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ALPPS for Colorectal Cancer Liver Metastases—Short and Long-Term Results

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Colorectal Cancer Liver Metastases

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Abstract

This chapter reviews the history, indications, and outcomes of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Various operative techniques are described, considerations for management of patients during the interstage period are discussed, and current evidence on short- and long-term outcomes following ALPPS performed in patients with colorectal liver metastases is summarized. Specific recommendations regarding patient selection and operative technique are offered.

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References

  1. Charnsangavej C, Clary B, Fong Y, Grothey A, Pawlik TM, Choti MA. Selection of patients for resection of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006;13:1261–8.

    Article  PubMed  Google Scholar 

  2. Rocha FG, Helton WS. Resectability of colorectal liver metastases: an evolving definition. HPB. 2012;14:283–4.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Adam R, Laurent A, Azoulay D, Castaing D, Bismuth H. Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg. 2000;232:777–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunvén P, Yamazaki S, Hasegawa H, Ozaki H. Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery. 1990;107:521–7.

    CAS  PubMed  Google Scholar 

  5. Jaeck D, Oussoultzoglou E, Rosso E, Greget M, Weber J-C, Bachellier P. A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg. 2004;240:1037–51.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lam VWT, Laurence JM, Johnston E, Hollands MJ, Pleass HCC, Richardson AJ. A systematic review of two-stage hepatectomy in patients with initially unresectable colorectal liver metastases. HPB. 2013;15:483–91.

    Article  PubMed  Google Scholar 

  7. Chua TC, Liauw W, Chu F, Morris DL. Summary outcomes of two-stage resection for advanced colorectal liver metastases: two-stage resection of CLM. J Surg Oncol. 2013;107:211–6.

    Article  PubMed  Google Scholar 

  8. Baumgart J, Lang S, Lang H. A new method for induction of liver hypertrophy prior to right trisectionectomy: a report of three cases. HPB (Oxford). 2011;13(suppl 2):1–145.

    Google Scholar 

  9. de Santibañes E, Alvarez FA, Ardiles V. How to avoid postoperative liver failure: a novel method. World J Surg. 2011;36:125–8.

    Article  Google Scholar 

  10. Schnitzbauer AA, Lang SA, Goessmann H, et al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012;255:405–14.

    Article  PubMed  Google Scholar 

  11. de Santibañes E, Clavien P-A. Playing Play-Doh to prevent postoperative liver failure: the “ALPPS” approach. Ann Surg. 2012;255:415–7.

    Article  PubMed  Google Scholar 

  12. Schadde E, Raptis DA, Schnitzbauer AA, et al. Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the International ALPPS Registry. Ann Surg. 2015;262:780–6.

    Article  PubMed  Google Scholar 

  13. Schadde E, Ardiles V, Robles-Campos R, et al. Early survival and safety of Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): first report of the International ALPPS Registry. Ann Surg. 2014;260:829–38.

    Article  PubMed  Google Scholar 

  14. Peng S-Y, Wang X-A, Huang C-Y, Zhang Y-Y, Li J-T, Hong D-F, Cai X-J. Evolution of associating liver partition and portal vein ligation for staged hepatectomy: simpler, safer and equally effective methods. World J Gastroenterol. 2017;23:4140.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Edmondson MJ, Sodergren MH, Pucher PH, Darzi A, Li J, Petrowsky H, Campos RR, Serrablo A, Jiao LR. Variations and adaptations of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS): many routes to the summit. Surgery. 2016;159:1058–72.

    Article  PubMed  Google Scholar 

  16. Alghamdi T, Viebahn C, Justinger C, Lorf T. Arterial blood supply of liver segment IV and its possible surgical consequences. Am J Transplant. 2017;17:1064–70.

    Article  CAS  PubMed  Google Scholar 

  17. Hernandez-Alejandro R, Bertens KA, Pineda-Solis K, Croome KP. Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases? Surgery. 2015;157:194–201.

    Article  PubMed  Google Scholar 

  18. Mise Y, Aloia TA, Conrad C, Huang SY, Wallace MJ, Vauthey J-N. Volume regeneration of segments 2 and 3 after right portal vein embolization in patients undergoing two-stage hepatectomy. J Gastrointest Surg. 2015;19:133–41.

    Article  PubMed  Google Scholar 

  19. Petrowsky H, Györi G, de Oliveira M, Lesurtel M, Clavien P-A. Is partial-ALPPS safer than ALPPS? A single-center experience. Ann Surg. 2015;261:e90–2.

    Article  PubMed  Google Scholar 

  20. Linecker M, Kambakamba P, Reiner CS, et al. How much liver needs to be transected in ALPPS? A translational study investigating the concept of less invasiveness. Surgery. 2017;161:453–64.

    Article  PubMed  Google Scholar 

  21. Schlegel A, Lesurtel M, Melloul E, Limani P, Tschuor C, Graf R, Humar B, Clavien PA. Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): from human to mice highlighting accelerated and novel mechanisms of liver regeneration. Ann Surg. 2014;260:839–47.

    Article  PubMed  Google Scholar 

  22. Alvarez FA, Ardiles V, de Santibañes M, Pekolj J, de Santibañes E. Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety: a prospective study at a single center. Ann Surg. 2015;261:723–32.

    Article  PubMed  Google Scholar 

  23. de Santibañes E, Alvarez FA, Ardiles V, Pekolj J, de Santibañes M. Inverting the ALPPS paradigm by minimizing first stage impact: the Mini-ALPPS technique. Langenbeck’s Arch Surg. 2016;401:557–63.

    Article  Google Scholar 

  24. Tanaka K, Kikuchi Y, Kawaguchi D, Murakami T, Hiroshima Y, Matsuo K. Modified ALPPS procedures avoiding division of portal pedicles. Ann Surg. 2017;265:e14–20.

    Article  PubMed  Google Scholar 

  25. Robles R, Parrilla P, López-Conesa A, Brusadin R, de la Peña J, Fuster M, García-López JA, Hernández E. Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg. 2014;101:1129–34.

    Article  CAS  PubMed  Google Scholar 

  26. Oldhafer KJ, Stavrou GA, van Gulik TM. ALPPS—where do we stand, where do we go?: eight recommendations from the first international expert meeting. Ann Surg. 2016;263:839–41.

    Article  PubMed  Google Scholar 

  27. Linecker M, Björnsson B, Stavrou GA, et al. Risk adjustment in ALPPS is associated with a dramatic decrease in early mortality and morbidity. Ann Surg. 2017;266:779–86.

    Article  PubMed  Google Scholar 

  28. Schiffman SC, Kim KH, Tsung A, Marsh JW, Geller DA. Laparoscopic versus open liver resection for metastatic colorectal cancer: a metaanalysis of 610 patients. Surgery. 2015;157:211–22.

    Article  PubMed  Google Scholar 

  29. Nachmany I, Pencovich N, Zohar N, Ben-Yehuda A, Binyamin C, Goykhman Y, Lubezky N, Nakache R, Klausner JM. Laparoscopic versus open liver resection for metastatic colorectal cancer. Eur J Surg Oncol. 2015;41:1615–20.

    Article  CAS  PubMed  Google Scholar 

  30. Parks KR, Kuo Y, Davis JM, O’Brien B, Hagopian EJ. Laparoscopic versus open liver resection: a meta-analysis of long-term outcome. HPB. 2014;16:109–18.

    Article  PubMed  Google Scholar 

  31. Machado MAC, Makdissi FF, Surjan RC. Totally laparoscopic ALPPS is feasible and may be worthwhile. Ann Surg. 2012;256:e13; author reply e16–19.

    Article  PubMed  Google Scholar 

  32. Machado MAC, Makdissi FF, Surjan RC, Basseres T, Schadde E. Transition from open to laparoscopic ALPPS for patients with very small FLR: the initial experience. HPB. 2017;19:59–66.

    Article  PubMed  Google Scholar 

  33. Yin Z, Liu C, Chen Y, Bai Y, Shang C, Yin R, Yin D, Wang J. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): simultaneous or delayed? Hepatology. 2013;57:2346–57.

    Article  PubMed  Google Scholar 

  34. Kelly ME, Spolverato G, Lê GN, Mavros MN, Doyle F, Pawlik TM, Winter DC. Synchronous colorectal liver metastasis: a network meta-analysis review comparing classical, combined, and liver-first surgical strategies: synchronous colorectal liver metastasis. J Surg Oncol. 2015;111:341–51.

    Article  CAS  PubMed  Google Scholar 

  35. Wanis KN, Buac S, Linecker M, Ardiles V, Tun-Abraham ME, Robles-Campos R, Malago M, de Santibañes E, Clavien P-A, Hernandez-Alejandro R. Patient survival after simultaneous ALPPS and colorectal resection. World J Surg. 2016;41:1119–25.

    Article  Google Scholar 

  36. Andersen KJ, Knudsen AR, Jepsen BN, Meier M, Gunnarsson APA, Jensen UB, Nyengaard JR, Hamilton-Dutoit S, Mortensen FV. A new technique for accelerated liver regeneration: an experimental study in rats. Surgery. 2017;162:233–47.

    Article  PubMed  Google Scholar 

  37. Deal R, Frederiks C, Williams L, Olthof PB, Dirscherl K, Keutgen X, Chan E, Deziel D, Hertl M, Schadde E. Rapid liver hypertrophy after portal vein occlusion correlates with the degree of collateralization between lobes—a study in pigs. J Gastrointest Surg. 2018;22:203–13.

    Article  PubMed  Google Scholar 

  38. Kawaguchi D, Hiroshima Y, Kikuchi Y, Matsuo K, Tanaka K. Associating liver partition and portal vein occlusion, including venous congestion, induction in rats. Anticancer Res. 2017;37:2919–25.

    CAS  PubMed  Google Scholar 

  39. Michalopoulos GK. Liver regeneration. J Cell Physiol. 2007;213:286–300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Kito Y, Nagino M, Nimura Y. Doppler sonography of hepatic arterial blood flow velocity after percutaneous transhepatic portal vein embolization. Am J Roentgenol. 2001;176:909–12.

    Article  CAS  Google Scholar 

  41. Eipel C. Regulation of hepatic blood flow: the hepatic arterial buffer response revisited. World J Gastroenterol. 2010;16:6046.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Tanaka K, Endo I. Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): short-term outcome and functional changes in the future liver remnant. Ann Surg. 2014;262:e88–9.

    Article  Google Scholar 

  43. de Graaf W, van den Esschert JW, van Lienden KP, van Gulik TM. Induction of tumor growth after preoperative portal vein embolization: is it a real problem? Ann Surg Oncol. 2009;16:423–30.

    Article  PubMed  Google Scholar 

  44. Joechle K, Moser C, Ruemmele P, Schmidt KM, Werner JM, Geissler EK, Schlitt HJ, Lang SA. ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases. World J Surg Oncol. 2017;15:57. https://doi.org/10.1186/s12957-017-1121-8.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Kambakamba P, Linecker M, Schneider M, et al. Impact of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) on growth of colorectal liver metastases. Surgery. 2017;15:57.

    Google Scholar 

  46. Schadde E, Malagó M, Hernandez-Alejandro R, Li J, Abdalla E, Ardiles V, Lurje G, Vyas S, Machado MA, de Santibañes E. Monosegment ALPPS hepatectomy: extending resectability by rapid hypertrophy. Surgery. 2015;157:676–89.

    Article  PubMed  Google Scholar 

  47. Adam R, Pascal G, Castaing D, Azoulay D, Delvart V, Paule B, Levi F, Bismuth H. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg. 2004;240:1052–64.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Brudvik KW, Kopetz SE, Li L, Conrad C, Aloia TA, Vauthey J-N. Meta-analysis of KRAS mutations and survival after resection of colorectal liver metastases: KRAS status and survival after resection of colorectal liver metastases. Br J Surg. 2015;102:1175–83.

    Article  CAS  PubMed  Google Scholar 

  49. Truant S, Scatton O, Dokmak S, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): impact of the inter-stages course on morbi-mortality and implications for management. Eur J Surg Oncol. 2015;41:674–82.

    Article  CAS  PubMed  Google Scholar 

  50. Croome KP, Hernandez-Alejandro R, Parker M, Heimbach J, Rosen C, Nagorney DM. Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis. HPB. 2015;17:477–84.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Heymsfield SB, Fulenwider T, Nordlinger B, Barlow R, Sones P, Kutner M. Accurate measurement of liver, kidney, and spleen volume and mass by computerized axial tomography. Ann Intern Med. 1979;90:185–7.

    Article  CAS  PubMed  Google Scholar 

  52. Pomposelli JJ, Tongyoo A, Wald C, Pomfret EA. Variability of standard liver volume estimation versus software-assisted total liver volume measurement. Liver Transpl. 2012;18:1083–92.

    Article  PubMed  Google Scholar 

  53. Vauthey J-N, Abdalla EK, Doherty DA, et al. Body surface area and body weight predict total liver volume in Western adults. Liver Transpl. 2002;8:233–40.

    Article  PubMed  Google Scholar 

  54. Johnson TN, Tucker GT, Tanner MS, Rostami-Hodjegan A. Changes in liver volume from birth to adulthood: a meta-analysis. Liver Transpl. 2005;11:1481–93.

    Article  PubMed  Google Scholar 

  55. Olthof PB, Tomassini F, Huespe PE, et al. Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: liver volume overestimates liver function. Surgery. 2017;162:775–83.

    Article  PubMed  Google Scholar 

  56. Chapelle T, Op De Beeck B, Huyghe I, Francque S, Driessen A, Roeyen G, Ysebaert D, De Greef K. Future remnant liver function estimated by combining liver volumetry on magnetic resonance imaging with total liver function on 99mTc-mebrofenin hepatobiliary scintigraphy: can this tool predict post-hepatectomy liver failure? HPB. 2016;18:494–503.

    Article  PubMed  PubMed Central  Google Scholar 

  57. de Graaf W, van Lienden KP, Dinant S, Roelofs JJTH, Busch ORC, Gouma DJ, Bennink RJ, van Gulik TM. Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection. J Gastrointest Surg. 2010;14:369–78.

    Article  PubMed  Google Scholar 

  58. Kishi Y, Abdalla EK, Chun YS, Zorzi D, Madoff DC, Wallace MJ, Curley SA, Vauthey J-N. Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Trans Meet Am Surg Assoc. 2009;127:171–9.

    Google Scholar 

  59. Shindoh J, Vauthey J-N, Zimmitti G, Curley SA, Huang SY, Mahvash A, Gupta S, Wallace MJ, Aloia TA. Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach. J Am Coll Surg. 2013;217:126–33.

    Article  PubMed  Google Scholar 

  60. Bennink RJ, Dinant S, Erdogan D, Heijnen BH, Straatsburg IH, van Vliet AK, van Gulik TM. Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med. 2004;45:965–71.

    PubMed  Google Scholar 

  61. Serenari M, Collaud C, Alvarez FA, de Santibañes M, Giunta D, Pekolj J, Ardiles V, de Santibañes E. Interstage assessment of remnant liver function in ALPPS using hepatobiliary scintigraphy: prediction of posthepatectomy liver failure and introduction of the HIBA index. Ann Surg. 2018;267:1141. https://doi.org/10.1097/SLA.0000000000002150.

    Article  PubMed  Google Scholar 

  62. de Liguori CN, O’Reilly DA, Dajani K, Ghaneh P, Poston GJ, Wu AV. Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure. Eur J Surg Oncol. 2009;35:957–62.

    Article  Google Scholar 

  63. Cheung TT, Chan SC, Chok KSH, Chan ACY, Yu WC, Poon RTP, Lo CM, Fan ST. Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2012;11:267–71.

    Article  CAS  PubMed  Google Scholar 

  64. Thomas MN, Weninger E, Angele M, et al. Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements. HPB. 2015;17:471–6.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Ratti F, Cipriani F, Gagliano A, Catena M, Paganelli M, Aldrighetti L. Defining indications to ALPPS procedure: technical aspects and open issues. Updat Surg. 2013;66:41–9.

    Article  Google Scholar 

  66. Torres OJM, Fernandes Ede SM, CVC O, Lima CX, Waechter FL, JMA M-J, Linhares MM, Pinto RD, Herman P, MAC M. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): the Brazilian experience. Arq Bras Cir Dig. 2013;26:40–3.

    Article  PubMed  Google Scholar 

  67. Li J, Girotti P, Königsrainer I, Ladurner R, Königsrainer A, Nadalin S. ALPPS in right trisectionectomy: a safe procedure to avoid postoperative liver failure? J Gastrointest Surg. 2013;17:956–61.

    Article  PubMed  Google Scholar 

  68. Nadalin S, Capobianco I, Li J, Girotti P, Königsrainer I, Königsrainer A. Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Lessons Learned from 15 cases at a single centre. Z Gastroenterol. 2014;52:35–42.

    Article  CAS  PubMed  Google Scholar 

  69. Schadde E, Ardiles V, Slankamenac K, et al. ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: results of a multicenter analysis. World J Surg. 2014;38:1510–9.

    Article  PubMed  Google Scholar 

  70. Sala S, Ardiles V, Ulla M, Alvarez F, Pekolj J, de Santibañes E. Our initial experience with ALPPS technique: encouraging results. Updat Surg. 2012;64:167–72.

    Article  Google Scholar 

  71. Oldhafer KJ, Donati M, Jenner RM, Stang A, Stavrou GA. ALPPS for patients with colorectal liver metastases: effective liver hypertrophy, but early tumor recurrence. World J Surg. 2013;38:1504–9.

    Article  Google Scholar 

  72. Røsok BI, Björnsson B, Sparrelid E, Hasselgren K, Pomianowska E, Gasslander T, Bjørnbeth BA, Isaksson B, Sandström P. Scandinavian multicenter study on the safety and feasibility of the associating liver partition and portal vein ligation for staged hepatectomy procedure. Surgery. 2016;159:1279–86.

    Article  PubMed  Google Scholar 

  73. Linecker M, Stavrou GA, Oldhafer KJ, et al. The ALPPS risk score: avoiding futile use of ALPPS. Ann Surg. 2016;264:763–71.

    Article  PubMed  Google Scholar 

  74. Eshmuminov D, Raptis DA, Linecker M, Wirsching A, Lesurtel M, Clavien P-A. Meta-analysis of associating liver partition with portal vein ligation and portal vein occlusion for two-stage hepatectomy: ALPPS versus portal vein occlusion for staged hepatectomy. Br J Surg. 2016;103:1768–82.

    Article  CAS  PubMed  Google Scholar 

  75. Moris D, Ronnekleiv-Kelly S, Kostakis ID, Tsilimigras DI, Beal EW, Papalampros A, Dimitroulis D, Felekouras E, Pawlik TM. Operative results and oncologic outcomes of Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) versus two-stage hepatectomy (TSH) in patients with unresectable colorectal liver metastases: a systematic review and meta-analysis. World J Surg. 2018;42:806–15.

    Article  PubMed  Google Scholar 

  76. Sandström P, Røsok BI, Sparrelid E, et al. ALPPS improves resectability compared with conventional two-stage hepatectomy in patients with advanced colorectal liver metastasis: results from a Scandinavian Multicenter Randomized Controlled Trial (LIGRO Trial). Ann Surg. 2018;267:833. https://doi.org/10.1097/SLA.0000000000002511.

    Article  PubMed  Google Scholar 

  77. Tschuor C, Croome KP, Sergeant G, et al. Salvage parenchymal liver transection for patients with insufficient volume increase after portal vein occlusion – an extension of the ALPPS approach. Eur J Surg Oncol. 2013;39:1230–5.

    Article  PubMed  Google Scholar 

  78. Björnsson B, Sparrelid E, Røsok B, Pomianowska E, Hasselgren K, Gasslander T, Bjørnbeth BA, Isaksson B, Sandström P. Associating liver partition and portal vein ligation for staged hepatectomy in patients with colorectal liver metastases – intermediate oncological results. Eur J Surg Oncol. 2016;42:531–7.

    Article  PubMed  Google Scholar 

  79. Wanis KN, Ardiles V, Alvarez FA, Tun-Abraham ME, Linehan D, de Santibañes E, Hernandez-Alejandro R. Intermediate-term survival and quality of life outcomes in patients with advanced colorectal liver metastases undergoing associating liver partition and portal vein ligation for staged hepatectomy. Surgery. 2018;163:691–7.

    Article  PubMed  Google Scholar 

  80. Rees JR, Blazeby JM, Brookes ST, John T, Welsh FK, Rees M. Patient-reported outcomes in long-term survivors of metastatic colorectal cancer needing liver resection. Br J Surg. 2014;101:1468–74.

    Article  CAS  PubMed  Google Scholar 

  81. Langenhoff BS, Krabbe PFM, Peerenboom L, Wobbes T, Ruers TJM. Quality of life after surgical treatment of colorectal liver metastases. Br J Surg. 2006;93:1007–14.

    Article  CAS  PubMed  Google Scholar 

  82. Rees JR, Blazeby JM, Fayers P, Friend EA, Welsh FKS, John TG, Rees M. Patient-reported outcomes after hepatic resection of colorectal cancer metastases. J Clin Oncol. 2012;30:1364–70.

    Article  PubMed  Google Scholar 

  83. Hagness M, Foss A, Line P-D, et al. Liver transplantation for nonresectable liver metastases from colorectal cancer. Ann Surg. 2013;257:800–6.

    Article  PubMed  Google Scholar 

  84. Dueland S, Guren TK, Hagness M, Glimelius B, Line P-D, Pfeiffer P, Foss A, Tveit KM. Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer? Ann Surg. 2015;261:956–60.

    Article  PubMed  Google Scholar 

  85. Line P-D, Hagness M, Berstad AE, Foss A, Dueland S. A novel concept for partial liver transplantation in nonresectable colorectal liver metastases: the RAPID concept. Ann Surg. 2015;262:e5–9.

    Article  PubMed  Google Scholar 

  86. Nadalin S, Templin S, Koenigsrainer I, Capobianco I, Kopp H-G, Zender L, Sipos B, Kanz L, Wagner S, Konigsrainer A. Living Donor APOLT-ALPPS: paradigm shift in the management of irresectable colorectal liver metastases. Presented at the 12th Biennial E-AHPBA Congress 2017, Mainz, Germany, May 23–May 26, 2017.

    Google Scholar 

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Authors and Affiliations

  1. Western University, London, ON, Canada

    Kerollos Nashat Wanis

  2. University of Rochester, Rochester, NY, USA

    Bao Tram Nghiem & Roberto Hernandez-Alejandro

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  1. Kerollos Nashat Wanis
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  2. Bao Tram Nghiem
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  3. Roberto Hernandez-Alejandro
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Correspondence to Roberto Hernandez-Alejandro .

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Editors and Affiliations

  1. National Cancer Institute, Rio de Janeiro, Brazil

    Mauro Monteiro Correia

  2. Banner MD Anderson Cancer Center, Phoenix, AZ, USA

    Michael A. Choti

  3. Virginia Mason Medical Center, Seattle, WA, USA

    Flavio G. Rocha

  4. Center for Advanced Treatment of HBP Diseases, Ageo Central General Hospital, Ageo Shi, Saitama, Japan

    Go Wakabayashi

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Wanis, K.N., Nghiem, B.T., Hernandez-Alejandro, R. (2020). ALPPS for Colorectal Cancer Liver Metastases—Short and Long-Term Results. In: Correia, M., Choti, M., Rocha, F., Wakabayashi, G. (eds) Colorectal Cancer Liver Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-25486-5_35

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