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Microfluidic Technologies for Head and Neck Cancer: From Single-Cell Analysis to Tumor-on-a-Chip

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Early Detection and Treatment of Head & Neck Cancers

Abstract

Emerging microfluidic technologies involving miniaturization for high throughput and integration with various on-line detection modalities hold intriguing advantages for cancer diagnosis, tumor microenvironment modeling, and drug evaluation. This book chapter overviews recent advances in diagnosis and therapy for head and neck cancer using microfluidic-based techniques. The basic working principles and experimental results of key microfluidic platforms for head and neck cancer biomarker analysis, cancer cell detection at single-cell levels, and tumor-on-chip model reconstruction for therapeutic assessment and drug evaluation are introduced.

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, China

    Yamin Yang

  2. Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA

    Hongjun Wang

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  1. Yamin Yang
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  2. Hongjun Wang
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Correspondence to Hongjun Wang .

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Editors and Affiliations

  1. Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Palo Alto, CA, USA

    Rami El Assal

  2. Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA

    Dyani Gaudilliere

  3. Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, CA, USA

    Stephen Thaddeus Connelly

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Yang, Y., Wang, H. (2021). Microfluidic Technologies for Head and Neck Cancer: From Single-Cell Analysis to Tumor-on-a-Chip. In: El Assal, R., Gaudilliere, D., Connelly, S.T. (eds) Early Detection and Treatment of Head & Neck Cancers. Springer, Cham. https://doi.org/10.1007/978-3-030-69859-1_3

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  • DOI: https://doi.org/10.1007/978-3-030-69859-1_3

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  • Print ISBN: 978-3-030-69858-4

  • Online ISBN: 978-3-030-69859-1

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