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Anal Fistula: Glue and Paste Injection

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Anal Fistula and Abscess

Part of the book series: Coloproctology ((COLOPROCT))

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Abstract

The use of glue or paste as a sealant for anal fistula is an attractive treatment concept, as it can effect closure without jeopardizing fecal continence or interfering with potential future interventions. Multiple substances have been explored in the past, with fibrin glue and collagen paste being the most recent. This chapter presents the findings of non-randomized controlled studies with ≥25 patients and available randomized controlled trials. Evidence for the clinical effectiveness of fistula closure with fibrin glue is low; for collagen paste, data are even fewer. Available information is heterogeneous with regard to indication, outcome monitoring, and assessment. Study methodology varies widely. Randomized trials with fibrin glue indicate that the clinical benefit is limited. Despite this, the therapeutic concept of fistula closure with glue and paste remains of interest because of its very low invasiveness.

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Author information

Authors and Affiliations

  1. Department of Surgery, University Erlangen, Erlangen, Germany

    Klaus E. Matzel & Birgit Bittorf

Authors
  1. Klaus E. Matzel
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  2. Birgit Bittorf
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Corresponding author

Correspondence to Klaus E. Matzel .

Editor information

Editors and Affiliations

  1. Clinica Chirurgica, Catholic University, ROMA, Roma, Italy

    Carlo Ratto

  2. Dept. of Abdominal Surgery, Catholic University, ROMA, Roma, Italy

    Angelo Parello

  3. Dept. of Abdominal Surgery, Catholic University, ROMA, Roma, Italy

    Francesco Litta

  4. Dept. of Abdominal Surgery, Catholic University, Roma, Italy

    Veronica De Simone

  5. Proctology Unit, Dept. of Abdominal Surg, Foundation University Hospital “A. Gem, Roma, Roma, Italy

    Paola Campennì

Section Editor information

  1. University Hospital “A. Gemelli”, Proctology Unit, Catholic University, Rome, Italy

    Carlo Ratto MD, FASCRS

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Matzel, K.E., Bittorf, B. (2022). Anal Fistula: Glue and Paste Injection. In: Ratto, C., Parello, A., Litta, F., De Simone, V., Campennì, P. (eds) Anal Fistula and Abscess. Coloproctology. Springer, Cham. https://doi.org/10.1007/978-3-030-30902-2_26-1

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  • DOI: https://doi.org/10.1007/978-3-030-30902-2_26-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-30902-2

  • Online ISBN: 978-3-030-30902-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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