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Mesoporous Silica Nanomaterials as Antibacterial and Antibiofilm Agents

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Nanostructures for Antimicrobial and Antibiofilm Applications

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

Abstract

Antimicrobial agents are vital to fight infectious diseases which are pooling up day by day. The treatment of microbial infections is increasingly getting convoluted by the ability of microorganisms to develop resistance towards a wide range of antimicrobial agents. Resistance is most often an evolutionary process taking place either through lateral gene transfer or during antibiotic therapy, thereby contributing to the emergence of diseases that were under good control for many years.

Further, drug resistance enforces high-dose administration of antibiotics leading to adverse side effects and intolerable toxicity. This has prompted the search for alternative strategies to treat microbial infections either by controlling their growth or by preventing the formation of bacterial biofilms. Recently tremendous developments in the field of nanotechnology have been recorded with nanoscale materials emerging as novel antimicrobial agents.

Nanotechnology is an interdisciplinary area of science with promising interests across the globe steering into nanoindustrial revolution with innumerable applications. The enormous diversity of the nanoparticles that exhibit new and enhanced size-dependent properties compared to their bulk material are being exploited as antimicrobials for treating infectious diseases. Numerous nanodevices like carbon nanotubes, quantum dots, and polymeric micelles have been reported as potential antibacterial candidates. In the present scenario, mesoporous silica nanoparticles (MSNs) are emerging for their widespread applications as antibacterial and antibiofilm agents. MSNs are constituted of an amorphous silica matrix with ordered porous molecular sieves characterized by periodic arrangements of uniformly sized mesopores (diameter between 2 and 50 nm). MSNs with uniform and tailorable pore dimensions with high surface areas are currently being employed in a number of applications such as wastewater remediation, indoor air cleaning, bio-catalysis, drug delivery, CO2 capture, bioanalytical sample preparation, pervaporation membrane improvement, etc. MSNs with their unique properties like chemical stability, surface functionality, and biocompatibility are used in quorum quenching as well as prospective antibacterial agents. The present book chapter deals with MSNs and their applications as possible antibacterial and antibiofilm agents.

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Authors and Affiliations

  1. Department of Microbiology, AUCST, Andhra University, Visakhapatnam, Andhra Pradesh, India

    Pethakamsetty Lakshmi

  2. Department of Biotechnology, AUCST, Andhra University, Visakhapatnam, Andhra Pradesh, India

    Sudhakar Pola

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  1. Pethakamsetty Lakshmi
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Correspondence to Sudhakar Pola .

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Editors and Affiliations

  1. Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India

    Ram Prasad

  2. Department of Microbiology, School of Life Sciences, Pondicherry University, Pondicherry, India

    Busi Siddhardha

  3. Department of Biochemistry & Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India

    Madhu Dyavaiah

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Lakshmi, P., Pola, S. (2020). Mesoporous Silica Nanomaterials as Antibacterial and Antibiofilm Agents. In: Prasad, R., Siddhardha, B., Dyavaiah, M. (eds) Nanostructures for Antimicrobial and Antibiofilm Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-40337-9_16

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