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Endoscopic Management and Follow-Up of Intraductal Papillary Mucinous Neoplasia (IPMN)

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Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy

Abstract

Intraductal papillary mucinous neoplasms (IPMN) are common and increasingly detected in patients undergoing cross-sectional imaging for reasons unrelated to the pancreas. Individuals diagnosed with an IPMN should be followed over time because of the malignant potential of these cystic lesions. The primary goal of surveillance is to identify the small minority of IPMN that progresses into advanced neoplasia and benefits from resection, while simultaneously avoiding unnecessary pancreatic surgery in the majority of IPMN that remains benign. Cross-sectional imaging and endoscopic ultrasound with or without fluid and tissue acquisition are currently used to evaluate the risk of malignancy in IPMN. This chapter summarizes the diagnostic workup, surveillance, and treatment of IPMN, focusing on endoscopic modalities and adjacent tests.

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References

  1. Adsay NV, Fukushima N, Furukawa T et al (2010) WHO classification of tumours of the digestive system, intraductal neoplasms of the pancreas. WHO Press, Lyon

    Google Scholar 

  2. Ohashi K, Murakami Y, Muruayama M (1982) Four cases of “mucin-producing” cancer of the pancreas on specific findings of the papilla of vater. Prog Dig Endosc 20:348

    Google Scholar 

  3. Del Chiaro M et al (2013) European experts consensus statement on cystic tumours of the pancreas. Dig Liver Dis 45(9):703–711

    Article  PubMed  Google Scholar 

  4. de Jong K, Bruno MJ, Fockens P (2012) Epidemiology, diagnosis, and management of cystic lesions of the pancreas. Gastroenterol Res Pract 2012:147465

    PubMed  Google Scholar 

  5. Lee KS et al (2010) Prevalence of incidental pancreatic cysts in the adult population on MR imaging. Am J Gastroenterol 105(9):2079–2084

    Article  PubMed  Google Scholar 

  6. Kromrey M-L et al (2018) Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study. Gut 67(1):138–145

    Article  PubMed  Google Scholar 

  7. Laurent L et al (2017) Estimation of the prevalence of intraductal papillary mucinous neoplasm of the pancreas in the French population through patients waiting for liver transplantation. United European Gastroenterol J 5(4):499–503

    Article  PubMed  Google Scholar 

  8. Laffan TA et al (2008) Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol 191(3):802–807

    Article  PubMed  PubMed Central  Google Scholar 

  9. Valsangkar NP et al (2012) 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery 152(3 Suppl 1):S4–S12

    Article  PubMed  Google Scholar 

  10. Salvia R et al (2004) Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 239(5):678–685; discussion 685-7

    Article  PubMed  PubMed Central  Google Scholar 

  11. Sohn TA et al (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239(6):788–799

    Article  PubMed  PubMed Central  Google Scholar 

  12. Tanaka M et al (2017) Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology 17(5):738–753

    Article  PubMed  Google Scholar 

  13. Vege SS et al (2015) American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology 148(4):819–822

    Article  PubMed  Google Scholar 

  14. European Study Group on Cystic Tumours of the Pancreas (2018) European evidence-based guidelines on pancreatic cystic neoplasms. Gut 67(5):789–804

    Article  Google Scholar 

  15. Elta GH et al (2018) ACG clinical guideline: diagnosis and management of pancreatic cysts. Am J Gastroenterol 113(4):464–479

    Article  PubMed  Google Scholar 

  16. Jang DK et al (2015) Preoperative diagnosis of pancreatic cystic lesions: the accuracy of endoscopic ultrasound and cross-sectional imaging. Pancreas 44(8):1329–1333

    Article  PubMed  Google Scholar 

  17. Lee HJ et al (2011) Relative accuracy of CT and MRI in the differentiation of benign from malignant pancreatic cystic lesions. Clin Radiol 66(4):315–321

    Article  PubMed  Google Scholar 

  18. Sainani NI et al (2009) Comparative performance of MDCT and MRI with MR cholangiopancreatography in characterizing small pancreatic cysts. Am J Roentgenol 193(3):722–731

    Article  Google Scholar 

  19. Visser BC et al (2008) Diagnostic evaluation of cystic pancreatic lesions. HPB 10(1):63–69

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Song SJ et al (2007) Differentiation of intraductal papillary mucinous neoplasms from other pancreatic cystic masses: comparison of multirow-detector CT and MR imaging using ROC analysis. J Magn Reson Imaging 26(1):86–93

    Article  PubMed  Google Scholar 

  21. Sahani DV et al (2013) Diagnosis and management of cystic pancreatic lesions. Am J Roentgenol 200(2):343–354

    Article  Google Scholar 

  22. Waters JA et al (2008) CT vs MRCP: optimal classification of IPMN type and extent. J Gastrointest Surg 12(1):101–109

    Article  PubMed  Google Scholar 

  23. Pilleul F et al (2005) Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings. J Magn Reson Imaging 21(3):237–244

    Article  PubMed  Google Scholar 

  24. Hruban RH et al (2007) Clinical importance of precursor lesions in the pancreas. J Hepato-Biliary-Pancreat Surg 14(3):255–263

    Article  Google Scholar 

  25. Tada M et al (2006) Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients. Clin Gastroenterol Hepatol 4(10):1265–1270

    Article  PubMed  Google Scholar 

  26. Uehara H et al (2008) Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasm of the pancreas. Gut 57(11):1561–1565

    Article  CAS  PubMed  Google Scholar 

  27. Tanno S et al (2010) Incidence of synchronous and metachronous pancreatic carcinoma in 168 patients with branch duct intraductal papillary mucinous neoplasm. Pancreatology 10(2–3):173–178

    Article  PubMed  Google Scholar 

  28. Ingkakul T et al (2010) Predictors of the presence of concomitant invasive ductal carcinoma in intraductal papillary mucinous neoplasm of the pancreas. Ann Surg 251(1):70–75

    Article  PubMed  Google Scholar 

  29. Omori Y et al (2019) Pathways of progression from intraductal papillary mucinous neoplasm to pancreatic ductal adenocarcinoma based on molecular features. Gastroenterology 156(3):647–661.e2

    Article  CAS  PubMed  Google Scholar 

  30. Tanaka M et al (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12(3):183–197

    Article  PubMed  Google Scholar 

  31. Rossi RE, Massironi S (2018) Intraductal papillary mucinous neoplasms of the pancreas: a clinical challenge. Expert Rev Gastroenterol Hepatol 12(11):1123–1133

    Article  CAS  PubMed  Google Scholar 

  32. Crippa S et al (2010) Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol 8(2):213–219

    Article  PubMed  Google Scholar 

  33. Hwang DW et al (2012) Clinicopathologic analysis of surgically proven intraductal papillary mucinous neoplasms of the pancreas in SNUH: a 15-year experience at a single academic institution. Langenbeck's Arch Surg 397(1):93–102

    Article  Google Scholar 

  34. Suzuki Y et al (2004) Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor. Pancreas 28(3):241–246

    Article  PubMed  Google Scholar 

  35. Nagai K et al (2008) Intraductal papillary mucinous neoplasms of the pancreas: clinicopathologic characteristics and long-term follow-up after resection. World J Surg 32(2):271–278; discussion 279-80

    Article  PubMed  Google Scholar 

  36. Schmidt CM et al (2007) Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathology. Ann Surg 246(4):644–651; discussion 651-4

    Article  PubMed  Google Scholar 

  37. Fritz S et al (2014) Pancreatic main-duct involvement in branch-duct IPMNs: an underestimated risk. Ann Surg 260(5):848–855; discussion 855-6

    Article  PubMed  Google Scholar 

  38. Nara S et al (2009) Preoperative evaluation of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas: clinical, radiological, and pathological analysis of 123 cases. Pancreas 38(1):8–16

    Article  PubMed  Google Scholar 

  39. Rodriguez JR et al (2007) Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology 133(1):72–79; quiz 309-10

    Article  PubMed  Google Scholar 

  40. Shimizu Y et al (2013) Predictors of malignancy in intraductal papillary mucinous neoplasm of the pancreas: analysis of 310 pancreatic resection patients at multiple high-volume centers. Pancreas 42(5):883–888

    Article  CAS  PubMed  Google Scholar 

  41. Marchegiani G et al (2015) IPMN involving the main pancreatic duct: biology, epidemiology, and long-term outcomes following resection. Ann Surg 261(5):976–983

    Article  PubMed  Google Scholar 

  42. Castellano-Megías VM et al (2014) Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas. World J Gastrointest Oncol 6(9):311–324

    Article  PubMed  PubMed Central  Google Scholar 

  43. Pergolini I et al (2017) Long-term risk of pancreatic malignancy in patients with branch duct intraductal papillary mucinous neoplasm in a referral center. Gastroenterology 153(5):1284–1294.e1

    Article  PubMed  Google Scholar 

  44. Marchegiani G et al (2018) Systematic review, meta-analysis, and a high-volume center experience supporting the new role of mural nodules proposed by the updated 2017 international guidelines on IPMN of the pancreas. Surgery 163(6):1272–1279

    Article  PubMed  Google Scholar 

  45. Pausawasdi N, Ratanachu-ek T (2017) Endoscopic ultrasonography evaluation for pancreatic cysts: necessity or overkill? Dig Endosc 29(4):444–454

    Article  PubMed  Google Scholar 

  46. Ahmad NA et al (2003) Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc 58(1):59–64

    Article  PubMed  Google Scholar 

  47. Kim YC et al (2010) Comparison of MRI and endoscopic ultrasound in the characterization of pancreatic cystic lesions. Am J Roentgenol 195(4):947–952

    Article  Google Scholar 

  48. Salom F, Prat F (2019) Current indications and yield of endoscopic ultrasound and ancillary techniques in pancreatic cystic neoplasms. Clin J Gastroenterol 12(2):93–101

    Article  PubMed  Google Scholar 

  49. Zhong N et al (2012) Histologic and imaging features of mural nodules in mucinous pancreatic cysts. Clin Gastroenterol Hepatol 10(2):192–198.e2

    Article  PubMed  Google Scholar 

  50. Kim KW et al (2014) Imaging features to distinguish malignant and benign branch-duct type intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis. Ann Surg 259(1):72–81

    Article  PubMed  Google Scholar 

  51. Kamata K et al (2016) Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts. Endoscopy 48(1):35–41

    PubMed  Google Scholar 

  52. Correas J-M et al (2001) Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 11(8):1316–1328

    Article  CAS  PubMed  Google Scholar 

  53. Piscaglia F, Bolondi L (2006) The safety of Sonovue® in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 32(9):1369–1375

    Article  PubMed  Google Scholar 

  54. de Jong K et al (2011) Endoscopic ultrasound-guided fine-needle aspiration of pancreatic cystic lesions provides inadequate material for cytology and laboratory analysis: initial results from a prospective study. Endoscopy 43(7):585–590

    Article  PubMed  Google Scholar 

  55. Gress FG (ed) (2016) Endoscopic ultrasonography. In: Levy MJ, Fujii LL, Wiersema MJ (eds) Fundamentals of EUS-FNA, 3rd edn. Wiley, Chichester, pp. 72–81

    Google Scholar 

  56. Polkowski M et al (2017) Technical aspects of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) technical guideline – march 2017. Endoscopy 49(10):989–1006

    Article  PubMed  Google Scholar 

  57. van Riet PA, Cahen DL, Poley JW, Bruno MJ (2016) Mapping international practice patterns in EUS-guided tissue sampling: outcome of a global survey. Endosc Int Open 4:E360–E370

    Article  PubMed  PubMed Central  Google Scholar 

  58. Nagle JA, Wilbur DC, Pitman MB (2005) Cytomorphology of gastric and duodenal epithelium and reactivity to B72.3: a baseline for comparison to pancreatic lesions aspirated by EUS-FNAB. Diagn Cytopathol 33(6):381–386

    Article  PubMed  Google Scholar 

  59. Mitselos IV et al (2019) Endoscopic ultrasonography in pancreatic diseases: advances in tissue acquisition. Endosc Int Open 7(7):E922–e930

    Article  PubMed  PubMed Central  Google Scholar 

  60. Hong SK et al (2012) Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc 75(4):775–782

    Article  PubMed  Google Scholar 

  61. Barresi L, Tarantino I, Traina M et al (2014) Endoscopic ultrasound-guided fine needle aspiration and biopsy using a 22-gauge needle with side fenestration in pancreatic cystic lesions. Dig Liver Dis 46:45–50

    Article  PubMed  Google Scholar 

  62. Rogart JN, Loren D, Singu BS et al (2011) Cyst wall puncture and aspiration during EUS-guided fine needle aspiration may increase the diagnostic yield of mucinous cysts of the pancreas. J Clin Gastroenterol 45:164–169

    Article  PubMed  Google Scholar 

  63. Lim LG et al (2013) Factors determining diagnostic yield of endoscopic ultrasound guided fine-needle aspiration for pancreatic cystic lesions: a multicentre Asian study. Dig Dis Sci 58(6):1751–1757

    Article  PubMed  Google Scholar 

  64. Maker AV et al (2008) Cytology from pancreatic cysts has marginal utility in surgical decision-making. Ann Surg Oncol 15(11):3187–3192

    Article  PubMed  Google Scholar 

  65. Thosani N et al (2010) Role of EUS-FNA-based cytology in the diagnosis of mucinous pancreatic cystic lesions: a systematic review and meta-analysis. Dig Dis Sci 55(10):2756–2766

    Article  PubMed  PubMed Central  Google Scholar 

  66. Wang QX et al (2015) EUS-guided FNA for diagnosis of pancreatic cystic lesions: a meta-analysis. Cell Physiol Biochem 36(3):1197–1209

    Article  CAS  PubMed  Google Scholar 

  67. Barresi L et al (2019) Tissue acquisition in pancreatic cystic lesions. Dig Liver Dis 51(2):286–292

    Article  PubMed  Google Scholar 

  68. Bick BL et al (2015) The string sign for diagnosis of mucinous pancreatic cysts. Endoscopy 47(7):626–631

    Article  PubMed  Google Scholar 

  69. van Huijgevoort NCM et al (2019) Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines. Nat Rev Gastroenterol Hepatol 16(11):676–689

    Article  PubMed  Google Scholar 

  70. Oh HC, Kang H, Brugge WR (2014) Cyst fluid amylase and CEA levels in the differential diagnosis of pancreatic cysts: a single-center experience with histologically proven cysts. Dig Dis Sci 59(12):3111–3116

    Article  PubMed  Google Scholar 

  71. Ngamruengphong S, Lennon AM (2016) Analysis of pancreatic cyst fluid. Surg Pathol Clin 9(4):677–684

    Article  PubMed  PubMed Central  Google Scholar 

  72. Brugge WR et al (2004) Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 126(5):1330–1336

    Article  PubMed  Google Scholar 

  73. Gaddam S et al (2015) Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study. Gastrointest Endosc 82(6):1060–1069

    Article  PubMed  Google Scholar 

  74. Kadayifci A et al (2017) Value of adding GNAS testing to pancreatic cyst fluid KRAS and carcinoembryonic antigen analysis for the diagnosis of intraductal papillary mucinous neoplasms. Dig Endosc 29(1):111–117

    Article  PubMed  Google Scholar 

  75. Khalid A et al (2009) Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc 69(6):1095–1102

    Article  PubMed  Google Scholar 

  76. Winner M et al (2015) The role of molecular analysis in the diagnosis and surveillance of pancreatic cystic neoplasms. JOP 16(2):143–149

    PubMed  Google Scholar 

  77. Cizginer S et al (2011) Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts. Pancreas 40(7):1024–1028

    Article  CAS  PubMed  Google Scholar 

  78. Jin DX, Small A, Vollmer CM et al (2015) A lower cyst fluid CEA cut-off increases diagnostic accuracy in identifying mucinous pancreatic cystic lesions. Journal of the Pancreas 16:271–277

    Google Scholar 

  79. van Huijgevoort NCM et al (2018) Su1347 - the diagnostic accuracy of carcinoembryonic antigen in differentiating mucinous and non- mucinous pancreatic cystic neoplasms — a systematic review and individual patient data meta- analysis. In UEGW - Su1347. Gastroenterology 154(Supl 1):S528

    Article  Google Scholar 

  80. Raman A, Lennon AM (2018) Cyst fluid biomarkers - diagnosis and prediction of malignancy for cystic lesions of the pancreas. Visc Med 34(3):178–181

    Article  PubMed  PubMed Central  Google Scholar 

  81. Carr RA et al (2018) Pancreatic cyst fluid glucose: rapid, inexpensive, and accurate diagnosis of mucinous pancreatic cysts. Surgery 163(3):600–605

    Article  PubMed  Google Scholar 

  82. Wu J et al (2011) Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 108(52):21188–21193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Khalid A et al (2005) The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology. Clin Gastroenterol Hepatol 3(10):967–973

    Article  CAS  PubMed  Google Scholar 

  84. Singhi AD, Nikiforova MN, McGrath K (2017) DNA testing of pancreatic cyst fluid: is it ready for prime time? Lancet Gastroenterol Hepatol 2(1):63–72

    Article  PubMed  Google Scholar 

  85. Rosenbaum MW et al (2017) Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts. Cancer Cytopathol 125(1):41–47

    Article  CAS  PubMed  Google Scholar 

  86. Pea A et al (2017) Targeted DNA sequencing reveals patterns of local progression in the pancreatic remnant following resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the pancreas. Ann Surg 266(1):133–141

    Article  PubMed  Google Scholar 

  87. Yu J et al (2017) Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms. Gut 66(9):1677

    Article  CAS  PubMed  Google Scholar 

  88. Singhi AD et al (2018) Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia. Gut 67(12):2131

    Article  CAS  PubMed  Google Scholar 

  89. Early DS et al (2013) Adverse events associated with EUS and EUS with FNA. Gastrointest Endosc 77(6):839–843

    Article  PubMed  Google Scholar 

  90. Levy P, Rebours V (2018) The role of endoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Visc Med 34(3):192–196

    Article  PubMed  PubMed Central  Google Scholar 

  91. Guarner-Argente C et al (2011) Use of antimicrobials for EUS-guided FNA of pancreatic cysts: a retrospective, comparative analysis. Gastrointest Endosc 74(1):81–86

    Article  PubMed  Google Scholar 

  92. Lee LS et al (2005) EUS-guided fine needle aspiration of pancreatic cysts: a retrospective analysis of complications and their predictors. Clin Gastroenterol Hepatol 3(3):231–236

    Article  PubMed  Google Scholar 

  93. O'Toole D et al (2001) Assessment of complications of EUS-guided fine-needle aspiration. Gastrointest Endosc 53(4):470–474

    Article  CAS  PubMed  Google Scholar 

  94. Wang KX et al (2011) Assessment of morbidity and mortality associated with EUS-guided FNA: a systematic review. Gastrointest Endosc 73(2):283–290

    Article  PubMed  Google Scholar 

  95. Gress FG et al (1997) Endoscopic ultrasound–guided fine-needle aspiration biopsy using linear array and radial scanning endosonography. Gastrointest Endosc 45(3):243–250

    Article  CAS  PubMed  Google Scholar 

  96. Affi A et al (2001) Acute extraluminal hemorrhage associated with EUS-guided fine needle aspiration: frequency and clinical significance. Gastrointest Endosc 53(2):221–225

    Article  CAS  PubMed  Google Scholar 

  97. Singh P et al (2008) Hemosuccus pancreaticus after EUS-FNA of pancreatic cyst (with video). Gastrointest Endosc 67(3):543

    Article  PubMed  Google Scholar 

  98. Cheruvattath R, Diehl DL (2009) Hemosuccus pancreaticus after EUS-FNA of a pancreatic tail cyst. Gastrointest Endosc 70(4):817

    Article  PubMed  Google Scholar 

  99. Ahmed K et al (2011) A case of EUS-guided FNA–related pancreatic cancer metastasis to the stomach. Gastrointest Endosc 74(1):231–233

    Article  PubMed  Google Scholar 

  100. Hirooka Y et al (2003) Case of intraductal papillary mucinous tumor in which endosonography- guided fine-needle aspiration biopsy caused dissemination [1]. Journal of Gastroenterology and Hepatology (Australia) 18(11):1323–1324

    Article  Google Scholar 

  101. Yoon WJ et al (2014) Peritoneal seeding in intraductal papillary mucinous neoplasm of the pancreas patients who underwent endoscopic ultrasound-guided fine-needle aspiration: the PIPE study. Endoscopy 46(5):382–387

    Article  PubMed  Google Scholar 

  102. Silvis SE et al (1976) Endoscopic complications: results of the 1974 American Society for Gastrointestinal Endoscopy Survey. JAMA 235(9):928–930

    Article  CAS  PubMed  Google Scholar 

  103. Eisen GM et al (2002) Complications of upper GI endoscopy. Gastrointest Endosc 55(7):784–793

    Article  PubMed  Google Scholar 

  104. Samarasena J et al (2019) EUS-guided through-the-needle biopsy for pancreatic cystic lesions. VideoGIE 4(9):436–439

    Article  PubMed  PubMed Central  Google Scholar 

  105. Basar O et al (2018) Feasibility and safety of microforceps biopsy in the diagnosis of pancreatic cysts. Gastrointest Endosc 88(1):79–86

    Article  PubMed  Google Scholar 

  106. Yang D et al (2018) Endoscopic ultrasound-guided through-the-needle microforceps biopsy in the evaluation of pancreatic cystic lesions: a multicenter study. Endosc Int Open 6(12):E1423–e1430

    Article  PubMed  PubMed Central  Google Scholar 

  107. Barresi L et al (2018) Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: a multicenter study. Dig Endosc 30(6):760–770

    Article  PubMed  Google Scholar 

  108. Zhang ML et al (2018) Moray micro forceps biopsy improves the diagnosis of specific pancreatic cysts. Cancer Cytopathol 126(6):414–420

    Article  CAS  PubMed  Google Scholar 

  109. Mittal C et al (2018) Technical feasibility, diagnostic yield, and safety of microforceps biopsies during EUS evaluation of pancreatic cystic lesions (with video). Gastrointest Endosc 87(5):1263–1269

    Article  PubMed  Google Scholar 

  110. Kovacevic B et al (2018) Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: a multicenter feasibility study (with video). Endosc Ultrasound 7(6):383–388

    Article  PubMed  PubMed Central  Google Scholar 

  111. Yang D et al (2019) Histologic analysis of endoscopic ultrasound-guided through the needle microforceps biopsies accurately identifies mucinous pancreas cysts. Clin Gastroenterol Hepatol 17(8):1587–1596

    Article  PubMed  Google Scholar 

  112. Trindade AJ et al (2018) Digital pancreatoscopy in the evaluation of main duct intraductal papillary mucinous neoplasm: a multicenter study. Endoscopy 50(11):1095–1098

    PubMed  Google Scholar 

  113. Hara T et al (2002) Diagnosis and patient management of intraductal papillary-mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography. Gastroenterology 122(1):34–43

    Article  PubMed  Google Scholar 

  114. Napoleon B et al (2019) Needle-based confocal laser endomicroscopy of pancreatic cystic lesions: a prospective multicenter validation study in patients with definite diagnosis. Endoscopy 51(9):825–835

    Article  PubMed  Google Scholar 

  115. Moyer MT, Maranki JL, DeWitt JM (2019) EUS-guided pancreatic cyst ablation: a clinical and technical review. Curr Gastroenterol Rep 21(5):19

    Article  PubMed  Google Scholar 

  116. DiMaio CJ, DeWitt JM, Brugge WR (2011) Ablation of pancreatic cystic lesions: the use of multiple endoscopic ultrasound-guided ethanol lavage sessions. Pancreas 40(5):664–668

    Article  PubMed  Google Scholar 

  117. Gomez V et al (2016) EUS-guided ethanol lavage does not reliably ablate pancreatic cystic neoplasms (with video). Gastrointest Endosc 83(5):914–920

    Article  PubMed  Google Scholar 

  118. Gan SI et al (2005) Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc 61(6):746–752

    Article  PubMed  Google Scholar 

  119. DeWitt J et al (2009) EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study. Gastrointest Endosc 70(4):710–723

    Article  PubMed  Google Scholar 

  120. Caillol F et al (2012) Ethanol lavage of 14 mucinous cysts of the pancreas: a retrospective study in two tertiary centers. Endoscopic Ultrasound 1(1):48–52

    Article  PubMed  PubMed Central  Google Scholar 

  121. Oh HC et al (2009) Septated cystic tumors of the pancreas: is it possible to treat them by endoscopic ultrasonography-guided intervention? Scand J Gastroenterol 44(2):242–247

    Article  PubMed  Google Scholar 

  122. Oh HC et al (2011) Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology 140(1):172–179

    Article  CAS  PubMed  Google Scholar 

  123. DeWitt JM et al (2014) Alterations in cyst fluid genetics following endoscopic ultrasound-guided pancreatic cyst ablation with ethanol and paclitaxel. Endoscopy 46(6):457–464

    Article  PubMed  Google Scholar 

  124. Moyer MT et al (2017) The safety and efficacy of an alcohol-free pancreatic cyst ablation protocol. Gastroenterology 153(5):1295–1303

    Article  PubMed  Google Scholar 

  125. Barthet M et al (2019) Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumors and pancreatic cystic neoplasms: a prospective multicenter study. Endoscopy 51(09):836–842

    Article  PubMed  Google Scholar 

  126. Del Chiaro M et al (2017) Survival analysis and risk for progression of Intraductal Papillary Mucinous Neoplasia of the pancreas (IPMN) under surveillance: a single-institution experience. Ann Surg Oncol 24(4):1120–1126

    Article  PubMed  Google Scholar 

  127. Lawrence SA et al (2017) Should patients with cystic lesions of the pancreas undergo long-term radiographic surveillance?: Results of 3024 patients evaluated at a single institution. Ann Surg 266(3):536–544

    Article  PubMed  Google Scholar 

  128. Crippa S et al (2017) Active surveillance beyond 5 years is required for presumed branch-duct intraductal papillary mucinous neoplasms undergoing non-operative management. Am J Gastroenterol 112(7):1153–1161

    Article  PubMed  Google Scholar 

  129. Overbeek KA et al (2019) Development of a stratification tool to identify pancreatic intraductal papillary mucinous neoplasms at lowest risk of progression. Aliment Pharmacol Ther 50(7):789–799

    Article  PubMed  PubMed Central  Google Scholar 

  130. Springer S et al (2019) A multimodality test to guide the management of patients with a pancreatic cyst. Sci Transl Med 11(501):eaav4772

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  131. Kurita Y et al (2019) Diagnostic ability of artificial intelligence using deep learning analysis of cyst fluid in differentiating malignant from benign pancreatic cystic lesions. Sci Rep 9(1):6893–6893

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  132. Levink I, Bruno MJ, Cahen DL (2018) Management of intraductal papillary mucinous neoplasms: controversies in guidelines and future perspectives. Curr Treat Options Gastroenterol 16(3):316–332

    Article  PubMed  PubMed Central  Google Scholar 

  133. Al Efishat M et al (2018) Progression patterns in the remnant pancreas after resection of non-invasive or micro-invasive Intraductal Papillary Mucinous Neoplasms (IPMN). Ann Surg Oncol 25(6):1752–1759

    Article  PubMed  PubMed Central  Google Scholar 

  134. Raut CP et al (2006) Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival. Ann Surg Oncol 13(4):582–594

    Article  PubMed  Google Scholar 

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Hoogenboom, S.A., Fockens, P., Wallace, M.B., van Hooft, J.E. (2020). Endoscopic Management and Follow-Up of Intraductal Papillary Mucinous Neoplasia (IPMN). In: Testoni, P.A., Inoue, H., Wallace, M.B. (eds) Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29964-4_104-1

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  • DOI: https://doi.org/10.1007/978-3-030-29964-4_104-1

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