Abstract
Enhanced mechanical forces are imposed on small and large vessels in hypertension. The enhanced transmural pressure increases predominantly circumferential wall stress that is returned toward control by adaptive mechanisms such as active constriction and eutrophic remodeling with concomitant increases of wall thickness. However, other hemodynamic, mechanical stresses are enhanced by such adaptive responses. Specifically, wall shear stress rises by pressure-induced constriction in smaller vessels provoking an endothelium-dependent dilation. A fine balance between these two homeostatic mechanisms that control wall stress and wall shear stress determines vascular tone in small resistance vessels which is shifted in hypertension toward higher vascular tone with enhanced peripheral resistance. Wall shear stress equals the frictional pressure loss during blood flow and must be larger to keep downstream capillary pressure stable, in the face of an increased pressure head. In this light, adaptive responses that decrease luminal diameter to control wall stress appear as maladaptive and energy-consuming. In large arteries, wall thickening is also observed in hypertension. However, the main impact of hypertension in large arteries, specifically elastic proximal vessels, is the profound consequence on pulse wave transmission. Pressure distends elastic arteries and consequently changes their capacity to store further volume during cardiac ejection in systole. This capacity depends on distensibility or compliance (the inverse of stiffness) which is decreased solely due to higher pressure. Changes in stiffness attributable to structural changes in the vessel wall are only found in young hypertensive individuals. Nevertheless, pulse wave velocity is largely increased due to the less compliant arteries at the prevailing pressure. This impacts hemodynamics in the pulsatile compartment of the vascular system that is governed by the Moens–Korteweg equation and wave reflections with dramatic consequences on other organs in the long run.
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References
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JLJ, Jones DW, Materson BJ, Oparil S, Wright JTJ, Roccella EJ (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206–1252
Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O’Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS (2019) Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation 139:e56–e528
Kokubo Y, Iwashima Y (2015) Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease. Hypertension 66:254–259
Humphrey JD, Schwartz MA, Tellides G, Milewicz DM (2015) Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res 116:1448–1461
Humphrey JD (2008) Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress. Hypertension 52:195–200
Wagenseil JE, Mecham RP (2009) Vascular extracellular matrix and arterial mechanics. Physiol Rev 89:957–989
Davis MJ (2012) Perspective: physiological role(s) of the vascular myogenic response. Microcirculation 19:99–114
Busse R, Fleming I (1998) Pulsatile stretch and shear stress: physical stimuli determining the production of endothelium-derived relaxing factors. J Vasc Res 35:73–84
Davies PF (1995) Flow-mediated endothelial mechanotransduction. Physiol Rev 75:519–560
Owens GK, Kumar MS, Wamhoff BR (2004) Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84:767–801
Lehoux S, Castier Y, Tedgui A (2006) Molecular mechanisms of the vascular responses to haemodynamic forces. J Intern Med 259:381–392
Lemarie CA, Tharaux PL, Lehoux S (2010) Extracellular matrix alterations in hypertensive vascular remodeling. J Mol Cell Cardiol 48:433–439
Humphrey JD, Dufresne ER, Schwartz MA (2014) Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 15:802–812
Brown IAM, Diederich L, Good ME, DeLalio LJ, Murphy SA, Cortese-Krott MM, Hall JL, Le TH, Isakson BE (2018) Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension. Arterioscler Thromb Vasc Biol 38:1969–1985
Lacolley P, Regnault V, Segers P, Laurent S (2017) Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease. Physiol Rev 97:1555–1617
Ingber DE (1997) Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol 59:575–599
Bayliss WM (1902) On the local reaction of the arterial wall to changes of internal pressure. J Physiol 28:220–231
Martinez-Lemus LA, Wu X, Wilson E, Hill MA, Davis GE, Davis MJ, Meininger GA (2003) Integrins as unique receptors for vascular control. J Vasc Res 40:211–233
Borgstrom P, Gestrelius S (1987) Integrated myogenic and metabolic control of vascular tone in skeletal muscle during autoregulation of blood flow. Microvasc Res 33:353–376
D’Angelo G, Meininger GA (1994) Transduction mechanisms involved in the regulation of myogenic activity. Hypertension 23:1096–1105
Davis MJ, Hill MA (1999) Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79:387–423
Davis MJ, Wu X, Nurkiewicz TR, Kawasaki J, Davis GE, Hill MA, Meininger GA (2001) Integrins and mechanotransduction of the vascular myogenic response. Am J Physiol Heart Circ Physiol 280:H1427–H1433
Hill MA, Zou H, Potocnik SJ, Meininger GA, Davis MJ (2001) Signal transduction in smooth muscle – Invited review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity. J Appl Physiol 91:973–983
Sharif-Naeini R, Dedman A, Folgering JHA, Duprat F, Patel A, Nilius B, Honore E (2008) TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch 456:529–540
Schubert R, Lidington D, Bolz SS (2008) The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res 77:8–18
Lidington D, Schubert R, Bolz SS (2013) Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. Cardiovasc Res 97:404–412
Earley S, Brayden JE (2015) Transient receptor potential channels in the vasculature. Physiol Rev 95:645–690
Mederos Y, Schnitzler M, Storch U, Gudermann T (2016) Mechanosensitive Gq/11 protein-coupled receptors mediate myogenic vasoconstriction. Microcirculation 23:621–625
Smulyan H, Mookherjee S, Safar ME (2016) The two faces of hypertension: role of aortic stiffness. J Am Soc Hypertens 10:175–183
Pohl U, Holtz J, Busse R, Bassenge E (1986) Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8:37–44
Beyer AM, Gutterman DD (2012) Regulation of the human coronary microcirculation. J Mol Cell Cardiol 52:814–821
Green DJ, Dawson EA, Groenewoud HMM, Jones H, Thijssen DHJ (2014) Is flow-mediated dilation nitric oxide mediated?: A meta-analysis. Hypertension 63:376–382
Hecker M, Mulsch A, Bassenge E, Busse R (1993) Vasoconstriction and increased flow – two principal mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol 265:H828–H833
Kurjiaka DT, Segal SS (1996) Autoregulation during pressor response elevates wall shear rate in arterioles. J Appl Physiol 80:598–604
Thorin-Trescases N, Bevan JA (1998) High levels of myogenic tone antagonize the dilator response to flow of small rabbit cerebral arteries. Stroke 29:1194–1200
de Wit C, Jahrbeck B, Schafer C, Bolz SS, Pohl U (1998) Nitric oxide opposes myogenic pressure responses predominantly in large arterioles in vivo. Hypertension 31:787–794
Koller A (2002) Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation 9:277–294
Muller JM, Davis MJ, Chilian WM (1996) Integrated regulation of pressure and flow in the coronary microcirculation. Cardiovasc Res 32:668–678
Harrigan TP (1997) Regulatory interaction between myogenic and shear-sensitive arterial segments: conditions for stable steady states. Ann Biomed Eng 25:635–643
Frisbee JC (2002) Regulation of in situ skeletal muscle arteriolar tone: interactions between two parameters. Microcirculation 9:443–462
Carlson BE, Arciero JC, Secomb TW (2008) Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses. Am J Physiol Heart Circ Physiol 295:H1572–H1579
Pohl U, de Wit C (1999) A unique role of NO in the control of blood flow. News Physiol Sci 14:74–80
Duncker DJ, Bache RJ (2008) Regulation of coronary blood flow during exercise. Physiol Rev 88:1009–1086
Falloon BJ, Bund SJ, Tulip JR, Heagerty AM (1993) In vitro perfusion studies of resistance artery function in genetic hypertension. Hypertension 22:486–495
Shimbo D, Muntner P, Mann D, Viera AJ, Homma S, Polak JF, Barr RG, Herrington D, Shea S (2010) Endothelial dysfunction and the risk of hypertension: the multi-ethnic study of atherosclerosis. Hypertension 55:1210–1216
Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT (2014) AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension. Sci Signal 7:ra66
Greaney JL, Kutz JL, Shank SW, Jandu S, Santhanam L, Alexander LM (2017) Impaired hydrogen sulfide-mediated vasodilation contributes to microvascular endothelial dysfunction in hypertensive adults. Hypertension 69:902–909
Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FBM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y (2017) Endothelial function is impaired in patients receiving antihypertensive drug treatment regardless of blood pressure level: FMD-J Study (Flow-Mediated Dilation Japan). Hypertension 70:790–797
Vanhoutte PM, Shimokawa H, Feletou M, Tang EHC (2017) Endothelial dysfunction and vascular disease – a 30th anniversary update. Acta Physiol (Oxf) 219:22–96
Seals DR, Brunt VE, Rossman MJ (2018) Keynote lecture: strategies for optimal cardiovascular aging. Am J Physiol Heart Circ Physiol 315:H183–H188
Donato AJ, Machin DR, Lesniewski LA (2018) Mechanisms of dysfunction in the aging vasculature and role in age-related disease. Circ Res 123:825–848
Fulop T, Jebelovszki E, Erdei N, Szerafin T, Forster T, Edes I, Koller A, Bagi Z (2007) Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension. Arterioscler Thromb Vasc Biol 27:2348–2354
Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD (2014) An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol 307:H1587–H1593
Wilson C, Zhang X, Buckley C, Heathcote HR, Lee MD, McCarron JG (2019) Increased vascular contractility in hypertension results from impaired endothelial calcium signaling. Hypertension 74:1200–1214
Dora KA, Doyle MP, Duling BR (1997) Elevation of intracellular calcium in smooth muscle causes endothelial cell generation of NO in arterioles. Proc Natl Acad Sci U S A 94:6529–6534
Isakson BE, Ramos SI, Duling BR (2007) Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction. Circ Res 100:246–254
Garland CJ, Bagher P, Powell C, Ye X, Lemmey HAL, Borysova L, Dora KA (2017) Voltage-dependent Ca(2+) entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles. Sci Signal 10:eaal3806
Folkow B (1982) Physiological aspects of primary hypertension. Physiol Rev 62:347–504
Prewitt RL, Rice DC, Dobrian AD (2002) Adaptation of resistance arteries to increases in pressure. Microcirculation 9:295–304
Heerkens EHJ, Izzard AS, Heagerty AM (2007) Integrins, vascular remodeling, and hypertension. Hypertension 49:1–4
Agabiti-Rosei E, Heagerty AM, Rizzoni D (2009) Effects of antihypertensive treatment on small artery remodelling. J Hypertens 27:1107–1114
Heagerty AM, Heerkens EH, Izzard AS (2010) Small artery structure and function in hypertension. J Cell Mol Med 14:1037–1043
Mulvany MJ (2012) Small artery remodelling in hypertension. Basic Clin Pharmacol Toxicol 110:49–55
Laurent S, Boutouyrie P (2015) The structural factor of hypertension: large and small artery alterations. Circ Res 116:1007–1021
Pires PW, Jackson WF, Dorrance AM (2015) Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol 309:H127–H136
Gao YJ, Yang LF, Stead S, Lee RMKW (2008) Flow-induced vascular remodeling in the mesenteric artery of spontaneously hypertensive rats. Can J Physiol Pharmacol 86:737–744
van den Akker J, Schoorl MJC, Bakker ENTP, Vanbavel E (2010) Small artery remodeling: current concepts and questions. J Vasc Res 47:183–202
Rosei EA, Rizzoni D (2010) Small artery remodelling in diabetes. J Cell Mol Med 14:1030–1036
Touyz RM, Schiffrin EL (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 52:639–672
Schiffrin EL, Touyz RM (2004) From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol 287:H435–H446
Intengan HD, Thibault G, Li JS, Schiffrin EL (1999) Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats: effects of angiotensin receptor antagonism and converting enzyme inhibition. Circulation 100:2267–2275
Intengan HD, Deng LY, Li JS, Schiffrin EL (1999) Mechanics and composition of human subcutaneous resistance arteries in essential hypertension. Hypertension 33:569–574
Intengan HD, Schiffrin EL (2000) Structure and mechanical properties of resistance arteries in hypertension – role of adhesion molecules and extracellular matrix determinants. Hypertension 36:312–318
Bakker ENTP, Buus CL, VanBavel E, Mulvany MJ (2004) Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodeling. J Vasc Res 41:174–182
Bakker ENTP, van der Meulen ET, van den Berg BM, Everts V, Spaan JAE, VanBavel E (2002) Inward remodeling follows chronic vasoconstriction in isolated resistance arteries. J Vasc Res 39:12–20
Bakker ENTP, Matlung HL, Bonta P, de Vries CJ, van Rooijen N, Vanbavel E (2008) Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone. Cardiovasc Res 78:341–348
Schiffrin EL, Park JB, Intengan HD, Touyz RM (2000) Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 101:1653–1659
Li JS, Sharifi AM, Schiffrin EL (1997) Effect of AT(1) angiotensin-receptor blockade on structure and function of small arteries in SHR. J Cardiovasc Pharmacol 30:75–83
Sorop O, Bakker ENTP, Pistea A, Spaan JAE, VanBavel E (2006) Calcium channel blockade prevents pressure-dependent inward remodeling in isolated subendocardial resistance vessels. Am J Physiol Heart Circ Physiol 291:H1236–H1245
Intengan HD, Schiffrin EL (2001) Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38:581–587
Martinez-Lemus LA, Hill MA, Meininger GA (2009) The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology (Bethesda) 24:45–57
Tuna BG, Bakker ENTP, VanBavel E (2012) Smooth muscle biomechanics and plasticity: relevance for vascular calibre and remodelling. Basic Clin Pharmacol Toxicol 110:35–41
Huelsz-Prince G, Belkin AM, VanBavel E, Bakker ENTP (2013) Activation of extracellular transglutaminase 2 by mechanical force in the arterial wall. J Vasc Res 50:383–395
Isnard RN, Pannier BM, Laurent S, London GM, Diebold B, Safar ME (1989) Pulsatile diameter and elastic modulus of the aortic arch in essential hypertension: a noninvasive study. J Am Coll Cardiol 13:399–405
Benetos A, Laurent S, Hoeks AP, Boutouyrie PH, Safar ME (1993) Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries. Arterioscler Thromb 13:90–97
Laurent S, Girerd X, Mourad JJ, Lacolley P, Beck L, Boutouyrie P, Mignot JP, Safar M (1994) Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension. Arterioscler Thromb 14:1223–1231
Laurent S, Caviezel B, Beck L, Girerd X, Billaud E, Boutouyrie P, Hoeks A, Safar M (1994) Carotid artery distensibility and distending pressure in hypertensive humans. Hypertension 23:878–883
Milan A, Tosello F, Caserta M, Naso D, Puglisi E, Magnino C, Comoglio C, Rabbia F, Mulatero P, Veglio F (2011) Aortic size index enlargement is associated with central hemodynamics in essential hypertension. Hypertens Res 34:126–132
Duca L, Blaise S, Romier B, Laffargue M, Gayral S, El Btaouri H, Kawecki C, Guillot A, Martiny L, Debelle L, Maurice P (2016) Matrix ageing and vascular impacts: focus on elastin fragmentation. Cardiovasc Res 110:298–308
Boutouyrie P, Bussy C, Lacolley P, Girerd X, Laloux B, Laurent S (1999) Association between local pulse pressure, mean blood pressure, and large-artery remodeling. Circulation 100:1387–1393
O’Rourke M (1990) Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. Hypertension 15:339–347
Sherratt MJ (2009) Tissue elasticity and the ageing elastic fibre. Age (Dordr) 31:305–325
Shapiro SD, Endicott SK, Province MA, Pierce JA, Campbell EJ (1991) Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 87:1828–1834
Lehoux S, Tedgui A (2003) Cellular mechanics and gene expression in blood vessels. J Biomech 36:631–643
Dinardo CL, Venturini G, Zhou EH, Watanabe IS, Campos LCG, Dariolli R, da Motta-Leal-Filho JM, Carvalho VM, Cardozo KHM, Krieger JE, Alencar AM, Pereira AC (2014) Variation of mechanical properties and quantitative proteomics of VSMC along the arterial tree. Am J Physiol Heart Circ Physiol 306:H505–H516
Cattaruzza M, Lattrich C, Hecker M (2004) Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells. Hypertension 43:726–730
Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wojtowicz A, Sticht C, Gretz N, Wagner AH, Korff T, Hecker M (2015) Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells. J Am Heart Assoc 4:e001712
Pfisterer L, Feldner A, Hecker M, Korff T (2012) Hypertension impairs myocardin function: a novel mechanism facilitating arterial remodelling. Cardiovasc Res 96:120–129
Bussy C, Boutouyrie P, Lacolley P, Challande P, Laurent S (2000) Intrinsic stiffness of the carotid arterial wall material in essential hypertensives. Hypertension 35:1049–1054
Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27:2588–2605
Safar ME, Levy BI, Struijker-Boudier H (2003) Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 107:2864–2869
The Reference Values for Arterial Stiffness’ Collaboration X (2010) Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’. Eur Heart J 31:2338–2350
Langewouters GJ, Wesseling KH, Goedhard WJ (1984) The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. J Biomech 17:425–435
Westenberg JJM, van Poelgeest EP, Steendijk P, Grotenhuis HB, Jukema JW, de Roos A (2012) Bramwell-Hill modeling for local aortic pulse wave velocity estimation: a validation study with velocity-encoded cardiovascular magnetic resonance and invasive pressure assessment. J Cardiovasc Magn Reson 14:2
Megerman J, Hasson JE, Warnock DF, L’Italien GJ, Abbott WM (1986) Noninvasive measurements of nonlinear arterial elasticity. Am J Physiol 250:H181–H188
Hayoz D, Rutschmann B, Perret F, Niederberger M, Tardy Y, Mooser V, Nussberger J, Waeber B, Brunner HR (1992) Conduit artery compliance and distensibility are not necessarily reduced in hypertension. Hypertension 20:1–6
Hayashi K, Naiki T (2009) Adaptation and remodeling of vascular wall; biomechanical response to hypertension. J Mech Behav Biomed Mater 2:3–19
Merillon JP, Fontenier GJ, Lerallut JF, Jaffrin MY, Motte GA, Genain CP, Gourgon RR (1982) Aortic input impedance in normal man and arterial hypertension: its modification during changes in aortic pressure. Cardiovasc Res 16:646–656
Sehgel NL, Zhu Y, Sun Z, Trzeciakowski JP, Hong Z, Hunter WC, Vatner DE, Meininger GA, Vatner SF (2013) Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension. Am J Physiol Heart Circ Physiol 305:H1281–H1287
London GM, Pannier B (2010) Arterial functions: how to interpret the complex physiology. Nephrol Dial Transplant 25:3815–3823
Safar ME, Nilsson PM, Blacher J, Mimran A (2012) Pulse pressure, arterial stiffness, and end-organ damage. Curr Hypertens Rep 14:339–344
Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB (2014) Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 63:636–646
Bruno RM, Cartoni G, Stea F, Armenia S, Bianchini E, Buralli S, Giannarelli C, Taddei S, Ghiadoni L (2017) Carotid and aortic stiffness in essential hypertension and their relation with target organ damage: the CATOD study. J Hypertens 35:310–318
Safar ME, Asmar R, Benetos A, Blacher J, Boutouyrie P, Lacolley P, Laurent S, London G, Pannier B, Protogerou A, Regnault V (2018) Interaction between hypertension and arterial stiffness. Hypertension 72:796–805
Safar ME (2010) Arterial aging–hemodynamic changes and therapeutic options. Nat Rev Cardiol 7:442–449
Benetos A, Gautier S, Labat C, Salvi P, Valbusa F, Marino F, Toulza O, Agnoletti D, Zamboni M, Dubail D, Manckoundia P, Rolland Y, Hanon O, Perret-Guillaume C, Lacolley P, Safar ME, Guillemin F (2012) Mortality and cardiovascular events are best predicted by low central/peripheral pulse pressure amplification but not by high blood pressure levels in elderly nursing home subjects: the PARTAGE (Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population) study. J Am Coll Cardiol 60:1503–1511
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This work was supported by grants from the German Ministry of Research (BMBF) and the German Centre for Cardiovascular Research (DZHK).
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Work in my lab is funded by grants from the German Ministry of Research (BMBF) and the German Centre for Cardiovascular Research (DZHK).
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The author declares that he has no conflict of interest.
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de Wit, C. (2021). Mechanobiology of Arterial Hypertension. In: Hecker, M., Duncker, D.J. (eds) Vascular Mechanobiology in Physiology and Disease. Cardiac and Vascular Biology, vol 8. Springer, Cham. https://doi.org/10.1007/978-3-030-63164-2_10
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