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Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1224))

Abstract

CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naïve TH cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector TH cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of TH cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators.

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Acknowledgement

This work was supported by grants from the Canadian Institutes of Health Research (CIHR FDN-143345 to W.L.L. and PJT-156017 to G.D.) and scholarships from CIHR, Vanier Canada, and the BC Cancer Foundation. F.G. is supported by the Ligue nationale contre le cancer (Paris, France), the Fonds de Recherche en Santé Respiratoire (appel d’offres 2018 emis en commun avec la Fondation du Souffle, Paris, France), ADIR Association and the Foundation Charles Nicolle (Rouen, France). M.C.B.-F. is supported by the São Paulo Research Foundation (FAPESP 2015/17707-5 and 2018/06138-8). L.D.R. is supported by the BC Cancer Foundation and the University of British Columbia, Faculty of Dentistry. E.A.M. is supported by CIHR and the UBC, Faculty of Medicine and is a Vanier Canada Graduate scholar. G.D. is a senior scientist of the Beatrice Hunter Cancer Research Institute (BHCRI), and M.S.-W. is a trainee in the Cancer Research Training Program of the BHCRI, with funds provided by the QEII Health Sciences Centre Foundation and GIVETOLIVE.

Conflict of interest: The authors have no conflicts to declare.

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Author notes

  1. Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, and Megan Strachan-Whaley contributed equally to this work.

Authors and Affiliations

  1. Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada

    Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, Erin A. Marshall & Wan L. Lam

  2. Department of Pneumology, Thoracic Oncology and Intensive Respiratory Care, Rouen University Hospital, Rouen, France

    Florian Guisier

  3. International Research Center, A.C.Camargo Cancer Center, Sao Paulo, SP, Brazil

    Mateus Camargo Barros-Filho

  4. Department of Oral and Biological Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada

    Leigha D. Rock

  5. Department of Cancer Control Research, British Columbia Cancer Research Centre, Vancouver, BC, Canada

    Leigha D. Rock

  6. Faculty of Dentistry, Dalhousie University, Halifax, NS, Canada

    Leigha D. Rock

  7. Department of Pathology, Dalhousie University, Halifax, NS, Canada

    Megan Strachan-Whaley & Graham Dellaire

  8. Canadian Environmental Exposures in Cancer (CE2C) Network (CE2C.ca), Halifax, NS, Canada

    Graham Dellaire & Wan L. Lam

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  1. Columbia University Medical Center, Department of Radiology, New York, NY, USA, Federal University of Minas Gerais, Department of Pathology, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Guisier, F. et al. (2020). Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1224. Springer, Cham. https://doi.org/10.1007/978-3-030-35723-8_3

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