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Cardiovascular Manifestations of Panic and Anxiety

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Brain and Heart Dynamics

Abstract

Anxiety disorders are prevalent in 10–23% of persons with coronary heart disease (CHD) and are therefore quite commonly encountered in typical cardiology practice settings. Because anxiety disorder patients frequently present to emergency departments and outpatient appointments for atypical cardiovascular symptoms, the accurate identification and treatment of anxiety is therefore a major priority for all persons involved in cardiovascular care. The substantial overlap in subjective cardiorespiratory symptoms shared between anxiety and cardiovascular diseases does little to improve our understanding of this complex association. Herein we describe the complex nature of anxiety disorders such as panic disorder in relation to CHD. Particular attention is paid to overviewing the empirical evidence demonstrating aetiological and prognostic links between anxiety disorders with incident and recurrent cardiovascular diseases, respectively. We also discuss potential biobehavioral mechanisms that lead to atherosclerosis and major cardiovascular event recurrence. This chapter also discusses the extant treatment approaches to anxiety, making suggestions for improving clinical interventions in the population with anxiety and comorbid CHD. After summarizing these facets of the anxiety-CHD link, suggestions are made for future research.

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References

  1. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(9):655–79.

    Article  CAS  PubMed  Google Scholar 

  2. Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L, et al. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry. 2008;30(3):208–25.

    Article  PubMed  Google Scholar 

  3. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999;282(18):1737–44.

    Article  CAS  PubMed  Google Scholar 

  4. Coley KC, Saul MI, Seybert AL. Economic burden of not recognizing panic disorder in the emergency department. J Emerg Med. 2009;36(1):3–7.

    Article  PubMed  Google Scholar 

  5. Lamb CE, Ratner PH, Johnson CE, Ambegaonkar AJ, Joshi AV, Day D, et al. Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective. Curr Med Res Opin. 2006;22(6):1203–10.

    Article  PubMed  Google Scholar 

  6. Baumeister H, Haschke A, Munzinger M, Hutter N, Tully PJ. Inpatient and outpatient costs in patients with coronary artery disease and mental disorders: a systematic review. Biopsychosoc Med. 2015;9:11.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Baxter AJ, Vos T, Scott KM, Norman RE, Flaxman AD, Blore J, et al. The regional distribution of anxiety disorders: implications for the Global Burden of Disease Study, 2010. Int J Methods Psychiatr Res. 2014;23(4):422–38.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res. 2012;21(3):169–84.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tully PJ, Cosh SM, Baumeister H. The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease. J Psychosom Res. 2014;77(6):439–48.

    Article  PubMed  Google Scholar 

  10. Miles HHW, Cobb S. Neurocirculatory asthenia, anxiety and neurosis. N Engl J Med. 1951;245(19):711–9.

    Article  CAS  PubMed  Google Scholar 

  11. Walsh JJ. Psychotherapy: including the history of the use of mental influence, directly and indirectly in healing and the principles for the application of energies derived from the mind to the treatment of disease. New York: D. Appleton & Company; 1912. p. 819.

    Google Scholar 

  12. Suls J, Bunde J. Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psychol Bull. 2005;131(2):260–300.

    Article  PubMed  Google Scholar 

  13. Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010;56(1):38–46.

    Article  PubMed  Google Scholar 

  14. Tully PJ, Turnbull DA, Beltrame JF, Horowitz JD, Cosh S, Baumeister H, et al. Panic disorder and incident coronary heart disease: a systematic review and meta-regression in 1,131,612 persons and 58,111 cardiac events. Psychol Med. 2015;45(14):2909–20.

    Article  CAS  PubMed  Google Scholar 

  15. Roest AM, Martens EJ, Denollet J, de Jonge P. Prognostic association of anxiety post myocardial infarction with mortality and new cardiac events: a meta-analysis. Psychosom Med. 2010;72(6):563–9.

    Article  PubMed  Google Scholar 

  16. Teng EJ, Chaison AD, Bailey SD, Hamilton JD, Dunn NJ. When anxiety symptoms masquerade as medical symptoms: what medical specialists know about panic disorder and available psychological treatments. J Clin Psychol Med Settings. 2008;15(4):314–21.

    Article  PubMed  Google Scholar 

  17. American Psychiatric Association. The Diagnostic and statistical manual of mental disorders DSM-V. Washington, DC: American Psychiatric Association; 2013.

    Book  Google Scholar 

  18. Carmin CN, Ownby RL, Wiegartz PS, Kondos GT. Women and non-cardiac chest pain: gender differences in symptom presentation. Arch Womens Ment Health. 2008;11(4):287–93.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Frommeyer G, Eckardt L, Breithardt G. Panic attacks and supraventricular tachycardias: the chicken or the egg? Neth Hear J. 2013;21(2):74–7.

    Article  CAS  Google Scholar 

  20. Muller-Tasch T, Frankenstein L, Holzapfel N, Schellberg D, Lowe B, Nelles M, et al. Panic disorder in patients with chronic heart failure. J Psychosom Res. 2008;64(3):299–303.

    Article  PubMed  Google Scholar 

  21. Karatas MB, Sahan E, Ozcan KS, Canga Y, Gungor B, Onuk T, et al. Anxiety, depression, and general psychological distress in patients with coronary slow flow. Arq Bras Cardiol. 2015;105(4):362–70.

    PubMed  PubMed Central  Google Scholar 

  22. Vural M, Satiroglu O, Akbas B, Goksel I, Karabay O. Coronary artery disease in association with depression or anxiety among patients undergoing angiography to investigate chest pain. Tex Heart Inst J. 2009;36(1):17–23.

    PubMed  PubMed Central  Google Scholar 

  23. Beitman BD, Basha I, Flaker G, DeRosear L, Mukerji V, Trombka L, et al. Atypical or nonanginal chest pain. Panic disorder or coronary artery disease? Arch Intern Med. 1987;147(9):1548–52.

    Article  CAS  PubMed  Google Scholar 

  24. Esan OB, Baiyewu O. Panic disorder prevalence among patients referred for an electrocardiogram in a Nigerian teaching hospital. Psychosomatics. 2013;54(5):472–8.

    Article  PubMed  Google Scholar 

  25. Christoph M, Christoph A, Dannemann S, Poitz D, Pfluecke C, Strasser RH, et al. Mental symptoms in patients with cardiac symptoms and normal coronary arteries. Open Heart. 2014;1(1):e000093.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Delewi R, Vlastra W, Rohling WJ, Wagenaar TC, Zwemstra M, Meesterman MG, et al. Anxiety levels of patients undergoing coronary procedures in the catheterization laboratory. Int J Cardiol. 2017;228:926–30.

    Article  PubMed  Google Scholar 

  27. Hernandez-Palazon J, Fuentes-Garcia D, Falcon-Arana L, Roca-Calvo MJ, Burguillos-Lopez S, Domenech-Asensi P, et al. Assessment of preoperative anxiety in cardiac surgery patients lacking a history of anxiety: contributing factors and postoperative morbidity. J Cardiothorac Vasc Anesth. 2018;32(1):236–44.

    Article  PubMed  Google Scholar 

  28. Tully PJ, Sardinha A, Nardi AE. A new CBT model of panic attack treatment in comorbid heart diseases (PATCHD): how to calm an anxious heart and mind. Cogn Behav Pract. 2017;24(3):329–41.

    Article  Google Scholar 

  29. Carleton RN, Duranceau S, Freeston MH, Boelen PA, McCabe RE, Antony MM. “But it might be a heart attack”: intolerance of uncertainty and panic disorder symptoms. J Anxiety Disord. 2014;28(5):463–70.

    Article  PubMed  Google Scholar 

  30. van Beek MH, Oude Voshaar RC, van Deelen FM, van Balkom AJ, Pop G, Speckens AE. Inverse correlation between cardiac injury and cardiac anxiety: a potential role for communication. J Cardiovasc Nurs. 2014;29(5):448–53.

    Article  PubMed  Google Scholar 

  31. Tully PJ, Newland RF, Baker RA. Cardiovascular risk profile before coronary artery bypass graft surgery in relation to depression and anxiety disorders: an age and sex propensity matched study. Aust Crit Care. 2015;28(1):24–30.

    Article  PubMed  Google Scholar 

  32. Ali SS, Khan SA, Khosa F, Aneni EC, Jones A, St Leger AS, et al. Noninvasive assessment of subclinical atherosclerosis in persons with symptoms of depression. Atherosclerosis. 2017;264:92–9.

    Article  CAS  PubMed  Google Scholar 

  33. Clay FJ, Watson WL, Newstead SV, McClure RJ. A systematic review of early prognostic factors for persisting pain following acute orthopedic trauma. Pain Res Manag. 2012;17(1):35–44.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Vladan S, David B. Cognitive specificity of anxiety disorders: a review of selected key constructs. Depress Anxiety. 2006;23(2):51–61.

    Article  Google Scholar 

  35. Salkovskis PM, Jones DR, Clark DM. Respiratory control in the treatment of panic attacks: replication and extension with concurrent measurement of behaviour and pCO2. Br J Psychiatry. 1986;148:526–32.

    Article  CAS  PubMed  Google Scholar 

  36. Katon W, Lin EH, Kroenke K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry. 2007;29(2):147–55.

    Article  PubMed  Google Scholar 

  37. Fleet RP, Dupuis G, Marchand A, Burelle D, Arsenault A, Beitman BD. Panic disorder in emergency department chest pain patients: prevalence, comorbidity, suicidal ideation, and physician recognition. Am J Med. 1996;101(4):371–80.

    Article  CAS  PubMed  Google Scholar 

  38. Fang XY, Spieler D, Albarqouni L, Ronel J, Ladwig KH. Impact of generalized anxiety disorder (GAD) on prehospital delay of acute myocardial infarction patients. Findings from the multicenter MEDEA study. Clin Res Cardiol. 2018;107(6):471–8.

    Article  CAS  PubMed  Google Scholar 

  39. Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y. Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS One. 2012;7(6):e38915.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Ormel J, Von Korff M, Burger H, Scott K, Demyttenaere K, Huang YQ, et al. Mental disorders among persons with heart disease – results from World Mental Health surveys. Gen Hosp Psychiatry. 2007;29(4):325–34.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Salkovskis PM, Clark DM, Gelder MG. Cognition-behaviour links in the persistence of panic. Behav Res Ther. 1996;34(5–6):453–8.

    Article  CAS  PubMed  Google Scholar 

  42. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):617–27.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Edmondson D, Kronish IM, Shaffer JA, Falzon L, Burg MM. Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review. Am Heart J. 2013;166(5):806–14.

    Article  PubMed  Google Scholar 

  44. Tiller JW. Depression and anxiety. MJA Open. 2012;1(Suppl 4):28–31.

    Google Scholar 

  45. Penninx BW. Depression and anxiety: their insidious dance. Lancet Psychiatry. 2015;2(6):479–80.

    Article  PubMed  Google Scholar 

  46. Westermair AL, Schaich A, Willenborg B, Willenborg C, Nitsche S, Schunkert H, et al. Utilization of mental health care, treatment patterns, and course of psychosocial functioning in northern German coronary artery disease patients with depressive and/or anxiety disorders. Front Psychol. 2018;9:75.

    Article  Google Scholar 

  47. Celano CM, Mastromauro CA, Lenihan EC, Januzzi JL, Rollman BL, Huffman JC. Association of baseline anxiety with depression persistence at 6 months in patients with acute cardiac illness. Psychosom Med. 2012;74(1):93–9.

    Article  PubMed  Google Scholar 

  48. Walters K, Rait G, Petersen I, Williams R, Nazareth I. Panic disorder and risk of new onset coronary heart disease, acute myocardial infarction, and cardiac mortality: cohort study using the general practice research database. Eur Heart J. 2008;29(24):2981–8.

    Article  PubMed  Google Scholar 

  49. Scherrer JF, Chrusciel T, Zeringue A, Garfield LD, Hauptman PJ, Lustman PJ, et al. Anxiety disorders increase risk for incident myocardial infarction in depressed and nondepressed Veterans Administration patients. Am Heart J. 2010;159(5):772–9.

    Article  PubMed  Google Scholar 

  50. Jakobsen AH, Foldager L, Parker G, Munk-Jorgensen P. Quantifying links between acute myocardial infarction and depression, anxiety and schizophrenia using case register databases. J Affect Disord. 2008;109(1–2):177–81.

    Article  PubMed  Google Scholar 

  51. Janszky I, Ahnve S, Lundberg I, Hemmingsson T. Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. J Am Coll Cardiol. 2010;56(1):31–7.

    Article  PubMed  Google Scholar 

  52. Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, et al. Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation. 1994;89(5):1992–7.

    Article  CAS  PubMed  Google Scholar 

  53. Chen YH, Tsai SY, Lee HC, Lin HC. Increased risk of acute myocardial infarction for patients with panic disorder: a nationwide population-based study. Psychosom Med. 2009;71(7):798–804.

    Article  PubMed  Google Scholar 

  54. Buckley T, Hoo SYS, Fethney J, Shaw E, Hanson PS, Tofler GH. Triggering of acute coronary occlusion by episodes of anger. Eur Heart J Acute Cardiovasc Care. 2015;4(6):493–8.

    Article  PubMed  Google Scholar 

  55. Kubzansky LD, Cole SR, Kawachi I, Vokonas P, Sparrow D. Shared and unique contributions of anger, anxiety, and depression to coronary heart disease: a prospective study in the normative aging study. Ann Behav Med. 2006;31(1):21–9.

    Article  PubMed  Google Scholar 

  56. Tully PJ, Baune BT. Comorbid anxiety disorders alter the association between cardiovascular diseases and depression: the German National Health Interview and Examination Survey. Soc Psychiatry Psychiatr Epidemiol. 2014;49(5):683–91.

    Article  PubMed  Google Scholar 

  57. Tully PJ, Winefield HR, Baker RA, Denollet J, Pedersen SS, Wittert GA, et al. Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypass graft surgery: a five year longitudinal cohort study. Biopsychosoc Med. 2015;9:14.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Roest AM, de Jonge P, Lim CWW, Stein DJ, Al-Hamzawi A, Alonso J, et al. Fear and distress disorders as predictors of heart disease: a temporal perspective. J Psychosom Res. 2017;96:67–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Scott KM, de Jonge P, Alonso J, Viana MC, Liu Z, O’Neill S, et al. Associations between DSM-IV mental disorders and subsequent heart disease onset: beyond depression. Int J Cardiol. 2013;168(6):5293–9.

    Article  PubMed  Google Scholar 

  60. Frasure-Smith N, Lespérance F. Depression and anxiety as predictors of cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008;65(1):62–71.

    Article  CAS  PubMed  Google Scholar 

  61. Lichtman JH, Froelicher ES, Blumenthal JA, Carney RM, Doering LV, Frasure-Smith N, et al. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation. 2014;129(12):1350–69.

    Article  PubMed  Google Scholar 

  62. Ladwig KH, Lederbogen F, Albus C, Angermann C, Borggrefe M, Fischer D, et al. Position paper on the importance of psychosocial factors in cardiology: update 2013. German Medical Science. 2014;12:Doc09.

    Google Scholar 

  63. Martens EJ, de Jonge P, Na B, Cohen BE, Lett H, Whooley MA. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. Arch Gen Psychiatry. 2010;67(7):750–8.

    Article  PubMed  Google Scholar 

  64. Goodwin RD, Davidson KW, Keyes K. Mental disorders and cardiovascular disease among adults in the United States. J Psychosom Res. 2009;43(3):239–46.

    Article  Google Scholar 

  65. Strik JJ, Denollet J, Lousberg R, Honig A. Comparing depression and anxiety as predictors of cardiac events after myocardial infarction. J Am Coll Cardiol. 2003;42(10):1801–7.

    Article  PubMed  Google Scholar 

  66. Meyer T, Hussein S, Lange HW, Herrmann-Lingen C. Anxiety is associated with a reduction in both mortality and major adverse cardiovascular events five years after coronary stenting. Eur J Prev Cardiol. 2015;22(1):75–82.

    Google Scholar 

  67. Tully PJ, HN J, Cheung P, Cosh S. Anxiety and cardiovascular disease: a review. Curr Cardiol Rep. 2016;18(12):120.

    Article  PubMed  Google Scholar 

  68. Kubzansky LD, Kawachi I, Weiss ST, Sparrow D. Anxiety and coronary heart disease: a synthesis of epidemiological, psychological, and experimental evidence. Ann Behav Med. 1998;20(2):47–58.

    Article  CAS  PubMed  Google Scholar 

  69. Kollia N, Panagiotakos D, Georgousopoulou E, Chrysohoou C, Yannakoulia M, Stefanadis C, et al. Exploring the path between depression, anxiety and 10-year cardiovascular disease incidence, among apparently healthy Greek middle-aged adults: the ATTICA study. Maturitas. 2017;106:73–9.

    Article  PubMed  Google Scholar 

  70. Pierce GL, Kalil GZ, Ajibewa T, Holwerda SW, Persons J, Moser DJ, et al. Anxiety independently contributes to elevated inflammation in humans with obesity. Obesity (Silver Spring). 2017;25(2):286–9.

    Article  CAS  Google Scholar 

  71. Vogelzangs N, de Jonge P, Smit JH, Bahn S, Penninx BW. Cytokine production capacity in depression and anxiety. Transl Psychiatry. 2016;6(5):e825.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Roy-Byrne PP, Schmidt P, Cannon RO, Diem H, Rubinow DR. Microvascular angina and panic disorder. Int J Psychiatry Med. 1989;19(4):315–25.

    Article  CAS  PubMed  Google Scholar 

  73. Cicek Y, Durakoglugil ME, Kocaman SA, Guveli H, Cetin M, Erdogan T, et al. Increased pulse wave velocity in patients with panic disorder: independent vascular influence of panic disorder on arterial stiffness. J Psychosom Res. 2012;73(2):145–8.

    Article  PubMed  Google Scholar 

  74. Chen YH, Lin HC. Patterns of psychiatric and physical comorbidities associated with panic disorder in a nationwide population-based study in Taiwan. Acta Psychiatr Scand. 2011;123(1):55–61.

    Article  PubMed  Google Scholar 

  75. Bankier B, Barajas J, Martinez-Rumayor A, Januzzi JL. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Eur Heart J. 2008;29(18):2212–7.

    Article  CAS  PubMed  Google Scholar 

  76. van Reedt Dortland AK, Vreeburg SA, Giltay EJ, Licht CM, Vogelzangs N, van Veen T, et al. The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression. Psychoneuroendocrinology. 2013;38(2):209–18.

    Article  PubMed  CAS  Google Scholar 

  77. van Reedt Dortland AK, Giltay EJ, van Veen T, Zitman FG, Penninx BW. Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity. Psychosom Med. 2013;75(83–89):83–9.

    Article  PubMed  CAS  Google Scholar 

  78. Isensee B, Wittchen HU, Stein MB, Hofler M, Lieb R. Smoking increases the risk of panic: findings from a prospective community study. Arch Gen Psychiatry. 2003;60(7):692–700.

    Article  PubMed  Google Scholar 

  79. Hoertel N, Le Strat Y, De Maricourt P, Limosin F, Dubertret C. Are subjects in treatment trials of panic disorder representative of patients in routine clinical practice? Results from a national sample. J Affect Disord. 2013;146(3):383–9.

    Article  PubMed  Google Scholar 

  80. Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, Compton W, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61(8):807–16.

    Article  PubMed  Google Scholar 

  81. Wagner JA, Pietrzak RH, Petry NM. Psychiatric disorders are associated with hospital care utilization in persons with hypertension: results from the National Epidemiologic Survey on alcohol and related conditions. Soc Psychiatry Psychiatr Epidemiol. 2008;43(11):878–88.

    Article  PubMed  Google Scholar 

  82. Grant BF, Goldstein RB, Chou SP, Huang B, Stinson FS, Dawson DA, et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry. 2009;14(11):1051–66.

    Article  CAS  PubMed  Google Scholar 

  83. Buckner JD, Schmidt NB. Understanding social anxiety as a risk for alcohol use disorders: fear of scrutiny, not social interaction fears, prospectively predicts alcohol use disorders. J Psychiatr Res. 2009;43(4):477–83.

    Article  PubMed  Google Scholar 

  84. Berge LI, Skogen JC, Sulo G, Igland J, Wilhelmsen I, Vollset SE, et al. Health anxiety and risk of ischaemic heart disease: a prospective cohort study linking the Hordaland Health Study (HUSK) with the Cardiovascular Diseases in Norway (CVDNOR) project. BMJ Open. 2016;6(11):e012914.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Willis BL, Leonard D, Barlow CE, Martin SB, DeFina LF, Trivedi MH. Association of midlife cardiorespiratory fitness with incident depression and cardiovascular death after depression in later life. JAMA Psychiat. 2018;75(9):911–917.

    Google Scholar 

  86. Åberg MAI, Waern M, Nyberg J, Pedersen NL, Bergh Y, Åberg ND, et al. Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study. Br J Psychiatry. 2012;201(5):352–9.

    Article  PubMed  Google Scholar 

  87. Belem da Silva CT, Schuch F, Costa M, Hirakata V, Manfro GG. Somatic, but not cognitive, symptoms of anxiety predict lower levels of physical activity in panic disorder patients. J Affect Disord. 2014;164:63–8.

    Article  PubMed  Google Scholar 

  88. Muotri RW, Bernik MA. Panic disorder and exercise avoidance. Rev Bras Psiquiatr. 2014;36:68–75.

    Article  PubMed  Google Scholar 

  89. Sardinha A, Araújo CGS, Soares-Filho GLF, Nardi AE. Anxiety, panic disorder and coronary artery disease: issues concerning physical exercise and cognitive behavioral therapy. Expert Rev Cardiovasc Ther. 2011;9(2):165–75.

    Article  CAS  PubMed  Google Scholar 

  90. Ramos PS, Sardinha A, Nardi AE, Araújo CG. Cardiorespiratory optimal point: a submaximal exercise variable to assess panic disorder patients. PLoS One. 2014;26(9(8)):e104932.

    Article  CAS  Google Scholar 

  91. Daniel M, Agewall S, Berglund F, Caidahl K, Collste O, Ekenback C, et al. Prevalence of anxiety and depression symptoms in patients with myocardial infarction with non-obstructive coronary arteries. Am J Med. 2018;131:1118.

    Article  PubMed  Google Scholar 

  92. Kazukauskiene N, Burkauskas J, Macijauskiene J, Duoneliene I, Gelziniene V, Jakumaite V, et al. Mental distress factors and exercise capacity in patients with coronary artery disease attending cardiac rehabilitation program. Int J Behav Med. 2018;25(1):38–48.

    Article  PubMed  Google Scholar 

  93. Vickers K, Jafarpour S, Mofidi A, Rafat B, Woznica A. The 35% carbon dioxide test in stress and panic research: overview of effects and integration of findings. Clin Psychol Rev. 2012;32(3):153–64.

    Article  PubMed  Google Scholar 

  94. Woznica A, Vickers K, Koerner N, Fracalanza K. Reactivity to 35% carbon dioxide in bulimia nervosa and panic disorder. Psychiatry Res. 2015;228(3):571–5.

    Article  PubMed  Google Scholar 

  95. Taylor CB, King R, Ehlers A, Margraf J, Clark D, Hayward C, et al. Treadmill exercise test and ambulatory measures in panic attacks. Am J Cardiol. 1987;60(18):48J–52J.

    Article  CAS  PubMed  Google Scholar 

  96. Clark DM, Salkovskis PM, Chalkley AJ. Respiratory control as a treatment for panic attacks. J Behav Ther Exp Psychiatry. 1985;16(1):23–30.

    Article  CAS  PubMed  Google Scholar 

  97. Salkovskis PM, Warwick HM, Clark DM, Wessels DJ. A demonstration of acute hyperventilation during naturally occurring panic attacks. Behav Res Ther. 1986;24(1):91–4.

    Article  CAS  PubMed  Google Scholar 

  98. Fleet R, Lesperance F, Arsenault A, Gregoire J, Lavoie K, Laurin C, et al. Myocardial perfusion study of panic attacks in patients with coronary artery disease. Am J Cardiol. 2005;96(8):1064–8.

    Article  PubMed  Google Scholar 

  99. Fleet R, Foldes-Busque G, Grégoire J, Harel F, Laurin C, Burelle D, et al. A study of myocardial perfusion in patients with panic disorder and low risk coronary artery disease after 35% CO2 challenge. J Psychosom Res. 2014;76(1):41–5.

    Article  PubMed  Google Scholar 

  100. Esler M. Mental stress and human cardiovascular disease. Neurosci Biobehav Rev. 2017;74(Pt B):269–76.

    Article  PubMed  Google Scholar 

  101. Herrmann-Lingen C, al’Absi M. Exploring the association of hypertension with risk for depression: evidence for tamed neurobehavioral arousal versus central emotional dysregulation. Psychosom Med. 2018;80(6):504–7.

    Article  PubMed  Google Scholar 

  102. Tully PJ, Tzourio C. Psychiatric correlates of blood pressure variability in the elderly: the Three City cohort study. Physiol Behav. 2017;168:91–7.

    Article  CAS  PubMed  Google Scholar 

  103. Yeragani VK, Pohl R, Bar KJ, Chokka P, Tancer M. Exaggerated beat-to-beat R amplitude variability in patients with panic disorder after intravenous isoproterenol. Neuropsychobiology. 2007;55(3–4):213–8.

    Article  CAS  PubMed  Google Scholar 

  104. Sullivan GM, Kent JM, Kleber M, Martinez JM, Yeragani VK, Gorman JM. Effects of hyperventilation on heart rate and QT variability in panic disorder pre- and post-treatment. Psychiatry Res. 2004;125(1):29–39.

    Article  PubMed  Google Scholar 

  105. Yeragani VK, Pohl R, Balon R, Jampala VC, Jayaraman A. Twenty-four-hour QT interval variability: increased QT variability during sleep in patients with panic disorder. Neuropsychobiology. 2002;46(1):1–6.

    Article  PubMed  Google Scholar 

  106. Pohl R, Yeragani VK. QT interval variability in panic disorder patients after isoproterenol infusions. Int J Neuropsychopharmacol. 2001;4(1):17–20.

    Article  CAS  PubMed  Google Scholar 

  107. Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, et al. Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res. 1993;46(1):89–103.

    Article  CAS  PubMed  Google Scholar 

  108. Chalmers J, Quintana DS, Abbott MJ, Kemp AH. Anxiety disorders are associated with reduced heart rate variability: a meta-analysis. Front Psychol. 2014;5:80.

    Google Scholar 

  109. Fangauf SV, Herbeck Belnap B, Meyer T, Albus C, Binder L, Deter HC, et al. Associations of NT-proBNP and parameters of mental health in depressed coronary artery disease patients. Psychoneuroendocrinology. 2018;96:188–94.

    Article  CAS  PubMed  Google Scholar 

  110. Meyer T, Herrmann-Lingen C. Natriuretic peptides in anxiety and panic disorder. Vitam Horm. 2017;103:131–45.

    Article  CAS  PubMed  Google Scholar 

  111. Memon AA, Sundquist K, Ahmad A, Wang X, Hedelius A, Sundquist J. Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care. Psychiatry Res. 2017;254:311–6.

    Article  CAS  PubMed  Google Scholar 

  112. Tang Z, Ye G, Chen X, Pan M, Fu J, Fu T, et al. Peripheral proinflammatory cytokines in Chinese patients with generalised anxiety disorder. J Affect Disord. 2018;225:593–8.

    Article  CAS  PubMed  Google Scholar 

  113. Tayefi M, Shafiee M, Kazemi-Bajestani SMR, Esmaeili H, Darroudi S, Khakpouri S, et al. Depression and anxiety both associate with serum level of hs-CRP: a gender-stratified analysis in a population-based study. Psychoneuroendocrinology. 2017;81:63–9.

    Article  CAS  PubMed  Google Scholar 

  114. Glaus J, Vandeleur CL, von Kanel R, Lasserre AM, Strippoli MP, Gholam-Rezaee M, et al. Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. J Psychiatr Res. 2014;58:36–45.

    Article  PubMed  Google Scholar 

  115. Moons WG, Shields GS. Anxiety, not anger, induces inflammatory activity: an avoidance/approach model of immune system activation. Emotion. 2015;15(4):463–76.

    Article  PubMed  Google Scholar 

  116. Abbott R, Whear R, Nikolaou V, Bethel A, Coon JT, Stein K, et al. Tumour necrosis factor-alpha inhibitor therapy in chronic physical illness: a systematic review and meta-analysis of the effect on depression and anxiety. J Psychosom Res. 2015;79(3):175–84.

    Article  PubMed  Google Scholar 

  117. Meyer T, Herrmann-Lingen C, Chavanon ML, Pieske B, Wachter R, Edelmann F. Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: results from the observational DIAST-CHF study in patients with cardiovascular risk factors. Psychoneuroendocrinology. 2015;62:227–32.

    Article  CAS  PubMed  Google Scholar 

  118. Hoirisch-Clapauch S. Anxiety-related bleeding and thrombosis. Semin Thromb Hemost. 2018;44(7):656–661.

    Google Scholar 

  119. Zafar MU, Paz-Yepes M, Shimbo D, Vilahur G, Burg MM, Chaplin W, et al. Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression. Eur Heart J. 2010;31(13):1573–82.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Sardinha A, Nardi AE, Zin WA. Are panic attacks really harmless? The cardiovascular impact of panic disorder. Rev Bras Psiquiatr. 2009;31(1):57–62.

    Article  PubMed  Google Scholar 

  121. Kang HJ, Bae KY, Kim SW, Shin IS, Hong YJ, Ahn Y, et al. Effects of escitalopram on anxiety in patients with acute coronary syndrome: a randomized controlled trial. Clin Psychopharmacol Neurosci. 2017;15(2):126–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Rollman BL, Belnap BH, LeMenager MS, Mazumdar S, Houck PR, Counihan PJ, et al. Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. JAMA. 2009;302(19):2095–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P, et al. Psychological interventions for coronary heart disease: cochrane systematic review and meta-analysis. Eur J Prev Cardiol. 2018;25(3):247–59.

    Article  PubMed  Google Scholar 

  124. Huffman JC, Mastromauro CA, Beach SR, Celano CM, Dubois CM, Healy BC, et al. Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial. JAMA Intern Med. 2014;174(6):927–36.

    Article  CAS  PubMed  Google Scholar 

  125. Tully PJ, Selkow T, Bengel J, Rafanelli C. A dynamic view of comorbid depression and generalized anxiety disorder symptom change in chronic heart failure: discrete effects of cognitive behavioral therapy, exercise rehabilitation, and psychotropic medication. Disabil Rehabil. 2015;37(7):585–92.

    Article  PubMed  Google Scholar 

  126. Tully PJ, Wittert GA, Selkow T, Baumeister H. The real world mental health needs of heart failure patients are not reflected by the depression Randomized Controlled Trial Evidence. PLoS One. 2014;9(1):e85928.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  127. Tully PJ, Turnbull D, Horowitz JD, Beltrame JF, Selkow T, Baune BT, et al. Cardiovascular Health in Anxiety or Mood Problems Study (CHAMPS): study protocol for a RCT. Trials. 2016;17(1):18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  128. Wells A, McNicol K, Reeves D, Salmon P, Davies L, Heagerty A, et al. Improving the effectiveness of psychological interventions for depression and anxiety in the cardiac rehabilitation pathway using group-based metacognitive therapy (PATHWAY Group MCT): study protocol for a randomised controlled trial. Trials. 2018;19(1):215.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Oldenburg O, Spiesshofer J, Fox H, Bitter T, Horstkotte D. Cheyne-Stokes respiration in heart failure: friend or foe? Hemodynamic effects of hyperventilation in heart failure patients and healthy volunteers. Clin Res Cardiol. 2015;104(4):328–33.

    Article  CAS  PubMed  Google Scholar 

  130. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352(6):539–48.

    Article  CAS  PubMed  Google Scholar 

  131. Yavuzkir M, Atmaca M, Dagli N, Balin M, Karaca I, Mermi O, et al. P-wave dispersion in panic disorder. Psychosom Med. 2007;69(4):344–7.

    Article  PubMed  Google Scholar 

  132. Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66(7):848–60.

    Article  PubMed  Google Scholar 

  133. Cully JA, Paukert A, Falco J, Stanley M. Cognitive-behavioral therapy: innovations for cardiopulmonary patients with depression and anxiety. Cogn Behav Pract. 2009;16(4):394–407.

    Article  Google Scholar 

  134. Tully PJ. A good time to panic? Premorbid and postmorbid panic disorder in heart failure affects cardiac and psychiatric cause admissions. Australas Psychiatry. 2015;23(2):124–7.

    Article  PubMed  Google Scholar 

  135. Sommaruga M, Angelino E, Della Porta P, Abatello M, Baiardo G, Balestroni G, et al. Best practice in psychological activities in cardiovascular prevention and rehabilitation: Position Paper. Monaldi Arch Chest Dis. 2018;88(2):966.

    Article  PubMed  Google Scholar 

  136. Baumeister H, Hutter N, Bengel J. Psychological and pharmacological interventions for depression in patients with diabetes mellitus: a systematic Cochrane review. Diabet Med. 2014;31:773.

    Article  CAS  PubMed  Google Scholar 

  137. Baumeister H, Hutter N, Bengel J. Psychological and pharmacological interventions for depression in patients with coronary artery disease. Cochrane Database Syst Rev. 2011;9:CD008012.

    Google Scholar 

  138. Dickens C, Cherrington A, Adeyemi I, Roughley K, Bower P, Garrett C, et al. Characteristics of psychological interventions that improve depression in people with coronary heart disease: a systematic review and meta-regression. Psychosom Med. 2013;75(2):211–21.

    Article  PubMed  Google Scholar 

  139. Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. J Am Med Assoc. 2003;289(23):3106–16.

    Article  Google Scholar 

  140. Glassman AH, O’Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger JT Jr, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002;288(6):701–9.

    Article  CAS  PubMed  Google Scholar 

  141. Lesperance F, Frasure-Smith N, Koszycki D, Laliberte MA, van Zyl LT, Baker B, et al. Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA. 2007;297(4):367–79.

    Article  CAS  PubMed  Google Scholar 

  142. Saab PG, Bang H, Williams RB, Powell LH, Schneiderman N, Thoresen C, et al. The impact of cognitive behavioral group training on event-free survival in patients with myocardial infarction: the ENRICHD experience. J Psychosom Res. 2009;67(1):45–56.

    Article  PubMed  PubMed Central  Google Scholar 

  143. Scherrer JF, Chrusciel T, Garfield LD, Freedland KE, Carney RM, Hauptman PJ, et al. Treatment-resistant and insufficiently treated depression and all-cause mortality following myocardial infarction. Br J Psychiatry. 2012;200(2):137–42.

    Article  PubMed  Google Scholar 

  144. Taylor CB, Youngblood ME, Catellier D, Veith RC, Carney RM, Burg MM, et al. Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry. 2005;62(7):792–8.

    Article  CAS  PubMed  Google Scholar 

  145. Stewart JC, Perkins AJ, Callahan CM. Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial. Psychosom Med. 2014;76(1):29–37.

    Article  PubMed  Google Scholar 

  146. Davidson KW, Rieckmann N, Clemow L, Schwartz JE, Shimbo D, Medina V, et al. Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial. Arch Intern Med. 2010;170(7):600–8.

    Article  PubMed  PubMed Central  Google Scholar 

  147. Tully PJ, Baumeister H. Collaborative care for comorbid depression and coronary heart disease: a systematic review and meta-analysis of randomized controlled trials. BMJ Open. 2015;5(12):e009128.

    Article  PubMed  PubMed Central  Google Scholar 

  148. Huang Y, Wei X, Wu T, Chen R, Guo A. Collaborative care for patients with depression and diabetes mellitus: a systematic review and meta-analysis. BMC Psychiatry. 2013;13(1):1–11.

    Article  PubMed  PubMed Central  Google Scholar 

  149. Pogosova N, Kotseva K, De Bacquer D, von Känel R, De Smedt D, Bruthans J, et al. Psychosocial risk factors in relation to other cardiovascular risk factors in coronary heart disease: results from the EUROASPIRE IV survey. A registry from the European Society of Cardiology. Eur J Prev Cardiol. 2017;24(13):1371–80.

    Article  PubMed  Google Scholar 

  150. Wade V, Cheok F, Schrader G, Hordacre AL, Marker J. Depression after cardiac hospitalisation – the identifying depression as a comorbid condition (IDACC) study. Aust Fam Physician. 2005;34(11):985–9.

    PubMed  Google Scholar 

  151. Czarny MJ, Arthurs E, Coffie DF, Smith C, Steele RJ, Ziegelstein RC, et al. Prevalence of antidepressant prescription or use in patients with acute coronary syndrome: a systematic review. PLoS One. 2011;6(11):e27671.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Wu CK, Huang YT, Lee JK, Jimmy Juang JM, Tsai CT, Lai LP, et al. Anti-anxiety drugs use and cardiovascular outcomes in patients with myocardial infarction: a national wide assessment. Atherosclerosis. 2014;235(2):496–502.

    Article  CAS  PubMed  Google Scholar 

  153. Clark DB, Taylor CB, Roth WT, Hayward C, Ehlers A, Margraf J, et al. Surreptitious drug use by patients in a panic disorder study. Am J Psychiatry. 1990;147(4):507–9.

    Article  CAS  PubMed  Google Scholar 

  154. Clark DM, Salkovskis PM, Hackmann A, Middleton H, Anastasiades P, Gelder M. A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder. Br J Psychiatry. 1994;164(6):759–69.

    Article  CAS  PubMed  Google Scholar 

  155. Sowden GL, Huffman JC. The impact of mental illness on cardiac outcomes: a review for the cardiologist. Int J Cardiol. 2009;132(1):30–7.

    Article  PubMed  Google Scholar 

  156. van Melle JP, de Jonge P, Honig A, Schene AH, Kuyper AMG, Crijns HJGM, et al. Effects of antidepressant treatment following myocardial infarction. Br J Psychiatry. 2007;190(6):460–6.

    Article  PubMed  Google Scholar 

  157. Pizzi C, Rutjes AW, Costa GM, Fontana F, Mezzetti A, Manzoli L. Meta-analysis of selective serotonin reuptake inhibitors in patients with depression and coronary heart disease. Am J Cardiol. 2011;107(7):972–9.

    Article  CAS  PubMed  Google Scholar 

  158. van Zyl LT, Lesperance F, Frasure-Smith N, Malinin AI, Atar D, Laliberte MA, et al. Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study. J Thromb Thrombolysis. 2009;27(1):48–56.

    Article  CAS  PubMed  Google Scholar 

  159. Serebruany VL, Suckow RF, Cooper TB, O’Connor CM, Malinin AI, Krishnan KR, et al. Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. Am J Psychiatry. 2005;162(6):1165–70.

    Article  PubMed  Google Scholar 

  160. Labos C, Dasgupta K, Nedjar H, Turecki G, Rahme E. Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. CMAJ. 2011;183(16):1835.

    Article  PubMed  PubMed Central  Google Scholar 

  161. Gomes RM, Sardinha A, Soares de Araújo CG, Nardi AE, Deslandes AC. Aerobic training intervention in panic disorder: a case-series study. Med Express. 2014;1(4):195–201.

    Article  Google Scholar 

  162. Moylan S, Eyre HA, Maes M, Baune BT, Jacka FN, Berk M. Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours. Neurosci Biobehav Rev. 2013;37(4):573–84.

    Article  CAS  PubMed  Google Scholar 

  163. Pedersen SS, von Kanel R, Tully PJ, Denollet J. Psychosocial perspectives in cardiovascular disease. Eur J Prev Cardiol. 2017;24(3_suppl):108–15.

    Article  PubMed  Google Scholar 

  164. Abberger B, Haschke A, Tully PJ, Forkmann T, Berger J, Wirtz M, et al. Development and validation of parallel short forms PaSA-cardio for the assessment of general anxiety in cardiovascular rehabilitation patients using Rasch analysis. Clin Rehabil. 2017;31(1):104–14.

    Article  PubMed  Google Scholar 

  165. Blumenthal JA, Feger BJ, Smith PJ, Watkins LL, Jiang W, Davidson J, et al. Treatment of anxiety in patients with coronary heart disease: rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial. Am Heart J. 2016;176:53–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  166. Rollman BL, Huffman JC. Treating anxiety in the presence of medical comorbidity: calmly moving forward. Psychosom Med. 2013;75(8):710–2.

    Article  PubMed  PubMed Central  Google Scholar 

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Tully, P.J., Cosh, S., Pedersen, S. (2020). Cardiovascular Manifestations of Panic and Anxiety. In: Govoni, S., Politi, P., Vanoli, E. (eds) Brain and Heart Dynamics. Springer, Cham. https://doi.org/10.1007/978-3-030-28008-6_23

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