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Reproduction

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Emergent Medicine and the Law

Abstract

This chapter sets out the science of reproduction and the developments in forms of assisted reproduction. It also explains forms of manipulation of gametes in practices such as gene editing. It looks forward to the possibility of ectogenesis. For each of these it explores challenges to the traditional legal regulation, in particular over the definitions of parenthood and the status of the fetus. It considers the challenges posed to legal regulation of reproduction now that it can involve more than simply creating a child and can include changing their biological make-up.

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Notes

  1. 1.

    Evans v. UK (2007) 43 EHRR 21.

  2. 2.

    Abortion Act 1967, as amended by the Human Fertilisation and Embryology Act 1990.

  3. 3.

    Section 4A(3) of the Human Fertilisation and Embryology Act 1990.

  4. 4.

    Human Fertilisation and Embryology Act 1990, section 4A.

  5. 5.

    Paton v. British Pregnancy Advisory Service Trustees and Another [1978] QB 276.

  6. 6.

    CP (A Child) v. First-Tier Tribunal (Criminal Injuries Compensation) [2014] EWCA Civ 1554.

References

  • B. Alberts (2003) DNA replication and recombination. Nature, 421, 431–435.

    Article  Google Scholar 

  • B. Alberts, A. Johnson, J. Lewis, D. Morgan, M. Raff, K. Roberts and P. Walter (2014) Molecular Biology of the Cell. Garland Science, New York, USA, 6th edn.

    Google Scholar 

  • D. P. Alexander, H. G. Britton and D. A. Nixon (1968) Maintenance of sheep fetuses by an extracorporeal circuit for periods up to 24 hours. American Journal of Obstetrics and Gynecology, 102, 969–975.

    Article  Google Scholar 

  • C. D. Allis, M.-L. Caparros, T. Jenuwein, D. Reinberg and M. Lachner (2015) Epigenetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2nd edn.

    Google Scholar 

  • A. C. Allison (1954) Protection afforded by sickle-cell trait against subtertian malarial infection. British Medical Journal, 1(4857), 290–294.

    Article  Google Scholar 

  • R. Altmann (1881) Die Elementarorganismen und ihre Beziehungen zu den Zellen. Verlag von Veit und Comp., Leipzig, Germany.

    Google Scholar 

  • S. Andalib, M. S. Vafaee and A. Gjedde (2014) Parkinson’s disease and mitochondrial gene variations: a review. Journal of the Neurological Sciences, 346, 11–19.

    Article  Google Scholar 

  • S. Anderson, A. T. Bankier, B. G. Barrell, M. H. L. de Bruijn, A. R. Coulson, J. Drouin, I. C. Eperon, D. P. Nierlich, B. A. Roe, F. Sanger, P. H. Schreier, A. J. H. Smith, R. Staden and I. G. Young (1981) Sequence and organization of the human mitochondrial genome. Nature, 290, 457–465.

    Article  Google Scholar 

  • G. J. Annas (1994) Regulatory models for human embryo cloning: the free market, professional guidelines and government restrictions. Kennedy Institute of Ethics Journal, 4, 235–249.

    Article  Google Scholar 

  • G. J. Annas (1998) Human cloning: a choice or an echo? University of Dayton Law Review, 23, 247–275.

    Google Scholar 

  • G. J. Annas, L. B. Andrews and R. M. Isasit (2002) Protecting the endangered human: toward an international treaty prohibiting cloning and inheritable alterations. American Journal of Law and Medicine, 28, 151–178.

    Article  Google Scholar 

  • A. V. Anzalone, P. B. Randolph, J. R. Davis, A. A. Sousa, L. W. Koblan, J. M. Levy, P. J. Chen, C. Wilson, G. A. Newby, A. Raguram and D. R. Liu (2019) Search-and-replace genome editing without double-strand breaks or donor DNA. Nature, 576, 149–157.

    Article  Google Scholar 

  • R. H. Asch, L. R. Ellsworth, J. P. Balmaceda and P. C. Wong (1984) Pregnancy after translaparoscopic gamete intrafallopian transfer. Lancet, 324, 1034–1035.

    Article  Google Scholar 

  • O. T. Avery, C. M. MacLeod and M. McCarty (1944) Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Journal of Experimental Medicine, 79, 137–158.

    Article  Google Scholar 

  • R. Barrangou and J. A. Doudna (2016) Applications of CRISPR technologies in research and beyond. Nature Biotechnology, 34, 933–941.

    Article  Google Scholar 

  • F. Baylis (2013) The ethics of creating children with three genetic parents. Reproductive Biomedicine Online, 26, 531–534.

    Article  Google Scholar 

  • F. Baylis and M. McLeod (2017) First-in-human Phase 1 CRISPR gene editing cancer trials: are we ready? Current Gene Therapy, 17, 309–319.

    Google Scholar 

  • C. Benda (1898) Über die Spermatogenese der Vertebraten und höherer Evertebraten, II. Theil: Die Histiogenese der Spermien. Archiv für Anatomie und Physiologie, 73, 393–398.

    Google Scholar 

  • O. A. Bodamer, C. R. Scott and R. Giugliani (2017) Newborn screening for Pompe disease. Pediatrics, 140, S1–S13.

    Article  Google Scholar 

  • T. Boveri (1887) Zellenstudien I: Die Bildung der Richtungskörper bei Ascaris megalocephala und Ascaris lumbricoides. Jenaische Zeitschrift für Naturwissenschaft, 21, 423–515.

    Google Scholar 

  • T. Boveri (1889) Ein geschlechtlich erzeugter Organismus ohne mütterliche Eigenschaften. Sitzungsberichte der Gesellschaft für Morphologie und Physiologie in München, 5, 73–80.

    Google Scholar 

  • T. Boveri (1895) Über die Befruchtung- und Entwicklungsfähigkeit kernloser Seeigeleier und über die Möglichkeit ihrer Bastardierung. Archiv für Entwicklungsmechanik, 2, 394–443.

    Article  Google Scholar 

  • R. Briggs and T. J. King (1952) Transplantation of living nuclei from blastula cells into enucleated frog’s eggs. Proceedings of the National Academy of Science USA, 38, 455–463.

    Google Scholar 

  • B. Brown (2002) Human cloning and genetic engineering: the case for proceeding cautiously. Albany Law Review, 65, 649–677.

    Google Scholar 

  • B. Bryner, B. Gray, E. Perkins, R. Davis, H. Hoffman, J. Barks, G. Owens, M. Bocks, A. Rojas-Peña, R. Hirschl, R. Bartless and G. Mychaliska (2015) An extracorporeal artificial placenta supports extremely premature lambs for 1 week. Journal of Pediatric Surgery, 50, 44–49.

    Article  Google Scholar 

  • A. K. Burin (2014) Beyond pragmatism: defending the ‘bright line’ of birth. Medical Law Review, 22, 494–525.

    Article  Google Scholar 

  • J. Burley and J. Harris (1999) Human cloning and child welfare. Journal of Medical Ethics, 25, 108–113.

    Article  Google Scholar 

  • A. Burt (2000) Perspective: sex, recombination, and the efficacy of selection – was Weismann right? Evolution, 54, 337–351.

    Google Scholar 

  • J. C. Callaghan, D. Cardozo, B. Boracchia and A. Alesiuk (1962) Study of prepulmonary bypass in development of an artificial placenta for prematurity and respiratory distress syndrome of the newborn. Journal of Thoracic and Cardiovascular Surgery, 44, 600–607.

    Article  Google Scholar 

  • E. Callaway (2014) Reproductive medicine: the power of three. Nature, 509, 414–417.

    Article  Google Scholar 

  • C. S. Campbell (1998) Resistance and meaning: religious communities and human cloning. Valparaiso University Law Review, 32, 607–631.

    Google Scholar 

  • K. H. S. Campbell, P. Loi, P. J. Otaegui and I. Wilmut (1996a) Cell cycle co-ordination in embryo cloning by nuclear transfer. Reviews of Reproduction, 1, 40–46.

    Article  Google Scholar 

  • K. H. S. Campbell, J. McWhir, W. A. Ritchie and I. Wilmut (1996b) Sheep cloned by nuclear transfer from a cultured cell line. Nature, 380, 64–66.

    Article  Google Scholar 

  • H. Campo, I. Cervelló and C. Simón (2017) Bioengineering the uterus: an overview of recent advances and future perspectives in reproductive medicine. Annals of Biomedical Engineering, 45, 1710–1717.

    Article  Google Scholar 

  • A. L. Caplan (2018) Monkey see, humans won’t do — the misguided reaction to the cloning of primates. EMBO Reports, 19, article number e45912.

    Google Scholar 

  • L. Chen, T. Yang, Z. Zheng, H. Yu, H. Wang and J. Qin (2018) Birth prevalence of congenital malformations in singleton pregnancies resulting from in vitro fertilization/intracytoplasmic sperm injection worldwide: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 297, 1115–1130.

    Article  Google Scholar 

  • M. Chen and L. K. Heilbronn (2017) The health outcomes of human offspring conceived by assisted reproductive technologies (ART). Journal of Developmental Origins of Health and Disease, 8, 388–402.

    Article  Google Scholar 

  • S.-C. Chiang, W.-L. Hwu, N.-C. Lee, L.-W. Hsu and Y.-H. Chien (2012) Algorithm for Pompe disease newborn screening: results from the Taiwan screening program. Molecular Genetics and Metabolism, 106, 281–286.

    Article  Google Scholar 

  • M. Clamp, B. Fry, M. Kamal, X. Xie, J. Cuff, M. F. Lin, M. Kellis, K. Lindblad-Toh and E. S. Lander (2007) Distinguishing protein-coding and noncoding genes in the human genome. Proceedings of the National Academy of Sciences USA, 104, 19428–19433.

    Google Scholar 

  • A. Coleman (1999) Why human cloning should not be attempted. In: J. Burley, ed., The Genetic Revolution and Human Rights, pp. 14–18. Oxford University Press, Oxford, UK.

    Google Scholar 

  • M. L. Condic (2014) Totipotency: what it is and what it is not. Stem Cells and Development, 23, 796–812.

    Article  Google Scholar 

  • L. Craven, H. A. Tuppen, G. D. Greggains, S. J. Harbottle, J. L. Murphy, L. M. Cree, A. P. Murdoch, P. F. Chinnery, R. W. Taylor, R. N. Lightowlers, M. Herbert and D. M. Turnbull (2010) Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature, 465, 82–85.

    Article  Google Scholar 

  • D. Cyranoski (2016) CRISPR gene editing tested in a person. Nature, 539, 479.

    Article  Google Scholar 

  • D. Cyranoski and H. Ledford (2018) International outcry over genome-edited baby claim. Nature, 563, 607–608.

    Article  Google Scholar 

  • T. Q. Dang-Nguyen and M.-E. Torres-Padilla (2015) How cells build totipotency and pluripotency: nuclear, chromatin and transcriptional architecture. Current Opinion in Cell Biology, 34, 9–15.

    Article  Google Scholar 

  • G. Davies, A. Tenesa, A. Payton, J. Yang, S. E. Harris, D. Liewald, X. Ke, S. Le Hellard, A. Christoforou, M. Luciano, K. McGhee, L. Lopez, A. J. Gow, J. Corley, P. Redmond, H. C. Fox, P. Haggarty, L. J. Whalley, G. McNeill, M. E. Goddard, T. Espeseth, A. J. Lundervold, I. Reinvang, A. Pickles, V. M. Steen, W. Ollier, D. J. Porteous, M. Horan, J. M. Starr, N. Pendleton, P. M. Visscher and I. J. Deary (2011) Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry, 16, 996–1005.

    Article  Google Scholar 

  • D. S. Davis (1999) Religious attitudes towards cloning: a tale of two creatures. Hofstra Law Review, 27, 509–521.

    Google Scholar 

  • Department of Health (2020) Abortion Statistics England and Wales 2018. Department of Health, UK Government, London, UK.

    Google Scholar 

  • E. Dorff (1998) Human cloning: a Jewish perspective. Southern California Interdisciplinary Law Journal, 8, 117–129.

    Google Scholar 

  • ESHRE Capri Workshop Group (2009) Intrauterine insemination. Human Reproduction Update, 15, 265–277.

    Article  Google Scholar 

  • H. E. Fadel (2002) The Islamic viewpoint on new assisted reproductive technologies. Fordham Urban Law Journal, 30, 147–157.

    Google Scholar 

  • G. Felsenfeld and M. Groudine (2003) Controlling the double helix. Nature, 421, 448–453.

    Article  Google Scholar 

  • J. Finnis (1998) Public reason, abortion and cloning. Valparaiso University Law Review, 32, 361–382.

    Google Scholar 

  • E. P. Foley (2002) The constitutional implications of a cloning society. Cumberland Law Review, 32, 503–518.

    Google Scholar 

  • M. Ford (2005) A property model of pregnancy. International Journal of Law in Context, 1, 261–293.

    Article  Google Scholar 

  • M. Garavaglia (2002) The value of the post-modern child: property, personhood or purgatory. University of Detroit Mercy Law Review, 80, 1–30.

    Google Scholar 

  • S. F. Gilbert (1994) A Conceptual History of Modern Embryology. Johns Hopkins University Press, Baltimore, USA.

    Google Scholar 

  • R. E. Giles, H. Blanc, H. M. Cann and D. C. Wallace (1980) Maternal inheritance of human mitochondrial DNA. Proceedings of the National Academy of Sciences USA, 77, 6715–6719.

    Google Scholar 

  • M. R. Goddard, H. C. J. Godfray and A. Burt (2005) Sex increase the efficacy of natural selection in experimental yeast populations. Nature, 434, 636–640.

    Article  Google Scholar 

  • S. Golombok (2017) Parenting in new family forms. Current Opinion in Psychology, 15, 76–80.

    Article  Google Scholar 

  • R. G. Gosden (2000) Designing Babies: The Brave New World of Reproductive Technology. W.H. Freeman and Company, New York, USA.

    Google Scholar 

  • B. W. Gray, A. El-Sabbagh, A. Rojas-Peña, A. C. Kim, S. Gadepalli, K. L. Koch, T. R. Capizzani, R. H. Bartlett and G. B. Mychaliska (2012) Development of an artificial placenta IV: 24-hour venovenous extracorporeal life support in premature lambs. ASIAO Journal, 58, 148–154.

    Article  Google Scholar 

  • J. B. Gurdon, R. A. Laskey and O. R. Reeves (1975) The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. Journal of Embryology and Experimental Morphology, 34, 93–112.

    Google Scholar 

  • J. B. Gurdon, R. A. Laskey, E. M. de Robertis and G. A. Partington (1979) Reprogramming of transplanted nuclei in amphibia. In: J. F. Danielli and M. A. DiBernadino, eds., International Review of Cytology Supplement 9 Nuclear Transplanation, pp. 118–126. Academic Press, New York, USA.

    Google Scholar 

  • R. Guthrie (1992) The origin of newborn screening. Screening, 1, 5–15.

    Article  Google Scholar 

  • M. F. Guyer (1910) Accessory chromosomes in man. Biological Bulletin, 19, 219–234.

    Article  Google Scholar 

  • T. T. Hackett (1998) The legal implications of human cloning – (proliferation or extinction)? Thurgood Marshall Law Review, 24, 305–326.

    Google Scholar 

  • J. B. S. Haldane (1924) Daedalus, or Science and the Future. Kegan Paul, Trench, Trubner and Company, London, UK.

    Google Scholar 

  • A. H. Handyside, E. H. Kontogianni, K. Hardy and R. M. L. Winston (1990) Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature, 344, 768–770.

    Article  Google Scholar 

  • Y. Hara, F. Yuk, R. Puri, W. G. M. Janssen, P. R. Rapp and J. H. Morrison (2014) Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proceedings of the National Academy of Sciences USA, 111, 486–491.

    Google Scholar 

  • J. Harris (2016) How to be Good: the Possibility of Moral Enhancement. Oxford University Press, Oxford, UK.

    Book  Google Scholar 

  • J. B. Herrick (1910) Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Archives of Internal Medicine, 6, 517–521.

    Article  Google Scholar 

  • J. Herring (2019a) Ethics of care and the public good of abortion. University of Oxford Human Rights Hub Journal, 1, 1–22.

    Google Scholar 

  • J. Herring (2019b) Family Law. Pearson, Basingstoke, UK.

    Google Scholar 

  • J. Herring (2019c) Law and the Relational Self. Cambridge University Press, Cambridge, UK.

    Book  Google Scholar 

  • J. Herring (2020) Relational personhood. Keele Law Journal, 1.

    Google Scholar 

  • A. D. Hershey and M. Chase (1952) Independent functions of viral protein and nucleic acid in growth of bacteriophase. Journal of General Physiology, 36, 39–56.

    Article  Google Scholar 

  • P. Hoang, P. Park, L. J. Cobb, V. Paharkova-Vatchkova, M. Hakimi, P. Cohen and K. W. Lee (2010) The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in non-obese diabetc mice. Metabolism, 59, 343–349.

    Article  Google Scholar 

  • S. G. Holtan, D. J. Creedon, P. Haluska and S. N. Markovic (2009) Cancer and pregnancy: parallels in growth, invasion and immune modulation and implications for cancer therapeutic agents. Mayo Clinic Proceedings, 84, 985–1000.

    Google Scholar 

  • House of Lords (2002) House of Lords Select Committee on Stem Cell Research.

    Google Scholar 

  • J. M. Humber and R. F. Almeder (1998) Human Cloning. Humana Press, Totowa, New Jersey, USA.

    Book  Google Scholar 

  • L. A. Hyslop, P. Blakeley, L. Craven, J. Richardson, N. M. E. Fogarty, E. Fragouli, M. Lamb, S. E. Wamaitha, N. Prathalingam, Q. Zhang, H. O’Keefe, Y. Takeda, L. Arizzi, S. Alfarawati, H. A. Tuppen, L. Irving, D. Kalleas, M. Choudhary, D. Wells, A. P. Murdoch, D. M. Turnbull, K. K. Niakan and M. Herbert (2016) Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature, 534, 383–386.

    Article  Google Scholar 

  • V. M. Ingram (1956) A specific chemical difference between globins of normal and sickle-cell anaemia haemoglobins. Nature, 178, 792–794.

    Article  Google Scholar 

  • V. M. Ingram (1957) Gene mutations in human haemoglobin: the chemical difference between normal and sickle haemoglobin. Nature, 180, 326–328.

    Article  Google Scholar 

  • J. Jaenike (1978) An hypothesis to account for the maintenance of sex within populations. Evolution Theory, 3, 191–194.

    Google Scholar 

  • K. J. C. Janosek-Albright, P. N. Schlegel and A. A. Dabaja (2015) Testis sperm extraction. Asian Journal of Urology, 2, 79–84.

    Article  Google Scholar 

  • J. K. Joung and J. D. Sander (2013) TALENs: a widely applicable technology for targeted genome editing. Nature Reviews Molecular Cell Biology, 14, 49–55.

    Article  Google Scholar 

  • H. F. Judson (1979) The Eighth Day of Creation. Simon and Schuster, New York, USA.

    Google Scholar 

  • H. Kalmus (1932) Über den Erhaltungswert den phänotypischen (morphologischen) Anisogamie und die Entstehung der ersten Geschlectsunterschiede. Biologisches Zentralblatt, 52, 716–726.

    Google Scholar 

  • R. M. Kamel (2010) Management of the infertile couple: an evidence-based protocol. Reproductive Biology and Endocrinology, 8, article no. 21.

    Google Scholar 

  • F. M. Kamm (2000) Cloning and harm to offspring. New York University Journal of Legislation and Public Policy, 4, 65–76.

    Google Scholar 

  • L. R. Kass (1998) The wisdom of repugnance: why we should ban the cloning of humans. Valparaiso University Law Review, 32, 679–705.

    Google Scholar 

  • L. R. Kass and J. Q. Wilson (1998) The Ethics of Human Cloning. American Enterprise Institute Press, Washington DC, USA.

    Google Scholar 

  • M. C. Kaveny (1999) Cloning and positive liberty. Notre Dame Journal of Law, Ethics and Public Policy, 13, 15–35.

    Google Scholar 

  • A. K. Kiessling (2010) Timing is everything in the human embryo. Nature Biotechnology, 28, 1025–1026.

    Article  Google Scholar 

  • A. C. Komor, A. H. Badran and D. R. Liu (2017) CRISPR-based technologies for the manipulation of eukaryotic genomes. Cell, 168, 20–36.

    Article  Google Scholar 

  • Š. Konjar, U. C. Frising, C. Ferreira, R. Hinterleitner, T. Mayassi, Q. Zhang, B. Blankenhaus, N. Haberman, Y. Loo, J. Guedes, M. Baptista, S. Innocentin, J. Stange, D. Strathdee, B. Jabri and M. Veldhoen (2018) Mitochondria maintain controlled activation state of epithelia-resident T lymphocytes. Science Immunology, 3, article no. eaan2543.

    Google Scholar 

  • A. Kossel (1884) Über einen peptonartigen Bestandteil des Zellkerns. Hoppe-Seylers Zeitschrift für physiologische Chemie, 8, 511–515.

    Google Scholar 

  • A. Kossel (1885) Über eine neue Base aus dem Thierkörper. Berichte der Deutschen Chemischen Gesellschaft zu Berlin, 18, 79–81.

    Article  Google Scholar 

  • A. Kossel and A. Neumann (1893) Über das Thymin, ein Spaltungsproduct der Nucleïnsäure. Berichte der Deutschen Chemischen Gesellschaft zu Berlin, 26, 2753–2756.

    Article  Google Scholar 

  • A. Kossel and H. Steudel (1903) Weitere Untersuchungen über das Cytosin. Hoppe-Seylers Zeitschrift für physiologische Chemie, 38, 49–59.

    Article  Google Scholar 

  • J. C. Kunich (2002) The naked clone. Kentucky Law Journal, 91, 1–65.

    Google Scholar 

  • V. A. Kushnir, D. H. Barad, D. F. Albertini, S. K. Darmon and N. Gleicher (2017) Systematic review of worldwide trends in assisted reproductive technology 2004–2013. Reproductive Biology and Endocrinology, 15, article no. 6.

    Google Scholar 

  • Y. Kuwabara, T. Okai, S. Kozuma, N. Unno, K. Akiba, N. Shinozuka, T. Maeda and M. Mizuno (1989) Artificial placenta: long-term extrauterine incubation of isolated goat fetuses. Artificial Organs, 13, 527–531.

    Article  Google Scholar 

  • D. F. Lancy (2008) Anthropology of Childhood: Cherubs, Chattel and Changelings. Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • E. S. Lander, F. Baylis, F. Zhang, E. Charpentier, P. Berg, C. Bourgain, B. Friedrich, J. K. Joung, J. Li, D. Liu, L. Naldini, J.-B. Nie, R. Qiu, B. Schoene-Seifert, F. Shao, S. Terry, W. Wei and E.-L. Winnacker (2019) Adopt a moratorium on heritable genome editing. Nature, 567, 165–168.

    Article  Google Scholar 

  • P. Lauritzen (2001) Cloning and the Future of Human Embryo Research. Oxford University Press, Oxford, UK.

    Google Scholar 

  • L. Lawn and R. A. McCance (1962) Ventures with an artificial placenta. I. Principles and preliminary results. Proceedings of the Royal Society B, 155, 500–509.

    Google Scholar 

  • L. Lawn and R. A. McCance (1964) Artificial placentae: a progress report. Acta Paediatrica, 53, 317–325.

    Article  Google Scholar 

  • L. Lawn and R. A. McCance (1967) Artificial placentae: comparative results with two gas exchangers. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 52, 157–167.

    Article  Google Scholar 

  • H. Ledford (2019) Super-precise new CRISPR tool could tackle a plethora of genetic diseases. Nature, 574, 464–465.

    Article  Google Scholar 

  • T. J. Lindsay and K. R. Vitrikas (2015) Evaluation and treatment of infertility. American Family Physician, 91, 308–314.

    Google Scholar 

  • B. Liu, A. Saber and H. J. Haisma (2019) CRISPR/Cas9: a powerful tool for identification of new targets for cancer treatment. Drug Discovery Today, 24, 955–970.

    Article  Google Scholar 

  • Z. Liu, Y. Cai, Y. Wang, Y. Nie, C. Zhang, Y. Xu, X. Zhang, Y. Lu, Z. Wang, M. Poo and Q. Sun (2018) Cloning of macaque monkeys by somatic cell nuclear transfer. Cell, 172, 881–887.

    Article  Google Scholar 

  • M. de Los Rios, M. F. Criscitiello and V. V. Smider (2015) Structural and genetic diversity in antibody repertoires from diverse species. Current Opinion in Structural Biology, 33, 27–41.

    Article  Google Scholar 

  • P. Luijckx, E. K. H. Ho, M. Gasim, S. Chen, A. Stanic, C. Yanchus, Y. S. Kim and A. F. Agrawal (2017) Higher rates of sex evolve during adaptation to more complex environments. Proceedings of the National Academy of Science USA, 114, 534–539.

    Google Scholar 

  • M. B. Mahowald (2000a) Genes, clones, and gender equality. DePaul University Journal of Health Care Law, 3, 495–526.

    Google Scholar 

  • M. B. Mahowald (2000b) Genes, Women and Equality. Oxford University Press, Oxford, UK.

    Google Scholar 

  • A. L. Marston and A. Amon (2004) Meiosis: cell-cycle controls shuffle and deal. Nature Review Molecular Cell Biology, 5, 983–910.

    Article  Google Scholar 

  • A. M. Massie (1995) Regulating choice: a constitutional law response to Professor John A. Robertson’s Children of Choice. Washington and Lee Law Review, 52, 135–171.

    Google Scholar 

  • G. A. Maston, S. K. Evans and M. R. Green (2006) Transcriptional regulatory elements in the human genome. Annual Review of Genomics and Human Genetics, 7, 29–59.

    Article  Google Scholar 

  • M. Matsuoka (2011) Humanin signal for Alzheimer’s disease. Journal of Alzheimer’s Disease, 24, 27–32.

    Article  Google Scholar 

  • M. J. McDonald, D. P. Rice and M. M. Desai (2016) Sex speeds adaptation by altering the dynamics of molecular evolution. Nature, 531, 233–236.

    Article  Google Scholar 

  • M. Meiman, C. M. Lively and S. Meirmans (2017) Why sex? A pluralist approach revisited. Trends in Ecology and Evolution, 32, 589–600.

    Article  Google Scholar 

  • F. Miescher (1871) Über die chemische Zusammensetzung der Eiterzellen. Medicinisch-chemische Untersuchungen, 4, 441–460.

    Google Scholar 

  • S. M. Mitalipov, Q. Zhou, J. A. Byrne, W. Z. Ji, R. B. Norgren and D. P. Wolf (2007) Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Human Reproduction, 22, 2232–2242.

    Article  Google Scholar 

  • P. Mitchell (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature, 191, 144–148.

    Article  Google Scholar 

  • P. Mitchell (1966) Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation. Glynn Research Ltd., Bodmin, Cornwall, UK.

    Book  Google Scholar 

  • R. C. L. Moffat (1998) Cloning freedom: criminalization or empowerment in reproductive policy? Valparaiso University Law Review, 32, 583–605.

    Google Scholar 

  • G. Mor, P. Aldo and A. B. Alvero (2017) The unique immunological and microbial aspects of pregnancy. Nature Reviews Immunology, 17, 469–482.

    Article  Google Scholar 

  • H. J. Muller (1964) The relation of recombination to mutational advance. Mutation Research, 1, 2–9.

    Article  Google Scholar 

  • M. Muramatsu and T. Honjo (2001) Complex layers of genetic alteration in the generation of antibody diversity. Trends in Immunology, 22, 66–68.

    Article  Google Scholar 

  • M. Nazir-Ali (2015) Three-parent babies: an ethical boundary is being crossed. The Daily Telegraph newspaper, 3rd February 2015, London, UK.

    Google Scholar 

  • J. Needham (1959) A History of Embryology. Cambridge University Press, Cambridge, UK, 2nd edn.

    Google Scholar 

  • J. L. Nelson (1998) Cloning, families and the reproduction of persons. Valparaiso University Law Review, 32, 715–725.

    Google Scholar 

  • K. O. Obrant and P. S. Persson (1965) Zytologische Untersuchung des Hodens durch Aspirationsbiopsie zur Beurteilung der Fertilität. Urologia Internationalis, 20, 176–189.

    Article  Google Scholar 

  • D. Orentlicher (1999) Cloning and the preservation of family integrity. Louisiana Law Review, 59, 1019–1040.

    Google Scholar 

  • D. Orentlicher (2000) Beyond cloning: expanding reproductive options for same-sex couples. Brooklyn Law Review, 66, 651–683.

    Google Scholar 

  • T. S. Painter (1921) The Y-chromosome in mammals. Science, 53, 503–504.

    Article  Google Scholar 

  • C. Palacios-González, J. Harris and G. Testa (2014) Multiplex parenting: IVG and the generations to come. Journal of Medical Ethics, 40, 752–758.

    Article  Google Scholar 

  • S. Pandey, A. Shetty, M. Hamilton, S. Bhattacharya and A. Maheshwari (2012) Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Human Reproduction Update, 18, 485–503.

    Article  Google Scholar 

  • G. A. Parker (2011) The origin and maintenance of two sexes (anisogamy), and their gamete sizes by gamete competition. In: T. Togashi and P. A. Cox, eds., The Evolution of Anisogamy, pp. 17–74. Cambridge University Press, Cambridge, UK.

    Chapter  Google Scholar 

  • G. A. Parker, R. R. Baker and V. G. F. Smith (1972) The origin and evolution of gamete dimorphism and the male-female phenomenon. Journal of Theoretical Biology, 36, 529–553.

    Article  Google Scholar 

  • L. Pauling, H. A. Itano, S. J. Singer and I. C. Wells (1949) Sickle cell anemia, a molecular disease. Science, 110, 543–548.

    Article  Google Scholar 

  • A. H. Peden, D. L. Ritchie, H. P. Uddin, A. F. Dean, K. A. F. Schiller, M. W. Head and J. W. Ironside (2007) Abnormal prion protein in the pituitary in sporadic and variant Creutzfeldt-Jakob disease. Journal of General Virology, 88, 1068–1072.

    Article  Google Scholar 

  • R. P. Petchesky (1980) Reproductive freedom: beyond “a woman’s right to choose”. Signs: Journal of Women in Culture and Society, 5, 661–685.

    Article  Google Scholar 

  • H. Pfeiffer, S. Lutz-Bonengel, S. Pollak, R. Fimmers, M. P. Baur and B. Brinkmann (2004) Mitochondrial DNA control region diversity in hairs and body fluids of monozygotic triplets. International Journal of Legal Medicine, 118, 71–74.

    Article  Google Scholar 

  • J.-B. Qin, X.-Q. Sheng, H. Wang, G.-C. Chen, J. Yang, H. Yu and T.-B. Yang (2017a) Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization/intracytoplasmic sperm injection among multiple births: a systematic review and meta-analysis based on cohort studies. Archives of Gynecology and Obstetrics, 295, 577–597.

    Article  Google Scholar 

  • J.-B. Qin, X.-Q. Sheng, D. Wu, S.-Y. Gao, Y.-P. You, T.-B. Yang and H. Wang (2017b) Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, 295, 285–301.

    Article  Google Scholar 

  • P. Ramsey (1966) Moral and religious implications of genetic control. In: J. D. Roslansky, ed., Genetics and the Future of Man, pp. 107–169. North Holland Publishing Company, Amsterdam, Netherlands.

    Google Scholar 

  • R. Rao (2002) What’s so strange about human cloning? Hastings Law Journal, 53, 1007–1016.

    Google Scholar 

  • D. Rath, L. Amlinger, A. Rath and M. Lundgren (2015) The CRISPR-Cas immune system: biology, mechanisms and applications. Biochimie, 117, 119–128.

    Article  Google Scholar 

  • J. Raz (1988) The Morality of Freedom. Oxford University Press, Oxford, UK.

    Book  Google Scholar 

  • M. J. Reiss (2000) The ethics of genetic research on intelligence. Bioethics, 14, 1–15.

    Article  Google Scholar 

  • M. J. Reiss (2002) Ethical dimensions of therapeutic human cloning. Journal of Biotechnology, 98, 61–70.

    Article  Google Scholar 

  • K. A. Richardson (1998) Human reproduction by cloning in theological perspective. Valparaiso University Law Review, 32, 739–752.

    Google Scholar 

  • S. Ro, H.-Y. Ma, C. Park, N. Ortogero, R. Song, G. W. Hennig, H. Zheng, Y.-M. Lin, L. Moro, J.-T. Hsieh and W. Yan (2013) The mitochondrial genome encodes abundant small noncoding RNAs. Cell Research, 23, 759–774.

    Article  Google Scholar 

  • M. A. Roberts (1999) Cloning and harming: children, future persons and the best interest test. Notre Dame Journal of Law, Ethics and Public Policy, 13, 37–61.

    Google Scholar 

  • J. A. Robertson (1994) Children of Choice. Princeton University Press, Princeton, New Jersey, USA.

    Book  Google Scholar 

  • J. A. Robertson (2000) Why human reproductive cloning should not in all cases be prohibited. New York University Journal of Legislation and Public Policy, 4, 35–44.

    Google Scholar 

  • A. P. Rose (1999) Reproductive misconception: why cloning is not just another assisted reproductive technology. Duke Law Journal, 48, 1133–1156.

    Article  Google Scholar 

  • M. A. Ryan (1998) Cloning, genetic engineering and the limits of procreative liberty. Valparaiso University Law Review, 32, 753–771.

    Google Scholar 

  • S. P. Ryder (2018) #CRISPRbabies: notes on a scandal. CRISPR Journal, 1, 355–357.

    Article  Google Scholar 

  • T. W. Sadler (2012) Langman’s Medical Embryology. Lippincott Williams and Wilkins, Philadelphia, USA, 12th edn.

    Google Scholar 

  • T. W. Sadler (2018) Langman’s Medical Embryology. Wolters Kluwer Health, Philadelphia, USA, 14th edn.

    Google Scholar 

  • M. Sakata, K. Hisano, M. Okada and M. Yasufuku (1998) A new artificial placenta with a centrifugal pump: long-term total extrauterine support of goat fetuses. Journal of Thoracic and Cardiovascular Surgery, 115, 1023–1031.

    Article  Google Scholar 

  • J. Savulescu (2015) Mitochondrial disease kills 150 children a year. A micro-transplant can cure it. Guardian newspaper, 2nd Feburary 2015, London, UK.

    Google Scholar 

  • A. M. Schaefer, R. McFarland, E. L. Blakely, L. He, R. G. Whittaker, R. W. Taylor, P. F. Chinnery and D. M. Turnbull (2008) Prevalence of mitochondrial DNA disease in adults. Annals of Neurology, 63, 35–39.

    Article  Google Scholar 

  • F. M. Scudo (1967) The adaptive value of sexual dimorphism: I. anisogamy. Evolution, 21, 285–291.

    Article  Google Scholar 

  • J. Seymour (1990) Childbirth and the Law. Oxford University Press, Oxford, UK.

    Google Scholar 

  • E. L. Shanin (2002) International response to human cloning. Chicago Journal of International Law, 3, 255–261.

    Google Scholar 

  • D. Shrestha, X. La and H. L. Feng (2015) Comparison of different stimulation protocols used in in vitro fertilization: a review. Annals of Translational Medicine, 3, article no. 137.

    Google Scholar 

  • L. M. Silver (2000) Popular cloning versus scientific cloning in ethical debates. New York University Journal of Legislation and Public Policy, 4, 47–57.

    Google Scholar 

  • L. Simon, A. Zini, A. Dyachenko, A. Ciampi and D. T. Carrell (2017) A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome. Asian Journal of Andrology, 19, 80–90.

    Article  Google Scholar 

  • F. Simonstein (2006) Artificial reproduction technologies (RTs) — all the way to the artificial womb? Medicine, Health Care and Philosophy, 9, article no. 359.

    Google Scholar 

  • J. L. Simpson (2014) Birth defects and assisted reproductive technologies. Seminars in Fetal and Neonatal Medicine, 19, 177–182.

    Article  Google Scholar 

  • P. Singer and D. Wells (1984) The Reproduction Revolution: New Ways of Making Babies. Oxford University Press, Oxford, UK.

    Google Scholar 

  • D. M. Smolin (2001) Should a ban on reproductive cloning include a ban on cloning for purposes of research or therapy? Cumberland Law Review, 32, 487–502.

    Google Scholar 

  • N. Somekh (1999) The European total ban on human cloning: an analysis of the Council of Europe’s actions in prohibiting human cloning. Boston University International Law Journal, 17, 397–423.

    Google Scholar 

  • M. Sommerville (2010) Children’s human rights to natural biological origins and family structures. International Journal of the Jurisprudence of the Family, 1, 35–54.

    Google Scholar 

  • E. Steiger (2010) Not of woman born: how ectogenesis will change the way we view viability, birth and the status of the unborn. Journal of Law and Health, 23, 143–171.

    Google Scholar 

  • P. C. Steptoe and R. G. Edwards (1978) Birth after the reimplantation of a human embryo. Lancet, 312, 366.

    Article  Google Scholar 

  • C. Stolba and S. Satel (2000) Book review: Genes, Women and Equality. New England Journal of Medicine, 342, 1761.

    Article  Google Scholar 

  • T. Strachan and A. P. Read (2018) Human Molecular Genetics. Garland Science, New York, USA, 5th edn.

    Google Scholar 

  • R. R. Strausl (2010) To ensure prized baby boy, Indians flock to Bangkok. Times of India newspaper, 27th December 2010, Mumbai, India.

    Google Scholar 

  • C. S. Sullivan-Pyke, S. Senapati, M. A. Mainigi and K. T. Barnhart (2017) In vitro fertilization and adverse obstetric and perinatal outcomes. Seminars in Perinatology, 41, 345–353.

    Article  Google Scholar 

  • C. Sunstein (2002) Is there a constitutional right to clone? Hastings Law Journal, 53, 987–1005.

    Google Scholar 

  • W. S. Sutton (1902) On the morphology of the chromosome group in Brachystola magna. Biological Bulletin, 4, 24–39.

    Article  Google Scholar 

  • W. S. Sutton (1903) The chromosomes in heredity. Biological Bulletin, 4, 231–251.

    Article  Google Scholar 

  • M. Tachibana, P. Amato, M. Sparman, N. M. Gutierrez, R. Tippner-Hedges, H. Ma, E. Kang, A. Fulati, H.-S. Lee, H. Sritanaudomchai, K. Masterson, J. Larson, D. Eaton, K. Sadler-Fredd, D. Battaglia, D. Lee, D. Wu, J. Jensen, P. Patton, S. Gokhale, R. L. Stouffer, D. Wolf and S. Mitalipov (2013) Human embryonic stem cells derived by somatic cell nuclear transfer. Cell, 153, 1228–1238.

    Article  Google Scholar 

  • M. Tachibana, M. Sparman, H. Sritanaudomchai, H. Ma, L. Clepper, J. Woodward, Y. Li, C. Ramsey, O. Kolotushkina and S. Mitalipov (2009) Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature, 461, 367–372.

    Article  Google Scholar 

  • K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda and S. Yamanaka (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131, 861–872.

    Article  Google Scholar 

  • K. Takahashi and S. Yamanaka (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663–676.

    Article  Google Scholar 

  • J. H. Tjio and A. Levan (1956) The chromosome number of man. Hereditas, 42, 1–6.

    Article  Google Scholar 

  • S. Tonegawa (1983) Somatic generation of antibody diversity. Nature, 302, 575–581.

    Article  Google Scholar 

  • J. Traeger-Synodinos (2017) Pre-implantation genetic diagnosis. Best Practice and Research Clinical Obstetrics and Gynaecology, 39, 74–88.

    Article  Google Scholar 

  • D. Trense and D. T. Tietze (2018) Studying speciation: genomic essentials and approaches. In: D. T. Tietze, ed., Bird Species: How They Arise, Modify and Vanish, pp. 39–61. Springer, Cham, Switzerland.

    Chapter  Google Scholar 

  • L. Tribe (1998) On not banning cloning for the wrong reasons. In: M. C. Nussbaum and C. R. Sunstein, eds., Clones and Clones: Facts and Fantasies about Human Cloning, pp. 221–232. Norton, New York, USA.

    Google Scholar 

  • P. J. Turek, I. Cha and B. M. Ljung (1997) Systematic fine-needle aspiration of the testis: correlation to biopsy and results of organ “mapping” for mature sperm in azoospermic men. Urology, 49, 743–748.

    Article  Google Scholar 

  • B. Unger (1846) Das Guanin und seine Verbindungen. Annalen der Chemie und Pharmacie, 59, 58–68.

    Article  Google Scholar 

  • N. Unno, K. Baba, S. Kozuma, H. Nishina, T. Okai, Y. Kuwabara and Y. Taketani (1997) An evaluation of the system to control blood flow in maintaining goat fetuses on arterio-venous extracorporeal membrane oxygenation: a novel approach to the development of an artificial placenta. Artificial Organs, 21, 1239–1246.

    Article  Google Scholar 

  • N. Unno, Y. Kuwabara, T. Okai, K. Kido, H. Nakayama, A. Kikuchi, Y. Narumiya, S. Kozuma, Y. Taketani and M. Tamura (1993) Development of an artificial placenta: survival of isolated goat fetuses for three weeks with umbilical arteriovenous extracorporeal membrane oxygenation. Artificial Organs, 17, 996–1003.

    Article  Google Scholar 

  • F. D. Urnov, E. J. Rebar, M. C. Holmes, H. S. Zhang and P. D. Gregory (2010) Genome editing with engineered zinc finger nucleases. Nature Reviews Genetics, 11, 636–646.

    Article  Google Scholar 

  • A. Uyar and E. Seli (2014) The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion in Obstetrics and Gynecology, 26, 210–221.

    Article  Google Scholar 

  • L. van Valen (1973) A new evolutionary law. Evolution Theory, 1, 1–30.

    Google Scholar 

  • D. Vernimmen and W. A. Bickmore (2015) The hierarchy of transcriptional activation: from enhancer to promoter. Trends in Genetics, 31, 696–708.

    Article  Google Scholar 

  • S. Vijayavenkataraman, W.-C. Yan, W. F. Lu, C. H. Wang and J. Y. H. Fu (2018) 3D bioprinting of tissues and organs for regenerative medicine. Advanced Drug Delivery Reviews, 132, 296–332.

    Article  Google Scholar 

  • A. K. Voss, T. Thomas and P. Gruss (2000) Mice lacking HSP90β fail to develop a placental labyrinth. Development, 127, 1–11.

    Article  Google Scholar 

  • A. Wang (2001) Regulating human cloning within an environmental human rights framework. Colorado Journal of International Environmental Law and Policy, 12, 165–179.

    Google Scholar 

  • H. Wang and Y. Yang (2019) Gene-edited babies: what went wrong and what could go wrong. PLoS Biology, 17, article no. e3000224.

    Google Scholar 

  • J. D. Watson and F. H. C. Crick (1953a) Genetical implications of the structure of deoxyribosenucleic acid. Nature, 171, 964–967.

    Article  Google Scholar 

  • J. D. Watson and F. H. C. Crick (1953b) Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature, 171, 737–738.

    Article  Google Scholar 

  • W. Wei and P. F. Chinnery (2020) Inheritance of mitochondrial DNA in humans: implications for rare and common diseases. Journal of Internal Medicine, 287, 634–644.

    Article  Google Scholar 

  • A. Weismann (1891b) The significance of sexual reproduction in the theory of natural selection. In: E. B. Poulton and S. Schönland and A. E. Shipley, ed., Essays upon Heredity and Kindred Biological Problems, pp. 257–342. Clarendon Press, Oxford, UK.

    Google Scholar 

  • B. Westin, R. Nyberg and G. Enhörning (1958) A technique for perfusion of the previable human fetus. Acta Paediatrica, 47, 339–349.

    Article  Google Scholar 

  • R. J. Widmer, A. J. Flammer, J. Hermann, M. Rodriguez-Porcel, J. Wan, P. Cohen, L. O. Lerman and A. Lerman (2012) Circulating humanin levels are assocaited with preserved coronary endothelial function. American Journal of Physiology, 304, H393–H397.

    Google Scholar 

  • A. S. Wilkins and R. Holliday (2009) The evolution of meiosis from mitosis. Genetics, 181, 3–12.

    Article  Google Scholar 

  • D. Wilkinson, E. Verhagen and S. Johansson (2018) Thresholds for resuscitation of extremely preterm infants in the UK, Sweden and Netherlands. Pediatrics, 142, S574–S584.

    Article  Google Scholar 

  • R. Williamson (1999) Human reproductive cloning is unethical because it undermines autonomy: commentary on Savulescu. Journal of Medical Ethics, 25, 96–97.

    Article  Google Scholar 

  • I. Wilmut, A. E. Schnieke, J. McWhir, A. J. Kind and K. H. S. Campbell (1997) Viable offspring derived from fetal and adult mammalian cells. Nature, 385, 810–813.

    Article  Google Scholar 

  • J. M. G. Wilson and G. Jungner (1968) Principles and Practice of Screening for Disease. World Health Organisation, Geneva, Switzerland.

    Google Scholar 

  • Y. Xiong, Z. Bu, W. Dai, M. Zhang, X. Bao and Y. Sun (2014) Recombinant luteinizing hormone supplementation in women undergoing in vitro fertilization/intracytoplasmic sperm injection with gonadotropin releasing hormone antagonist protocol: a systematic review and meta-analysis. Reproductive Biology and Endocrinology, 12, article no. 109.

    Google Scholar 

  • K. Yen, C. Lee, H. Mehta and P. Cohen (2013) The emerging role of the mitochondrial-derived peptide humanin in stress resistance. Journal of Molecular Endocrinology, 50, R11–R19.

    Article  Google Scholar 

  • J. Yu, M. A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J. L. Frane, S. Tian, J. Nie, G. A. Jonsdottir, V. Ruotti, R. Stewart, I. I. Slukvin and J. A. Thomson (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science, 318, 1917–1920.

    Article  Google Scholar 

  • W. M. Zapol, T. Kolobow, J. E. Pierce, G. G. Vurek and R. L. Bowman (1969) Artificial placenta: two days of total extrauterine support of the isolated premature lamb fetus. Science, 166, 617–618.

    Article  Google Scholar 

  • F. Zegers-Hochschild, G. D. Adamson, J. de Mouzon, O. Ishihara, R. Mansour, K. Nygren, E. Sullivan and S. Vanderpoel (2009) International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertility and Sterility, 92, 1520–1524.

    Article  Google Scholar 

  • B. Zetsche, J. S. Gootenberg, O. O. Abudayyeh, I. M. Slaymaker, K. S. Makarova, P. Essletzbichler, S. E. Volz, J. Joung, J. van der Oost, A. Regev, E. V. Koonin and F. Zhang (2015) Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell, 163, 759–771.

    Article  Google Scholar 

  • J. Zhang, H. Liu, S. Luo, Z. Lu, A. Chavez-Badiola, Z. Liu, M. Yang, Z. Merhi, S. J. Silber, S. Munne, M. Konstandinidis, D. Wells and T. Huang (2017) Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reproductive Biomedicine Online, 34, 361–368.

    Article  Google Scholar 

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Chau, P.L., Herring, J. (2021). Reproduction. In: Emergent Medicine and the Law. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-030-60208-6_2

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