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Current and Emerging 3D Models to Study Breast Cancer

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Breast Cancer Metastasis and Drug Resistance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1152))

Abstract

For decades 2D culture has been used to study breast cancer. In recent years, however, the importance of 3D culture to recapitulate the complexity of human disease has received attention. A breakthrough for 3D culture came as a result of a Nature editorial ‘Goodbye Flat Biology’ (Anonymous, Nature 424:861–861, 2003). Since then scientists have developed and implemented a range of different and more clinically relevant models, which are used to study breast cancer. In this chapter multiple different 3D models will be discussed including spheroids, microfluidic and bio-printed models and in silico models.

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Acknowledgements

Sophie Roberts is supported by a studentship from the NC3Rs (NC/N00325X/1).

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Authors and Affiliations

  1. Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK

    Sophie Roberts & Valerie Speirs

  2. School of Physics and Astronomy, University of Leeds, Leeds, UK

    Sally Peyman

Authors
  1. Sophie Roberts
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  2. Sally Peyman
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  3. Valerie Speirs
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Corresponding author

Correspondence to Valerie Speirs .

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Editors and Affiliations

  1. Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

    Aamir Ahmad

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Roberts, S., Peyman, S., Speirs, V. (2019). Current and Emerging 3D Models to Study Breast Cancer. In: Ahmad, A. (eds) Breast Cancer Metastasis and Drug Resistance. Advances in Experimental Medicine and Biology, vol 1152. Springer, Cham. https://doi.org/10.1007/978-3-030-20301-6_22

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