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Immunotoxicity Testing – In Vitro Cell Culture Models

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Interaction of Nanomaterials with the Immune System

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

The understanding of how nanomaterials interact with cells, tissues, and organs is important to realize their potential for biomedical applications and for hazard assessment of occupational exposure. Depending on the nanomaterial characteristics, they can trigger various components of the immune system, that is, innate and adaptive immune systems, thereby either activating or suppressing immune system functions. In this chapter, we highlight the currently established immune cell models and readouts to address the possible effects of nanomaterials. In addition to the conventional 2D cultures, the design and use of more complex 3D models is emphasized.

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Acknowledgments

This work was supported by the Adolphe Merkle Foundation. BRR acknowledges the Swiss National Science Foundation (310030_159847/1), and BD acknowledges the Peter and Traudl Engelhorn Foundation.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. BioNanomaterials Group, Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland

    Barbara Rothen-Rutishauser, Barbara Drasler & Alke Petri-Fink

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  1. Barbara Rothen-Rutishauser
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  2. Barbara Drasler
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  3. Alke Petri-Fink
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Correspondence to Barbara Rothen-Rutishauser .

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Editors and Affiliations

  1. Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA

    James C. Bonner

  2. Department of Pharmaceutical Sciences Skaggs School of Pharmacy, University of Colorado, Aurora, CO, USA

    Jared M. Brown

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Rothen-Rutishauser, B., Drasler, B., Petri-Fink, A. (2020). Immunotoxicity Testing – In Vitro Cell Culture Models. In: Bonner, J., Brown, J. (eds) Interaction of Nanomaterials with the Immune System. Molecular and Integrative Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-33962-3_11

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