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Bioresorbable Nano-Hydroxyapatite Reinforced Magnesium Alloplastic Bone Substitute for Biomedical Applications: A Study

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Nanocomposites VI: Nanoscience and Nanotechnology in Advanced Composites

Part of the book series: The Minerals, Metals & Materials Series ((MMMS))

Abstract

Biodegradable magnesium, when reinforced with nanoparticles, displays significant improvements in its mechanical strength, cell proliferation, and corrosion resistance when compared to existing commercially available alloys. This inimitable behavior of magnesium-based composites makes it a unique offering in orthopedic and mandibular reconstruction applications. Additionally, it displays mechanical properties similar to the natural bone highlighting its huge potential as an orthopedic implant material. The present study focuses on the influence of hydroxyapatite (HA) nanoparticles on mechanical, immersion and cytocompatibility properties of magnesium processed by powder metallurgy technique coupled with hybrid microwave sintering. The inclusion of HA nanoreinforcement restricted the growth of grain size for Mg, thereby resulting in superior biodegradation and biocompatibility properties. Mg–HA nanocomposites displayed excellent corrosion resistance compared to its matrix counterpart showing a near-uniform degradation rate. MC3T3-E1 cells showed an increased cell viability percentage and subsequent low cytotoxicity levels. No obvious toxic effects were observed, which is consistent with the enhanced corrosion resistance of Mg alloys resulting in better cell attachment and viability. Structure–property correlations are drawn and analyzed.

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Authors and Affiliations

  1. Faculty of Dentistry, National University of Singapore, 1 Lower Kent Ridge Road, Singapore, 119083, Singapore

    Somasundaram Prasadh & Raymond Wong

  2. Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore

    Vyasaraj Manakari, Gururaj Parande & Manoj Gupta

  3. Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA

    T. S. Srivatsan

Authors
  1. Somasundaram Prasadh
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  2. Vyasaraj Manakari
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  3. Gururaj Parande
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  4. T. S. Srivatsan
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  5. Raymond Wong
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  6. Manoj Gupta
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Corresponding author

Correspondence to Raymond Wong .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, Auburn Science and Engineering Center, The University of Akron, Akron, OH, USA

    T. S. Srivatsan

  2. Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore

    Manoj Gupta

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Prasadh, S., Manakari, V., Parande, G., Srivatsan, T.S., Wong, R., Gupta, M. (2019). Bioresorbable Nano-Hydroxyapatite Reinforced Magnesium Alloplastic Bone Substitute for Biomedical Applications: A Study. In: Srivatsan, T., Gupta, M. (eds) Nanocomposites VI: Nanoscience and Nanotechnology in Advanced Composites. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-030-35790-0_6

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