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Mucocutaneous Manifestations in Gastrointestinal Disease

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Geriatric Gastroenterology

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Abstract

The gastrointestinal (GI) system of the human body is influenced by many factors that can cause age related and pathological changes in the skin and organ systems. Several GI disorders are associated with cutaneous manifestations. A thorough understanding of the cutaneous-gastrointestinal relationship can alert the astute clinician to the presence of GI disease in patients presenting with mucocutaneous manifestations. This overview provides insight into mucocutaneous manifestations of GI disorders including signs and symptoms, diagnosis, treatment, and prognosis.

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References

  • Abdelmaksoud A, et al. Classic and HIV-related Kaposi sarcoma treated with 0.1% topical timolol gel. J Am Acad Dermatol. 2017;76(1):153.

    Article  PubMed  Google Scholar 

  • Abenavoli L, Proietti I, Vonghia L, et al. Intestinal malabsorption and skin disorders. Dig Dis. 2008;26(2): 167–74.

    Article  PubMed  Google Scholar 

  • Adkisson K, Fiala KH. Cowden disease (Multiple hamartoma syndrome). n.d. Retrieved from http://wemedicine.medscape.com/article/1093383-overview. Accessed 15 Mar 2011.

  • Agarwal R, Liebe S, Turski ML, Vidwans SJ, Janku F, Garrido-Laguna I, Munoz J, Schwab R, Rodon J, Kurzrock R, Subbiah V, Pan-Cancer Working Group. Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome. Discov Med. 2015;19(103):109–16.

    PubMed  Google Scholar 

  • Aguilera P, Laguno M, To-Figueras J. Treatment of chronic hepatitis with boceprevir leads to remission of porphyria cutanea tarda. Br J Dermatol. 2014;171(6): 1595–6.

    Article  CAS  PubMed  Google Scholar 

  • Akbulut S, Ozaslan E, Topal F, et al. Ulcerative colitis presenting as leukocytoclastic vasculitis of skin. World J Gastroenterol. 2008;14(15):2448–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Akram Z, Javed F, Hosein M, Al-Qahtani MA, Alshehri F, Alzahrani AI, Vohra F. Photodynamic therapy in the treatment of symptomatic oral lichen planus: a systematic review. Photodermatol Photoimmunol Photomed. 2018;34(3):167–74.

    Article  CAS  PubMed  Google Scholar 

  • Alcántara-Reifs CM, et al. Classic Kaposi’s sarcoma treated with topical 0.5% timolol gel. Dermatol Ther. 2016;29(5):309.

    Article  PubMed  Google Scholar 

  • Al-Faouri A, Ajarma K, Alghazawi S, Al-Rawabdeh S, Zayaeen A. Glucagonoma and Glucagonoma syndrome: a case report with review of recent advances in management. Case Rep Surg. 2016;2016:1484089.

    PubMed  PubMed Central  Google Scholar 

  • Allan AE, Shoji T, Li N, Burlage A, Davis B, Bhawan J. Two cases of Kaposi’s sarcoma mimicking Stewart-Treves syndrome found to be human herpesvirus-8 positive. Am J Dermatopathol. 2001;23(5):431–6.

    Article  CAS  PubMed  Google Scholar 

  • Al-Maweri SA. Prevalence of oral mucosal lesions in patients with type 2 diabetes attending hospital universiti sains Malaysia. Malays J Med Sci. 2013;20(4):39–46.

    PubMed  PubMed Central  Google Scholar 

  • Alpsoy E. Behçet’s disease: a comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions. J Dermatol. 2016;43(6):620–32.

    Article  CAS  PubMed  Google Scholar 

  • American Academy of Family Physicians. Information from your family doctor. Intertrigo: what you should know. Am Fam Physician. 2005;72(5):840.

    Google Scholar 

  • Angeloni A, Heston L, Uccini S, Sirianni MC, Cottoni F, Masala MV, Cerimele D, Lin SF, Sun R, Rigsby M, Faggioni A, Miller G. High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi’s sarcoma from Sardinia. J Infect Dis. 1998;177(6):1715.

    Article  CAS  PubMed  Google Scholar 

  • Apak H, Celkan T, Ozkan A, et al. Blue rubber bleb nevus syndrome associated with consumption coagulopathy: treatment with interferon. Dermatology. 2004;208(4): 345–8.

    Article  CAS  PubMed  Google Scholar 

  • Asare GA, Bronz M, Naidoo V, Kew MC. Synergistic interaction between excess hepatic iron and alcohol ingestion in hepatic mutagenesis. Toxicology. 2008; 254(1–2):11–8.

    Article  CAS  PubMed  Google Scholar 

  • Ascari-Raccagni A, Baldari U, Righini MG. Cutaneous symptoms of Gardner’s syndrome. J Eur Acad Dermatol Venereol. 1999;12(1):80–1.

    Article  CAS  PubMed  Google Scholar 

  • Ashida R, Ihn H, Mimura Y, et al. Clinical and laboratory features of Japanese patients with scleroderma and telangiectasia. Clin Exp Dermatol. 2009;34(7):761–3.

    Article  Google Scholar 

  • Ayesh MH. Angular cheilitis induced by iron deficiency anemia. Cleve Clin J Med. 2018;85(8):581–2.

    Article  PubMed  Google Scholar 

  • Balasubramaniam P, Ogboli M, Moss C. Lichen planus in children: review of 26 cases. Clin Exp Dermatol. 2008;33(4):457–9.

    Article  CAS  PubMed  Google Scholar 

  • Barta Z, Zold E, Nagy A, Zeher M, Csipo I. Celiac disease and microscopic colitis: a report of 4 cases. World J Gastroenterol. 2011;17(16):2150–4.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bean WB. Blue rubber bleb nevi of the skin and gastrointestinal tract. In: Bean WB, editor. Vascular spiders and related lesions of the skin. Springfield: Charles C Thomas; 1958. p. 178–85.

    Google Scholar 

  • Benson CA, et al. Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the national institutes of health, and the HIV medicine association/infectious diseases society of America. MMWR Recomm Rep. 2004;53(RR-15):1.

    PubMed  Google Scholar 

  • Berger TG, Detlefs RL, Donatucci CF. Junctional epidermolysis bullosa, pyloric atresia, and genitourinary disease. Pediatr Dermatol. 1986;3(2):130–4.

    Article  CAS  PubMed  Google Scholar 

  • Bonciani D, et al. Dermatitis herpetiformis: from the genetics to the development of skin lesions. Clin Dev Immunol. 2012;2012:239691.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bonkovsky HL, Poh-Fitzpatrick M, Pimstone N, et al. Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. Hepatology. 1998;27(6): 1661–9.

    Article  CAS  PubMed  Google Scholar 

  • Bonkovsky HL, Lambrecht RW, Shan Y. Iron as a co-morbid factor in nonhemochromatotic liver disease. Alcohol. 2003;30(2):137–44.

    Article  CAS  PubMed  Google Scholar 

  • Brambilla L, Labianca R, Ferrucci SM, Taglioni M, Boneschi V. Treatment of classical Kaposi’s sarcoma with gemcitabine. Dermatology. 2001;202(2):119.

    Article  CAS  PubMed  Google Scholar 

  • Brambilla L, et al. Combination of vinblastine and bleomycin as first line therapy in advanced classic Kaposi’s sarcoma. Eur Acad Dermatol Venereol. 2006;20(9):1090.

    Article  CAS  Google Scholar 

  • Brambilla L, Bellinvia M, Tourlaki A, Scoppio B, Gaiani F, Boneschi V. Intralesional vincristine as first-line therapy for nodular lesions in classic Kaposi sarcoma: a prospective study in 151 patients. Br J Dermatol. 2010;162(4):854.

    Article  CAS  PubMed  Google Scholar 

  • Brambilla L, Recalcati S, Tourlaki A. Vinorelbine therapy in classic Kaposi’s sarcoma: a retrospective study of 20 patients. Eur J Dermatol. 2015;25(6):535.

    Article  CAS  PubMed  Google Scholar 

  • Brandhagen DJ, Fairbanks VF, Baldus W. Recognition and management of hereditary hemochromatosis. Am Fam Physician. 2002;65:853–60.

    PubMed  Google Scholar 

  • Brosens LA, van Hattem WA, Jansen M, et al. Gastrointestinal polyposis syndromes. Curr Mol Med. 2007;7(1):29–46.

    Article  CAS  PubMed  Google Scholar 

  • Bruzzone B, Magnani O, Sticchi L, Canepa P, Rappazzo E, Icardi G, Setti M. Resolution of porphyria cutanea tarda in HIV and mixed HCV coinfection after direct-acting antiviral (DAA) therapy. J Antimicrob Chemother. 2017;72(10):2955–8.

    Article  CAS  PubMed  Google Scholar 

  • Burger B, Itin P. Muir-Torre syndromee. Dermatology. 2008;217(1):56–7.

    Article  PubMed  Google Scholar 

  • Burnett MW. Cutaneous leishmaniasis. J Spec Oper Med. 2015;15(1):128–9.

    Article  PubMed  Google Scholar 

  • Caponetti G, Dezube BJ, Restrepo CS, Pantanowitz L. Kaposi sarcoma of the musculoskeletal system: a review of 66 patients. Cancer. 2007;109(6):1040.

    Article  PubMed  Google Scholar 

  • Castiñeiras I, et al. Disseminated classic Kaposi’s sarcoma. Two cases with excellent response to pegylated liposomal doxorubicin. J Dermatolog Treat. 2006;17(6):377.

    Article  PubMed  CAS  Google Scholar 

  • Cattani P, Cerimele F, Porta D, Graffeo R, Ranno S, Marchetti S, Ricci R, Capodicasa N, Fuga L, Amico R, Cherchi G, Gazzilli M, Zanetti S, Fadda G. Age-specific seroprevalence of human herpesvirus 8 in Mediterranean regions. Clin Microbiol Infect. 2003;9(4):274.

    Article  CAS  PubMed  Google Scholar 

  • CDC Parasistes-Leishmaniasis (page). Website title resources for health professionals. n.d. https://www.cdc.gov/parasites/leishmaniasis/health_professionals/index.html Updated 15 Oct 2018.

  • Chen TS, Chen PS. Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol. 1994;9(6):654–8.

    Article  CAS  PubMed  Google Scholar 

  • Chevrant-Breton J, Simon M, Bourel M, Ferrand B. Cutaneous manifestations of idiopathic hermochromatosis. Study of 100 cases. Arch Dermatol. 1977;113(2):161–5.

    Article  CAS  PubMed  Google Scholar 

  • Choi KK, et al. Radical resection of intestinal blue rubber bleb nevus syndrome. J Korean Surg Soc. 2012;83(5):316–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chuang, T, Stitle L. Lichen planus. n.d. Retrieved from http://emedicine.medscape.com/article/1123213-overview. Accessed 1 Mar 2011.

  • Cnudde F, Boulard F, Muller P, et al. Cowden disease: treatment with acitretine. Ann Dermatol Venereol. 1996;123(11):739–41.

    CAS  PubMed  Google Scholar 

  • Corrick F, Anand G. Question 2: would systemic steroids be useful in the management of Stevens-Johnson syndrome? Arch Dis Child. 2013;98(10):828–30.

    Article  PubMed  Google Scholar 

  • Cribier B, Frances C, Chosidow O. Treatment of lichen planus. An evidence-based medicine analysis of efficacy. Arch Dermatol. 1998;134(12):1521–30.

    Article  CAS  PubMed  Google Scholar 

  • Criteria for diagnosis of Behçet’s disease. International study Group for Behçet’s disease. Lancet. 1990;335(8697):1078.

    Google Scholar 

  • Curatolo P, et al. Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: a two-center prospective phase II trial. Ann Surg Oncol. 2012;19(1): 192.

    Article  PubMed  Google Scholar 

  • Danzig JB, Brandt LJ, Reinus JF, Klein RS. Gastrointestinal malignancy in patients with AIDS. Am J Gastroenterol. 1991;86(6):715.

    CAS  PubMed  Google Scholar 

  • Darmstadt GL, Yokel BK, Horn TD. Treatment of acanthosis nigricans with tretinoin. Ach Dermatol. 1991;127:1139–40.

    Article  CAS  Google Scholar 

  • DE Marchis ML, et al. Desmoid tumors in familial adenomatous polyposis. Anticancer Res. 2017;37(7):3357.

    Article  CAS  PubMed  Google Scholar 

  • de Wet NT, et al. A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis. Aliment Pharmacol Ther. 2005;21(7):899.

    Article  PubMed  CAS  Google Scholar 

  • Di Lorenzo G, et al. Activity and safety of pegylated liposomal doxorubicin as first-line therapy in the treatment of non-visceral classic Kaposi’s sarcoma: a multicenter study. J Invest Dermatol. 2008;128(6):1578.

    Article  PubMed  CAS  Google Scholar 

  • Di Monta G, et al. Electrochemotherapy as “new standard of care” treatment for cutaneous Kaposi’s sarcoma. Eur J Surg Oncol. 2014;40(1):61.

    Article  PubMed  Google Scholar 

  • Díaz-Ley B, et al. Classic Kaposi’s sarcoma treated with topical rapamycin. Dermatol Ther. 2015;28(1):40.

    Article  PubMed  Google Scholar 

  • Dinler G. Plummer-Vinson syndrome in a 15-year-old boy. Turk J Pediatr. 2009;51(4):384.

    PubMed  Google Scholar 

  • Dittmer DP, Damania B. Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy. J Clin Invest. 2016;126(9):3165–75.

    Article  PubMed  PubMed Central  Google Scholar 

  • Drobnik J, Schwartz RA. Hemochromatosis. n.d. Retrieved from http://emedicine.medscape.com/article/1104743-overview. Accessed 24 Feb 2011.

  • Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns. 2004;30(Suppl 1):S1.

    Article  PubMed  Google Scholar 

  • Eames T, Landthaler M, Karrer S. Crohn’s disease: an important differential diagnosis of granulomatous skin diseases. Eur J Dermatol. 2009;19(4):360–4.

    Article  PubMed  Google Scholar 

  • El Hachem M, et al. Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa. Orphanet J Rare Dis. 2014;9:76.

    Article  PubMed  PubMed Central  Google Scholar 

  • Elder GH, Smith SG, Herrero C, et al. Hepatoerythropoietic porphyria: a new uroporphyrinogen decarboxylase defect or homozygous porphyria cutanea tarda? Lancet. 1981;1(8226):916–9.

    Article  CAS  PubMed  Google Scholar 

  • Elkharwily A, Gottlieb K. The pancreas in familial adenomatous polyposis. J Pancreas. 2008;9(1):9–18.

    Google Scholar 

  • Ellis A. Tylosis with oesophageal cancer: diagnosis, management and molecular mechanisms. Orphanet J Rare Dis. 2015;10:126.

    Article  PubMed  PubMed Central  Google Scholar 

  • Escobar C, et al. Update on desmoid tumors. Ann Oncol. 2012;23(3):562–9.

    Article  CAS  PubMed  Google Scholar 

  • Everett JN, Raymond VM, Dandapani M, Marvin M, Kohlmann W, Chittenden A, Koeppe E, Gustafson SL, Else T, Fullen DR, Johnson TM, Syngal S, Gruber SB, Stoffel EM. Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm. JAMA Dermatol. 2014;150(12):1315–21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fardet L, et al. Treatment with taxanes of refractory or life-threatening Kaposi sarcoma not associated with human immunodeficiency virus infection. Cancer. 2006;106(8):1785.

    Article  CAS  PubMed  Google Scholar 

  • Forciea MA, Lavizzo-Mourne R, Schwab EP. Geriatric secrets. 2nd ed. Philadelphia: Hanley and Belfus; 2000. p. 127.

    Google Scholar 

  • Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. N Engl J Med. 1996;335(4):233.

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Doval I, et al. Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol. 2000;136(3):323.

    Article  CAS  PubMed  Google Scholar 

  • García-Pola MJ, González-Álvarez L, Garcia-Martin JM. Treatment of oral lichen planus. Systematic review and therapeutic guide. Med Clin (Barc). 2017;149(8): 351–62.

    Article  Google Scholar 

  • Geagea A, Cellier C. Scope of drug-induced, infectious and allergic esophageal injury. Curr Opin Gastroenterol. 2008;24(4):496.

    Article  PubMed  Google Scholar 

  • Ghyka G, Alecu M, Halalau F, Coman G. Intralesional human leukocyte interferon treatment alone or associated with IL-2 in non-AIDS related Kaposi’s sarcoma. J Dermatol. 1992;19(1):35–9.

    Article  CAS  PubMed  Google Scholar 

  • Gião Antunes AS, Peixe B, Guerreiro H. Blue rubber bleb nevus syndrome: a delayed diagnosis. GE Port J Gastroenterol. 2016;24(2):101–3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goel A, Bakshi SS, Soni N, Chhavi N. Iron deficiency anemia and Plummer-Vinson syndrome: current insights. J Blood Med. 2017;8:175–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goiriz R, et al. Treatment of classic Kaposi’s sarcoma with topical imiquimod. Dermatol Surg. 2009;35(1):147.

    CAS  PubMed  Google Scholar 

  • Gray M. Optimal management of incontinence-associated dermatitis in the elderly. Am J Clin Dermatol. 2010;11(3):201–10.

    Article  PubMed  Google Scholar 

  • Grayson PC, et al. Treatment of mucocutaneous manifestations in Behçet’s disease with anakinra: a pilot open-label study. Arthritis Res Ther. 2017;19(1):69.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gu GL, Wang SL, Wei XM, Bai L. Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature. World J Gastroenterol. 2008;14(13):2121–3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Guevara-Gutiérrez E, Tlacuilo-Parra A, Gutiérrez-Fajardo P, Sánchez-Tenorio T, Barba-Gómez F, Miranda-Díaz A. A study of the association of acanthosis nigricans with subclinical atherosclerosis. Indian J Dermatol Venereol Leprol. 2017;83(2):190–4.

    Article  PubMed  Google Scholar 

  • Hahler B. An overview of dermatological conditions commonly associated with the obese patient. Ostomy Wound Manage. 2006;52(6):34–6, 38, 40.

    PubMed  Google Scholar 

  • Hamzi MA, Alayoud A, Asseraji M, Akhmouch I, Oualim Z. Porphyria cutanea tarda in a hemodialysis patient with hepatitis C virus: efficacy of treatment with multiple phlebotomies and erythropoietin. n.d.

    Google Scholar 

  • Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA. Cutaneous and mucocutaneous leishmaniasis: differential diagnosis, diagnosis, histopathology, and management. J Am Acad Dermatol. 2015;73(6): 911–26.

    Article  PubMed  Google Scholar 

  • Hani U, Shivakumar HG, Vaghela R, Osmani RA, Shrivastava A. Candidiasis: a fungal infection-current challenges and progress in prevention and treatment. Infect Disord Drug Targets. 2015;15(1):42–52.

    Article  CAS  PubMed  Google Scholar 

  • Harper PS, Harper RMJ, Howell Evans AW. Carcinoma of the oesophagus with tylosis. Q J Med. 1970;39:317–33.

    CAS  PubMed  Google Scholar 

  • Hatemi G, et al. One year in review 2016: Behçet’s syndrome. Clin Exp Rheumatol. 2016;34(6 Suppl 102): 10–22.

    PubMed  Google Scholar 

  • Hauerstock D, Gerstein W, Vuong T. Results of radiation therapy for treatment of classic Kaposi sarcoma. J Cutan Med Surg. 2009;13(1):18.

    Article  PubMed  Google Scholar 

  • Hazin R, Abu-Rajab Tamimi TI, et al. Recognizing and treating cutaneous signs of liver disease. Cleve Clin J Med. 2009;76(10):599–606.

    Article  PubMed  Google Scholar 

  • Hemminki A, Markie D, Tomlinson I, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature. 1998;391(6663):184–7.

    Article  CAS  PubMed  Google Scholar 

  • Henriquez-Camacho C, Gotuzzo E, Echevarria J, White AC Jr, Terashima A, Samalvides F, Pérez-Molina JA, Plana MN. Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection. Cochrane Database Sys Rev. 2016;1:CD007745.

    Google Scholar 

  • Hernan I, et al. De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. Clin Genet. 2004;66(1): 58–62.

    Article  CAS  PubMed  Google Scholar 

  • Hirota WK. ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract. Gastrointest Endosc. 2006;63(4):570.

    Article  PubMed  Google Scholar 

  • Hoffman RM, Jaffe PE. Plummer-Vinson syndrome. A case report and literature review. Arch Intern Med. 1995;155(18):2008–11.

    Article  CAS  PubMed  Google Scholar 

  • Honchel R, Halling KC, Schaid DJ, et al. Microsatellite instability in Muir-Torre syndrome. Cancer Res. 1994;54(5):1159–63.

    CAS  PubMed  Google Scholar 

  • Hsu CK, et al. Treatment of hereditary epidermolysis bullosa: updates and future prospects. Am J Clin Dermatol. 2014;15(1):1–6.

    Article  PubMed  Google Scholar 

  • Iacopino AM, Wathen WF. Oral candidal infection and denture stomatitis: a comprehensive review. J Am Dent Assoc. 1992;123(1):46.

    Article  CAS  PubMed  Google Scholar 

  • Ichiki T, Jnnai S, Nakagawa R, Kohda F, Furue M. Case of widespread fat necrosis that was caused by severe pancreatitis and histologically resembled pancreatic panniculitis. J Dermatol. 2017;44(8):979–81.

    Article  PubMed  Google Scholar 

  • Ingafou M, Leao JC, Porter SR, Scully C. Oral lichen planus: a retrospective study of 690 British patients. Oral Dis. 2006;12(5):463–8.

    Article  CAS  PubMed  Google Scholar 

  • Intong LR, Murrell DF. Inherited epidermolysis bullosa: new diagnostic criteria and classification. Clin Dermatol. 2012;30(1):70–7.

    Article  PubMed  Google Scholar 

  • Iscovich J, Boffetta P, Winkelmann R, Brennan P, Azizi E. Classic Kaposi’s sarcoma in Jews living in Israel, 1961–1989: a population-based incidence study. AIDS. 1998;12(15):2067.

    Article  CAS  PubMed  Google Scholar 

  • Iwaya T. Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer. Gastroenterology. 1998;114(6): 1206.

    Article  CAS  PubMed  Google Scholar 

  • Jenne DE, Reimann H, Nezu J, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998;18(1):38–43.

    Article  CAS  PubMed  Google Scholar 

  • Jiménez-Gallo D, Ossorio-García L, de la Varga-Martínez R, Arjona-Aguilera C, Linares-Barrios M. Necrolytic migratory erythema associated with glucagonoma treated successfully with cyclosporine. Dermatol Ther. 2017;30(4):e12498.

    Article  Google Scholar 

  • Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY. Blue rubber bleb nevus syndrome: a case report and literature review. World J Gastroenterol. 2014;20(45): 17254–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • John AM, Schwartz RA. Muir-Torre syndrome (MTS): an update and approach to diagnosis and management. J Am Acad Dermatol. 2016;74(3):558–66.

    Article  PubMed  Google Scholar 

  • Kaposi M. Idiopathic multiple pigmented sarcoma of the skin. [English translation from Archiv Für Dermatolgie Und Syphillis 1872;4:265–273] CA Cancer J Clin 1982;32:342.

    Google Scholar 

  • Kappas A, Sassa S, Galbraith RA, et al. The porphyrias. In: Scriver CR, et al., editors. The metabolic basis of inherited disease. New York: McGraw-Hill; 1995. p. 2103–59.

    Google Scholar 

  • Karthikeyan P, Aswath N, Kumaresan R. Plummer Vinson syndrome: a rare syndrome in male with review of the literature. Case Rep Dent. 2017;2017:6205925.

    PubMed  PubMed Central  Google Scholar 

  • Kartsonis N, et al. Efficacy of caspofungin in the treatment of esophageal candidiasis resistant to fluconazole. J Acquir Immune Defic Syndr. 2002;31(2):183.

    Article  CAS  PubMed  Google Scholar 

  • Kaser DJ, Reichman DE, Laufer MR. Prevention of vulvovaginal sequelae in stevens-johnson syndrome and toxic epidermal necrolysis. Rev Obstet Gynecol. 2011;4(2):81.

    PubMed  PubMed Central  Google Scholar 

  • Khanfir MS, et al. Inflammatory optic neuropathy in Behçet’s disease. Reumatismo. 2015;67(4):156.

    Article  CAS  PubMed  Google Scholar 

  • Kim RH, Nagler AR, Meehan SA. Universal immunohistochemical screening of sebaceous neoplasms for Muir-Torre syndrome: putting the cart before the horse? J Am Acad Dermatol. 2016;75(5):1078–9.

    Article  PubMed  Google Scholar 

  • Kimbara S, Fujiwara Y, Toyoda M, Chayahara N, Imamura Y, Kiyota N, Mukohara T, Fukunaga A, Oka M, Nishigori C, Minami H. Rapid improvement of glucagonoma-related necrolytic migratory erythema with octreotide. Clin J Gastroenterol. 2014;7(3):255–9.

    Article  PubMed  Google Scholar 

  • Klotz SA. Oropharyngeal candidiasis: a new treatment option. Clin Infect Dis. 2006;42(8):1187.

    Article  PubMed  Google Scholar 

  • Krause DS, et al. A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. Clin Infect Dis. 2004;39(6): 770.

    Article  CAS  PubMed  Google Scholar 

  • Kroft EB. Ultraviolet a phototherapy for sclerotic skin diseases: a systematic review. J Am Acad Dermatol. 2008;59(6):1017.

    Article  PubMed  Google Scholar 

  • Krown SE. AIDS-associated Kaposi’s sarcoma: is there still a role for interferon alfa? Cytokine Growth Factor Rev. 2007;18(5–6):395.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Laine L, Amerian J, Rarick M, Harb M, Gill PS. The response of symptomatic gastrointestinal Kaposi’s sarcoma to chemotherapy: a prospective evaluation using an endoscopic method of disease quantification. Am J Gastroenterol. 1990;85(8):959.

    CAS  PubMed  Google Scholar 

  • Lake DE, et al. Fluconazole versus amphotericin B in the treatment of esophageal candidiasis in cancer patients. Chemotherapy. 1996;42(4):308.

    Article  CAS  PubMed  Google Scholar 

  • Lambiase P, Seery JP, Taylor-Robinson SD, et al. Resolution of panniculitis after placement of pancreatic duct stent in chronic pancreatitis. Am J Gastroenterol. 1996;91(9):1835.

    CAS  PubMed  Google Scholar 

  • Laube R, et al. Oral and upper gastrointestinal Crohn’s disease. J Gastroenterol Hepatol. 2018;33(2):355.

    Article  PubMed  Google Scholar 

  • Lee JB, Litzner BR, Vidal CI. Review of the current medical literature and assessment of current utilization patterns regarding mismatch repair protein immunohistochemistry in cutaneous Muir-Torre syndrome-associated neoplasms. J Cutan Pathol. 2017;44(11):931–7.

    Article  PubMed  Google Scholar 

  • Lescano MA, Tavares LC, Santos PCJL. Juvenile hemochromatosis: HAMP mutation and severe iron overload treated with phlebotomies and deferasirox. World J Clin Cases. 2017;5(10):381–3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lewis MAO, Williams DW. Diagnosis and management of oral candidosis. Br Dent J. 2017;223(9):675–81.

    Article  CAS  PubMed  Google Scholar 

  • Li Y, et al. Q-switched alexandrite laser treatment of facial and labial lentigines associated with Peutz-Jeghers syndrome. Photodermatol Photoimmunol Photomed. 2012;28(4):196–9.

    Article  CAS  PubMed  Google Scholar 

  • Li S, Bai L, Dong J, Sun R, Lan K. Kaposi’s sarcoma-associated herpesvirus: epidemiology and molecular biology. In: Cai Q, Yuan Z, Lan K, editors. Infectious agents associated cancers: epidemiology and molecular biology. Advances in experimental medicine and biology, vol. 1018. Singapore: Springer; 2017.

    Google Scholar 

  • Lim W, et al. High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations. Am J Gastroenterol. 2010;105(6):1258.

    Article  Google Scholar 

  • Lin P, Liang G. Behçet disease: recommendation for clinical management of mucocutaneous lesions. J Clin Rheumatol. 2006;12(6):282–6.

    Article  PubMed  Google Scholar 

  • Lindh E, et al. Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. J Autoimmun. 2013;42:1–6.

    Article  CAS  PubMed  Google Scholar 

  • Liu WB, Sun LW, Yang H, Wang YF. Treatment of oral lichen planus using 308-nm excimer laser. Dermatol Ther. 2017;30(5):e12510.

    Article  Google Scholar 

  • Longshore SJ, Taylor JS, Kennedy A, Nurko S. Malignant acanthosis nigricans and endometrioid adenocarcinoma of the parametrium: the search for malignancy. J Am Acad Dermatol. 2003;49(3):541–3.

    Article  PubMed  Google Scholar 

  • Lugović-Mihić L, et al. Differential diagnosis of cheilitis – how to classify cheilitis? Acta Clin Croat. 2018;57(2): 342–51.

    PubMed  PubMed Central  Google Scholar 

  • Lyell A. Toxic epidermal necrolysis: an eruption resembling scalding of the skin. Br J Dermatol. 1956;68(11): 355–61.

    Article  CAS  PubMed  Google Scholar 

  • Martinez-Perez A, Roure Díez S, Belhassen-Garcia M, Torrús-Tendero D, Perez-Arellano JL, Cabezas T, Soler C, Díaz-Menéndez M, Navarro M, Treviño B, Salvador F, Soil-Transmitted Helminths’ Study Group of the Spanish Society of Tropical Medicine and International Health (SEMTSI). Management of severe strongyloidiasis attended at reference centers in Spain. PLoS Negl Trop Dis. 2018;12(2):e0006272.

    Article  PubMed  PubMed Central  Google Scholar 

  • Matsuo T, Itami M, Nakagawa H, Nagayama M. The incidence and pathology of conjunctival ulceration in Behçet’s syndrome. Br J Ophthalmol. 2002;86(2):140.

    Article  PubMed  PubMed Central  Google Scholar 

  • May A, Gossner L, Behrens A, et al. A prospective randomized trial of two different endoscopic resection techniques for early stage cancer of the esophagus. Gastrointest Endosc. 2003;58(2):167–75.

    Article  PubMed  Google Scholar 

  • Mazzoccoli G, et al. Behçet syndrome: from pathogenesis to novel therapies. Clin Exp Med. 2016;16(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  • Mendes FB, Hissa-Elian A, Abreu MA, Gonçalves VS. Review: dermatitis herpetiformis. An Bras Dermatol. 2013;88(4):594–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Meseguer-Yebra C, et al. Successful treatment of classic Kaposi sarcoma with topical timolol: report of two cases. Br J Dermatol. 2015;173(3):860.

    Article  CAS  PubMed  Google Scholar 

  • Miller JH, Rapini RP. Acanthosis nigricans. n.d. Retrieved from http://emedicine.medscape.com/article/1102488-overview. Accessed 20 Feb 2011.

  • Millsop JW, Fazel N. Oral candidiasis. Clin Dermatol. 2016;34(4):487–94.

    Article  PubMed  Google Scholar 

  • Mirza YA, Altamura D, Hirbod T, Verdolini R. Long-term response of classic Kaposi’s sarcoma to intralesional doxorubicin: a case report. Case Rep Dermatol. 2015;7(1):17.

    Article  PubMed  PubMed Central  Google Scholar 

  • Moran-Jimenez MJ, Ged C, Romana M, et al. Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria. Am J Hum Genet. 1996;58(4):712–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Murata M, Bamba S, Takahashi K, Imaeda H, Nishida A, Inatomi O, Tsujikawa T, Kushima R, Sugimoto M, Andoh A. Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome. World J Gastroenterol. 2017;23(22):4121.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mutlu S, Scully C. The person behind the eponym: Hulûsi Behçet (1889–1948). J Oral Pathol Med. 1994;23(7): 289.

    Article  CAS  PubMed  Google Scholar 

  • Nathan N, Keppler-Noreuil KM, Biesecker LG, Moss J, Darling TN. Mosaic disorders of the PI3K/PTEN/AKT, TSC/mTORC1 signaling pathway. Dermatol Clin. 2017;35(1):51–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Neff R, Kremer S, Voutsinas L, Waxman M, Mitty W Jr. Primary Kaposi’s sarcoma of the ileum presenting as massive rectal bleeding. Am J Gastroenterol. 1987;82(3):276.

    CAS  PubMed  Google Scholar 

  • Nichols CM, Flaitz CM, Hicks MJ. Treating Kaposi’s lesions in the HIV-infected patient. J Am Dent Assoc. 1993;124(11):78.

    Article  CAS  PubMed  Google Scholar 

  • Nieuwenhuis MH, et al. Evaluation of management of desmoid tumours associated with familial adenomatous polyposis in Dutch patients. Br J Cancer. 2011;104(1): 37.

    Article  CAS  PubMed  Google Scholar 

  • Nikpour M, Baron M. Mortality in systemic sclerosis: lessons learned from population-based and observational cohort studies. Curr Opin Rheumatol. 2014;26(2):131–7.

    Article  PubMed  Google Scholar 

  • Noreuil KM, Parker VE, Darling TN, Martinez-Agosto JA. Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies. Am J Med Genet C Semin Med Genet. 2016;172(4):402–21.

    Article  CAS  Google Scholar 

  • Novacek G. Plummer-Vinson syndrome. Orphanet J Rare Dis. 2006;1:36.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oksüzoglu BC, Oksüzoglu G, Cakir U, et al. Blue rubber bleb nevus syndrome. Am J Gastroenterol. 1996;91(4):780–2.

    PubMed  Google Scholar 

  • Oranje AP. Blue rubber bleb nevus syndrome. Pediatr Dermatol. 1986;3(4):304–10.

    Article  CAS  PubMed  Google Scholar 

  • Ozdemir M, Toy H, Mevlitoglu I, et al. Generalized idiopathic acanthosis nigricans treated with acitreitn. J Dermatolog Treat. 2006;17:54–6.

    Article  PubMed  Google Scholar 

  • Palmieri TL, et al. A multicenter review of toxic epidermal necrolysis treated in U.S. burn centers at the end of the twentieth century. J Burn Care Rehabil. 2002;23(2):87.

    Article  CAS  PubMed  Google Scholar 

  • Pappas PG, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1.

    Article  PubMed  Google Scholar 

  • Park KK, Brodell RT, Helms SE. Angular cheilitis, Part 1: local etiologies. Cutis. 2011a;87(6):289.

    PubMed  Google Scholar 

  • Park KK, Brodell RT, Helms SE. Angular cheilitis, Part 2: nutritional, systemic, and drug-related causes and treatment. Cutis. 2011b;88(1):27.

    PubMed  Google Scholar 

  • Patel NU, Roach C, Alinia H, Huang WW, Feldman SR. Current treatment options for acanthosis nigricans. Clin Cosmet Investig Dermatol. 2018;11:407–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perfect JR, et al. Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis. 2003;36(9):1122.

    Article  CAS  PubMed  Google Scholar 

  • Pons V, et al. Oropharyngeal candidiasis in patients with AIDS: randomized comparison of fluconazole versus nystatin oral suspensions. Clin Infect Dis. 1997;24(6):1204.

    Article  CAS  PubMed  Google Scholar 

  • Ponti G, Losi L, Pedroni M, et al. Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. J Invest Dermatol. 2006;126(10):2302–7.

    Article  CAS  PubMed  Google Scholar 

  • Ponti G, et al. Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes. Crit Rev Oncol Hematol. 2013;85(3):239–56.

    Article  PubMed  Google Scholar 

  • Pouillot A, Polla A, Polla BS. Iron and iron chelators: a review on potential effects on skin aging. Curr Aging Sci. 2013;6(3):225–31.

    Article  CAS  PubMed  Google Scholar 

  • Pursley TJ, et al. Fluconazole-induced congenital anomalies in three infants. Clin Infect Dis. 1996;22(2):336.

    Article  CAS  PubMed  Google Scholar 

  • Randi BA, Felício MF, Lázari CS, Duarte MI, Halpern I, Ho YLA. Woman with AIDS and a neglected disease presenting with coma, periumbilical purpuric rash, and Alveolar Hemorrhage. Clin Infect Dis. 2016;63(9): 1262–3.

    Article  PubMed  Google Scholar 

  • Robbins HA, Pfeiffer RM, Shiels MS, Li J, Hall HI, Engels EA. Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015;107(4):pii:dju503.

    Article  Google Scholar 

  • Rocchi E, Cassanelli M, Borghi A, et al. Liver iron overload and desferrioxamine treatment of porphyria cutanea tarda. Dermatologica. 1991;182(1):27–31.

    Article  CAS  PubMed  Google Scholar 

  • Rodríguez G, Vargas E, Abaúnza C, Cáceres S. Necrolytic migratory erythema and pancreatic glucagonoma. Biomedica. 2016;36(2):176–81.

    Article  PubMed  Google Scholar 

  • Rongioletti F, Caputo V. Pancreatic panniculitis. G Ital Dermatol Venereol. 2013;148(4):419–25.

    CAS  PubMed  Google Scholar 

  • Rose S, Young MA, Reynolds JC. Gastrointestinal manifestations of scleroderma. Gastroenterol Clin N Am. 1998;27(3):563–94.

    Article  CAS  Google Scholar 

  • Rosen AC, et al. Life-threatening dermatologic adverse events in oncology. Anti-Cancer Drugs. 2014;25(2): 225.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rotondo C, et al. Mucocutaneous involvement in Behçet’s disease: how systemic treatment has changed in the last decades and future perspectives. Mediat Inflamm. 2015;2015:451675.

    Article  CAS  Google Scholar 

  • Sakaguchi H. Treatment and prevention of oral candidiasis in elderly patients. Med Mycol J. 2017;58(2):J43–9.

    Article  PubMed  Google Scholar 

  • Saleh Z, Arayssi T. Update on the therapy of Behçet disease. Ther Adv Chronic Dis. 2014;5(3):112–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sandborn WJ, et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med. 2012;367(16):1519–28.

    Article  CAS  PubMed  Google Scholar 

  • Sandborn WJ, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369(8):711.

    Article  CAS  PubMed  Google Scholar 

  • Sangeorzan JA, et al. Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance. Am J Med. 1994;97(4):339.

    Article  CAS  PubMed  Google Scholar 

  • Satta R, Biondi G, Cottoni F. Rainbow pattern: practical applications of dermoscopy in Kaposi’s sarcoma. G Ital Dermatol Venereol. 2016;107(2):206–7.

    Google Scholar 

  • Scherrer MAR, Rocha VB, Garcia LC. Behçet’s disease: review with emphasis on dermatological aspects. An Bras Dermatol. 2017;92(4):452–64.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schwartz RA, Cohen PF. Kaposi’s sarcoma. In: Newcomer VD, Young Jr EM, editors. Geriatric dermatology: clinical diagnosis and practical therapy. New York: Igaku-Shoin; 1989. p. 645–52.

    Google Scholar 

  • Schwartz RA, McDonough PH, Lee BW. Toxic epidermal necrolysis: Part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment. J Am Acad Dermatol. 2013;69(2):187.e1.

    Article  CAS  Google Scholar 

  • Senba M, Buziba N, Mori N, Morimoto K, Nakamura T. Increased prevalence of Kaposi΄s sarcoma-associated herpesvirus in the Kaposi΄s sarcoma-endemic area of western Kenya in 1981–2000. Acta Virol. 2011;55(2): 161–4.

    Article  CAS  PubMed  Google Scholar 

  • Serrano J. Oral lesions in Sjogren’s syndrome: a systematic review. Med Oral Patol Oral Cir Bucal. 2018;23(4):e391.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Seyahi E, Melikoglu M, Yazici H. Clinical features and diagnosis of Behcet’s syndrome. Int J Adv Rheumatol. 2007;5:8.

    Google Scholar 

  • Sharon V, Fazel N. Oral candidiasis and angular cheilitis. Dermatol Ther. 2010;23(3):230.

    Article  PubMed  Google Scholar 

  • Shay K, Truhlar MR, Renner RP. Oropharyngeal candidosis in the older patient. J Am Geriatr Soc. 1997;45(7):863.

    Article  CAS  PubMed  Google Scholar 

  • Shengyuan L, Songpo Y, Wen W, et al. Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol. 2009;145(9):1040–7.

    Article  PubMed  Google Scholar 

  • Shiga S, Cartotto R. What are the fluid requirements in toxic epidermal necrolysis? J Burn Care Res. 2010;31(1):100–4.

    Article  PubMed  Google Scholar 

  • Silverberg MJ, et al. Cumulative incidence of cancer among persons with HIV in North America: a cohort study. Ann Intern Med. 2015;163(7):507–18.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sing S, Gorouhi F, Konia T, Burrall B. Pancreatic acinar cell carcinoma-induced panniculitis. JAAD Case Rep. 2018;4(7):719–21.

    Article  Google Scholar 

  • Singal AK, Venkata KVR, Jampana S, Islam FU, Anderson KE. Hepatitis C treatment in patients with porphyria cutanea tarda. Am J Med Sci. 2017;353(6): 523–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol. 2007;57(3):502–8.

    Article  PubMed  Google Scholar 

  • Skiest DJ, et al. Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection. Clin Infect Dis. 2007;44(4):607.

    Article  CAS  PubMed  Google Scholar 

  • Smith JB, Taylor TB, Zone JJ. The site of blister formation in dermatitis herpetiformis is within the lamina lucida. J Am Acad Dermatol. 1992;27(2 Pt 1):209–13.

    Article  CAS  PubMed  Google Scholar 

  • Soblet J, et al. Blue rubber bleb nevus (BRBN) syndrome is caused by somatic TEK (TIE2) mutations. J Invest Dermatol. 2017;137(1):207.

    Article  CAS  PubMed  Google Scholar 

  • Soulier J, et al. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease. Blood. 1995;86(4):1276–80.

    Article  CAS  PubMed  Google Scholar 

  • Steen VD, Medsger TA Jr. Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum. 2000;43(11):2437–44.

    Article  CAS  PubMed  Google Scholar 

  • Stefan DC, Stones DK, Wainwright L, Newton R. Kaposi sarcoma in south African children. Pediatr Blood Cancer. 2011;56(3):392–6.

    Article  PubMed  Google Scholar 

  • Stevens HP, et al. Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas. Arch Dermatol. 1996;132(6):640.

    Article  CAS  PubMed  Google Scholar 

  • Syngal S, et al. ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015;110(2):223.

    Article  PubMed  PubMed Central  Google Scholar 

  • Takeuchi S, et al. Effects of oral moisturising gel containing egg yolk antibodies against Candida albicans in older people. Gerodontology. 2016;33(1): 128–34.

    Article  PubMed  Google Scholar 

  • Tas F, Sen F, Keskin S, Kilic L. Oral etoposide as first-line therapy in the treatment of patients with advanced classic Kaposi’s sarcoma (CKS): a single-arm trial (oral etoposide in CKS). J Eur Acad Dermatol Venereol. 2013;27(6):789–92.

    Article  CAS  PubMed  Google Scholar 

  • Terai H, Shimahara M. Cheilitis as a variation of Candida-associated lesions. Oral Dis. 2006;12(3):349.

    Article  CAS  PubMed  Google Scholar 

  • Tolliver S, Graham J, Kaffenberger BH. A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema. Int J Dermatol. 2018;57(6):642–5.

    Article  PubMed  Google Scholar 

  • Tong Y, Song YK, Tyring S. Resolution of porphyria cutanea tarda in patients with hepatitis C following ledipasvir-sofosbuvir combinatino therapy. JAMA Dermatol. 2016;152(12):1393–5.

    Article  PubMed  Google Scholar 

  • Tourlaki A, Bellinvia M, Brambilla L. Recommended surgery of Kaposi’s sarcoma nodules. J Dermatolog Treat. 2015;26(4):354.

    Article  PubMed  Google Scholar 

  • Tremblay C, Marcil I. Necrolytic migratory erythema: a forgotten paraneoplastic condition. J Cutan Med Surg. 2017;21(6):559–61.

    Article  PubMed  Google Scholar 

  • van Lier MG, et al. High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations. Am J Gastroenterol. 2010;105(6):1258.

    Article  PubMed  Google Scholar 

  • Vassallo C, Carugno A, Derlino F, Ciocca O, Brazzelli V, Borroni G. Intralesional vinblastine injections for treatment of classic Kaposi sarcoma in diabetic patients. Cutis. 2015;95(5):E28.

    PubMed  Google Scholar 

  • Vazquez JA, et al. A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS. Clin Infect Dis. 2006;42(8):1179.

    Article  CAS  PubMed  Google Scholar 

  • Verrando P, Ortonne JP. Insulin binding properties of normal and ransformed human epidermal cultured keratinocytes. J Invest Dermatol. 1985;85:328–32.

    Article  CAS  PubMed  Google Scholar 

  • Villanueva A, et al. A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasis. Am J Med. 2002;113(4):294.

    Article  CAS  PubMed  Google Scholar 

  • Vitale A, et al. New therapeutic solutions for Behçet’s syndrome. Expert Opin Investig Drugs. 2016;25(7): 827–40.

    Article  CAS  PubMed  Google Scholar 

  • Von Roenn JH, Cianfrocca M. Treatment of Kaposi’s sarcoma. Cancer Treat Res. 2001;104:127.

    Article  Google Scholar 

  • Vossen AR, Boesten LS, Siersema PD, Nellen RG. Porphyria cutanea tarda: the benefit of additional diagnostics. Ned Tijdschr Geneeskd. 2016;160:A9166.

    PubMed  Google Scholar 

  • Wen XH, Wang L, Wang YX, Qian JM. Cronkhite-Canada syndrome: report of six cases and review of literature. World J Gastroenterol. 2014;20(23):7518–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weprin L, Zollinger R, Clausen K, Thomas FB. Kaposi’s sarcoma: endoscopic observations of gastric and colon involvement. J Clin Gastroenterol. 1982;4(4):357.

    Article  CAS  PubMed  Google Scholar 

  • Witte M, Zillikens D, Schmidt E. Diagnosis of autoimmune blistering diseases. Front Med (Lausanne). 2018;5:296.

    Article  Google Scholar 

  • Woodley DT, Chen M. Epidermolysis bullosa: then and now. J Am Acad Dermatol. 2004;51(1 Suppl):S55–7.

    Article  PubMed  Google Scholar 

  • Wright JA, Richards T, Srai SK. The role of iron in the skin and cutaneous wound healing. Front Pharmacol. 2014;5:156.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yang XM, Zhang Y, Wang T, Liu YH. Sporadic porphyria cutanea tarda induced by alcohol abuse. Chin Med J. 2017;130(16):2011–2.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yazici H, Fresko I, Yurdakul S. Behçet’s syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol. 2007;3(3):148–55.

    Article  PubMed  Google Scholar 

  • Young EM Jr, Newcomer VD, Kligman AM. Kaposi’s sarcoma. In: Geriatric dermatology: color atlas and practitioner’s guide. Philadelphia: Lea & Febiger; 1993. p. 202–3.

    Google Scholar 

  • Zamir E. Conjunctival ulcers in Behçet’s disease. Ophthalmology. 2003;110(6):1137.

    Article  PubMed  Google Scholar 

  • Zhang L, et al. Propranolol inhibits angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell. Int J Clin Exp Pathol. 2014;7(1):48.

    PubMed  Google Scholar 

  • Zhao R, Huang M, Banafea O, Zhao J, Cheng L, Zou K, Zhu L. Cronkhite-Canada syndrome: a rare case report and literature review. BMC Gastroenterol. 2016;16:23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zustovich F, Ferro A, Toso S. Gemcitabine for the treatment of classic Kaposi’s sarcoma: a case series. Anticancer Res. 2013;33(12):5531.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Center for Geriatric Dermatology, Integrative Dermatology and Neuro-Dermatology, Nova Southeastern University, Tampa, FL, USA

    Robert A. Norman

  2. American University of Antigua COM MSIV University of Florida, B.S. Biology, Gainesville, FL, USA

    Trupal Patel

  3. Larkin Community Hospital, Miami, FL, USA

    Tam H. Nguyen

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  1. Robert A. Norman
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  2. Trupal Patel
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  3. Tam H. Nguyen
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Correspondence to Robert A. Norman .

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  1. Department of Medicine, Robert Wood Johnson School of Medicine, Rutgers University, New Brunswick, NJ, USA

    C. S. Pitchumoni

  2. Department of Medicine, Division of Geriatrics, Montefiore Medical Center, Wakefield Campus, Bronx, NY, USA

    T.S. Dharmarajan

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Norman, R.A., Patel, T., Nguyen, T.H. (2021). Mucocutaneous Manifestations in Gastrointestinal Disease. In: Pitchumoni, C.S., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-030-30192-7_90

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