Abstract
For over a century, the centrosome has been an organelle more easily tracked than understood, and the study of its peregrinations within the cell remains a chief underpinning of its functional investigation. Increasing attention and new approaches have been brought to bear on mechanisms that control centrosome localization in the context of cleavage plane determination, ciliogenesis, directional migration, and immunological synapse formation, among other cellular and developmental processes. The Golgi complex, often linked with the centrosome, presents a contrasting case of a pleiomorphic organelle for which functional studies advanced somewhat more rapidly than positional tracking. However, Golgi orientation and distribution has emerged as an area of considerable interest with respect to polarized cellular function. This chapter will review our current understanding of the mechanism and significance of the positioning of these organelles.
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Abbreviations
- ADAP:
-
Adhesion- and degranulation-promoting adapter protein
- Akt:
-
v-akt murine thymoma viral oncogene homolog 1
- Arf1:
-
ADP-ribosylation factor 1
- Arp2/3:
-
Actin-related protein 2/3
- APC:
-
Antigen-presenting cell
- BARS:
-
BFA-dependent ADP-ribosylation substrate
- BICD2:
-
Bicaudal D2
- CD3:
-
Cluster of differentiation 3
- Cdc42:
-
Cell division control protein 42 homolog
- Cdk1:
-
Cyclin-dependent kinase 1
- CENPF:
-
Centromere protein F
- CEP:
-
Centrosomal protein
- CLIP-170:
-
Cytoplasmic linker protein 170 alpha-2
- C-Nap1:
-
Centrosomal Nek2-associated protein 1
- DAG:
-
Diacylglycerol
- Dlg1:
-
Discs large-1
- DOCK:
-
Dedicator of cytokinesis
- EGF:
-
Epidermal growth factor
- ELMO:
-
Engulfment and cell motility
- EMS:
-
Endomesodermal
- ERM:
-
Ezrin-radixin-moesin
- Gαi:
-
G protein alpha i
- GAS2L1:
-
Growth arrest specific 2-like 1
- GEF:
-
Guanine nucleotide exchange factor
- GKAP:
-
Guanylate kinase-associated protein
- GM130:
-
Golgi membrane protein 130 kD
- GMAP:
-
Golgi microtubule-associated protein
- GOLPH3:
-
Golgi phosphoprotein 3
- GRASP55:
-
Golgi reassembly-stacking protein of 55 kDa
- GRASP65:
-
Golgi reassembly-stacking protein of 65 kDa
- HS1:
-
Hematopoietic lineage cell-specific protein 1
- IQGAP:
-
IQ motif-containing GTPase activating protein
- IS:
-
Immunological synapse
- KASH:
-
Klarsicht, ANC-1, Syne homology
- KIF25:
-
kinesin family member 25
- LIMK:
-
LIM domain kinase
- LIS1:
-
Lissencephaly-1
- Mst2:
-
Mammalian Ste20-like 2
- MYO18A:
-
Myosin XVIIIA
- Ncd:
-
Nonclaret disjunctional
- Nde1:
-
Nuclear distribution E homolog 1
- NE:
-
Nuclear envelope
- Nek2A:
-
NIMA-related kinase 2A
- NNE:
-
Notochord/neural/endoderm
- Num1:
-
Nuclear migration protein 1
- NuMA:
-
Nuclear mitotic apparatus
- PAR:
-
Partitioning defective
- PCP:
-
Planar cell polarity
- PI3 kinase:
-
Phosphatidylinositol-3 kinase
- PITPNA:
-
Phosphatidylinositol transfer protein alpha
- PITPNB:
-
Phosphatidylinositol transfer protein beta
- PKC:
-
Protein kinase C
- PKD:
-
Protein kinase D
- Plk1:
-
Polo-like kinase 1
- PP1:
-
Protein phosphatase 1
- PPP2CA:
-
Protein phosphatase 2A, catalytic subunit alpha
- Rac:
-
Ras-related C3 botulinum toxin substrate
- RanGTP:
-
GTP-bound form of ras-related nuclear protein
- Rap1:
-
Ras-associated protein 1
- Rho:
-
Ras homologous
- ROCK:
-
Rho-associated protein kinase
- RPE1:
-
Retinal pigmented epithelium-1
- Slk:
-
Ste20-like kinase
- STK25:
-
Serine/threonine protein kinase 25
- STRAD:
-
STE20-related kinase adapter protein
- SUN:
-
Sad1 and UNC-84
- TBCCD1:
-
Tubulin binding cofactor C domain-containing protein
- Wnt:
-
Wingless/integrated
- Zyg-12:
-
Zygote defective-12
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Orlofsky, A. (2019). Positioning of the Centrosome and Golgi Complex. In: Kloc, M. (eds) The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, vol 67. Springer, Cham. https://doi.org/10.1007/978-3-030-23173-6_7
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