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Brown Adipose Tissue in Obesity and Diabetes

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Obesity and Diabetes

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Abstract

The scientific community is leading efforts to find efficient therapies for obesity and diabetes, which led to the rediscovery in 2009 of the presence of functional brown adipose tissue (BAT) depots in adult humans. In this chapter, we describe the main characteristics of this tissue and the image techniques available for its detection. In addition, we discuss the secretory capacity of BAT that is responsible for crosstalk with other organs and confers a regulatory role in several processes beyond the canonical generation of heat. Finally, we explain the mechanisms through which obesity and diabetes interrupt the physiological role and development of BAT and we summarize the latest results of the studies that use BAT transplant as a new therapy in the treatment of metabolic diseases.

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Acknowledgments

This study was supported by the Ministry of Spain (MINECO) (SAF2017-83813-C3-1-R to DS and LH, cofounded by the ERDF), the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) (Grant CB06/03/0001 to DS), the Government of Catalonia (2017SGR278 to DS), the Universidad CEU San Pablo-Banco Santander (FUSP-BS-PPC-USP02/2017) to MA and the Fundació La Marató de TV3 (201627-30 to DS).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain

    Martín Alcalá & Marta Viana

  2. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain

    Laura Herrero & Dolors Serra

  3. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain

    Laura Herrero & Dolors Serra

Authors
  1. Martín Alcalá
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  2. Laura Herrero
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  3. Dolors Serra
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  4. Marta Viana
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Correspondence to Marta Viana .

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Editors and Affiliations

  1. Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil

    Joel Faintuch

  2. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Salomão Faintuch

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Alcalá, M., Herrero, L., Serra, D., Viana, M. (2020). Brown Adipose Tissue in Obesity and Diabetes. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_4

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