Abstract
The extensive uses of antifungal agents to treat fungal infections have created a global public health issue of drug resistance. Candida species and other pathogenic mycoses are the leading causes of invasive fungal infections and high mortality rate in human population. A limited number of antifungal agents show fungicidal effect; repetitive uses of fungistatic drugs lead to the development of drug resistance. New antifungal agents with a broader spectrum of activity and novel mechanisms of action have been recently developed to fight against resistant fungal strains and clinical isolates. This would create a possibility to investigate antifungal combinations in vitro, in yeast and in animal models. If the drugs have different mechanisms of action, increased drug potency and efficacy with reduced toxicity may be rewarded. Recently, there are several investigational antifungal agents on repurposing drugs and natural products from different sources––plants, microbial, and marines––which may be considered when designing antifungal drug combinations. Imminently, more classes of antifungals from natural products may be added to the current antifungal armamentarium. Therefore, the new frontier of combination therapy and natural drug discovery should continue to be pursued with anticipation while excessive and repetitive antifungal usage shall be refrained.
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References
Ahmad A et al (2010a) Proton translocating ATPase mediated fungicidal activity of eugenol and thymol. Fitoterapia 81(8):1157–1162
Ahmad A et al (2010b) In vitro synergy of eugenol and methyleugenol with fluconazole against clinical Candida isolates. J Med Microbiol 59(Pt 10):1178–1184
Ahmad A et al (2017) Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against Candida albicans. Med Chem Comm 8(12):2195–2207
Aicher TD et al (1992) Total synthesis of halichondrin B and norhalichondrin B. J Am Chem Soc 114(8):3162–3164
Akache B, Turcotte B (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254–21260
Alborzi A, Moeini M, Haddadi P (2012) Antifungal susceptibility of the Aspergillus species by Etest and CLSI reference methods. Arch Iran Med 15(7):429
Alvarez-Miranda M et al 2003 Characterization of the mechanism of action of ES-285, a novel antitumor drug from Mactromeris poynyma. In Clinical cancer research. American Association for Cancer Research, Philadelphia
Arendrup MC (2014) Update on antifungal resistance in Aspergillus and Candida. Clin Microbiol Infect 20:42–48
Armstrong AW, Bukhalo M, Blauvelt A (2016) A clinician’s guide to the diagnosis and treatment of Candidiasis in patients with psoriasis. Am J Clin Dermatol 17(4):329–336
Baddley JW (2011a) Clinical risk factors for invasive aspergillosis. Med Mycol 49(Suppl 1):S7–s12
Baddley JW (2011b) Clinical risk factors for invasive aspergillosis. Med Mycol 49(Suppl 1):S7–S12
Bao L et al (2010) (-)-Sclerotiorin from an unidentified marine fungus as an anti-meiotic and anti-fungal agent. Nat Prod Commun 5(11):1789–1792
Barrett D (2002a) From natural products to clinically useful antifungals. Biochim Biophys Acta 1587(2–3):224–233
Barrett D (2002b) From natural products to clinically useful antifungals. Biochim Biophys Acta (BBA) Mol Basis Dis 1587(2):224–233
Bartoletti M et al (2013) Incidence and outcome of early Candida peritonitis after liver and pancreas transplantation. Mycoses 56(2):162–167
Bassetti M et al (2006) Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis 6:21–21
Beardsley J et al (2018) Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside. Future Microbiol 13:1175–1191
Bezakova L et al (1996) Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium. Pharmazie 51(10):758–761
Bhatnagar I, Kim SK (2012) Pharmacologically prospective antibiotic agents and their sources: a marine microbial perspective. Environ Toxicol Pharmacol 34(3):631–643
Borjihan H et al (2009) The vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin. J Antibiot (Tokyo) 62(12):691–697
Brown GD, Denning DW, Levitz SM (2012a) Tackling human fungal infections. Science 336(6082):647–647
Brown GD et al (2012b) Hidden Killers: Human Fungal Infections. Sci Transl Med 4(165):165rv13
Campoy S, Adrio JL (2017a) Antifungals. Biochem Pharmacol 133:86–96
Campoy S, Adrio JL (2017b) Antifungals. Biochem Pharmacol 133:86–96
Cappelletty D, Eiselstein-McKitrick K (2007) The Echinocandins. Pharmacotherapy 27(3):369–388
Carter SB (1967) Effects of cytochalasins on mammalian cells. Nature 213(5073):261–264
Chang YL et al (2017) New facets of antifungal therapy. Virulence 8(2):222–236
Chen J et al (2008) Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray-time of flight mass spectrometry with different background electrolytes. Electrophoresis 29(10):2135–2147
Chin Y-W et al (2006) Drug discovery from natural sources. AAPS J 8(2):E239–E253
Chowdhary A et al (2014) Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms. Future Microbiol 9(5):697–711
Coste AT et al (2004) TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot Cell 3(6):1639–1652
Cragg GM (1998) Paclitaxel (Taxol®): a success story with valuable lessons for natural product drug discovery and development. Med Res Rev 18(5):315–331
Cragg GM, Newman DJ (2013) Natural products: A continuing source of novel drug leads. Biochim Biophys Acta Gen Subj 1830(6):3670–3695
Croteau R, Kutchan TM, Lewis NG (2000) Natural products (secondary metabolites). In: Biochemistry and molecular biology of plants, vol 24. West Sussex, Chichester, pp 1250–1319
Cruz LIB et al (2018) Anti-Candida albicans activity of thiazolylhydrazone derivatives in invertebrate and murine models. J Fungi (Basel) 4(4):1–14
Cuadros R et al (2000) The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers. Cancer Lett 152(1):23–29
de Aguiar Cordeiro R et al (2014) The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex. J Med Microbiol 63(7):936–944
De Rosa FG et al (2016) Appropriate treatment of invasive candidiasis in ICU: timing, colonization index, Candida Score & Biomarkers, Towards de-Escalation? Turkish J Anaesthesiol Reanimat 44(6):279–282
Denning DW (2003) Echinocandin antifungal drugs. Lancet 362(9390):1142–1151
Derengowski LS et al (2009) Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. Ann Clin Microbiol Antimicrob 8:13–13
Dhamgaye S et al (2014) Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans. PLoS One 9(8):e104554
Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Meta 2(2):303–336
Domínguez JM, Martín JJ (1998) Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans. Antimicrob Agents Chemother 42(9):2279–2283
Domínguez JM et al (1998) Sordarins: a new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts. Antimicrob Agents Chemother 42(9):2274–2278
Dominguez JM, Gomez-Lorenzo MG, Martin JJ (1999) Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. J Biol Chem 274(32):22423–22427
Dutcher JD (1968) The discovery and development of amphotericin B. Chest 54:296–298
Facts et al (2004) The review of natural products: formerly lawrence review of natural products published by facts and comparisons. Lippincott Williams & Wilkins, London
Faria NC et al (2011) Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. Lett Appl Microbiol 52(5):506–513
Farmakiotis D, Kontoyiannis DP (2016) Mucormycoses. Infect Dis Clin N Am 30(1):143–163
Faulkner DJ (2001) Marine natural products. Nat Prod Rep 18(1):1R–49R
Gao S-S et al (2011) Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S. Bioorg Med Chem Lett 21(10):2894–2897
Georgiev VS (2000) Membrane transporters and antifungal drug resistance. Curr Drug Targets 1(3):261–284
Golinska P et al (2014) Biogenic synthesis of metal nanoparticles from actinomycetes: biomedical applications and cytotoxicity. Appl Microbiol Biotechnol 98(19):8083–8097
Greenberg R et al (2006) Posaconazole as salvage therapy for zygomycosis. Antimicrob Agents Chemother 50(1):126–133
Guo N et al (2009) Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans. J Med Microbiol 58.(Pt 8:1074–1079
Haefner B (2003) Drugs from the deep: marine natural products as drug candidates. Drug Discov Today 8(12):536–544
Haidle AM, Myers AG (2004) An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B. Proc Natl Acad Sci U S A 101(33):12048–12053
Harvey AL, Edrada-Ebel R, Quinn RJ (2015a) The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 14(2):111–129
Harvey AL, Edrada-Ebel R, Quinn RJ (2015b) The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 14(2):111–129
Hauser D, Sigg HP (1971) Isolation and decomposition of sordarin. Helv Chim Acta 54(4):1178–1190
Howard SJ, Pasqualotto AC, Denning DW (2010) Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis. Clin Microbiol Infect 16(6):683–688
Ibrahim AS et al (2008) Combination echinocandin-polyene treatment of murine mucormycosis. Antimicrob Agents Chemother 52(4):1556–1558
Ishitsuka MO, Kusumi T, Kakisawa H (1988) Antitumor xenicane and norxenicane lactones from the brown alga Dictyota dichotoma. J Org Chem 53(21):5010–5013
Iwazaki RS et al (2010) In vitro antifungal activity of the berberine and its synergism with fluconazole. Antonie Van Leeuwenhoek 97(2):201
Jiang C et al (2012) Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. J Antimicrob Chemother 68(4):778–785
Justice MC et al (1998) Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis. J Biol Chem 273(6):3148–3151
Kim J et al (2008) Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochem Biophys Res Commun 372(1):266–271
Kofla G, Ruhnke M (2011) Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis-review of the literature. Eur J Med Res 16(4):159
Kolaczkowska A, Goffeau A (1999) Regulation of pleiotropic drug resistance in yeast. Drug Resist Updat 2(6):403–414
Kołaczkowska A, Kołaczkowski M (2016) Drug resistance mechanisms and their regulation in non-albicans Candida species. J Antimicrob Chemother 71(6):1438–1450
Kwon-Chung KJ, Sugui JA (2013) Aspergillus fumigatus – what makes the species a ubiquitous human fungal pathogen? PLoS Pathog 9(12):e1003743
Laniado-Laborin R, Cabrales-Vargas MN (2009) Amphotericin B: side effects and toxicity. Rev Iberoam Micol 26(4):223–227
Lei J, Xu J, Wang T (2018) In vitro susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and the correlation between triazoles susceptibility: results from a five-year study. Journal de mycologie medicale 28(2):310–313
Levy ER et al (2013) Treatment of pediatric refractory coccidioidomycosis with combination voriconazole and caspofungin: a retrospective case series. Clin Infect Dis 56(11):1573–1578
Li D-D et al (2013) Fluconazole assists berberine to kill fluconazole-resistant Candida albicans. Antimicrob Agents Chemother 57:6016–6027
Litaudon M et al (1994) Isohomohalichondrin B, a new antitumour polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp. Tetrahedron Lett 35(50):9435–9438
MacPherson S et al (2005) Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrob Agents Chemother 49(5):1745–1752
MacPherson S, Larochelle M, Turcotte B (2006) A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev 70(3):583–604
Mandala SM et al (1997a) Khafrefungin, a novel inhibitor of sphingolipid synthesis. J Biol Chem 272(51):32709–32714
Mandala SM et al (1997b) Khafrefungin, a novel inhibitor of sphingolipid synthesis. J Biol Chem 272(51):32709–32714
Mann J (2000) Murder, magic, and medicine. Oxford University Press, New York
Marchese A et al (2016) Antibacterial and antifungal activities of thymol: A brief review of the literature. Food Chem 210:402–414
Marchetti O et al (2000) Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrob Agents Chemother 44(9):2373–2381
Marinelli F (2009) Chapter 2. from microbial products to novel drugs that target a multitude of disease indications. 2009/04/21 ed. Methods Enzymol 458:29–58
Marr KA et al (2015) Combination antifungal therapy for invasive aspergillosis: a randomized trial. Ann Intern Med 162(2):81–89
Martin KW, Ernst E (2004) Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials. Mycoses 47(3–4):87–92
Maschmeyer G, Haas A, Cornely OA (2007) Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients. Drugs 67(11):1567–1601
Mayer AM et al (2010) The odyssey of marine pharmaceuticals: a current pipeline perspective. Trends Pharmacol Sci 31(6):255–265
Mesa-Arango AC, Scorzoni L, Zaragoza O (2012) It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug. Front Microbiol 3:286
Miceli MH, Kauffman CA (2015) Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent. Clin Infect Dis 61(10):1558–1565
Mišík V et al (1995) Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium. Planta Med 61(04):372–373
Mogavero S et al (2011) Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1. Antimicrob Agents Chemother 55:2061
Mora C et al (2011) How many species are there on earth and in the ocean? PLoS Biol 9(8):e1001127
Moreno I et al (2003) Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity. FEMS Microbiol Lett 226(1):159–167
Morschhäuser J et al (2007) The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathog 3(11):e164
Moye-Rowley WS (2003a) Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences. Eukaryot Cell 2(3):381–389
Moye-Rowley WS (2003b) Transcriptional control of multidrug resistance in the yeast Saccharomyces. Prog Nucleic Acid Res Mol Biol 73:251–279
Negri M et al (2014) Early state research on antifungal natural products. Molecules 19(3):2925–2956
Nishikawa JL et al (2016) Inhibiting fungal multidrug resistance by disrupting an activator-mediator interaction. Nature 530(7591):485–489
O’Hagan D (1991) The polyketide metabolites. Ellis Horwood Ltd, Chichester
Odds FC (2001) Sordarin antifungal agents. Expert Opin Ther Pat 11(2):283–294
Papich MG (2016) Griseofulvin. In Papich MG (ed) Saunders handbook of veterinary drugs, 4th edn. W.B. Saunders, St. Louis, pp 367–368
Pappas PG et al (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48(5):503–535
Pappas PG et al (2010) Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 50(8):1101–1111
Pappas PG et al (2016) Clinical practice guideline for the management of Candidiasis: 2016 update by the infectious diseases Society of America. Clin Infect Dis 62(4):e1–e50
Perfect JR (2017) The antifungal pipeline: a reality check. Nat Rev Drug Discov 16(9):603–616
Perfect JR et al (2010) Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis 50(3):291–322
Perkhofer S et al (2008) Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro. Antimicrob Agents Chemother 52(7):2636–2638
Perlin DS (2011) Current perspectives on echinocandin class drugs. Future Microbiol 6(4):441–457
Pettit GR et al (1991) Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp. J Med Chem 34(11):3339–3340
Pettit GR et al (1993) Antineoplastic agents. 251. Isolation and structure of stylostatin 1 from the Papua New Guinea marine sponge Stylotella sp. [Erratum to document cited in CA118 (5): 36157a]. J Org Chem 58(11):3222–3222
Pinkofsky HB, Dwyer DS, Bradley RJ (2000) The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants. Life Sci 66(3):271–278
Pongcharoen W et al (2007) Cytotoxic metabolites from the wood-decayed fungus Xylaria sp. BCC 9653. Chem Pharm Bull 55(11):1647–1648
Radulovic NS et al (2013) Antimicrobial plant metabolites: structural diversity and mechanism of action. Curr Med Chem 20(7):932–952
Richter SS et al (2005) Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases. J Clin Microbiol 43(5):2155–2162
Ringel S et al (1977) Ambruticin (W7783), a new antifungal antibiotic. J Antibiot 30(5):371–375
Rivero-Menendez O et al (2016) Triazole resistance in Aspergillus spp.: a worldwide problem? J Fungi (Basel, Switzerland) 2(3):21
Robbins N, Wright GD, Cowen LE (2016) Antifungal drugs: the current armamentarium and development of new agents. Microbiol Spectr 4(5):903–922
Roemer T, Krysan DJ (2014) Antifungal drug development: challenges, unmet clinical needs, and new approaches. Cold Spring Harb Perspect Med 4(5):a019703
Rothweiler W, Tamm C (1966) Isolation and structure of Phomin. Experientia 22(11):750–752
Salcedo M et al (2003) The marine antitumor compound ES 285 activates EGD receptors. In: Clinical cancer research. American Association for Cancer Research, Philadelphia
Sanglard D (2002) Resistance of human fungal pathogens to antifungal drugs. Curr Opin Microbiol 5(4):379–385
Savoia D (2012) Plant-derived antimicrobial compounds: alternatives to antibiotics. Future Microbiol 7(8):979–990
Scherlach K et al (2010) The chemistry and biology of cytochalasans. Nat Prod Rep 27(6):869–886
Scorzoni L et al (2017) Antifungal therapy: new advances in the understanding and treatment of mycosis. Front Microbiol 8:36
Shao J et al (2016) Antiproliferation of berberine in combination with fluconazole from the perspectives of reactive oxygen species, ergosterol and drug efflux in a fluconazole-resistant Candida tropicalis isolate. Front Microbiol (7):1516
Sharma M et al (2010) Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis. FEMS Yeast Res 10(5):570–578
Shastry M et al (2001) Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2. Microbiology 147(Pt 2):383–390
Shi D et al (2016) Antifungal effects of undecylenic acid on the biofilm formation of Candida albicans. Int J Clin Pharmacol Ther 54(5):343–353
Silver PM, Oliver BG, White TC (2004) Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryot Cell 3(6):1391–1397
Skiada A et al (2013) Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3). Haematologica 98(4):492–504
Somboon P et al (2017) Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae. Future Microbiol 12:417–440
Song F et al (2010) Trichodermaketones A− D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. J Nat Prod 73(5):806–810
Song F et al (2014) Secondary metabolites from the genus Xylaria and their bioactivities. Chem Biodivers 11(5):673–694
Soontorngun N et al (2007) Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2. Mol Cell Biol 27(22):7895–7905
Spellberg B et al (2005) Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice. Antimicrob Agents Chemother 49(2):830–832
Spitzer M, Robbins N, Wright GD (2017) Combinatorial strategies for combating invasive fungal infections. Virulence 8(2):169–185
Stone NR et al (2016) Liposomal amphotericin B (AmBisome®): a review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. Drugs 76(4):485–500
Sucher AJ, Chahine EB, Balcer HE (2009) Echinocandins: the newest class of antifungals. Ann Pharmacother 43(10):1647–1657
Susan JH et al (2009) Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis J 15(7):1068
Taborda CP, Nosanchuk JD (2017) Editorial: vaccines, immunotherapy and new antifungal therapy against fungi: updates in the New Frontier. Front Microbiol 8:1743
Talibi D, Raymond M (1999) Isolation of a Putative Candida albicans Transcriptional Regulator Involved in Pleiotropic Drug Resistance by Functional Complementation of a pdr1 pdr3 Mutation in Saccharomyces cerevisiae. J Bacteriol 181(1):231–240
Tan W et al (2011) Berberine hydrochloride: anticancer activity and nanoparticulate delivery system. Int J Nanomedicine 6:1773–1777
Tarman K et al (2011) Biological and chemical study of two Indonesian marine endophytic fungi. Planta Med 77(12):SL71
Tarman K et al (2012) Helicascolide C, a new lactone from an Indonesian marine algicolous strain of Daldinia eschscholzii (Xylariaceae, Ascomycota). Phytochem Lett 5(1):83–86
Tedesco D, Haragsim L (2012) Cyclosporine: a review. J Transplant 2012:230386–230386
Trimurtulu G et al (1994) Total structures of cryptophycins, potent antitumor depsipeptides from the blue-green alga Nostoc sp. strain GSV 224. J Am Chem Soc 116(11):4729–4737
Tsiodras S et al (2008) Fungal infections complicating tumor necrosis factor alpha blockade therapy. Mayo Clin Proc 83(2):181–194
Uemura D et al (1985) Norhalichondrin A: an antitumor polyether macrolide from a marine sponge. J Am Chem Soc 107(16):4796–4798
Vallabhaneni S, Chiller TM (2016) Fungal infections and new biologic therapies. Curr Rheumatol Rep 18(5):29
Vandeputte P et al (2011a) Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata. Mycopathologia 171(1):11–21
Vandeputte P, Ferrari S, Coste AT (2011b) Antifungal resistance and new strategies to control fungal infections. Intl J Microbiol 2012
Vazquez JA (2007) Combination antifungal therapy: the new frontier. Future Microbiol 2(2):115–139
Verweij PE et al (2016) Azole resistance in Aspergillus fumigatus: Can we retain the clinical use of mold-active antifungal azoles? Clin Infect Dis 62(3):362–368
Vetcher L et al (2007) The antifungal polyketide ambruticin targets the HOG pathway. Antimicrob Agents Chemother 51(10):3734–3736
Wakabayashi T, Mori K, Kobayashi S (2001) Total synthesis and structural elucidation of khafrefungin. J Am Chem Soc 123(7):1372–1375
Walsh TJ et al (2008a) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46(3):327–360
Walsh TJ et al (2008b) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46(3):327–360
Wang X et al (2012) Waikialoid A Suppresses Hyphal Morphogenesis and Inhibits Biofilm Development in Pathogenic Candida albicans. J Nat Prod 75(4):707–715
Wang B et al (2014) Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation. J Nat Prod 77(10):2273–2279
Watve MG et al (2001) How many antibiotics are produced by the genus Streptomyces? Arch Microbiol 176(5):386–390
Weber K, Schulz B, Ruhnke M (2010) The quorum-sensing molecule E,E-farnesol—its variable secretion and its impact on the growth and metabolism of Candida species. Yeast 27(9):727–739
Wei H et al (2015) Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. Phytochemistry 118:102–108
Wu B et al (2014) Two new antibiotic pyridones produced by a marine fungus, Trichoderma sp. strain MF106. Mar Drugs 12(3):1208–1219
Xia J et al (2017) In vitro inhibitory effects of farnesol and interactions between farnesol and antifungals against biofilms of Candida albicans resistant strains. Biofouling 33(4):283–293
You J et al (2013) Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chem Biol 8(4):840–848
Zheng Y-H et al (2018) An insight into new strategies to combat antifungal drug resistance. Drug Des Devel Ther 12:3807
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This work is supported by Thailand Research Fund, National Research Council of Thailand, and King Mongkut’s University of Technology Thonburi through the KMUTT 55th Anniversary commemorative fund.
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Soontorngun, N., Somboon, P., Watchaputi, K. (2019). Frontier in Antifungal Treatments Against Major Human Fungal Opportunistic Pathogen Candida Species and Medically Important Fungi. In: Sibirny, A. (eds) Non-conventional Yeasts: from Basic Research to Application. Springer, Cham. https://doi.org/10.1007/978-3-030-21110-3_13
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