Skip to main content

Effects of Diabetes on Neurocognitive Function of Children

  • Chapter
  • First Online:
Behavioral Diabetes
  • 1025 Accesses

Abstract

A coherent model of brain-behaviour relationships specific to type 1 diabetes in children remains a work in progress, but there is consensus that the brain is one of the organ systems impacted by the disease. This chapter reviews current evidence for morphologic changes, altered cerebral growth trajectories and reduced functional interconnectivity in the central nervous system in children and adolescents with diabetes, especially following early onset disease. Effects of diabetes on cognition and functional outcomes such as academic achievement, mental health, work participation and quality of life are discussed, and persisting challenges in understanding precise causal mechanisms that may facilitate preventive interventions are noted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001). The prevalence of co-morbid depression in adults with diabetes. A meta-analysis. Diabetes Care, 24, 1069–1078.

    Article  PubMed  Google Scholar 

  • Antenor-Dorsey, J. A., Meyer, E., Rutlin, J., Perantie, D. C., White, N. H., Arbelaez, A. M., … Hershey, T. (2013). White matter microstructural integrity in youth with type 1 diabetes. Diabetes, 62, 581–589.

    Article  PubMed  PubMed Central  Google Scholar 

  • Arbelaez, A., Semenkovich, K., & Hershey, T. (2013). Glycemic extremes in youth with TIDM: The structural and functional integrity of the developing brain. Pediatric Diabetes, 14, 541–553.

    Article  PubMed  Google Scholar 

  • Aye, T., Reiss, A. L., Kesler, S., Hoang, S., Drobny, J., Park, Y., … Buckingham, B. A. (2011). The feasibility of detecting neuropsychologic and neuroanatomic effects of type 1 diabetes in young children. Diabetes, 34, 1458–1462.

    Google Scholar 

  • Aye, T., Barnea-Goraly, N., Ambler, C., Hoang, S., Schleifer, K., Park, Y., … Buckingham, B. A. (2012). White matter structural differences in young children with type 1 diabetes: A diffusion tensor imaging study. Diabetes Care, 35, 2167–2173.

    Article  PubMed  PubMed Central  Google Scholar 

  • Barnea-Goraly, N., Raman, M., Mazaika, P., Marzelli, M., Hershey, T., Weinzimer, S. A., … Reiss, A. L. (2014). Alterations in white matter structure in young children with type 1 diabetes. Diabetes Care, 37, 332–340.

    Article  PubMed  PubMed Central  Google Scholar 

  • Battelino, T., Phillip, M., Bratina, N., Nimri, R., Oskarsson, P., & Bolinder, J. (2011). Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes. Diabetes Care, 34, 795–800.

    Article  PubMed  PubMed Central  Google Scholar 

  • Benedict, L., Nelson, C. A., Schunk, L., Sullwold, K., & Seaquist, E. R. (2006). Effects of insulin on the brain activity obtained during visual and memory tasks in healthy human subjects. Neuroendocrinology, 83, 20–26.

    Article  PubMed  Google Scholar 

  • Biessels, G., Deary, I. J., & Ryan, C. M. (2008). Cognition and diabetes: A lifespan perspective. Lancet Neurology, 7, 184–190.

    Article  PubMed  Google Scholar 

  • Blasetti, A., Chiuri, R. M., Tocco, A. M., Di Guilio, C., Mattei, P. A., Ballone, E., … Verrotti, A. (2011). The effect of recurrent severe hypoglycemia on cognitive performance in children with type 1 diabetes: A meta-analysis. Journal of Child Neurology, 26, 1383–1391.

    Article  PubMed  Google Scholar 

  • Brands, A. M., Kappelle, L. J., Biessels, G. J., Kessels, R. P., & de Haan, E. H. (2005). The effects of type 1 diabetes on cognitive performance. Diabetes Care, 28, 726–735.

    Article  PubMed  Google Scholar 

  • Buchberger, B., Huppertz, H., Krabbbe, L., Lux, B., Mattivi, J. T., & Siafarikas, A. (2016). Symptoms of depression and anxiety in youth with type 1 diabetes: A systematic review and meta-analysis. Psychoneuroendocrinolgy, 70, 70–84.

    Article  Google Scholar 

  • Butwicka, A., Frisen, L., Almqvist, C., Zethelius, B., & Lichenstein, P. (2015). Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: A population-based cohort study. Diabetes Care, 38, 453–459.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cameron, F., & Northam, E. (2012). Screening for psychological disorders in youth with type 21 diabetes: Who, when, what and how? Diabetes Management, 2, 513–520.

    Article  Google Scholar 

  • Cameron, F. J., Scratch, S. E., Nadebaum, C., Northam, E. A., Koves, I., Jennings, J., … Inder, T. E. (2014). Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. Diabetes Care, 37, 1554–1562.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cato, A. M., Maurus, N., Ambrosino, J., Bondurant, A., Conrad, A. L., Kollman, C., … Hershey, T. (2014). Cognitive functioning in young children with type 1 diabetes. Journal of the International Neuropsychological Society, 20, 238–247.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cooper, M. N., McNamara, K. A. R., de Klerk, N. H., Davis, E. A., & Jones, T. W. (2016). School performance in children with type 1 diabetes: A contemporary population-based study. Pediatric Diabetes, 17, 101–101.

    Article  PubMed  Google Scholar 

  • Cooray, G. K., Hillienmark, L., & Brismar, T. (2011). Decreased cortical connectivity and information flow in type 1 diabetes. Clinical Neurophysiology, 122, 1943–1950.

    Article  PubMed  Google Scholar 

  • Csajbok, E. A., & Tamas, G. (2016). Cerebral cortex: A target and source of insulin? Diabetologia, 59, 1609–1615.

    Article  PubMed  Google Scholar 

  • Dahlquist, G., & Kallen, B. (2007). School performance in children with type 1 diabetes - a population-based register study. Diabetologia, 50, 957–964.

    Article  PubMed  Google Scholar 

  • Daneman, D. (2006). Type 1 diabetes. The Lancet, 367, 847–858.

    Article  Google Scholar 

  • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. (2007). Long-term effect of diabetes and its treatment on cognitive function. The New England Journal of Medicine, 356, 1842–1852.

    Article  Google Scholar 

  • Desrocher, M., & Rovet, J. (2004). Neurocognitive correlates of type 1 diabetes mellitus in childhood. Child Neuropsychology, 10, 36–52.

    Article  PubMed  Google Scholar 

  • Gaudieri, P. A., Greer, T. F., Chen, R., & Holmes, C. S. (2009). Cognitive function in children with type 1 diabetes: A meta-analysis. Diabetes Care, 31, 1892–1897.

    Article  Google Scholar 

  • Glaser, N. S., Wootton-Gorges, S., Buoncore, M. H., Marcin, J. P., Rewers, A., Strain, J., … Kuppermann, N. (2006). Frequency of sub-clinical cerebral edema in children with diabetes ketoacidosis. Pediatric Diabetes, 7, 75–80.

    Article  PubMed  Google Scholar 

  • Gonder-Frederick, L. A., Zebriec, J. F., Bauchowitz, A. U., Ritterband, L. M., Mageee, J. C., Cox, D. L., & Clarke, D. J. (2009). Cognitive function is disrupted by both hypo-and hyperglycemia in school-aged children with type 1 diabetes: A field study. Diabetes Care, 32, 1001–1006.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hannonen, R., Komulainen, J., Rikonen, R., Ahonen, T., Eklund, K., Tolvanen, A., … Nuuja, A. (2012). Academic skills in children with early-onset type 1 diabetes: The effects of diabetes related risk factors. Developmental Medicine and Child Neurology, 54, 457–463.

    Article  PubMed  Google Scholar 

  • Hassan, K., Loar, R., Anderson, B. J., & Heptulla, R. A. (2006). The role of socio-economic status, depression, quality of life, and glycemic control in type 1 diabetes mellitus. The Journal of Pediatrics, 149, 526–531.

    Article  PubMed  Google Scholar 

  • Hershey, T., Perantie, D. C., Wu, J., Weaver, P. M., Black, K. J., & White, N. H. (2010). Hippocampal volumes in youth with type 1 diabetes. Diabetes, 59, 236–241.

    Article  PubMed  Google Scholar 

  • Ho, M. S., Weller, N., Ives, F. J., Carne, C. L., Murray, K., van den Driesen, R. I., … Jones, T. W. (2008). Prevalence of structural central nervous system abnormalities in early onset- type 1 diabetes mellitus. The Journal of Pediatrics, 153, 385–390.

    Article  PubMed  Google Scholar 

  • Hood, K. K., & Nansel, T. R. (2007). Commonalities in effective behavioural interventions of children and adolescents with type 1 diabetes: A review of reviews. Diabetes Spectrum, 20, 251–254.

    Article  Google Scholar 

  • Hyllienmark, L., Maltez, J., Dandenell, A., Ludvigsson, J., & Brismar, T. (2005). EEG abnormalities with and without relation to severe hypoglycaemia in adolescents with type 1 diabetes. Diabetologia, 48, 412–419.

    Article  PubMed  Google Scholar 

  • Johnson, B., Eiser, C., Young, V., Brierley, S., & Heller, S. (2013). Prevalence of depression among young people with type 1 diabetes: A systematic review. Diabetic Medicine, 30, 199–208.

    Article  PubMed  Google Scholar 

  • Kaufmann, L., Pixner, S., Starke, M., Zotter, S., Kohle, J., Meraner, D., … Hofer, S. (2012). Neurocognition and brain structure in pediatric patients with type 1 diabetes. Journal of Pediatric Neuroradiology, 1, 25–35.

    Google Scholar 

  • Kirchhoff, B. A., Jundt, D. K., Doty, T., & Hershey, T. (2016). A longitudinal investigation of cognitive function in children and adolescents with type 1 diabetes mellitus. Pediatric Diabetes. https://doi.org/10.1111/pedi.12414

    Article  PubMed  PubMed Central  Google Scholar 

  • Knight, S. J., Northam, E. A., Cameron, F. J., & Ambler, G. R. (2011). Behaviour and metabolic control in children with type 1 diabetes mellitus on insulin pump therapy: 2 year follow-up. Diabetic Medicine, 28, 1109–1112.

    Article  PubMed  Google Scholar 

  • Knight, S., Northam, E., Donath, S., Gardner, A., Harkin, N., Taplin, C., … Ambler, G. R. (2009). Improvements in cognition, mood and behaviour following commencement of continuous subcutaneous insulin infusion therapy in children with type 1 diabetes mellitus: A pilot study. Diabetologia, 52, 193–198.

    Article  PubMed  Google Scholar 

  • Lin, A., Northam, E. A., Rankins, D., Werther, G. A., & Cameron, F. J. (2010). Neuropsychological profiles of young people with type 1 diabetes 12 yr after disease onset. Pediatric Diabetes, 11, 235–243.

    Article  PubMed  Google Scholar 

  • Lin, A., Northam, E. A., Werther, G. A., & Cameron, F. J. (2015). Risk factors for decline in IQ in youth with type 1 diabetes over the 12 years from diagnosis/illness onset. Diabetes Care, 38, 236–242.

    Article  PubMed  Google Scholar 

  • Lustman, P. J., Anderson, R. J., Freedland, K., de Groot, M., Carney, R. M., & Clouse, R. E. (2000). Depression and poor glycemic control. A meta-analytic review of the literature. Diabetes Care, 23, 934–942.

    Article  PubMed  Google Scholar 

  • Lyoo, I. K., Yoon, S. J., Musen, G., Simonson, D. C., Weinger, K., Bolo, N., … Jacobson, A. M. (2009). Altered prefrontal glutamate-glutamine-gamma-aminobutyric acid levels and relation to low cognitive performance and depressive symptoms in type 1 diabetes mellitus. Archives of General Psychiatry, 66, 878–887.

    Article  PubMed  Google Scholar 

  • Mäkimattila, S., Malmberg-Cèder, K., Häkkinen, A.M., Vuori, K., Salonen, O., Summanen, P., … Roine, R.O. (2004). Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury. Journal of Cerebral Blood Flow & Metabolism, 24(12), 1393–1399. https://doi.org/10.1097/01.WCB.0000143700.15489.B2.

    Article  Google Scholar 

  • Malone, J. I., Hanna, S. K., & Saporta, S. (2006). Hyperglycemic brain injury in the rat. Brain Research, 1076, 9–15.

    Article  PubMed  Google Scholar 

  • Malone, J. I., Hanna, S. K., & Saporta, S. (2008). Hyperglycemia NOT hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatric Diabetes, 45, 1259–1266.

    Google Scholar 

  • Marzelli, M. J., Mazaika, P. K., Barnea-Goraly, N., Hershey, T., Tsalikian, E., Tamborlane, W., … Reiss, A. L. (2014). Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes, 63, 343–353.

    Article  PubMed  Google Scholar 

  • Maurus, N., Beck, R., Xing, D., Ruedy, K., Buckingham, B., Tansey, M., … Diabetes Research in Children Network (DirecNet) Study Group. (2012). A randomised clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 < 10 years. Diabetes Care, 35, 2014–2210.

    Google Scholar 

  • Mazaika, P. K., Peng, D., Raman, M., Marzelli, M., Reiss, A. L., Weinzimer, S. A., … Moran, A. (2016). Variations in brain volume and growth in young children with type 1 diabetes. Diabetes, 65, 476–485.

    Article  PubMed  Google Scholar 

  • McIntyre, R. S., Kenna, H. A., Nguyen, H. T., Law, C. A., Sultan, F., Woldeyohannes, H. O., … Rasgon, N. L. (2010). Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: Points of pathophysiological commonality with mood disorders? Advances in Therapy, 27, 63–80.

    Article  PubMed  Google Scholar 

  • Mackay, M. T., Molesworth, C., Northam, E. A., Inder, T. E., & Cameron, F. J. (2016). Diabetic ketoacidosis and electroencephalographic changes in newly diagnosed pediatric patients. Pediatric Diabetes, 17, 244–248.

    Article  PubMed  Google Scholar 

  • McNally, K., Rohan, J., Pendley, J., Delamater, A., & Drotar, D. (2010). Executive functioning, treatment adherence, and glycemic control in children with type 1 diabetes. Diabetes Care, 33, 1159–1162.

    Article  PubMed  PubMed Central  Google Scholar 

  • Moulton, C. D., Costafreda, S. G., Horton, P., Ismail, K., & Fu, C. H. (2015). Meta-analyses of structural regional effects in type 1 and type 2 diabetes. Brain Imaging and Behavior, 9, 651–662.

    Article  PubMed  Google Scholar 

  • Musen, G., Lyoo, I. K., Sparks, C. R., Weinger, K., Hwang, J., Ryan, C. M., … Jacobson, A. M. (2006). Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry. Diabetes, 55, 326–333.

    Article  PubMed  Google Scholar 

  • Nadebaum, C., Scratch, S. E., Northam, E. A., & Cameron, F. J. (2012). Clinical utility of mental state screening as a predictor of intellectual outcomes 6 months after diagnosis of type 1 diabetes. Pediatric Diabetes, 13, 632–637.

    Article  PubMed  Google Scholar 

  • Naguib, J.M., Kulinskaya, E., Lomax, C.L., Garralda, E. (2009). Neuro-cognitive Performance in Children with Type 1 Diabetes- A Meta-analysis. Journal of Pediatric Psychology, 34(3), 271–282. https://doi.org/10.1093/jpepsy/jsn074.

    Article  PubMed  Google Scholar 

  • Northam, E. A., & Cameron, F. J. (2013). Understanding the diabetic brain: New technologies but old challenges. Diabetes, 62, 341–342.

    Article  PubMed  PubMed Central  Google Scholar 

  • Northam, E. A., Lin, A., Finch, S. J., Werther, G. A., & Cameron, F. J. (2010). Psychosocial well-being and functional outcome in youth with Type 1 diabetes 12 years after disease onset. Diabetes Care, 33, 1430–1437.

    Article  PubMed  PubMed Central  Google Scholar 

  • Northam, E. A., Rankins, D., Lin, A., Wellard, R. M., Pell, G. S., Finch, S. J., … Cameron, F. J. (2009). Central nervous system function in youth with type 1 diabetes 12 years after disease onset. Diabetes Care, 32, 445–450.

    Article  PubMed  PubMed Central  Google Scholar 

  • Patino-Fernandez, A. M., Delamater, A. M., Applegate, E. B., Brady, E., Eidson, M., Nemery, R., … Richton, S. (2010). Neurocognitive functioning in preschool-age children with type 1 diabetes. Pediatric Diabetes, 11, 424–431.

    Article  PubMed  PubMed Central  Google Scholar 

  • Perantie, D. C., Koller, J. M., Weave, P. M., Lugar, H. M., Black, K. J., White, N. H., & Hershey, T. (2011). Prospectively determined impact of type 1 diabetes on brain volume during development. Diabetes, 60, 3006–3014.

    Article  PubMed  PubMed Central  Google Scholar 

  • Perantie, D. C., Lim, A., Wu, J., Weaver, P., Warran, S. L., Sadler, M., … Hershey, T. (2008). Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatric Diabetes, 9, 87–95.

    Article  PubMed  Google Scholar 

  • Perantie, D. C., Wu, J., Koller, J. M., Lim, A., Warren, S. L., Black, K. J., … Hershey, T. (2007). Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care, 30, 2331–2337.

    Article  PubMed  Google Scholar 

  • Persson, S., Dahlquist, G., Gerdtham, UG., Carlsson, K.S. (2013). Impact of childhood-onset type 1 diabetes on schooling: a population-based register study. Diabetologia, 56, 1254–1262. https://doi.org/10.1007/s00125-013-2870-8

    Article  PubMed  Google Scholar 

  • Reynolds, K. A., & Helgeson, V. S. (2011). Children with diabetes compared to peers: Depressed? Distressed? Annals of Behavioral Medicine, 42, 29–41.

    Article  PubMed  Google Scholar 

  • Russo, V., Higgins, S., Werther, G. A., & Cameron, F. J. (2012). Effects of fluctuating glucose levels on neuronal cells in vitro. Neurochemical Research, 37, 1768–1782.

    Article  PubMed  Google Scholar 

  • Ryan, C. M. (2008). Searching for the origin of brain dysfunction in diabetic children: Going back to the beginning. Pediatric Diabetes, 9, 527–530.

    Article  PubMed  Google Scholar 

  • Salem, M. A. K., Matta, L. F., Tantawy, A. A. G., Hussein, M., & Gad, G. I. (2002). Single photon emission tomography (SPECT) study of regional blood flow in normoalbuminuric children and adolescents with type 1 diabetes. Pediatric Diabetes, 3, 155–162.

    Article  PubMed  Google Scholar 

  • Sarac, K., Akinci, A., Alkan, A., Aslan, M., Baysal, T., & Ozcan, C. (2005). Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes. Neuroradiology, 47, 562–565.

    Article  PubMed  Google Scholar 

  • Schoenle, E. J., Schoenle, D., Molinari, L., & Largo, R. H. (2002). Impaired intellectual development in children with type 1 diabetes: Association with HbA1c, age at diagnosis and sex. Diabetologia, 45, 108–114.

    Article  PubMed  Google Scholar 

  • Schwartz, D.D., Axelrad, M.E., Anderson, B.J. (2014). Neurocognitive functioning in children and adolescents at the time of type 1 diabetes diagnosis: Associations with glycemic control 1 year after diagnosis. Diabetes Care, 37(9) 2475–2482. https://doi.org/10.2337/dc14-0103

    Article  PubMed  Google Scholar 

  • Schwartz, D.D., Wasserman, R., Powell, P.W., Axelrad, M.E. (2014). Neurocognitive outcomes in pediatric diabetes: a developmental perspective. Curr Diab Rep 14, 533. https://doi.org/10.1007/s11892-014-0533-x

  • Serlachius, A., Scratch, S. E., Northam, E. A., Frydenberg, E., Lee, K. J., & Cameron, F. J. (2016). A randomised controlled trial of cognitive behavior therapy to improve glycemic control and psychosocial wellbeing in adolescents with type 1 diabetes. Journal of Health Psychology, 21, 1157–1169.

    Article  PubMed  Google Scholar 

  • Siller, A. F., Lugar, H., Rutlin, J., Koller, J. M., Semenkovich, K., White, N. H., … Hershey, T. (2016). Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatric Diabetes. https://doi.org/10.1111/pedi12420

  • Sima, A. A. (2010). Encephalopathies: The emerging diabetic complications. Acta Diabetologica, 47, 279–293.

    Article  PubMed  Google Scholar 

  • Strudwick, S. K., Carne, C., Gardiner, J., Foster, J. K., Davis, E., & Jones, T. W. (2005). Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycaemia. The Journal of Pediatrics, 147, 680–685.

    Article  PubMed  Google Scholar 

  • Tomlinson, D. R., & Gardiner, N. J. (2008). Glucose neurotoxicity. Nature Reviews. Neuroscience, 9, 36–45.

    Article  PubMed  Google Scholar 

  • Tonoli, C., Heyman, E., Roelands, B., Pattyn, N., Buyse, L., Piacentini, M. F., … Meeusen, R. (2014). Type 1 diabetes-associated cognitive decline: A meta-analysis and update of the current literature. Journal of Diabetes, 6, 499–513.

    Article  PubMed  Google Scholar 

  • Westrupp, E., Northam, E., Lee, K., Scratch, S., & Cameron, F. (2015). Reducing and preventing internalizing and externalizing behavior problems in children with type 1 diabetes: A randomized controlled trial of the triple P-positive parenting program. Pediatric Diabetes, 16, 554–563.

    Article  PubMed  Google Scholar 

  • Winkley, K., Miranda-da-Cruz, B., & Sonneville, L. (2006). Psychological interventions to improve glycaemic control in type 1 diabetes: Systematic review and meta-analysis of randomised controlled trials. BMJ, 333, 65.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wootton-Gorges, S. L., Buonocore, M. H., Kupperman, N., Marcin, J. P., Barnes, P. D., Neely, E. K., … Glaser, N. S. (2007). Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis. American Journal of Neuroradiology, 28, 895–899.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Elisabeth Northam .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Northam, E. (2020). Effects of Diabetes on Neurocognitive Function of Children. In: Delamater, A., Marrero, D. (eds) Behavioral Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-33286-0_7

Download citation

Publish with us

Policies and ethics