Skip to main content

The Lymphatic System and Lymph Nodes of the Pancreas

  • Chapter
  • First Online:
Textbook of Pancreatic Cancer
  • 2976 Accesses

Abstract

The lymphatic system of the pancreas is an intricate network of lymphatic vessels and nodes responsible for the drainage of head, neck, body, and tail of the pancreas. The complexity of this system presents variable drainage patterns across anatomical studies. The anatomical divisions have been extensively described in the literature with focus on clinical relevance regarding pancreatic pathologies, of which the nomenclature of the Japanese Pancreatic Society is used most widely. Knowledge and understanding of the lymphatic system around the pancreas are essential for physicians in providing diagnostic and treatment strategies for patients with pancreatic pathologies. Pancreatic cancer spreads rapidly to the regional lymph nodes with a high number of metastatic lymph nodes found even in early cancers, which in itself is considered a dismal prognostic factor. In this chapter the anatomy of lymphatic system of the pancreas as well as lymphadenectomy procedure are described. Future perspectives include understanding of pathomorphological features in lymph node metastases, as well as the effect of neoadjuvant treatment and immunotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014;14(3):159–72.

    Article  CAS  Google Scholar 

  2. Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, et al. Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med. 2007;204(10):2349–62.

    Article  CAS  Google Scholar 

  3. Alitalo A, Detmar M. Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene. 2012;31(42):4499–508.

    Article  CAS  Google Scholar 

  4. O’Morchoe CC. Lymphatic system of the pancreas. Microsc Res Tech. 1997;37(5–6):456–77.

    Article  Google Scholar 

  5. Cesmebasi A, Malefant J, Patel SD, Du Plessis M, Renna S, Tubbs RS, et al. The surgical anatomy of the lymphatic system of the pancreas. Clin Anat. 2015;28(4):527–37.

    Article  Google Scholar 

  6. Fink DM, Steele MM, Hollingsworth MA. The lymphatic system and pancreatic cancer. Cancer Lett. 2016;381(1):217–36.

    Article  CAS  Google Scholar 

  7. Kurahara H, Takao S, Shinchi H, Maemura K, Mataki Y, Sakoda M, et al. Significance of lymphangiogenesis in primary tumor and draining lymph nodes during lymphatic metastasis of pancreatic head cancer. J Surg Oncol. 2010;102(7):809–15.

    Article  Google Scholar 

  8. Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, et al. Lymphatic vessel remodeling and invasion in pancreatic cancer progression. EBioMedicine. 2019;47:98–113.

    Article  Google Scholar 

  9. Cubilla AL, Fortner J, Fitzgerald PJ. Lymph node involvement in carcinoma of the head of the pancreas area. Cancer. 1978;41(3):880–7.

    Article  CAS  Google Scholar 

  10. Renard Y, Perrenot C, Labrousse M, Avisse C, Rhaiem R, Piardi T, et al. Exploration of peripancreatic lymphatic pathways in a live porcine model. Ann Anat. 2019;225:57–64.

    Article  Google Scholar 

  11. Kayahara M, Nagakawa T, Kobayashi H, Mori K, Nakano T, Kadoya N, et al. Lymphatic flow in carcinoma of the head of the pancreas. Cancer. 1992;70(8):2061–6.

    Article  CAS  Google Scholar 

  12. Nagakawa T, Konishi I, Ueno K, Ohta T, Kayahara M. A clinical study on lymphatic flow in carcinoma of the pancreatic head area—peripancreatic regional lymph node grouping. Hepato-Gastroenterology. 1993;40(5):457–62.

    CAS  PubMed  Google Scholar 

  13. Nagakawa T, Kobayashi H, Ueno K, Ohta T, Kayahara M, Miyazaki I. Clinical study of lymphatic flow to the paraaortic lymph nodes in carcinoma of the head of the pancreas. Cancer. 1994;73(4):1155–62.

    Article  CAS  Google Scholar 

  14. Deki H, Sato T. An anatomic study of the peripancreatic lymphatics. Surg Radiol Anat. 1988;10(2):121–35.

    Article  CAS  Google Scholar 

  15. Isaji S, Kawarada Y. [Evaluation of classification of pancreatic cancer by the Japan Pancreas Society and Union Internationale Contre le Cancer and proposal for a new international classification]. Nihon Geka Gakkai Zasshi. 2000;101(2):205–11.

    Google Scholar 

  16. Yamada S, Fujii T, Hirakawa A, Kanda M, Sugimoto H, Kodera Y. Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer. Langenbeck’s Arch Surg. 2016;401(8):1143–52.

    Article  Google Scholar 

  17. Sun W, Leong CN, Zhang Z, Lu JJ. Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence. Radiat Oncol. 2010;5:28.

    Article  Google Scholar 

  18. Tol JA, Gouma DJ, Bassi C, Dervenis C, Montorsi M, Adham M, et al. Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery. 2014;156(3):591–600.

    Article  Google Scholar 

  19. Kanehara. Classification of pancreatic carcinoma. 4th English edition. Japan Pancreas Society; 2017.

    Google Scholar 

  20. Chusilp Charnsangavej MAM. Pathways of regional spread in pancreatic cancer. Dynamic radiology of the abdomen, normal and pathologic anatomy. Springer; 2005. p. 595–606.

    Google Scholar 

  21. Dasari BV, Pasquali S, Vohra RS, Smith AM, Taylor MA, Sutcliffe RP, et al. Extended versus standard lymphadenectomy for pancreatic head cancer: meta-analysis of randomized controlled trials. J Gastrointest Surg. 2015;19(9):1725–32.

    Article  Google Scholar 

  22. Li K, Yao Q, Xiao J, Li M, Yang J, Hou W, et al. Contrast-enhanced CT radiomics for predicting lymph node metastasis in pancreatic ductal adenocarcinoma: a pilot study. Cancer Imaging. 2020;20(1):12.

    Article  Google Scholar 

  23. Beisani M, Roca I, Cardenas R, Blanco L, Abu-Suboh M, Dot J, et al. Initial experience in sentinel lymph node detection in pancreatic cancer. Rev Esp Med Nucl Imagen Mol. 2016;35(5):287–91.

    CAS  PubMed  Google Scholar 

  24. van Manen L, Handgraaf HJM, Diana M, Dijkstra J, Ishizawa T, Vahrmeijer AL, et al. A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery. J Surg Oncol. 2018;118(2):283–300.

    Article  Google Scholar 

  25. Vuijk FA, Hilling DE, Mieog JSD, Vahrmeijer AL. Fluorescent-guided surgery for sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted fluorescent-guided surgery in colorectal and pancreatic cancer. J Surg Oncol. 2018;118(2):315–23.

    Article  CAS  Google Scholar 

  26. Kostov D. Recent advances in pancreatic cancer. Lymphadenectomy in pancreatic cancer surgery: avid science; 2017.

    Google Scholar 

  27. Niesen W, Hank T, Büchler M, Strobel O. Local radicality and survival outcome of pancreatic cancer surgery. Ann Gastroenterol Surg. 2019;3(5):464–75.

    Article  Google Scholar 

  28. Nimura Y, Nagino M, Takao S, Takada T, Miyazaki K, Kawarada Y, et al. Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: long-term results of a Japanese multicenter randomized controlled trial. J Hepatobiliary Pancreat Sci. 2012;19(3):230–41.

    Article  Google Scholar 

  29. Kanda M, Fujii T, Nagai S, Kodera Y, Kanzaki A, Sahin TT, et al. Pattern of lymph node metastasis spread in pancreatic cancer. Pancreas. 2011;40(6):951–5.

    Article  Google Scholar 

  30. Schwarz RE, Smith DD. Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database. Ann Surg Oncol. 2006;13(9):1189–200.

    Article  Google Scholar 

  31. Eskander MF, de Geus SW, Kasumova GG, Ng SC, Al-Refaie W, Ayata G, et al. Evolution and impact of lymph node dissection during pancreaticoduodenectomy for pancreatic cancer. Surgery. 2017;161(4):968–76.

    Article  Google Scholar 

  32. Motoi F, Kosuge T, Ueno H, Yamaue H, Satoi S, Sho M, et al. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05). Jpn J Clin Oncol. 2019;49(2):190–4.

    Article  Google Scholar 

  33. Macedo FI, Picado O, Hosein PJ, Dudeja V, Franceschi D, Mesquita-Neto JW, et al. Does neoadjuvant chemotherapy change the role of regional lymphadenectomy in pancreatic cancer survival? Pancreas. 2019;48(6):823–31.

    Article  Google Scholar 

  34. Roland CL, Yang AD, Katz MH, Chatterjee D, Wang H, Lin H, et al. Neoadjuvant therapy is associated with a reduced lymph node ratio in patients with potentially resectable pancreatic cancer. Ann Surg Oncol. 2015;22(4):1168–75.

    Article  Google Scholar 

  35. Versteijne E, Suker M, Groothuis K, Akkermans-Vogelaar JM, Besselink MG, Bonsing BA, et al. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III PREOPANC trial. J Clin Oncol. 2020;38(16):1763–73. JCO1902274.

    Article  CAS  Google Scholar 

  36. Griffin JF, Poruk KE, Wolfgang CL. Pancreatic cancer surgery: past, present, and future. Chin J Cancer Res. 2015;27(4):332–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Kooby DA. Pancreas and duodenum. In: Wood WC, Staley C, Skandalakis JE, editors. Anatomic basis of tumor surgery. 2nd ed. Berlin: Springer; 2010. p. 562.

    Google Scholar 

  38. Cancer AJCo. AJCC cancer staging atlas. New York: Springer; 2006.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefan Stättner .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fodor, M., Stättner, S. (2021). The Lymphatic System and Lymph Nodes of the Pancreas. In: Søreide, K., Stättner, S. (eds) Textbook of Pancreatic Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-53786-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-53786-9_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53785-2

  • Online ISBN: 978-3-030-53786-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics