Abstract
Adipocyte glucose transport is a key event for glucose homeostasis and is perturbed in insulin resistant situations like in obesity and type 2 diabetes. We will discuss how glucose transport is regulated in adipocyte, in normal, and in physiopathological conditions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abel ED, Peroni OD, Kim JK et al (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409:729–733
Aran V, Bryant NJ, GG W (2011) Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to syntaxin 4. BMC Biochem 12:19
Bogan JS, Kandror KV (2010) Biogenesis and regulation of insulin-responsive vesicles containing Glut4. Curr Opin Cell Biol 22:506–512
Bryant NJ, Gould GW (2011) SNARE proteins underpin insulin-regulated GLUT4 traffic. Traffic 12:657–664
Carvalho E, Kotani K, Peroni OD et al (2005) Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab 289:E551–E561
Cushman SW, Wardzala LJ (1980) Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem 255:4758–4762
Dash S, Langenberg C, Fawcett KA et al (2010) Analysis of TBC1D4 in patients with severe insulin resistance. Diabetologia 53:1239–1342
Dhalla AK, Wong MY, Voshol PJ et al (2007) A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents. Am J Physiol Endocrinol Metab 292:E1358–E1363
Dong Q, Ginsberg HN, Erlanger BF (2001) Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Diabetes Obes Metab 3:360–366
Faulhaber-Walter R, Jou W, Mizel D et al (2011) Impaired glucose tolerance in the absence of adenosine A1 receptor signaling. Diabetes 60:2578–2587
Figler RA, Wang G, Srinivasan S et al (2011) Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes 60:669–679
Fujita H, Hatakeyama H, Watanabe TM et al (2010) Identification of three disting functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging. Mol Biol Cell 21:2721–2731
Garvey WT, Maianu L, Zhu J-H et al (1993) Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters. Diabetes 42:1773–1785
Graham TE, Kahn BB (2007) Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes. Horm Metab Res 39:717–721
Gual P, Le Marchand-Brustel Y, Tanti JF (2003) Positive and negative regulation of glucose uptake by hyperosmotic stress. Diabetes Metab 29:566–575
Hajduch E, Darakhshan F, Hundal HS (1998) Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes. 41:821–828
Heseltine L, Webster JM, Taylor R (1995) Adenosine effects upon insulin action on lipolysis and glucose transport in human adipocytes. Mol Cell Biochem 144:147–151
Hoehn KL, Hohnen-Behrens C, Cederberg A et al (2008) IRS1-independent defects define major nodes of insulin resistance. Cell Metab 7:233–421
Im S–S, Kwon S-K, Kim T-H et al (2007) Regulation of glucose transporter type 4 isoform gene expression in muscles and adipocytes. IUBMB Life 59:134–145
Jewell JL, Oh E, Ramalingam L et al (2011) Munc18c phosphorylation by insulin receptor links cell signaling directly to SNARE exocytosis. J Cell Biol 193:185–199
Kaddai V, Gonzalez T, Bolla M et al (2008a) The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 192:E162–E169
Kaddai V, Le Marchand-Brustel Y, Cormont M (2008b) Rab proteins in endocytosis and Glut4 trafficking. Acta Physiol 192:75–88
Kaddai V, Jager J, Gonzalez T et al (2009a) Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabetologia 2009:932–940
Kaddai V, Gonzalez T, Keslair F et al. (2009b) Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte. PLoS One 4(4):e5257
Kobayashi M, Nikami H, Morimatsu M et al (1996) Expression and localisation of insulin-regulatable glucocse transporter (GLUT4) in rat brain. Neurosci Lett 213:103–106
Koumanov F, Jin B, Yang J et al (2005) Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step. Cell Metab 2:179–189
Lewko B, Bryl E, Witkowski JM et al (2005) Characterization of glucose uptake by cultured rat podocytes. Kidney Blood Press Res 28:1–7
Liao W, Nguyen MT, Imamura T et al (2006) Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology 147:2245–2252
Long SD, Pekala PH (1996) Regulation of GLUT4 mRNA stability by tumor necrosis factor-alpha: alterations in both protein binding to the 3′ untranslated region and initiation of translation. Biochem Biophys Res Commun 220:949–953
Lumeng CN, Deyoung SM, Saltiel AR (2006) Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Pysiol Endocrinol Metab 292:E166–E174
Maianu L, Keller SR, Garvey WT (2001) Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implication regarding defects in vesicle trafficking. J Clin Endocrinol Metab 86:5450–5456
Mari M, Monzo P, Kaddai V et al (2006) The Rab4 effector Rabip4 plays a role in intracellular trafficking of Glut 4 in 3T3-L1 adipocytes. J Cell Sci 119:1297–1306
Novick P, Medkova M, Dong G et al (2006) Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis. Biochem Soc Trans 34:683–686
Pessler-Cohen D, Pekala PH, Kosvan J et al (2006) GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes. Arch Physiol Biochem 112:3–12
Purcell SC, Aerni-Flessner LB, Willcockson AR et al (2011) Improved insulin sensitivity by GLUT12 overexpression in mice. Diabetes 60:1478–1482
Qi L, Saberi M, Zmuda E et al (2009) Adipocyte CREB promotes insulin resistance in obesity. Cell Metab 9:277–286
Regazzetti C, Peraldi P, Grémeaux T et al (2009) Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 58:95–103
Rowland AF, Fazakerley DJ, James DE (2011) Mapping insulin/GLUT4 circuitry. Traffic 12:672–681
Ruan H, Hacohen N, Golub TR et al (2002) Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 51:1319–1336
Rubin BR, Bogan JS (2009) Intracellular retention and insulin stimulated mobilization of GLUT4 glucose transporters. Vitam Horm 80:155–192
Sano H, Peck GR, Kettenbach AN et al (2011) Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. J Biol Chem 286:16541–16545
Skrypski M, Le T, Kaczmarek P T et al (2011) Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes. Diabetologia 54:1841–1852
Sparling DP, Griesel BA, Weems J et al (2008) GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate GLUT4 promoter in adipocytes. J Biol Chem 283:7429–7434
Suzuki K, Kono T (1980) Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc Natl Acad Sci USA 77:2542–2545
Thorens B, Mueckler M (2009) Glucose transporters in the 21st century. Am J Physiol Endocrinol Metab 298:E141–E145
Weber-Boyvat M, Aro N, Chernov KG et al (2011) Sec1p and Mso1p C-terminal tails cooperate with SNAREs and Sec4 in ploarized exocytosis. Mol Biol Cell 22:230–244
Wu X, Motoshima H, Mahadev K et al. (2003) Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 1355–1363
Xie X, Gong Z, Mansuy-Aubert V et al (2011) C2 domain-containing phosphoprotein CDP138 regulates Glut4 insertion into the plasma membrane. Cell Metab 14:378–389
Xu Y, Rubin BR, Orme CM et al (2011) Dual-mode of insulin action controls GLUT4 vesicle exocytosis. J Cell Biol 193:643–653
Yang Q, Graham TE, Mody N et al (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436:337–338
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag France
About this chapter
Cite this chapter
Cormont, M., Kaddai, V. (2013). Glucose Transport in White Adipocyte. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_7
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0343-2_7
Published:
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0342-5
Online ISBN: 978-2-8178-0343-2
eBook Packages: MedicineMedicine (R0)