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Dietary Botanicals and Supplements

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Geriatric Practice
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Abstract

Clinical research has now shown that dietary supplements can be of benefit for geriatric patients, and many elders do take them. Understanding the science of dietary supplements is central to providing good medical counsel to geriatric patients. Like pharmaceuticals, there are attendant risks to the use of supplements, both intrinsic risks, and through drug-supplement interactions. In addition, the FDA does not regulate dietary supplements as stringently, so the medical provider must understand clearly the evidence of dietary supplements, as well as how to evaluate products on the market. This chapter reviews the science of dietary supplements, identifying mechanisms of action, indications, and adverse effects of beneficial dietary supplements. It also identifies a process of vetting supplements so as to optimize benefit while mitigating risks, with an emphasis on a shared decision-making model, so as to both inform patients and be clear in the medical record.

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References

  1. FDA US. Dietary supplements: what you need to know [updated 11/29/179/13/18]. Available from: https://www.fda.gov/Food/DietarySupplements/UsingDietarySupplements/ucm109760.htm.

  2. Gahche JJ, Bailey RL, Potischman N, Dwyer JT. Dietary supplement use was very high among older adults in the United States in 2011–2014. J Nutr. 2017;147(10):1968–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Consumerlab.com. [1/10/18]. Available from: https://www.consumerlab.com.

  4. Pharmacopeia US. Dietary Supplements Verification Program. Available from: http://www.usp.org/verification-services/dietary-supplements-verification-program.

  5. NSF. Dietary Supplements GMP Registration. Available from: http://www.nsf.org/services/by-industry/dietary-supplements/dietary-supplements-gmp-registration.

  6. Farahani MS, Bahramsoltani R, Farzaei MH, Abdollahi M, Rahimi R. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. Rev Neurosci. 2015;26(3):305–21.

    Article  CAS  PubMed  Google Scholar 

  7. Concerto C, Boo H, Hu C, Sandilya P, Krish A, Chusid E, et al. Hypericum perforatum extract modulates cortical plasticity in humans. Psychopharmacology. 2018;235(1):145–53.

    Article  CAS  PubMed  Google Scholar 

  8. Linde K, Berner MM, Kriston L. St John’s wort for major depression. Cochrane Database Syst Rev. 2008;(4):CD000448.

    Google Scholar 

  9. Varteresian T, Lavretsky H. Natural products and supplements for geriatric depression and cognitive disorders: an evaluation of the research. Curr Psychiatry Rep. 2014;16(8):456.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kasper S. Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trials. Wien Med Wochenschr. 2015;165(11–12):217–28.

    Article  PubMed  Google Scholar 

  11. Kasper S, Gastpar M, Muller WE, Volz HP, Dienel A, Kieser M, et al. Efficacy of St. John’s wort extract WS 5570 in acute treatment of mild depression: a reanalysis of data from controlled clinical trials. Eur Arch Psychiatry Clin Neurosci. 2008;258(1):59–63.

    Article  CAS  PubMed  Google Scholar 

  12. Shi S, Klotz U. Drug interactions with herbal medicines. Clin Pharmacokinet. 2012;51(2):77–104.

    Article  CAS  PubMed  Google Scholar 

  13. Knüppel L, Linde K. Adverse effects of St. John’s Wort: a systematic review. J Clin Psychiatry. 2004.

    Google Scholar 

  14. Council AAB. [Updated 8/12/19]. Available from: http://cms.herbalgram.org/herbclip/149/review42254.html. This is a monograph on Gingko biloba published by the American Botanical Council.

  15. Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010;10:14.

    Article  PubMed  PubMed Central  Google Scholar 

  16. von Gunten A, Schlaefke S, Uberla K. Efficacy of Ginkgo biloba extract EGb 761((R)) in dementia with behavioural and psychological symptoms: a systematic review. World J Biol Psychiatry. 2016;17(8):622–33.

    Article  Google Scholar 

  17. Gauthier S, Schlaefke S. Efficacy and tolerability of Ginkgo biloba extract EGb 761(R) in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials. Clin Interv Aging. 2014;9:2065–77.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Tan J, Peng H. Clinical analysis of Ginkgo biloba injection combined with traditional therapy in treatment of explosive deafness. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015;33(4):279–81.

    PubMed  Google Scholar 

  19. Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. Int Psychogeriatr. 2017:30(3):285–293.

    Google Scholar 

  20. Birks J, Evans JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2009;(1):CD003120.

    Google Scholar 

  21. Butler M, Nelson VA, Davila H, Ratner E, Fink HA, Hemmy LS, et al. Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical Alzheimer-type dementia: a systematic review. Ann Intern Med. 2018;168(1):52–62.

    Article  PubMed  Google Scholar 

  22. Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011;31(5):490–502.

    Article  CAS  PubMed  Google Scholar 

  23. Markowitz JS, Donovan JL, Lindsay DeVane C, Sipkes L, Chavin KD. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. J Clin Psychopharmacol. 2003;23(6):576–81.

    Article  CAS  PubMed  Google Scholar 

  24. Guo CX, Pei Q, Yin JY, Peng XD, Zhou BT, Zhao YC, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784–90.

    Article  CAS  PubMed  Google Scholar 

  25. Dai LL, Fan L, Wu HZ, Tan ZR, Chen Y, Peng XD, et al. Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects. Xenobiotica. 2013;43(10):862–7.

    Article  CAS  PubMed  Google Scholar 

  26. Dylag K, Hubalewska-Mazgaj M, Surmiak M, Szmyd J, Brzozowski T. Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Curr Pharm Des. 2014;20(7):1149–55.

    Article  CAS  PubMed  Google Scholar 

  27. Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of gut bacteria on human health and diseases. Int J Mol Sci. 2015;16(4):7493–519.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Esposito S, Rigante D, Principi N. Do children’s upper respiratory tract infections benefit from probiotics? BMC Infect Dis. 2014;14:194.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Donskey CJ. Clostridium difficile in older adults. Infect Dis Clin N Am. 2017;31(4):743–56.

    Article  Google Scholar 

  30. Shen NT, Leff JA, Schneider Y, Crawford CV, Maw A, Bosworth B, et al. Cost-effectiveness analysis of probiotic use to prevent Clostridium difficile infection in hospitalized adults receiving antibiotics. Open Forum Infect Dis. 2017;4(3):ofx148.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017;(12):CD006095.

    Google Scholar 

  32. Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307(18):1959–69.

    Article  CAS  PubMed  Google Scholar 

  33. Hauser G, Salkic N, Vukelic K, JajacKnez A, Stimac D. Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2015;94(17):e685.

    Article  Google Scholar 

  34. Hempel S, Newberry S, Ruelaz A, Wang Z, Miles JN, Suttorp MJ, et al. Safety of probiotics used to reduce risk and prevent or treat disease. Evid Rep Technol Assess. 2011;200:1–645.

    Google Scholar 

  35. Besselink MG, van Santvoort HC, van der Heijden GJ, Buskens E, Gooszen HG, Dutch Acute Pancreatitis Study G. New randomized trial of probiotics in pancreatitis needed? Caution advised. Langenbeck’s Arch Surg. 2009;394(1):191–2; author reply 3–4.

    Article  Google Scholar 

  36. Sterzi S, Giordani L, Morrone M, Lena E, Magrone G, Scarpini C, et al. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study. Eur J Phys Rehabil Med. 2016;52(3):321–30.

    PubMed  Google Scholar 

  37. Kanzaki N, Saito K, Maeda A, Kitagawa Y, Kiso Y, Watanabe K, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric. 2012;92(4):862–9.

    Article  CAS  PubMed  Google Scholar 

  38. Runhaar J, Rozendaal RM, van Middelkoop M, Bijlsma HJW, Doherty M, Dziedzic KS, et al. Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Ann Rheum Dis. 2017;76(11):1862–9.

    Article  PubMed  Google Scholar 

  39. Harrison-Munoz S, Rojas-Briones V, Irarrazaval S. Is glucosamine effective for osteoarthritis? Medwave. 2017;17(Suppl1):e6867.

    Article  PubMed  Google Scholar 

  40. Roman-Blas JA, Castaneda S, Sanchez-Pernaute O, Largo R, Herrero-Beaumont G, Group CGCTS. Combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis: a six-month multicenter, randomized, double-blind, placebo-controlled clinical trial. Arthritis Rheumatol. 2017;69(1):77–85.

    Article  CAS  PubMed  Google Scholar 

  41. Selvan T, Rajiah K, Nainar MS, Mathew EM. A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis. Sci World J. 2012;2012:902676.

    Article  CAS  Google Scholar 

  42. Saengnipanthkul S, Waikakul S, Rojanasthien S, Totemchokchyakarn K, Srinkapaibulaya A, Cheh Chin T, Mai Hong N, Bruyere O, Cooper C, Reginster JY, Lwin M. International Journal of Rheumatic Diseases. 2019;22(3):376–385.

    Google Scholar 

  43. Fransen M, Agaliotis M, Nairn L, Votrubec M, Bridgett L, Su S, et al. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis. 2015;74(5):851–8.

    Article  CAS  PubMed  Google Scholar 

  44. National Center for Complimentary and Alternative Medicine, National Institutes of Health. The NIH glucosamine/chondroitin arthritis intervention trial (GAIT). J Pain Palliat Care Pharmacother. 2008;22(1):39–43.

    Article  CAS  Google Scholar 

  45. Reginster JY, Neuprez A, Lecart MP, Sarlet N, Bruyere O. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012;32(10):2959–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81.

    Article  CAS  PubMed  Google Scholar 

  47. Tremezaygues L, Sticherling M, Pfohler C, Friedrich M, Meineke V, Seifert M, et al. Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections. Anticancer Res. 2006;26(4A):2743–8.

    CAS  PubMed  Google Scholar 

  48. Pludowski P, Karczmarewicz E, Bayer M, Carter G, Chlebna-Sokol D, Czech-Kowalska J, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319–27.

    Google Scholar 

  49. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011.

    Google Scholar 

  50. Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, et al. S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev. 2016;(10):CD011286.

    Google Scholar 

  51. Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, et al. S-Adenosylmethionine (SAMe) for neuropsychiatric disorders: a clinician-oriented review of research. J Clin Psychiatry. 2017;78(6):e656–e67.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Sarris J; Byrne GJ; Bousman C; Stough C; Murphy J; MacDonald P; Adams L; Nazareth S; Oliver G; Cribb L; Savage K; Menon R; Chamoli S; Berk M; Ng C; Mischoulon D. European Neuropsychopharmacology. 2018;28(10):1126–1136.

    Google Scholar 

  53. Guo T, Chang L, Xiao Y, Liu Q. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. Jacobsen S, Danneskiold-Samsoe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol. 1991;20(4):294–302.

    Article  CAS  PubMed  Google Scholar 

  55. Shehzad A, Qureshi M, Anwar MN, Lee YS. Multifunctional curcumin mediate multitherapeutic effects. J Food Sci. 2017;82(9):2006–15.

    Article  CAS  PubMed  Google Scholar 

  56. Akuri MC, Barbalho SM, Val RM, Guiguer EL. Reflections about osteoarthritis and Curcuma longa. Pharmacogn Rev. 2017;11(21):8–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Amalraj A, Varma K, Jacob J, Divya C, Kunnumakkara AB, Stohs SJ, et al. A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study. J Med Food. 2017;20(10):1022–30.

    Article  CAS  PubMed  Google Scholar 

  58. Hewlings SJ, Kalman DS. Curcumin: a review of its’ effects on human health. Foods. 2017;6(10):92.

    Article  PubMed Central  CAS  Google Scholar 

  59. Perkins K, Sahy W, Beckett RD. Efficacy of curcuma for treatment of osteoarthritis. J Evid Based Complementary Altern Med. 2017;22(1):156–65.

    Article  CAS  PubMed  Google Scholar 

  60. Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52:167–75.

    Article  PubMed  Google Scholar 

  61. Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2016;19(8):717–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Ross SM. Turmeric (Curcuma longa): effects of Curcuma longa extracts compared with ibuprofen for reduction of pain and functional improvement in patients with knee osteoarthritis. Holist Nurs Pract. 2016;30(3):183–6.

    Article  PubMed  Google Scholar 

  63. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, et al. Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15(4):337–44.

    PubMed  Google Scholar 

  64. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451–8.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Pinsornsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thail. 2012;95(Suppl 1):S51–8.

    Google Scholar 

  66. Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014;19(6):933–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 2009;15(8):891–7.

    Article  PubMed  Google Scholar 

  68. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26(11):1719–25.

    Article  CAS  PubMed  Google Scholar 

  69. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(11):1625–31.

    Article  CAS  PubMed  Google Scholar 

  70. Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized double-blind placebo-controlled trial. Drug Res (Stuttg). 2015;65(10):521–5.

    CAS  Google Scholar 

  71. Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013;2(1):56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  72. Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20(Suppl 1):32–7.

    PubMed  Google Scholar 

  73. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: a recent update. Food Chem Toxicol. 2015;83:111–24.

    Article  CAS  PubMed  Google Scholar 

  75. Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem. 2014;25(2):144–50.

    Article  CAS  PubMed  Google Scholar 

  76. Gasiorowski A, Dutkiewicz J. Comprehensive rehabilitation in chronic heart failure. Ann Agric Environ Med. 2013;20(3):606–12.

    PubMed  Google Scholar 

  77. Lee JH, Jarreau T, Prasad A, Lavie C, O’Keefe J, Ventura H. Nutritional assessment in heart failure patients. Congest Heart Fail. 2011;17(4):199–203.

    Article  PubMed  Google Scholar 

  78. Allard ML, Jeejeebhoy KN, Sole MJ. The management of conditioned nutritional requirements in heart failure. Heart Fail Rev. 2006;11(1):75–82.

    Article  CAS  PubMed  Google Scholar 

  79. Witte KK, Nikitin NP, Parker AC, von Haehling S, Volk HD, Anker SD, et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J. 2005;26(21):2238–44.

    Article  CAS  PubMed  Google Scholar 

  80. Sole MJ, Jeejeebhoy KN. Conditioned nutritional requirements: therapeutic relevance to heart failure. Herz. 2002;27(2):174–8.

    Article  PubMed  Google Scholar 

  81. Aslanabadi N, Safaie N, Asgharzadeh Y, Houshmand F, Ghaffari S, Garjani A, et al. The randomized clinical trial of coenzyme Q10 for the prevention of periprocedural myocardial injury following elective percutaneous coronary intervention. Cardiovasc Ther. 2016;34(4):254–60.

    Article  CAS  PubMed  Google Scholar 

  82. Alehagen U, Alexander J, Aaseth J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One. 2016;11(7):e0157541.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  83. Marazzi G, Pelliccia F, Campolongo G, Quattrino S, Cacciotti L, Volterrani M, et al. Usefulness of nutraceuticals (Armolipid Plus) versus ezetimibe and combination in statin-intolerant patients with dyslipidemia with coronary heart disease. Am J Cardiol. 2015;116(12):1798–801.

    Article  CAS  PubMed  Google Scholar 

  84. Okello E, Jiang X, Mohamed S, Zhao Q, Wang T. Combined statin/coenzyme Q10 as adjunctive treatment of chronic heart failure. Med Hypotheses. 2009;73(3):306–8.

    Article  CAS  PubMed  Google Scholar 

  85. Taylor BA, Lorson L, White CM, Thompson PD. A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy. Atherosclerosis. 2015;238(2):329–35.

    Article  CAS  PubMed  Google Scholar 

  86. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014;2(6):641–9.

    Article  PubMed  Google Scholar 

  87. Oleck S, Ventura HO. Coenzyme Q10 and utility in heart failure: just another supplement? Curr Heart Fail Rep. 2016;13(4):190–5.

    Article  CAS  PubMed  Google Scholar 

  88. Jankowski J, Korzeniowska K, Cieslewicz A, Jablecka A. Coenzyme Q10 – a new player in the treatment of heart failure? Pharmacol Rep. 2016;68(5):1015–9.

    Google Scholar 

  89. Fotino AD, Thompson-Paul AM, Bazzano LA. Effect of coenzyme Q(1)(0) supplementation on heart failure: a meta-analysis. Am J Clin Nutr. 2013;97(2):268–75.

    Article  CAS  PubMed  Google Scholar 

  90. Zhao Q, Kebbati AH, Zhang Y, Tang Y, Okello E, Huang C. Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure. J Investig Med. 2015;63(5):735–9.

    Article  CAS  PubMed  Google Scholar 

  91. Bagheri Nesami N, Mozaffari-Khosravi H, Najarzadeh A, Salehifar E. The effect of coenzyme Q10 supplementation on pro-inflammatory factors and adiponectin in mildly hypertensive patients: a randomized, double-blind, placebo-controlled trial. Int J Vitam Nutr Res. 2015;85(3–4):156–64.

    Article  PubMed  CAS  Google Scholar 

  92. Li Z, Wang P, Yu Z, Cong Y, Sun H, Zhang J, et al. The effect of creatine and coenzyme q10 combination therapy on mild cognitive impairment in Parkinson’s disease. Eur Neurol. 2015;73(3–4):205–11.

    Article  CAS  PubMed  Google Scholar 

  93. Yoritaka A, Kawajiri S, Yamamoto Y, Nakahara T, Ando M, Hashimoto K, et al. Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Parkinsonism Relat Disord. 2015;21(8):911–6.

    Article  PubMed  Google Scholar 

  94. Johansson P, Dahlstrom O, Dahlstrom U, Alehagen U. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. results from a double blind, placebo-controlled prospective study. J Nutr Health Aging. 2015;19(9):870–7.

    Article  CAS  PubMed  Google Scholar 

  95. Cicero AF, Morbini M, Rosticci M, D’Addato S, Grandi E, Borghi C. Middle-term dietary supplementation with red yeast rice plus coenzyme Q10 improves lipid pattern, endothelial reactivity and arterial stiffness in moderately hypercholesterolemic subjects. Ann Nutr Metab. 2016;68(3):213–9.

    Article  CAS  PubMed  Google Scholar 

  96. Marazzi G, Campolongo G, Pelliccia F, Quattrino S, Vitale C, Cacciotti L, et al. Comparison of low-dose statin versus low-dose statin + Armolipid Plus in high-intensity statin-intolerant patients with a previous coronary event and percutaneous coronary intervention (ADHERENCE Trial). Am J Cardiol. 2017;120(6):893–7.

    Article  CAS  PubMed  Google Scholar 

  97. Raygan F, Rezavandi Z, Dadkhah Tehrani S, Farrokhian A, Asemi Z. The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. Eur J Nutr. 2016;55(8):2357–64.

    Article  CAS  PubMed  Google Scholar 

  98. Cicero AF, Colletti A, Fogacci F, Bove M, Rosticci M, Borghi C. Effects of a combined nutraceutical on lipid pattern, glucose metabolism and inflammatory parameters in moderately hypercholesterolemic subjects: a double-blind, cross-over, randomized clinical trial. High Blood Press Cardiovasc Prev. 2017;24(1):13–8.

    Article  CAS  PubMed  Google Scholar 

  99. Rodriguez-Carrizalez AD, Castellanos-Gonzalez JA, Martinez-Romero EC, Miller-Arrevillaga G, Pacheco-Moises FP, Roman-Pintos LM, et al. The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: a phase IIa, randomized, double-blind, and placebo-controlled study. Redox Rep. 2016;21(4):155–63.

    Article  CAS  PubMed  Google Scholar 

  100. Domanico D, Fragiotta S, Cutini A, Carnevale C, Zompatori L, Vingolo EM. Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up. Indian J Ophthalmol. 2015;63(1):9–14.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Zmitek K, Pogacnik T, Mervic L, Zmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Biofactors. 2017;43(1):132–40.

    Article  CAS  PubMed  Google Scholar 

  102. Di Cerbo A, Laurino C, Palmieri B, Iannitti T. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins. J Photochem Photobiol B. 2015;144:94–103.

    Article  PubMed  CAS  Google Scholar 

  103. Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M, Engali KA. Functions of coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver disease: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2016;35(4):346–53.

    Article  CAS  PubMed  Google Scholar 

  104. Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, Kuratsune H, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42(4):431–40.

    Article  CAS  PubMed  Google Scholar 

  105. Castro-Marrero J, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Roman-Malo L, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015;22(8):679–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Iwase S, Kawaguchi T, Yotsumoto D, Doi T, Miyara K, Odagiri H, et al. Efficacy and safety of an amino acid jelly containing coenzyme Q10 and L-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01). Support Care Cancer. 2016;24(2):637–46.

    Article  PubMed  Google Scholar 

  107. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: a double blind randomized clinical trial. Nutr Neurosci. 2016;19(3):138–43.

    Article  CAS  PubMed  Google Scholar 

  108. Yeung CK, Billings FT, Claessens AJ, Roshanravan B, Linke L, Sundell MB, et al. Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress. BMC Nephrol. 2015;16:183.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  109. Gaul C, Diener HC, Danesch U, Migravent Study G. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516.

    Article  PubMed  CAS  Google Scholar 

  110. Engelsen Engelsen reference: Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost. 2002;87(6):1075–6.

    Google Scholar 

  111. Bertinato J, Wang KC, Hayward S. Serum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance. Nutrients. 2017;9(3). pii: E296

    Google Scholar 

  112. Ross AC. Modern nutrition in health and disease. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2014.

    Google Scholar 

  113. Shardha AK, Vaswani AS, Faraz A, Alam MT, Kumar P. Frequency and risk factors associated with hypomagnesaemia in hypokalemic type-2 diabetic patients. J Coll Physicians Surg Pak. 2014;24(11):830–5.

    PubMed  Google Scholar 

  114. Tin A, Grams ME, Maruthur NM, Astor BC, Couper D, Mosley TH, et al. Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease. Kidney Int. 2015;87(4):820–7.

    Article  CAS  PubMed  Google Scholar 

  115. Cheungpasitporn W, Thongprayoon C, Mao MA, Srivali N, Ungprasert P, Varothai N, et al. Hypomagnesaemia linked to depression: a systematic review and meta-analysis. Intern Med J. 2015;45(4):436–40.

    Article  CAS  PubMed  Google Scholar 

  116. Haider DG, Lindner G, Ahmad SS, Sauter T, Wolzt M, Leichtle AB, et al. Hypermagnesemia is a strong independent risk factor for mortality in critically ill patients: results from a cross-sectional study. Eur J Intern Med. 2015;26(7):504–7.

    Article  CAS  PubMed  Google Scholar 

  117. Sharara AI, Chalhoub JM, Hammoud N, Harb AH, Sarkis FS, Hamadeh G. Low prevalence of hypomagnesemia in long-term recipients of proton pump inhibitors in a managed care cohort. Clin Gastroenterol Hepatol. 2016;14(2):317–21.

    Article  CAS  PubMed  Google Scholar 

  118. Luk CP, Parsons R, Lee YP, Hughes JD. Proton pump inhibitor-associated hypomagnesemia: what do FDA data tell us? Ann Pharmacother. 2013;47(6):773–80.

    Article  PubMed  CAS  Google Scholar 

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Remde, A., Teets, R. (2020). Dietary Botanicals and Supplements. In: Chun, A. (eds) Geriatric Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-19625-7_15

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