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Evaluating the Business Case for Continuous Manufacturing of Pharmaceuticals: A Supply Network Perspective

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Continuous Pharmaceutical Processing

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 42))

Abstract

This chapter addresses the challenges of evaluating the business case for continuous manufacturing of pharmaceuticals, looking beyond traditional technical assessments made at the unit operations or individual production facility level. It provides an overview of key concepts, approaches, and tools for the early assessment of supply network configuration opportunities enabled by continuous production processing interventions. Multiple levels of analysis are considered with the aid of examples based on major UK research programs on continuous production process technologies. Particular emphasis is placed on the potential for achieving enhanced product flexibility (in terms of volume and variety) and, depending on scale, the optimum number and location of manufacturing operations to support speed to market and system-level cost benefits. In the case of multiple manufacturing operations using continuous production process technologies, where production facility replication through digital twins is becoming a key enabler, the chapter sets out a supply network design and analysis approach that evaluates the commercial and operational viability of alternative manufacturing supply network scenarios.

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Author information

Authors and Affiliations

  1. Department of Engineering, Institute for Manufacturing, Centre for International Manufacturing, University of Cambridge, Cambridge, UK

    Jagjit Singh Srai, Ettore Settanni & Parminder Kaur Aulakh

Authors
  1. Jagjit Singh Srai
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  2. Ettore Settanni
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  3. Parminder Kaur Aulakh
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Correspondence to Jagjit Singh Srai .

Editor information

Editors and Affiliations

  1. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, USA

    Zoltan K Nagy

  2. Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Arwa El Hagrasy

  3. Department of Chemical and Biochemical Engineering, The University of Sheffield, Sheffield, UK

    Jim Litster

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Srai, J.S., Settanni, E., Aulakh, P.K. (2020). Evaluating the Business Case for Continuous Manufacturing of Pharmaceuticals: A Supply Network Perspective. In: Nagy, Z., El Hagrasy, A., Litster, J. (eds) Continuous Pharmaceutical Processing. AAPS Advances in the Pharmaceutical Sciences Series, vol 42. Springer, Cham. https://doi.org/10.1007/978-3-030-41524-2_14

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