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Embryonic and Pluripotent Stem Cells

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Regenerative Medicine and Stem Cell Biology

Part of the book series: Learning Materials in Biosciences ((LMB))

Abstract

This chapter will focus on pluripotency as a key feature in determining the differentiation potential of cells and the importance of embryonic and pluripotent stem cells in research together with their promising applications in regenerative medicine. It also includes a brief description of the major findings on embryonic stem cells’ derivation, characterization, and differentiation. The differences between naïve and primed pluripotency will be highlighted, and the in vitro growth conditions contributing to these differences. This chapter will also cover major findings in nuclear reprogramming and the recent developments in induced pluripotent stem cell technology. Finally, we will conclude with the limitations of embryonic stem cells in clinical applications and areas for future research.

Shaimaa Shouman and Alaa E. Hussein contributed equally.

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Acknowledgments

This work was supported by grant # 5300 from the Egyptian Science and Technology Development Fund (STDF), and by internal funding from Zewail City of Science and Technology (ZC 003-2019).

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Authors and Affiliations

  1. Center of Excellence for Stem Cells and Regenerative Medicine (CESC), Helmy Institute of Biomedical Sciences, Zewail City of Science and Technology, Giza, Egypt

    Shaimaa Shouman, Alaa E. Hussein, Mohamed Essawy & Nagwa El-Badri

  2. Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

    Ahmed Abdelfattah-Hassan

  3. Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt

    Ahmed Abdelfattah-Hassan

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  1. Shaimaa Shouman
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  2. Alaa E. Hussein
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  3. Mohamed Essawy
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  4. Ahmed Abdelfattah-Hassan
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  5. Nagwa El-Badri
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Correspondence to Shaimaa Shouman , Alaa E. Hussein or Nagwa El-Badri .

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  1. Center of Excellence of Stem Cells and Regenerative Medicine, Zewail City of Science and Technology, Giza, Egypt

    Nagwa El-Badri

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Shouman, S., Hussein, A.E., Essawy, M., Abdelfattah-Hassan, A., El-Badri, N. (2020). Embryonic and Pluripotent Stem Cells. In: El-Badri, N. (eds) Regenerative Medicine and Stem Cell Biology . Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-55359-3_2

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