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Mechanisms of Hepatitis B Virus-Induced Hepatocarcinogenesis

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Viruses and Human Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 217))

Abstract

Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). There are approximately 250 million people in the world that are chronically infected by this virus, resulting in nearly 1 million deaths every year. Many of these patients die from severe liver diseases, including HCC. HBV may induce HCC through the induction of chronic liver inflammation, which can cause oxidative stress and DNA damage. However, many studies also indicated that HBV could induce HCC via the alteration of hepatocellular physiology that may involve genetic and epigenetic changes of the host DNA, the alteration of cellular signaling pathways, and the inhibition of DNA repair mechanisms. This alteration of cellular physiology can lead to the accumulation of DNA damages and the promotion of cell cycles and predispose hepatocytes to oncogenic transformation.

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  1. Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA, 90033, USA

    Jiyoung Lee, Kuen-Nan Tsai & Jing-hsiung James Ou

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  2. Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan

    Mei-Hwei Chang

  3. Molecular Virology Section, Laboratory of Mole, National Institute of Allergy and Infect, Bethesda, MD, USA

    Kuan-Teh Jeang

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Lee, J., Tsai, KN., Ou, Jh.J. (2021). Mechanisms of Hepatitis B Virus-Induced Hepatocarcinogenesis. In: Wu, TC., Chang, MH., Jeang, KT. (eds) Viruses and Human Cancer. Recent Results in Cancer Research, vol 217. Springer, Cham. https://doi.org/10.1007/978-3-030-57362-1_3

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