; s.s = 1; P = 0.003). The youngest patient was 40 years old and the oldest 92 years. The average age was 63 years.

Most of the subjects in our study who had hyperparathyroidism also had parathyroid adenoma (χ2 = 6.74; s.s. = 1; P = 0,009).

The most common surgical procedure was partial parathyroidectomy, with almost the same ratio between women and men. There were no differences in surgical procedures with respect to sex (χ2 = 1.25; s.s. = 1; P = 0.262).

Parathyroidectomy of the lower and upper left as well as the lower and upper right parathyroid glands was equally common in our study (Table 4).

Conclusion. The incidence of primary hyperparathyroidism was higher than secondary. Primary occured more frequently in females while secondary hyperparathyroidism occured equally in both sexes. The most common cause of primary hyperparathyroidism was parathyroid adenoma, and secondary chronic renal failure. The most common surgical procedure was partial parathyroidectomy. Parathyroidectomy of the lower and upper left as well as the lower and upper right parathyroid glands was equally common.

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References

  1. Van de Water, T.R., Staecker, H.: Otolaryngology Basic Science and Clinical Review 1th ed. Thieme (2005)

    Google Scholar 

  2. Lalwani, A.K.: Diagnosis & Treatment Otolaryngology Head and Neck surgery 3rd ed. The Mc Grow Hill Companies (2012)

    Google Scholar 

  3. Michels, T.C., Kelly, K.M.: Parathyroid Disordrs. Am Fam Physi. 88, 249–257 (2013)

    Google Scholar 

  4. Fraser, W.D.: Hyperparathyroidism. Lancet. 11, 145–158 (2009)

    Article  Google Scholar 

  5. Miller, B.S., Dimick, J., Wainess, R., Burney, R.E.: Age- and sex-related incidence of surgically treated primary hyperparathyroidism. World J. Surg. 32, 795–799 (2008)

    Article  Google Scholar 

  6. Mokrysheva, N.G., Eremkina, A.K., Mirnaya, S.S., et al.: A case of pregnancy complicated by primary hyperparathyroidism due to a parathyroid adenoma. Am. J. Case Rep. 20, 53–59 (2019)

    Article  Google Scholar 

  7. Walker, M.D., Silverberg, S.J.: Primary hyperparathyroidism. Nat. Rev. Endocrinol. 14, 115–125 (2018)

    Google Scholar 

  8. Flint, P.W., Haughey, B.H., Lund, V.J., et al.: Cummings Otolaryngology Head & Neck Surgery, 5th ed. Mosby Elsevier (2010)

    Google Scholar 

  9. Silverberg, S.J., Walker, M.D., Bilezikian, J.P.: Asymptomatic primary hyperparathyroidism. J. Clin. Densitom. 16, 14–21 (2013)

    Article  Google Scholar 

  10. Pasha, R.: Otolaryngology Head & Neck Surgery Clinical Reference Guide 1th ed. Singular/Thomson Learning (2000)

    Google Scholar 

  11. Pitt, S.C., Sippel, R.S., Chen, H.: Secondary and tertiary hyperparathyroidism. State Art Surg. Manage. Surg. Cli.n North Am. 89, 1227–1239 (2009)

    Article  Google Scholar 

  12. Cozzolino, M., Galassi, A., Conte, F., et al.: Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide. Ther. Clin. Risk Manag. 13, 679–689 (2017)

    Article  Google Scholar 

  13. Nikodimopoulou, N., Liakos, S.: Secondary hyperparathyroidism and target organs in chronic kidney disease. Hippokratia. 15, 33–38 (2011)

    Google Scholar 

  14. Perm, J.: Hyperparathyroidism of renal disease. Permanente J. 20, 15–127 (2016)

    Google Scholar 

  15. Mizobuchi, M., Ogata, H., Koiwa, F.: Secondary hyperparathyroidism: pathogenesis and latest treatment. Ther. Apher. Dial. 22, 229–235 (2018)

    Article  Google Scholar 

  16. Saliba, W., El-Haddad, B.: Secondary hyperparathyroidism: pathophysiology and treatment. J. Am. Board. Fam. Med. 22, 574–581 (2009)

    Article  Google Scholar 

  17. Eidman, K.E., Wetmore, J.B.: The role of parathyroidectomy in the management of secondary hyperparathyroidism. Curr. Opin. Nephrol. Hypertens. 26, 516–522 (2017)

    Article  Google Scholar 

  18. Jamal, S.A., Miller, P.D.: Secondary and tertiary hyperparathyroidism. J. Clin. Densitom. 16, 64–68 (2013)

    Article  Google Scholar 

  19. Pitt, S.C., Panneerselvan, R., Chen, H., Sippel, R.S.: Secondary and tertiary hyperparathyroidism: the utility of ioPTH. Monitoring. World J. Surg. 34, 1343–1349 (2010)

    Article  Google Scholar 

  20. Castellano, E., Attanasio, R., Boriano, A., et al.: Sex Difference in the clinical presentation of primary hyperparathyroidism: influence of menopausal status. J. Clin. Endocrinol. Metab. 102, 4148–4152 (2017)

    Article  Google Scholar 

  21. Shah, V.N., Bhadada, S.K., Bhansali, A., et al.: Influence of age and gender on presentation of symptomatic primary hyperparathyroidism. J. Postgrad. Med. 58, 107–111 (2012)

    Article  Google Scholar 

  22. Bandeira, F., Caldas, G., Freese, E., et al.: Relationship between serum vitamin d status and clinical manifestations of primary hyperparathyroidism. Endocr Pract. 8, 266–270 (2002)

    Article  Google Scholar 

  23. Carsote, M., Paduraru, D.N., Nica, A.E., Valea, A.: Parathyroidectomy: is vitamin D a player for a good outcome? J. Med. Life. 9, 348–352 (2016)

    Google Scholar 

  24. Sharma, S., Rastogi, A., Bhadada, S.K., et al.: Prevalence and predictors of primary hyperparathyroidism among patients with urolithiasis. Endocr. Pract. 23, 1311–1315 (2017)

    Article  Google Scholar 

  25. Jiang, T., Yao, X.A., Wei, B.B., Chang, H.: The influence of gender on clinical manifestations of primary hyperparathyroidism. Zhonghua Nei Ke Za Zhi. 57, 753–755 (2018)

    Google Scholar 

  26. La, J., Wang, T.S., Hammad, A.Y., et al.: Parathyroidectomy for primary hyperparathyroidism improves sleep quality: a prospective study. Surgery. 161, 25–34 (2017)

    Article  Google Scholar 

  27. Ma, L., Zhao, S., Li, Z.: Effects of parathyroidectomy on bone metabolism in haemodialysis patients with secondary hyperparathyroidism. Scand. J. Clin. Lab. Invest. 77, 527–534 (2017)

    Article  Google Scholar 

  28. Littbarski, S.A., Kaltenborn, A., Gwiasda, J., et al.: Timing of parathyroidectomy in kidney transplant candidates with secondary hyperparathryroidism: effect of pretransplant versus early or late posttransplant parathyroidectomy. Surgery 16, 373–380 (2018)

    Article  Google Scholar 

  29. Parikh, S., Nagaraja, H., Agarwal, A., et al.: Impact of post-kidney transplant parathyroidectomy on allograft function. Clin. Transplant. 27, 397–402 (2013)

    Article  Google Scholar 

  30. Chudzinski, W., Wyrzykowska, M., Nazarewski, S., et al.: Does the Parathyroidectomy Endanger the Transplanted Kidney? Transplant Proc. 48, 1633–1636 (2016)

    Article  Google Scholar 

  31. Konturek, A., Barczyński, M., Stopa, M., Nowak, W.: Subtotal parathyroidectomy for secondary renal hyperparathyroidism: a 20-year surgical outcome study. Langenbeck’s Archives Surg. 401(7), 965–974 (2016). https://doi.org/10.1007/s00423-016-1447-7

    Article  Google Scholar 

  32. Isaksson, E., Ivarsson, K., Akaberi, S., et al.: Total versus subtotal parathyroidectomy for secondary hyperparathyroidism. Surgery 165, 142–150 (2019)

    Article  Google Scholar 

  33. Filho, W.A., van der Plas, W.Y., Brescia, M.D.G., et al.: Quality of life after surgery in secondary hyperparathyroidism, comparing subtotalparathyroidectomy with total parathyroidectomy with immediate parathyroid autograft: Prospective randomized trial. Surgery 164, 978–985 (2018)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

    Josip Lesko

  2. Department of Family Medicine, DZ Mostar, Mostar, Bosnia and Herzegovina

    Nikolina Obradović & Vana Turudić

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  1. Josip Lesko
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  2. Nikolina Obradović
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  3. Vana Turudić
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Editors and Affiliations

  1. Verlab Ltd Sarajevo and Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    Almir Badnjevic

  2. Verlab Ltd Sarajevo and International Burch University Sarajevo, Sarajevo, Bosnia and Herzegovina

    Lejla Gurbeta Pokvić

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Lesko, J., Obradović, N., Turudić, V. (2021). Frequency and Causes of Primary and Secondary Hyperparathyroidism in Patients Treated with Surgery at the University Clinical Hospital Mostar. In: Badnjevic, A., Gurbeta Pokvić, L. (eds) CMBEBIH 2021. CMBEBIH 2021. IFMBE Proceedings, vol 84. Springer, Cham. https://doi.org/10.1007/978-3-030-73909-6_71

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  • DOI: https://doi.org/10.1007/978-3-030-73909-6_71

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-73908-9

  • Online ISBN: 978-3-030-73909-6

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