Therapy of Sleep Disorders in Parkinson’s Disease

Gandor, F.; Ebersbach, G.

doi:10.1007/978-3-030-62059-2_460

F. Gandor^6,7 &
G. Ebersbach⁶

36 Accesses

Abstract

Up to 80% of patients with Parkinson’s disease suffer from a wide range of sleep disorders in all stages of the disease. While restless legs syndrome as one contributor to a disturbed night sleep can be present at any stage in the disease, sleep disturbances in the advanced stages of Parkinson’s disease are usually linked to motor impairment during the night. In late stages of the disease psychiatric symptoms, with nocturnal hallucinations and disorientation due to cognitive decline, often contribute to disturbance of night sleep. In contrast, rapid eye movement sleep behavioral disorder can antedate the onset of motor symptoms in Parkinson’s disease and is considered a robust marker and thereby prodromal symptom of an emerging neurodegeneration due to alphasynuclein accumulation. The heterogeneity in pathophysiology and clinical manifestation makes it impossible to recommend one uniform therapy strategy for sleep disorders associated with Parkinson’s disease. This chapter offers a comprehensive approach to diagnosis and management of the different sleep disorders in Parkinson’s disease.

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Abbreviations

AHI:: Aapnea-hypoxia-index
CNS:: central nervous system
COMT:: catechol-O-methyl-transferase
EDS:: excessive daytime sleepiness
ESS:: Epworth sleepiness scale
ICD:: impulse control disorder
ISCS:: inappropriate sleep composite scale
MAO-B:: mono-amino-oxidase B
MRI:: magnetic resonance imaging
MSLT:: multiple sleep latency test
NMDA:: N-methyl-_D-aspartate
PAP:: positive airway pressure
aPAP:: automatic PAP
bi-PAP:: biphasic PAP
cPAP:: chronic PAP
PD:: Parkinson’s disease
PDSS:: Parkinson’s disease sleep scale
PLMD:: periodic limb movement disorder
PSG:: polysomnography
PSQI:: Pittsburgh sleep quality index
RBD:: REM-sleep behavior disorder
RCT:: randomized clinical trial
REM:: rapid eye movements
RERA:: respiratory effort related arousal
RLS:: restless legs syndrome
SCOPA:: scale for outcomes in Parkinson’s disease
SNRI:: serotonin and noradrenaline reuptake inhibitors
SSRI:: selective serotonin reuptake inhibitors
SSS:: Stanford sleepiness scale

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Authors and Affiliations

Movement Disorders Hospital, Kliniken Beelitz GmbH, Beelitz-Heilstätten, Brandenburg, Germany
F. Gandor & G. Ebersbach
Department of Neurology, Otto-von-Guericke University, Magdeburg, Saxony-Anhalt, Germany
F. Gandor

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F. Gandor
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G. Ebersbach
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Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
Peter Riederer
Institute of Psychological Medicine (IPM), Soyen, Germany
Gerd Laux
Centre for Research Promotion and Support, Fujita Health University, Toyoake, Aichi, Japan
Toshiharu Nagatsu
Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China
Weidong Le
Würzburg, Germany
Christian Riederer

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Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany
Peter Riederer
Center for Research Promotion and Support, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Toshiharu Nagatsu

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Gandor, F., Ebersbach, G. (2022). Therapy of Sleep Disorders in Parkinson’s Disease. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-030-62059-2_460

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DOI: https://doi.org/10.1007/978-3-030-62059-2_460
Published: 05 November 2022
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-62058-5
Online ISBN: 978-3-030-62059-2
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