Skip to main content
SpringerLink
Log in

Gonadal Dysfunction and Fertility Preservation in Hodgkin Lymphoma Patients

  • Chapter
  • First Online:
Hodgkin Lymphoma

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

  • 988 Accesses

Abstract

Patients with Hodgkin lymphoma (HL) are generally young, and high cure rates can be achieved. Thus, HL diagnosis and therapy frequently occur at a time of life when family planning plays an important role. It is therefore of major importance for the patients to discuss this subject and to consider fertility preservation techniques as early as possible after diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gorman JR, Su HI, Roberts SC, Dominick SA, Malcarne VL (2015) Experiencing reproductive concerns as a female cancer survivor is associated with depression. Cancer 121(6):935–942

    Article  PubMed  Google Scholar 

  2. Murphy D, Orgel E, Termuhlen A, Shannon S, Warren K, Quinn GP (2013) Why healthcare providers should focus on the fertility of AYA Cancer survivors: It’s not too late! Front Oncol 3:248

    Article  PubMed  PubMed Central  Google Scholar 

  3. Skaczkowski G, White V, Thompson K, Bibby H, Coory M, Orme LM et al (2018) Factors influencing the provision of fertility counseling and impact on quality of life in adolescents and young adults with cancer. J Psychosoc Oncol 15:1–19

    Google Scholar 

  4. Letourneau JM, Ebbel EE, Katz PP, Katz A, Ai WZ, Chien AJ et al (2012) Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer. Cancer 118(6):1710–1717

    Article  PubMed  Google Scholar 

  5. Rueffer U, Breuer K, Josting A, Lathan B, Sieber M, Manzke O et al (2001) Male gonadal dysfunction in patients with Hodgkin’s disease prior to treatment. Ann Oncol 12(9):1307–1311

    Article  CAS  PubMed  Google Scholar 

  6. Sieniawski M, Reineke T, Josting A, Nogova L, Behringer K, Halbsguth T et al (2008) Assessment of male fertility in patients with Hodgkin’s lymphoma treated in the German Hodgkin study group (GHSG) clinical trials. Ann Oncol 19(10):1795–1801

    Article  CAS  PubMed  Google Scholar 

  7. Viviani S, Ragni G, Santoro A, Perotti L, Caccamo E, Negretti E et al (1991) Testicular dysfunction in Hodgkin’s disease before and after treatment. Eur J Cancer 27(11):1389–1392

    Article  CAS  PubMed  Google Scholar 

  8. Sieniawski M, Reineke T, Nogova L, Josting A, Pfistner B, Diehl V et al (2008) Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin study group (GHSG). Blood 111(1):71–76

    Article  CAS  PubMed  Google Scholar 

  9. Paoli D, Rizzo F, Fiore G, Pallotti F, Pulsoni A, Annechini G et al (2016) Spermatogenesis in Hodgkin’s lymphoma patients: a retrospective study of semen quality before and after different chemotherapy regimens. Hum Reprod 31(2):263–272

    CAS  PubMed  Google Scholar 

  10. Agarwal A, Allamaneni SS (2005) Disruption of spermatogenesis by the cancer disease process. J Natl Cancer Inst Monogr 34:9–12

    Article  Google Scholar 

  11. Barr RD, Clark DA, Booth JD (1993) Dyspermia in men with localized Hodgkin’s disease. A potentially reversible, immune-mediated disorder. Med Hypotheses 40(3):165–168

    Article  CAS  PubMed  Google Scholar 

  12. Dousset B, Hussenet F, Daudin M, Bujan L, Foliguet B, Nabet P (1997) Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod 12(7):1476–1479

    Article  CAS  PubMed  Google Scholar 

  13. Huleihel M, Lunenfeld E, Levy A, Potashnik G, Glezerman M (1996) Distinct expression levels of cytokines and soluble cytokine receptors in seminal plasma of fertile and infertile men. Fertil Steril 66(1):135–139

    Article  CAS  PubMed  Google Scholar 

  14. Redman J, Bajorunas D, Goldstein M, Evenson D, Gralla R, Lacher M et al (1987) Semen cryopreservation and artificial insemination for Hodgkin’s disease. J Clin Oncol 5(2):233–238

    Article  CAS  PubMed  Google Scholar 

  15. Chapman R, Sutcliffe S, Malpas J (1981) Male gonadal dysfunction in Hodgkin’s disease. A prospective study. JAMA 245(13):1323–1328

    Article  CAS  PubMed  Google Scholar 

  16. Kreuser E, Felsenberg D, Behles C, Seibt-Jung H, Mielcarek M, Diehl V et al (1992) Long-term gonadal dysfunction and its impact on bone mineralization in patients following COPP/ABVD chemotherapy for Hodgkin’s disease. Ann Oncol 3(Suppl 4):105–110

    Article  PubMed  Google Scholar 

  17. Kreuser ED, Xiros N, Hetzel WD, Heimpel H (1987) Reproductive and endocrine gonadal capacity in patients treated with COPP chemotherapy for Hodgkin’s disease. J Cancer Res Clin Oncol 113(3):260–266

    Article  CAS  PubMed  Google Scholar 

  18. Viviani S, Santoro A, Ragni G, Bonfante V, Bestetti O, Bonadonna G (1985) Gonadal toxicity after combination chemotherapy for Hodgkin’s disease. Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21(5):601–605

    Article  CAS  PubMed  Google Scholar 

  19. Waxman J, Terry Y, Wrigley P, Malpas J, Rees L, Besser G et al (1982) Gonadal function in Hodgkin’s disease: long-term follow-up of chemotherapy. Br Med J (Clin Res Ed) 285(6355):1612–1613

    Article  CAS  Google Scholar 

  20. Andrieu J, Masson D, Fiet J, Gourmel B, Czyglik F, Bernard J (1981) Male fertility in Hodgkin’s disease before and after chemotherapy (author’s transl). Nouv Press Med 10(25):2085–2088

    CAS  Google Scholar 

  21. da CM, Meistrich M, Fuller L, Cundiff J, Hagemeister F, Velasquez W et al (1984) Recovery of spermatogenesis after treatment for Hodgkin’s disease: limiting dose of MOPP chemotherapy. J Clin Oncol 2(6):571–577

    Article  Google Scholar 

  22. Bonadonna G, Santoro A, Viviani S, Lombardi C, Ragni G (1984) Gonadal damage in Hodgkin’s disease from cancer chemotherapeutic regimens. Arch Toxicol Suppl 7:140–145

    Article  CAS  PubMed  Google Scholar 

  23. Kulkarni S, Sastry P, Saikia T, Parikh P, Gopal R, Advani S (1997) Gonadal function following ABVD therapy for Hodgkin’s disease. Am J Clin Oncol 20(4):354–357

    Article  CAS  PubMed  Google Scholar 

  24. Gandini L, Lombardo F, Salacone P, Paoli D, Anselmo AP, Culasso F et al (2003) Testicular cancer and Hodgkin’s disease: evaluation of semen quality. Hum Reprod 18(4):796–801

    Article  CAS  PubMed  Google Scholar 

  25. van der Kaaij MA, Heutte N, Le Stang N, Raemaekers JM, Simons AH, Carde P et al (2007) Gonadal function in males after chemotherapy for early-stage Hodgkin’s lymphoma treated in four subsequent trials by the European Organisation for Research and Treatment of Cancer: EORTC lymphoma group and the Groupe d’Etude des Lymphomes de l’Adulte. J Clin Oncol 25(19):2825–2832

    Article  PubMed  CAS  Google Scholar 

  26. Andersson AM, Petersen JH, Jorgensen N, Jensen TK, Skakkebaek NE (2004) Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men. J Clin Endocrinol Metab 89(6):2873–2879

    Article  CAS  PubMed  Google Scholar 

  27. Bordallo MA, Guimaraes MM, Pessoa CH, Carrico MK, Dimetz T, Gazolla HM et al (2004) Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence. J Pediatr Endocrinol Metab 17(6):879–887

    Article  CAS  PubMed  Google Scholar 

  28. van Casteren NJ, van der Linden GH, Hakvoort-Cammel FG, Hahlen K, Dohle GR, Van den Heuvel-Eibrink MM (2009) Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. Pediatr Blood Cancer 52(1):108–112

    Article  PubMed  Google Scholar 

  29. Kumanov P, Nandipati K, Tomova A, Agarwal A (2006) Inhibin B is a better marker of spermatogenesis than other hormones in the evaluation of male factor infertility. Fertil Steril 86(2):332–338

    Article  CAS  PubMed  Google Scholar 

  30. van Beek RD, Smit M, Van den Heuvel-Eibrink MM, de Jong FH, Hakvoort-Cammel FG, van den Bos C et al (2007) Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood. Hum Reprod 22(12):3215–3222

    Article  PubMed  CAS  Google Scholar 

  31. Behringer K, Mueller H, Goergen H, Thielen I, Eibl AD, Stumpf V et al (2013) Gonadal function and fertility in survivors after Hodgkin lymphoma treatment within the German Hodgkin study group HD13 to HD15 trials. J Clin Oncol 31(2):231–239

    Article  CAS  PubMed  Google Scholar 

  32. Kiserud CE, Fossa A, Bjoro T, Holte H, Cvancarova M, Fossa SD (2009) Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy. Br J Cancer 100(3):455–463

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Nuver J, Smit AJ, Wolffenbuttel BH, Sluiter WJ, Hoekstra HJ, Sleijfer DT et al (2005) The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol 23(16):3718–3725

    Article  CAS  PubMed  Google Scholar 

  34. van der Kaaij MA, van Echten-Arends J, Heutte N, Meijnders P, Abeilard-Lemoisson E, Spina M et al (2014) Cryopreservation, semen use and the likelihood of fatherhood in male Hodgkin lymphoma survivors: an EORTC-GELA lymphoma group cohort study. Hum Reprod 29(3):525–533

    Article  PubMed  Google Scholar 

  35. Jahnukainen K, Ehmcke J, Nurmio M, Schlatt S (2012) Autologous ectopic grafting of cryopreserved testicular tissue preserves the fertility of prepubescent monkeys that receive sterilizing cytotoxic therapy. Cancer Res 72(20):5174–5178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Familiari G, Caggiati A, Nottola S, Ermini M, Di BM, Motta P (1993) Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin’s disease. Hum Reprod 8(12):2080–2087

    Article  CAS  PubMed  Google Scholar 

  37. Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG (1983) The effect of combination chemotherapy on ovarian function in women treated for Hodgkin’s disease. Cancer 52(6):988–993

    Article  CAS  PubMed  Google Scholar 

  38. Schilsky RL, Sherins RJ, Hubbard SM, Wesley MN, Young RC, DeVita VT (1981) Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin’s disease. Am J Med 71(4):552–556

    Article  CAS  PubMed  Google Scholar 

  39. Franchi-Rezgui P, Rousselot P, Espie M, Briere J, Pierre Marolleau J, Gisselbrecht C et al (2003) Fertility in young women after chemotherapy with alkylating agents for Hodgkin and non-Hodgkin lymphomas. Hematol J 4(2):116–120

    Article  CAS  PubMed  Google Scholar 

  40. Haukvik UK, Dieset I, Bjoro T, Holte H, Fossa SD (2006) Treatment-related premature ovarian failure as a long-term complication after Hodgkin’s lymphoma. Ann Oncol 17(9):1428–1433

    Article  CAS  PubMed  Google Scholar 

  41. Behringer K, Breuer K, Reineke T, May M, Nogova L, Klimm B et al (2005) Secondary amenorrhea after Hodgkin’s lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin’s lymphoma study group. J Clin Oncol 23(30):7555–7564

    Article  PubMed  Google Scholar 

  42. van der Kaaij MA, Heutte N, Meijnders P, Abeilard-Lemoisson E, Spina M, Moser EC et al (2012) Premature ovarian failure and fertility in long-term survivors of Hodgkin’s lymphoma: a European Organisation for Research and Treatment of Cancer lymphoma group and Groupe d’Etude des Lymphomes de l’Adulte cohort study. J Clin Oncol 30(3):291–299

    Article  PubMed  Google Scholar 

  43. Falorio S, Biasoli I, Luminari S, Quintana G, Musso M, Dell’olio M et al (2013) Risk factors for impaired gonadal function in female Hodgkin lymphoma survivors: final analysis of a retrospective multicenter joint study from Italian and Brazilian institutions. Hematol Oncol 31(2):72–78

    Article  PubMed  Google Scholar 

  44. Bonadonna G (1994) Modern treatment of malignant lymphomas: a multidisciplinary approach? The Kaplan memorial lecture. Ann Oncol 5(Suppl 2):5–16

    Article  PubMed  Google Scholar 

  45. Brusamolino E, Lunghi F, Orlandi E, Astori C, Passamonti F, Barate C et al (2000) Treatment of early-stage Hodgkin’s disease with four cycles of ABVD followed by adjuvant radio-therapy: analysis of efficacy and long-term toxicity. Haematologica 85(10):1032–1039

    CAS  PubMed  Google Scholar 

  46. Hodgson DC, Pintilie M, Gitterman L, Dewitt B, Buckley CA, Ahmed S et al (2007) Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy. Hematol Oncol 25(1):11–15

    Article  PubMed  Google Scholar 

  47. Andre M, Brice P, Cazals D, Hennequin C, Ferme C, Kerneis Y et al (1997) Results of three courses of adriamycin, bleomycin, vindesine, and dacarbazine with subtotal nodal irradiation in 189 patients with nodal Hodgkin’s disease (stage I, II and IIIA). Hematol Cell Ther 39(2):59–65

    Article  CAS  PubMed  Google Scholar 

  48. Horning SJ, Hoppe RT, Kaplan HS, Rosenberg SA (1981) Female reproductive potential after treatment for Hodgkin’s disease. N Engl J Med 304(23):1377–1382

    Article  CAS  PubMed  Google Scholar 

  49. Howell SJ, Shalet SM (2002) Fertility preservation and management of gonadal failure associated with lymphoma therapy. Curr Oncol Rep 4(5):443–452

    Article  PubMed  Google Scholar 

  50. Anderson RA, Remedios R, Kirkwood AA, Patrick P, Stevens L, Clifton-Hadley L et al (2018) Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin’s lymphoma (RATHL): a secondary analysis of a randomised phase 3 trial. Lancet Oncol 19(10):1328–1133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Weibull CE, Johansson ALV, Eloranta S, Smedby KE, Bjorkholm M, Lambert PC et al (2018) Contemporarily treated patients with Hodgkin lymphoma have childbearing potential in line with matched comparators. J Clin Oncol 36(26):2718–2725

    Article  CAS  PubMed  Google Scholar 

  52. Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy C, Englert Y (2007) Stable serum levels of anti-Mullerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum Reprod 22(7):1837–1840

    Article  CAS  PubMed  Google Scholar 

  53. van Beek RD, Van den Heuvel-Eibrink MM, Laven JS, de Jong FH, Themmen AP, Hakvoort-Cammel FG et al (2007) Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin’s lymphoma during childhood. J Clin Endocrinol Metab 92(10):3869–3874

    Article  PubMed  CAS  Google Scholar 

  54. Visser JA, de Jong FH, Laven JS, Themmen AP (2006) Anti-Mullerian hormone: a new marker for ovarian function. Reproduction 131(1):1–9

    Article  CAS  PubMed  Google Scholar 

  55. Lawrenz B, Fehm T, von Wolff M, Soekler M, Huebner S, Henes J et al (2012) Reduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin lymphoma or non-Hodgkin-lymphoma--evaluation by using antimullerian hormone and retrieved oocytes. Fertil Steril 98(1):141–144

    Article  CAS  PubMed  Google Scholar 

  56. Paradisi R, Vicenti R, Macciocca M, Seracchioli R, Rossi S, Fabbri R (2016) High cytokine expression and reduced ovarian reserve in patients with Hodgkin lymphoma or non-Hodgkin lymphoma. Fertil Steril 106(5):1176–1182

    Article  CAS  PubMed  Google Scholar 

  57. von Wolff M, Bruckner T, Strowitzki T, Germeyer A (2018) Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant diseases-an analysis of 992 stimulations. J Assist Reprod Genet 35(9):1713–1719

    Article  Google Scholar 

  58. Wallace WH, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18(1):117–121

    Article  CAS  PubMed  Google Scholar 

  59. Wo JY, Viswanathan AN (2009) Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients. Int J Radiat Oncol Biol Phys 73(5):1304–1312

    Article  PubMed  PubMed Central  Google Scholar 

  60. Lambertini M, Moore HCF, Leonard RCF, Loibl S, Munster P, Bruzzone M et al (2018) Gonadotropin-releasing hormone agonists during chemotherapy for preservation of ovarian function and fertility in premenopausal patients with early breast Cancer: a systematic review and meta-analysis of individual patient-level data. J Clin Oncol 36(19):1981–1990

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Demeestere I, Brice P, Peccatori FA, Kentos A, Dupuis J, Zachee P et al (2016) No evidence for the benefit of gonadotropin-releasing hormone agonist in preserving ovarian function and fertility in lymphoma survivors treated with chemotherapy: final long-term report of a prospective randomized trial. J Clin Oncol 34(22):2568–2574

    Article  CAS  PubMed  Google Scholar 

  62. Dittrich R, Kliesch S, Schuring A, Balcerek M, Baston-Bust DM, Beck R et al (2018) Fertility preservation for patients with malignant disease. Guideline of the DGGG, DGU and DGRM (S2k-level, AWMF registry no. 015/082, November 2017)—recommendations and statements for girls and women. Geburtshilfe Frauenheilkd 78(6):567–584

    Article  PubMed  PubMed Central  Google Scholar 

  63. von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM et al (2009 Oct) Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril 92(4):1360–1365

    Article  CAS  Google Scholar 

  64. von Wolff M, Capp E, Jauckus J, Strowitzki T, Germeyer A (2016) Timing of ovarian stimulation in patients prior to gonadotoxic therapy: an analysis of 684 stimulations. Eur J Obstet Gynecol Reprod Biol 199:146–149

    Article  CAS  Google Scholar 

  65. Vaiarelli A, Venturella R, Vizziello D, Bulletti F, Ubaldi FM (2017) Dual ovarian stimulation and random start in assisted reproductive technologies: from ovarian biology to clinical application. Curr Opin Obstet Gynecol 29(3):153–159

    Article  PubMed  Google Scholar 

  66. Rosendahl M, Schmidt KT, Ernst E, Rasmussen PE, Loft A, Byskov AG et al (2011) Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique. Reprod BioMed Online 22(2):162–171

    Article  PubMed  Google Scholar 

  67. Liebenthron J, Montag M, Reinsberg J, Köster M, Isachenko V, van der Ven K et al (2019) Overnight ovarian tissue transportation for centralized cryobanking—a feasible option. Reprod BioMed Online 38(5):740–749

    Article  PubMed  Google Scholar 

  68. Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT et al (2013) Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril 99(6):1503–1513

    Article  PubMed  Google Scholar 

  69. Demeestere I, Simon P, Dedeken L, Moffa F, Tsepelidis S, Brachet C et al (2015) Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod 30(9):2107–2109

    Article  PubMed  Google Scholar 

  70. Anderson RA, Hindmarsh PC, Wallace WH (2013) Induction of puberty by autograft of cryopreserved ovarian tissue in a patient previously treated for Ewing sarcoma. Eur J Cancer 49(13):2960–2961

    Article  PubMed  Google Scholar 

  71. Poirot C, Abirached F, Prades M, Coussieu C, Bernaudin F, Piver P (2012) Induction of puberty by autograft of cryopreserved ovarian tissue. Lancet 379(9815):588

    Article  PubMed  Google Scholar 

  72. Dolmans MM, Luyckx V, Donnez J, Andersen CY, Greve T (2013) Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue. Fertil Steril 99(6):1514–1522

    Article  PubMed  Google Scholar 

  73. McLaughlin M, Albertini DF, Wallace WHB, Anderson RA, Telfer EE (2018) Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system. Mol Hum Reprod 24(3):135–142

    Article  CAS  PubMed  Google Scholar 

  74. Dittrich R, Lotz L, Fehm T, Krussel J, von Wolff M, Toth B et al (2015) Xenotransplantation of cryopreserved human ovarian tissue—a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment. Fertil Steril 103(6):1557–1565

    Article  PubMed  Google Scholar 

  75. Huober-Zeeb C, Lawrenz B, Popovici RM, Strowitzki T, Germeyer A, Stute P et al (2011) Improving fertility preservation in cancer: ovarian tissue cryobanking followed by ovarian stimulation can be efficiently combined. Fertil Steril 95(1):342–344

    Article  PubMed  Google Scholar 

  76. Barahmeh S, Al Masri M, Badran O, Masarweh M, El-Ghanem M, Jaradat I et al (2013) Ovarian transposition before pelvic irradiation: indications and functional outcome. J Obstet Gynaecol Res 39(11):1533–1537

    Article  PubMed  Google Scholar 

  77. Mossa B, Schimberni M, Di Benedetto L, Mossa S (2015) Ovarian transposition in young women and fertility sparing. Eur Rev Med Pharmacol Sci 19(18):3418–3425

    CAS  PubMed  Google Scholar 

  78. Kicinski M, Springate DA, Kontopantelis E (2015) Publication bias in meta-analyses from the Cochrane database of systematic reviews. Stat Med 34(20):2781–2793

    Article  PubMed  Google Scholar 

  79. Hwang JH, Yoo HJ, Park SH, Lim MC, Seo SS, Kang S et al (2012) Association between the location of transposed ovary and ovarian function in patients with uterine cervical cancer treated with (postoperative or primary) pelvic radiotherapy. Fertil Steril 97(6):1387–1393.e1–2

    Article  PubMed  Google Scholar 

  80. Kurt M, Uncu G, Cetintas SK, Kucuk N, Guler S, Ozkan L (2007) Successful spontaneous pregnancy in a patient with rectal carcinoma treated with pelvic radiotherapy and concurrent chemotherapy: the unique role of laparoscopic lateral ovary transposition. Eur J Gynaecol Oncol 28(5):408–410

    CAS  PubMed  Google Scholar 

  81. Salih SM, Albayrak S, Seo S, Stewart SL, Bradley K, Kushner DM (2015) Diminished utilization of in vitro fertilization following ovarian transposition in cervical Cancer patients. J Reprod Med 60(7–8):345–353

    PubMed  PubMed Central  Google Scholar 

  82. Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C et al (2006) Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Inst 98(13):890–896

    Article  PubMed  Google Scholar 

  83. De Bruin ML, Huisbrink J, Hauptmann M, Kuenen MA, Ouwens GM, van Veer MB et al (2008) Treatment-related risk factors for premature menopause following Hodgkin lymphoma. Blood 111(1):101–108

    Article  PubMed  CAS  Google Scholar 

  84. Swerdlow AJ, Cooke R, Bates A, Cunningham D, Falk SJ, Gilson D et al (2014) Risk of premature menopause after treatment for Hodgkin’s lymphoma. J Natl Cancer Inst 106(9):pii: dju207

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Internal Medicine, German Hodgkin Study Group (GHSG), University Hospital Cologne, Cologne, Germany

    Karolin Behringer

  2. Department of Gynecological Endocrinology and Reproductive Medicine, University Hospital—Inselspital Berne, Berne, Switzerland

    Michael von Wolff

Authors
  1. Karolin Behringer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael von Wolff
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Karolin Behringer .

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University Hospital Cologne, Köln, Nordrhein-Westfalen, Germany

    Andreas Engert

  2. Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Anas Younes

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Behringer, K., von Wolff, M. (2020). Gonadal Dysfunction and Fertility Preservation in Hodgkin Lymphoma Patients. In: Engert, A., Younes, A. (eds) Hodgkin Lymphoma. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-32482-7_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-32482-7_28

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32481-0

  • Online ISBN: 978-3-030-32482-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation