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NMR-Based Metabolomics in Cancer Research

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Cancer Metabolomics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1280))

Abstract

Nuclear magnetic resonance (NMR) spectroscopy offers reproducible quantitative analysis and structural identification of metabolites in various complex biological samples, such as biofluids (plasma, serum, and urine), cells, tissue extracts, and even intact organs. Therefore, NMR-based metabolomics, a mainstream metabolomic platform, has been extensively applied in many research fields, including pharmacology, toxicology, pathophysiology, nutritional intervention, disease diagnosis/prognosis, and microbiology. In particular, NMR-based metabolomics has been successfully used for cancer research to investigate cancer metabolism and identify biomarker and therapeutic targets. This chapter highlights the innovations and challenges of NMR-based metabolomics platform and its applications in cancer research.

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Authors and Affiliations

  1. State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan, Wuhan National Laboratory for Optoelectronics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

    Rui Hu, Tao Li, Yunhuang Yang, Yuan Tian & Limin Zhang

  2. University of Chinese Academy of Sciences, Beijing, China

    Tao Li

  3. Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA

    Yuan Tian

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  1. Rui Hu
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  1. University of California, Los Angeles, Los Angeles, CA, USA

    Shen Hu

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Hu, R., Li, T., Yang, Y., Tian, Y., Zhang, L. (2021). NMR-Based Metabolomics in Cancer Research. In: Hu, S. (eds) Cancer Metabolomics. Advances in Experimental Medicine and Biology, vol 1280. Springer, Cham. https://doi.org/10.1007/978-3-030-51652-9_14

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