Abstract
Nanomedicine is a research area at the interface between nanotechnology and biotechnology that aims at developing nanosystems for diagnosis and therapy. As active materials to be used in both diagnosis and therapy, inorganic nanoparticles (INPs), in particular, are of great interest in nanomedicine. INPs have been applied in several therapy strategies, including active drug delivery, hyperthermia, and magnetothermia against cancer, and their use offer advantages in medical applications due to their physicochemical characteristics, such as localized surface plasmon resonance (LSPR) effect—present in Au and Ag nanoparticles, for example—and the magnetic and photoluminescence properties of magnetic nanoparticles and quantum dots, respectively. The application of INPs in molecular imaging and drug delivery has benefited from their reduced size, which allows the INPs to overcome cell barriers that conventional drugs cannot do, such as the blood–brain barrier. In addition to the physical and chemical properties of the INPs, their surface modifications using biomolecules provide specificity to the nanocarrier systems to increase absorption and biodistribution. This chapter describes the main characteristics and the most relevant applications of gold, silver, quantum dots, ceramics, and magnetic nanoparticles in biomedicine.
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References
Abdelhamid HN, El-Bery HM, Metwally AA et al (2019) Synthesis of CdS-modified chitosan quantum dots for the drug delivery of Sesamol. Carbohydr Polym 214:90–99. https://doi.org/10.1016/j.carbpol.2019.03.024
Affonso de Oliveira JF, Scheffer FR, Landis RF et al (2018) Dual functionalization of nanoparticles for generating corona-free and noncytotoxic silica nanoparticles. ACS Appl Mater Interfaces 10:41917–41923. https://doi.org/10.1021/acsami.8b12351
Akbarzadeh A, Samiei M, Davaran S (2012) Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Lett 7:144. https://doi.org/10.1186/1556-276X-7-144
Akter S, Huq MA (2020) Biologically rapid synthesis of silver nanoparticles by Sphingobium sp. MAH-11T and their antibacterial activity and mechanisms investigation against drug-resistant pathogenic microbes. Artif Cells Nanomed Biotechnol 48:672–682. https://doi.org/10.1080/21691401.2020.1730390
Alexander JW (2009) History of the medical use of silver. Surg Infect (Larchmt) 10:289–292. https://doi.org/10.1089/sur.2008.9941
Ali I (2012) New generation adsorbents for water treatment. Chem, Rev
Amendola V, Bakr OM, Stellacci F (2010) A study of the surface plasmon resonance of silver nanoparticles by the discrete dipole approximation method: effect of shape, size, structure, and assembly. Plasmonics 5:85–97. https://doi.org/10.1007/s11468-009-9120-4
Anselmo AC, Mitragotri S (2019) Nanoparticles in the clinic: an update. Bioeng Transl Med 4:e10143–e10143. https://doi.org/10.1002/btm2.10143
AshaRani PV, Mun GLK, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279–290. https://doi.org/10.1021/nn800596w
Babaei M, Eshghi H, Abnous K et al (2017) Promising gene delivery system based on polyethylenimine-modified silica nanoparticles. Cancer Gene Ther 24:156–164. https://doi.org/10.1038/cgt.2016.73
Bagalkot V, Zhang L, Levy-Nissenbaum E et al (2007) Quantum dot−aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer. Nano Lett 7:3065–3070. https://doi.org/10.1021/nl071546n
Bakalova R, Ohba H, Zhelev Z et al (2004) Quantum dot anti-CD conjugates: are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? Nano Lett 4:1567–1573. https://doi.org/10.1021/nl049627w
Baram-Pinto D, Shukla S, Perkas N et al (2009) Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug Chem 20:1497–1502. https://doi.org/10.1021/bc900215b
Bastus NG, Merkoci F, Piella J, Puntes V (2014) Synthesis of highly monodisperse citrate-stabilized silver nanoparticles of up to 200 nm: kinetic control and catalytic properties. Chem Mater 26:2836–2846. https://doi.org/10.1021/cm500316k
Behr J-P (1997) The proton sponge: a trick to enter cells the viruses did not exploit. Chim Int J Chem 51:34–36
Bharali DJ, Lucey DW, Jayakumar H et al (2005) Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. J Am Chem Soc 127:11364–11371. https://doi.org/10.1021/ja051455x
Birla SS, Gaikwad SC, Gade AK, Rai MK (2013) Rapid synthesis of silver nanoparticles from fusarium oxysporum by optimizing physicocultural conditions. Sci World J 2013:12. https://doi.org/10.1155/2013/796018
Bisso S, Leroux JC (2020) Nanopharmaceuticals: a focus on their clinical translatability. Int J Pharm. https://doi.org/10.1016/j.ijpharm.2020.119098
Brett DW (2006) A discussion of silver as an antimicrobial agent: alleviating the confusion. Ostomy Wound Manag 52:34–41
Bruchez M, Moronne M, Gin P et al (1998) Semiconductor nanocrystals as fluorescent biological labels. Science (80- ) 281:2013–2016. https://doi.org/10.1126/science.281.5385.2013
Brust M, Fink J, Bethell D et al (1995) Synthesis and reactions of functionalized gold nanoparticles. J Chem Soc Commun 1655–1656. https://doi.org/10.1039/c39950001655
Buchman YK, Lellouche E, Zigdon S et al (2013) Silica nanoparticles and polyethyleneimine (PEI)-mediated functionalization: a new method of PEI covalent attachment for siRNA delivery applications. Bioconjug Chem 24:2076–2087. https://doi.org/10.1021/bc4004316
Cai YX, Chen S, Grandfield K et al (2015) Fabrication of translucent nanoceramics via a simple filtration method. Rsc Adv 5:99848–99855. https://doi.org/10.1039/c5ra17866e
Cardoso DA, Jansen JA, Leeuwenburgh SCG (2012) Synthesis and application of nanostructured calcium phosphate ceramics for bone regeneration. J Biomed Mater Res Part B-Applied Biomater 100B:2316–2326. https://doi.org/10.1002/jbm.b.32794
Carlson C, Hussain SM, Schrand AM et al (2008) Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 112:13608–13619. https://doi.org/10.1021/jp712087m
Cavassin ED, de Figueiredo LFP, Otoch JP et al (2015) Comparison of methods to detect the in vitro activity of silver nanoparticles (AgNP) against multidrug resistant bacteria. J Nanobiotechnol 13:64. https://doi.org/10.1186/s12951-015-0120-6
Chang HH, Murphy CJ (2018) Mini gold nanorods with tunable plasmonic peaks beyond 1000 nm. Chem Mater. https://doi.org/10.1021/acs.chemmater.7b05310
Chapman J, Regan F, Sullivan T, Chemistry RS (2012) Nanoparticles in anti-microbial materials: use and characterisation. Royal Society of Chemistry
Charron G, Stuchinskaya T, Edwards DR et al (2012) Insights into the mechanism of quantum dot-sensitized singlet oxygen production for photodynamic therapy. J Phys Chem C 116:9334–9342. https://doi.org/10.1021/jp301103f
Chen Y, Cordero JM, Wang H et al (2018) A ligand system for the flexible functionalization of quantum dots via click chemistry. Angew Chemie Int Ed. https://doi.org/10.1002/anie.201801113
Cheng X, Sun R, Yin L et al (2017) Light-triggered assembly of gold nanoparticles for photothermal therapy and photoacoustic imaging of tumors in vivo. Adv Mater. https://doi.org/10.1002/adma.201604894
Cho KH, Park JE, Osaka T, Park SG (2005) The study of antimicrobial activity and preservative effects of nanosilver ingredient. Electrochim Acta 51:956–960. https://doi.org/10.1016/j.electacta.2005.04.071
Cobley CM, Chen J, Cho EC et al (2011) Gold nanostructures: a class of multifunctional materials for biomedical applications. Chem Soc Rev 40:44–56
Colombo M, Carregal-Romero S, Casula MF et al (2012) Biological applications of magnetic nanoparticles. Chem Soc Rev 41:4306–4334. https://doi.org/10.1039/c2cs15337h
Conde J, Dias JT, Grazu V et al (2014) Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine. Front Chem 2:27. https://doi.org/10.3389/fchem.2014.00048
Dadfar SM, Roemhild K, Drude NI et al (2019) Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications. Adv Drug Deliv, Rev
Danhier F (2016) To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine? J Control Release 244:108–121. https://doi.org/10.1016/j.jconrel.2016.11.015
Deepak KLN, Kuladeep R, Alee KS, Rao DN (2012) Synthesis of silver nanoparticles in poly(vinyl alcohol) matrix in solution and thin films through laser irradiation. J Nanosci Nanotechnol. https://doi.org/10.1166/jnn.2012.5153
Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18. https://doi.org/10.1021/nl0347334
Dréno B, Alexis A, Chuberre B, Marinovich M (2019) Safety of titanium dioxide nanoparticles in cosmetics. J Eur Acad Dermatology Venereol
Durán N, Durán M, de Jesus MB et al (2016) Silver nanoparticles: a new view on mechanistic aspects on antimicrobial activity. Nanomed Nanotechnol Biol Med 12:789–799. https://doi.org/10.1016/j.nano.2015.11.016
Elbaz NM, Ziko L, Siam R, Mamdouh W (2016) Core-shell silver/polymeric nanoparticles-based combinatorial therapy against breast cancer in-vitro. Sci Rep 6:30729. https://doi.org/10.1038/srep30729, http://www.nature.com/articles/srep30729#supplementary-information
Emam HE, Manian AP, Siorka B et al (2013) Treatments to impart antimicrobial activity to clothing and household cellulosic-textiles—why “nano”-silver? J Clean Prod 39:17–23. https://doi.org/10.1016/j.jclepro.2012.08.038
Espinosa A, Reguera J, Curcio A et al (2020) Janus magnetic-plasmonic nanoparticles for magnetically guided and thermally activated cancer therapy. Small. https://doi.org/10.1002/smll.201904960
Fang W, Wang Z, Zong S et al (2014) pH-controllable drug carrier with SERS activity for targeting cancer cells. Biosens Bioelectron 57:10–15. https://doi.org/10.1016/j.bios.2014.01.042
Farzin A, Etesami SA, Quint J et al (2020) Magnetic nanoparticles in cancer therapy and diagnosis. Adv Healthc Mater 1901058:1–29. https://doi.org/10.1002/adhm.201901058
Faunce T, Watal A (2010) Nanosilver and global public health: international regulatory issues. Nanomedicine 5:617–632. https://doi.org/10.2217/nnm.10.33
Foldbjerg R, Dang DA, Autrup H (2011) Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol 85:743–750. https://doi.org/10.1007/s00204-010-0545-5
Fotukian SM, Barati A, Soleymani M, Alizadeh AM (2020) Solvothermal synthesis of CuFe2O4 and Fe3O4 nanoparticles with high heating efficiency for magnetic hyperthermia application. J Alloys Compd. https://doi.org/10.1016/j.jallcom.2019.152548
Frens G (1973) Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nature 241:20–22
Fujii M, Fujii R, Takada M, Sugimoto H (2020) Silicon quantum dot supraparticles for fluorescence bioimaging. ACS Appl Nano Mater. https://doi.org/10.1021/acsanm.0c01295
Gao L, Zhang L, Zhu X et al (2020) Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy. J Mater Chem B. https://doi.org/10.1039/D0TB00097C
Garanina AS, Naumenko VA, Nikitin AA et al (2020) Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination. Nanomed Nanotechnol Biol Med. https://doi.org/10.1016/j.nano.2020.102171
González-Rubio G, Kumar V, Llombart P et al (2019) Disconnecting symmetry breaking from seeded growth for the reproducible synthesis of high quality gold nanorods. ACS Nano. https://doi.org/10.1021/acsnano.8b09658
Guo D, Zhu L, Huang Z et al (2013) Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 34:7884–7894. https://doi.org/10.1016/j.biomaterials.2013.07.015
Haefeli C, Franklin C, Hardy K (1984) Plasmid-determined silver resistance in pseudomonas-stutzeri isolated from a silver mine. J Bacteriol 158:389–392
Han MY, Gao XH, Su JZ, Nie S (2001) Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol 19:631–635. https://doi.org/10.1038/90228
Hayat A (2008) Safety issues with intravenous iron products in the management of anemia in chronic kidney disease. Clin Med Res
He H, Liu L, Zhang S et al (2020) Smart gold nanocages for mild heat-triggered drug release and breaking chemoresistance. J Control Release. https://doi.org/10.1016/j.jconrel.2020.04.029
Hess U, Shahabi S, Treccani L et al (2017) Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy. Mater Sci Eng C 77:427–435. https://doi.org/10.1016/j.msec.2017.03.164
Hines MA, Guyot-Sionnest P (1996) Synthesis and characterization of strongly luminescing ZnS-capped CdSe nanocrystals. J Phys Chem 100:468–471. https://doi.org/10.1021/jp9530562
Hobson DW (2009) Commercialization of nanotechnology. Wiley Interdiscip Rev Nanobiotechnol 1:189–202. https://doi.org/10.1002/wnan.28
Holt KB, Bard AJ (2005) Interaction of silver(I) ions with the respiratory chain of Escherichia coli: an electrochemical and scanning electrochemical microscopy study of the antimicrobial mechanism of micromolar Ag. Biochemistry 44:13214–13223. https://doi.org/10.1021/bi0508542
Huang X, Neretina S, El-Sayed MA (2009) Gold nanorods: from synthesis and properties to biological and biomedical applications. Adv Mater 21:4880–4910
Huang X, Li L, Liu T et al (2011) The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano 5:5390–5399. https://doi.org/10.1021/nn200365a
Jana NR, Gearheart L, Murphy CJ (2001) Seeding growth for size control of 5–40 nm diameter gold nanoparticles. Langmuir 17:6782–6786
Jaque D, Maestro LM, Del Rosal B et al (2014) Nanoparticles for photothermal therapies. Nanoscale 6:9494–9530
Kairdolf BA, Smith AM, Stokes TH et al (2013) Semiconductor quantum dots for bioimaging and biodiagnostic applications. Annu Rev Anal Chem 6:143–162. https://doi.org/10.1146/annurev-anchem-060908-155136
Kang SJ, Jeong HY, Kim MW et al (2018) Anti-EGFR lipid micellar nanoparticles co-encapsulating quantum dots and paclitaxel for tumor-targeted theranosis. Nanoscale. https://doi.org/10.1039/c8nr05099f
Kaur N, Aditya RN, Singh A, Kuo TR (2018) Biomedical applications for gold nanoclusters: recent developments and future perspectives. Nanoscale Res, Lett
Kelkar SS, Reineke TM (2011) Theranostics: combining imaging and therapy. Bioconjug Chem 22:1879–1903. https://doi.org/10.1021/bc200151q
Klaus T, Joerger R, Olsson E, Granqvist C-G (1999) Silver-based crystalline nanoparticles, microbially fabricated. Proc Natl Acad Sci 96:13611–13614. https://doi.org/10.1073/pnas.96.24.13611
Kohle FFE, Li S, Turker MZ, Wiesner UB (2020) Ultrasmall PEGylated and targeted core-shell silica nanoparticles carrying methylene blue photosensitizer. ACS Biomater Sci Eng 6:256–264. https://doi.org/10.1021/acsbiomaterials.9b01359
Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C (2010) Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnol 8:1. https://doi.org/10.1186/1477-3155-8-1
Lee SY, Shieh MJ (2020) Platinum(II) drug-loaded gold nanoshells for chemo-photothermal therapy in colorectal cancer. ACS Appl Mater Interfaces. https://doi.org/10.1021/acsami.9b18855
Lee JH, Jang JT, Choi JS et al (2011) Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol 6:418–422. https://doi.org/10.1038/nnano.2011.95
Lee Y-J, Schade NB, Sun L et al (2013) Ultrasmooth, highly spherical monocrystalline gold particles for precision plasmonics. ACS Nano 7:11064–11070
Lemire JA, Harrison JJ, Turner RJ (2013) Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Micro 11:371–384. https://doi.org/10.1038/nrmicro3028, http://www.nature.com/nrmicro/journal/v11/n6/abs/nrmicro3028.html#supplementary-information
Levy L (2019) Nanobiotix announces first ever radioenhancer to recieve european market approval. 1–3
Li Y-F, Chen C (2011) Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small 7:2965–2980. https://doi.org/10.1002/smll.201101059
Li S-Y, Wang M (2013) Novel core–shell structured Paclitaxel-loaded PLGA@Ag–Au nanoparticles. Mater Lett 92:350–353. https://doi.org/10.1016/j.matlet.2012.10.129
Li H, Granados A, Fernández E et al (2020) Anti-inflammatory cotton fabrics and silica nanoparticles with potential topical medical applications. ACS Appl Mater Interfaces. https://doi.org/10.1021/acsami.0c06629
Lin P, Chen Jw Fau, Chang LW, Chang Lw Fau, Wu J-P et al (2008) Computational and ultrastructural toxicology of a nanoparticle, quantum dot 705, in mice
Liu J, Hurt RH (2010) Ion release kinetics and particle persistence in aqueous nano-silver colloids. Environ Sci Technol 44:2169–2175. https://doi.org/10.1021/es9035557
Liu J, Sonshine DA, Shervani S, Hurt RH (2010) Controlled release of biologically active silver from nanosilver surfaces. ACS Nano 4:6903–6913. https://doi.org/10.1021/nn102272n
Liu Q, Song L, Chen S et al (2017) A superparamagnetic polymersome with extremely high T2 relaxivity for MRI and cancer-targeted drug delivery. Biomaterials 114:23–33. https://doi.org/10.1016/j.biomaterials.2016.10.027
Liu Y, Zhang P, Li F et al (2018a) Metal-based nanoenhancers for future radiotherapy: radiosensitizing and synergistic effects on tumor cells. Theranostics
Liu Z, Tan H, Zhang X et al (2018b) Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells. Artif Cells Nanomed Biotechnol 46:S922–S930. https://doi.org/10.1080/21691401.2018.1518912
Liu B, Ejaz W, Gong S et al (2020) Engineered interactions with mesoporous silica facilitate intracellular delivery of proteins and gene editing. Nano Lett 20:4014–4021. https://doi.org/10.1021/acs.nanolett.0c01387
Lok C-N, Ho C-M, Chen R et al (2007) Silver nanoparticles: partial oxidation and antibacterial activities. JBIC J Biol Inorg Chem 12:527–534. https://doi.org/10.1007/s00775-007-0208-z
Lu AH, Salabas EL, Schuth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed Engl 46:1222–1244. https://doi.org/10.1002/anie.200602866
Mahmoudi M, Sant S, Wang B et al (2011) Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev 63:24–46. https://doi.org/10.1016/j.addr.2010.05.006
Manivasagan P, Bharathiraja S, Bui NQ et al (2016) Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging. Int J Biol Macromol 91:578–588
Marangoni VS, Cancino Bernardi J, Reis IB et al (2019a) Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and β-lapachone. ACS Appl Bio Mater. https://doi.org/10.1021/acsabm.8b00603
Marangoni VS, Cancino Bernardi J, Reis IB et al (2019b) Photothermia and activated drug release of natural cell membrane coated plasmonic gold nanorods and β-lapachone. ACS Appl Bio Mater. https://doi.org/10.1021/acsabm.8b00603
Miclăuş T, Beer C, Chevallier J et al (2016) Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro. Nat Commun 7:11770. https://doi.org/10.1038/ncomms11770
Min KD, Youk AH, Kwark YJ, Park WH (2007) Preparation of inorganic silica nanofibers containing silver nanoparticles. Fibers Polym 8:591–600. https://doi.org/10.1007/bf02875995
Mock JJ, Barbic M, Smith DR et al (2002) Shape effects in plasmon resonance of individual colloidal silver nanoparticles. J Chem Phys 116:6755–6759
Mogensen KB, Kneipp K (2014) Size-dependent shifts of plasmon resonance in silver nanoparticle films using controlled dissolution: monitoring the onset of surface screening effects. J Phys Chem C 118:28075–28083. https://doi.org/10.1021/jp505632n
Morones-Ramirez JR, Winkler JA, Spina CS, Collins JJ (2013) Silver enhances antibiotic activity against gram-negative bacteria. Sci Transl Med 5:11. https://doi.org/10.1126/scitranslmed.3006276
Morris D, Ansar M, Speshock J et al (2019) Antiviral and immunomodulatory activity of silver nanoparticles in experimental RSV infection. Viruses 11
Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12:991–1003. https://doi.org/10.1038/nmat3776
Murray CB, Norris DJ, Bawendi MG (1993) Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites. J Am Chem Soc 115:8706–8715. https://doi.org/10.1021/ja00072a025
Nguyen DT, Kim D-J, Kim K-S (2011) Controlled synthesis and biomolecular probe application of gold nanoparticles. Micron 42:207–227
Nikoobakht B, El-Sayed MA (2003) Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem Mater 15:1957–1962
Obonyo O, Fisher E, Edwards M, Douroumis D (2010) Quantum dots synthesis and biological applications as imaging and drug delivery systems. Crit Rev Biotechnol 30:283–301. https://doi.org/10.3109/07388551.2010.487184
Pandey S, Bodas D (2020) High-quality quantum dots for multiplexed bioimaging: a critical review. Adv Colloid Interface Sci 278:102137. https://doi.org/10.1016/j.cis.2020.102137
Pardo A, Yáñez S, Piñeiro Y et al (2020) Cubic anisotropic Co- And Zn-substituted ferrite nanoparticles as multimodal magnetic agents. ACS Appl Mater Interfaces. https://doi.org/10.1021/acsami.9b20496
Park Y-H, Kim JN, Jeong SH et al (2010) Assessment of dermal toxicity of nanosilica using cultured keratinocytes, a human skin equivalent model and an in vivo model. Toxicology 267:178–181. https://doi.org/10.1016/j.tox.2009.10.011
Parveen S, Misra R, Sahoo SK (2012) Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomed Nanotechnol Biol Med 8:147–166. https://doi.org/10.1016/j.nano.2011.05.016
Pencheva D, Bryaskova R, Kantardjiev T (2012) Polyvinyl alcohol/silver nanoparticles (PVA/AgNps) as a model for testing the biological activity of hybrid materials with included silver nanoparticles. Mater Sci Eng C 32:2048–2051. https://dx.doi.org/10.1016/j.msec.2012.05.016
Pereira MGC, Leite ES, Pereira GAL et al (2016) Quantum dots. In: Nanocolloids: a meeting point for scientists and technologists
Perez JE, Van de Walle A, Wilhelm C (2020) Versatile iron cobalt nanoparticles for theranostics. Nat Biomed Eng 4:252–253. https://doi.org/10.1038/s41551-020-0532-y
Perez-Herrero E, Fernandez-Medarde A (2015) Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm 93:52–79. https://doi.org/10.1016/j.ejpb.2015.03.018
Prasher P, Sharma M, Mudila H et al (2020) Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery. Colloid Interface Sci Commun 35:100244. https://doi.org/10.1016/j.colcom.2020.100244
Raffi M, Hussain F, Bhatti TM et al (2008) Antibacterial characterization of silver nanoparticles against E. coli ATCC-15224. J Mater Sci Technol 24:192–196
Rajendran K, Anwar A, Khan NA et al (2019) Oleic acid coated silver nanoparticles showed better in vitro amoebicidal effects against Naegleria fowleri than amphotericin B. ACS Chem Neurosci. https://doi.org/10.1021/acschemneuro.9b00289
Rodzinski A, Guduru R, Liang P et al (2016) Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles. Sci Rep 6:20867. https://doi.org/10.1038/srep20867
Sabah A, Tasleem S, Murtaza M et al (2020) Effect of polymer capping on photonic multi-core–shell quantum dots CdSe/CdS/ZnS: impact of sunlight and antibacterial activity. J Phys Chem C. https://doi.org/10.1021/acs.jpcc.9b11656
Samberg ME, Orndorff PE, Monteiro-Riviere NA (2011) Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods. Nanotoxicology 5:244–253. https://doi.org/10.3109/17435390.2010.525669
Samia ACS, Chen X, Burda C (2003) Semiconductor quantum dots for photodynamic therapy. J Am Chem Soc. https://doi.org/10.1021/ja0386905
Scarabelli L, Sánchez-Iglesias A, Pérez-Juste J, Liz-Marzán LM (2015) A “tips and tricks” practical guide to the synthesis of gold nanorods. J Phys Chem Lett. https://doi.org/10.1021/acs.jpclett.5b02123
Shah M, Badwaik VD, Dakshinamurthy R (2014) Biological applications of gold nanoparticles. J Nanosci Nanotechnol 14:344–362
Shinto Y, Uchida A, Korkusuz F et al (1992) Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Jt Surgery-British 74:600–604
Singh RK, Kim HW (2013) Inorganic nanobiomaterial drug carriers for medicine. Tissue Eng Regen Med 10:296–309. https://doi.org/10.1007/s13770-013-1092-y
Singh D, Singh S, Sahu J et al (2016) Ceramic nanoparticles: recompense, cellular uptake and toxicity concerns. Artif Cells Nanomed Biotechnol 44:401–409. https://doi.org/10.3109/21691401.2014.955106
Sivakumar B, Aswathy RG, Nagaoka Y et al (2014) Augmented cellular uptake and antiproliferation against pancreatic cancer cells induced by targeted curcumin and SPION encapsulated PLGA nanoformulation. Mater Express 4:183–195. https://doi.org/10.1166/mex.2014.1160
Skrabalak SE, Au L, Li XD, Xia YN (2007) Facile synthesis of Ag nanocubes and Au nanocages. Nat Protoc 2:2182–2190. https://doi.org/10.1038/nprot.2007.326
Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: A case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci 275:177–182. https://doi.org/10.1016/j.jcis.2004.02.012
Sperling RA, Parak WJ (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Trans R Soc London A Math Phys Eng Sci 368:1333–1383
Sperling RA, Gil PR, Zhang F et al (2008) Biological applications of gold nanoparticles. Chem Soc Rev 37:1896–1908
Stöber W, Fink A, Bohn E (1968) Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Interface Sci 26:62–69. https://doi.org/10.1016/0021-9797(68)90272-5
Sun C, Lee JS, Zhang M (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60:1252–1265. https://doi.org/10.1016/j.addr.2008.03.018
Swanner J, Mims J, Carroll DL et al (2015) Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Int J Nanomed 10:3937–3953
Teranishi T, Hasegawa S, Shimizu T, Miyake M (2001) Heat-induced size evolution of gold nanoparticles in the solid state. Adv Mater 13:1699–1701. https://doi.org/10.1002/1521-4095(200111)13:22%3c1699:aid-adma1699%3e3.0.co;2-3
Tong R, Kohane DS (2016) New strategies in cancer nanomedicine. In: Insel PA (ed) Annual review of pharmacology and toxicology, vol 56. Annual Reviews, Palo Alto, pp 41–57
Turkevich J, Stevenson PC, Hillier J (1951) A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss Faraday Soc 11:55–75
Ventola CL (2017) Progress in nanomedicine: approved and investigational nanodrugs. P T
Vines JB, Yoon JH, Ryu NE et al (2019) Gold nanoparticles for photothermal cancer therapy. Front, Chem
von Maltzahn G, Park J-H, Agrawal A et al (2009) Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res 69:3892–3900
Wady AF, Machado AL, Zucolotto V et al (2012) Evaluation of Candida albicans adhesion and biofilm formation on a denture base acrylic resin containing silver nanoparticles. J Appl Microbiol 112:1163–1172. https://doi.org/10.1111/j.1365-2672.2012.05293.x
Wagner AM, Knipe JM, Orive G, Peppas NA (2019) Quantum dots in biomedical applications. Acta Biomater 94:44–63. https://doi.org/10.1016/j.actbio.2019.05.022
Wan C, Tai J, Zhang J et al (2019) Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication. Cell Death Dis 10:392. https://doi.org/10.1038/s41419-019-1624-z
Wang YL, Newell BB, Irudayaraj J (2012) Folic acid protected silver nanocarriers for targeted drug delivery. J Biomed Nanotechnol 8:751–759. https://doi.org/10.1166/jbn.2012.1437
Wang P, Zhang L, Zheng W et al (2018) Thermo-triggered Release of CRISPR-Cas9 System by lipid-encapsulated gold nanoparticles for tumor therapy. Angew Chemie Int Ed. https://doi.org/10.1002/anie.201708689
Williams MJ, Corr SA (2013) Nanomedicine: chapter 2. Magnetic nanoparticles for targeted cancer diagnosis and therapy. Elsevier Science
Wu H, Lin J, Liu P et al (2016) Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs. Biomaterials 101:1–9. https://doi.org/10.1016/j.biomaterials.2016.05.031
Xia Y, Halas NJ (2005) Shape-controlled synthesis and surface plasmonic properties of metallic nanostructures. MRS Bull 30:338–348
Xin W, Severino J, De Rosa IM et al (2018) One-step synthesis of tunable-size gold nanoplates on graphene multilayers. Nano Lett. https://doi.org/10.1021/acs.nanolett.7b05173
Xu C, Nam J, Hong H et al (2019) Positron emission tomography-guided photodynamic therapy with biodegradable mesoporous silica nanoparticles for personalized cancer immunotherapy. ACS Nano 13:12148–12161. https://doi.org/10.1021/acsnano.9b06691
Yadav C, Surana K, Singh PK, Bhattacharya B (2019) An ultra-simple method for synthesis of violet CdS quantum dots at sub-room temperature. J Nanosci Nanotechnol 20:3935–3938. https://doi.org/10.1166/jnn.2020.17496
Yamada M, Foote M, Prow TW (2015) Therapeutic gold, silver, and platinum nanoparticles. Wiley Interdiscip Rev Nanobiotechnol 7:428–445. https://doi.org/10.1002/wnan.1322
Yang Y, Lan J, Xu Z et al (2014) Toxicity and biodistribution of aqueous synthesized ZnS and ZnO quantum dots in mice. Nanotoxicology 8:107–116. https://doi.org/10.3109/17435390.2012.760014
Yang X, Yang M, Pang B et al (2015) Gold nanomaterials at work in biomedicine. Chem Rev 115:10410–10488
Ye XC, Jin LH, Caglayan H et al (2012) Improved size-tunable synthesis of monodisperse gold nanorods through the use of aromatic additives. ACS Nano 6:2804–2817. https://doi.org/10.1021/nn300315j
Yoo J-W, Chambers E, Mitragotri S (2010) Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects. Curr Pharm Des 16:2298–2307
Zhang ZQ, Song SC (2016) Thermosensitive/superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels for multiple cancer hyperthermia. Biomaterials 106:13–23. https://doi.org/10.1016/j.biomaterials.2016.08.015
Zhang R, Wang L, Wang X et al (2020) Acid-induced in vivo assembly of gold nanoparticles for enhanced photoacoustic imaging-guided photothermal therapy of tumors. Adv Healthc Mater 9:2000394. https://doi.org/10.1002/adhm.202000394
Zhao P, Li N, Astruc D (2013) State of the art in gold nanoparticle synthesis. Coord Chem Rev 257:638–665
Zheng YQ, Zhong XL, Li ZY, Xia YN (2014) Successive, seed-mediated growth for the synthesis of single-crystal gold nanospheres with uniform diameters controlled in the range of 5–150 nm. Part Part Syst Charact 31:266–273. https://doi.org/10.1002/ppsc.201300256
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Lins, P.M.P., Ribovski, L., Sampaio, I., Santos, O.A., Zucolotto, V., Cancino-Bernardi, J. (2021). Inorganic Nanoparticles for Biomedical Applications. In: Eloy, J.O., Abriata, J.P., Marchetti, J.M. (eds) Nanocarriers for Drug Delivery. Nanomedicine and Nanotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-63389-9_3
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