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Aging Studies in Drosophila Melanogaster

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Biological Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1048))

Abstract

Drosophila is a genetically tractable system ideal for investigating the mechanisms of aging and developing interventions for promoting healthy aging. Here we describe methods commonly used in Drosophila aging research. These include basic approaches for preparation of diets and measurements of lifespan, food intake, and reproductive output. We also describe some commonly used assays to measure changes in physiological and behavioral functions of Drosophila in aging, such as stress resistance and locomotor activity.

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Notes

  1. 1.

    Jason Yolitz and Cecilia Wang have contributed equally to this project.

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Acknowledgements

We would like to thank three anonymous reviewers for their constructive comments on the manuscript. This work was supported by the Intramural Research Program at the National Institute on Aging, NIH, to S.Z.

Author information

Authors and Affiliations

  1. Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA

    Yaning Sun, Jason Yolitz, Edward Spangler & Sige Zou

  2. Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, MD, USA

    Cecilia Wang

  3. Department of Systems Medicine and Bioengineering, Methodist Hospital Research Institute – Weill Cornell Medical College, Houston, TX, USA

    Ming Zhan

Authors
  1. Yaning Sun
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  2. Jason Yolitz
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  3. Cecilia Wang
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  4. Edward Spangler
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  5. Ming Zhan
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  6. Sige Zou
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Editors and Affiliations

  1. Dept. Biology, University of Alabama, Birmingham Dept. Biology, Birmingham, Alabama, USA

    Trygve O. Tollefsbol

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Sun, Y., Yolitz, J., Wang, C., Spangler, E., Zhan, M., Zou, S. (2013). Aging Studies in Drosophila Melanogaster. In: Tollefsbol, T. (eds) Biological Aging. Methods in Molecular Biology, vol 1048. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-556-9_7

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  • DOI: https://doi.org/10.1007/978-1-62703-556-9_7

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-555-2

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