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State of the Art of Bone Regeneration

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Advances in Integrated Design and Production (CPI 2019)

Part of the book series: Lecture Notes in Mechanical Engineering ((LNME))

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Abstract

Scaffold design for bone tissue engineering try to mimic the function of the natural extracellular matrix, to promote the regeneration of damage tissue.

Improving their bioactivity requires a better understanding of the structural effects and mechanical behavior on the bone reconstruction process. This article reviews the relevant literature on mechanobiology of bone reconstruction at different length scales. In the first part the reader is introduced to structure and bone composition. Then the remodeling process associated with cellular mechanotransduction is presented. Indeed, bone cells are extremely sensitive to mechanical loads, so bone has the ability to optimize its architecture according to the mechanical stresses it undergoes. The interest and specificity of the piezoelectric effects of bone compared to a conventional piezoelectric material are analyzed. Finally, we suggest that interdisciplinary approaches, combining mechanobiology and Materiobiology will inspire innovative ideas to satisfy the design requirements of scaffolds for bone tissue regeneration.

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Author information

Authors and Affiliations

  1. Applied Polymer Research Team, ERAP ENSEM, Hassan II University, Casablanca, Morocco

    Fatima Haddani

Authors
  1. Fatima Haddani
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  2. Anas El Maliki
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Corresponding author

Correspondence to Fatima Haddani .

Editor information

Editors and Affiliations

  1. Ecole Nationale des Sciences Appliquées, Fès, Morocco

    Abdelmjid Saka

  2. Institut supérieur de mécanique de Paris, Saint-Ouen, France

    Jean-Yves Choley

  3. National School of Engineers of Sfax, Sfax, Tunisia

    Jamel Louati

  4. Ecole Nationale des Sciences Appliquées, Fès, Morocco

    Zakaria Chalh

  5. National School of Engineers of Sfax, Sfax, Tunisia

    Maher Barkallah

  6. Ecole Nationale des Sciences Appliquées, Fès, Morocco

    Mohammed Alfidi

  7. Laboratoire des Sciences des Procédés, Villetaneuse, France

    Mounir Ben Amar

  8. National School of Engineers of Sfax, Sfax, Tunisia

    Fakher Chaari

  9. National School of Engineers of Sfax, Sfax, Tunisia

    Mohamed Haddar

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Haddani, F., El Maliki, A. (2021). State of the Art of Bone Regeneration. In: Saka, A., et al. Advances in Integrated Design and Production. CPI 2019. Lecture Notes in Mechanical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-62199-5_41

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  • DOI: https://doi.org/10.1007/978-3-030-62199-5_41

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-62198-8

  • Online ISBN: 978-3-030-62199-5

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