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TRP Expression and Function in the Lung Airways

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TRP Channels in Drug Discovery

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

The airways of the lungs are composed of the epithelium, smooth muscle cells, and sensory nerve cells as well as resident immune cells. Transient receptor potential (TRP) channels are expressed in all of these tissues and cells and there is increasing evidence that they play a key role in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). This chapter focuses on what is currently known about TRP expression and function in lung airways by studying specific channel blockers as well as TRP-deficient mouse models. Targeting selected TRP functions may have important therapeutic benefits for respiratory diseases in the future.

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Authors and Affiliations

  1. Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, Munich, Germany

    Alexander Dietrich & Thomas Gudermann

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  1. Alexander Dietrich
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  2. Thomas Gudermann
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Correspondence to Alexander Dietrich .

Editor information

Editors and Affiliations

  1. , Transfusion Services, Monmouth Medical Center, Second Avenue 300, Long Branch, 07740, New Jersey, USA

    Arpad Szallasi

  2. Medical and Health Science Center, Department of Physiology, University of Debrecen, Nagyerdei Krt. 98, Debrecen, 4032, Hungary

    Tamás Bíró

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Dietrich, A., Gudermann, T. (2012). TRP Expression and Function in the Lung Airways. In: Szallasi, A., Bíró, T. (eds) TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-077-9_14

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  • DOI: https://doi.org/10.1007/978-1-62703-077-9_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-076-2

  • Online ISBN: 978-1-62703-077-9

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