Abstract
The developing cerebellum granule cells migrate from their birthplace to their final destination. The active translocation of granule cells is essential for the formation of a well-organized cerebellar cortex. In this chapter, we will review (1) how granule cells migrate from their origin to their resident destination in the developing cerebellum, (2) the cellular and molecular mechanisms underlying granule cell migration, (3) how exposure to toxic chemicals and natural environmental factors affects the migration of granule cells, and (4) the cellular and molecular mechanisms underlying the differentiation of postmigratory granule cells.
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Komuro, Y. et al. (2022). Granule Cell Migration and Differentiation. In: Manto, M.U., Gruol, D.L., Schmahmann, J.D., Koibuchi, N., Sillitoe, R.V. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-23810-0_7
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