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Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy

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Cancer Metabolomics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1280))

Abstract

Cancer cells exhibit different metabolic patterns compared to their normal counterparts. Although the reprogrammed metabolism has been indicated as strong biomarkers of cancer initiation and progression, increasing evidences suggest that metabolic alteration tuned by oncogenic drivers contributes to the occurrence and development of cancers rather than just being a hallmark of cancer. With this notion, targeting cancer metabolism holds promise as a novel anticancer strategy and is embracing its renaissance during the past two decades. Herein we have summarized the most recent developments in omics technology, including both metabolomics and proteomics, and how the combined use of these analytical tools significantly impacts this field by comprehensively and systematically recording the metabolic changes in cancer and hence reveals potential therapeutic targets that function by modulating the disrupted metabolic pathways.

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Acknowledgments

This study was financially supported by the National Key R&D Program ofChina (2018YFD0901101), the National Natural Science Foundation of China (grants No. 81872838, 81720108032), the Natural Science Foundation of Jiangsu Province (BK20180079), the Project of State Key Laboratory of Natural Medicines in ChinaPharmaceutical University (SKLNMZZCX201817), the Double First-Rate University project (CPU2018GY09, CPU2018GF09), and the Project for Major New Drugs Innovation and Development (2018ZX09711001-002-003,2018ZX09711002-001-004, 2017ZX09301013).

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Authors and Affiliations

  1. Pharmacy Department, Shenzhen Luohu People’s Hospital, Shenzhen, China

    Chang Shao

  2. School of Pharmacy, China Pharmaceutical University, Nanjing, China

    Chang Shao & Haiping Hao

  3. Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China

    Wenjie Lu, Haiping Hao & Hui Ye

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  1. Chang Shao
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  2. Wenjie Lu
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  3. Haiping Hao
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  4. Hui Ye
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Correspondence to Haiping Hao or Hui Ye .

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  1. University of California, Los Angeles, Los Angeles, CA, USA

    Shen Hu

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Shao, C., Lu, W., Hao, H., Ye, H. (2021). Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy. In: Hu, S. (eds) Cancer Metabolomics. Advances in Experimental Medicine and Biology, vol 1280. Springer, Cham. https://doi.org/10.1007/978-3-030-51652-9_9

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