Skip to main content

Oral Pharyngeal Cancer Epidemiology and Prevention

  • Chapter
  • First Online:
Nutrition and Oral Medicine

Part of the book series: Nutrition and Health ((NH))

  • 2227 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94:153–6.

    Article  PubMed  CAS  Google Scholar 

  2. Blot WJ, McLaughlin JK, Winn DM, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48:3282–7.

    PubMed  CAS  Google Scholar 

  3. Cleveland JL, Junger ML, Saralya M, Markowitz LEW, Dunne EF, Epstein JB. The connection between human papillomavirus and oropharyngeal squamous cell carcinomas in the United States: implications for dentistry. J Am Dent Assoc. 2011;142(8):915–24.

    Article  PubMed  Google Scholar 

  4. Jemal A, Simard EP, Dorell C, Noone Am, Markowitz LE et al. Annual report to the nation on the status of cancer, 1975–2009, featuring the burden and trends in HPV-associated cancers and HPV vaccination levels. J Natl Ca Inst. 2013;105(3):Epub 2014.

    Google Scholar 

  5. Rothman J, Greenland S. Modern epidemiology. Philadelphia: Lippincott-Raven Publishers; 1998.

    Google Scholar 

  6. Wynder EL, Hultberg S, Jacobson F, Bross IJ. Environmental factors in cancer of the upper alimentary tract: Swedish study with special reference to Plummer-Vinson (Paterson-Kelly) syndrome. Cancer. 1957;10:470–87.

    Article  PubMed  CAS  Google Scholar 

  7. Larsson LG, Sandstrom A, Westling P. Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden. Cancer Res. 1975;35:3308–16.

    PubMed  CAS  Google Scholar 

  8. Martinez I. Factors associated with cancer of the esophagus, mouth, and pharynx in Puerto Rico. J Natl Cancer Inst. 1969;42:1069–94.

    PubMed  CAS  Google Scholar 

  9. Graham S, Dayal H, Rohrer T, et al. Dentition, diet, tobacco, and alcohol in the epidemiology of oral cancer. J Natl Cancer Inst. 1977;59:1611–8.

    PubMed  CAS  Google Scholar 

  10. Winn DM, Ziegler RG, Pickle LW, Gridley G, Blot WJ, Hoover RN. Diet in the etiology of oral and pharyngeal cancer among women from the southern United States. Cancer Res. 1984;44:1216–22.

    PubMed  CAS  Google Scholar 

  11. McLaughlin JK, Gridley G, Block G, et al. Dietary factors in oral and pharyngeal cancer. J Natl Cancer Inst. 1988;80:1237–43.

    Article  PubMed  CAS  Google Scholar 

  12. Franco EL, Kowalski LP, Oliveira BV, et al. Risk factors for oral cancer in Brazil: a case-control study. Int J Cancer. 1989;43:992–1000.

    Article  PubMed  CAS  Google Scholar 

  13. Gridley G, McLaughlin JK, Block G, et al. Diet and oral and pharyngeal cancer among blacks. Nutr Cancer. 1990;14:219–25.

    Article  PubMed  CAS  Google Scholar 

  14. Franceschi S, Bidoli E, Baron AE, et al. Nutrition and cancer of the oral cavity and pharynx in northeast Italy. Int J Cancer. 1991;47:20–5.

    Article  PubMed  CAS  Google Scholar 

  15. Zheng W, Blot WJ, Shu XO, et al. Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet. Cancer Epidemiol Biomarkers Prev. 1992;1:441–8.

    PubMed  CAS  Google Scholar 

  16. Notani PN, Jayant K. Role of diet in upper aerodigestive tract cancers. Nutr Cancer. 1987;10:103–13.

    Article  PubMed  CAS  Google Scholar 

  17. Franceschi S, Barra S, La Vecchia C, Bidoli E, Negri E, Talamini R. Risk factors for cancer of the tongue and the mouth: a case-control study from northern Italy. Cancer. 1992;70:2227–33.

    Article  PubMed  CAS  Google Scholar 

  18. Zheng T, Boyle P, Willett WC, et al. A case-control study of oral cancer in Beijing, People’s Republic of China: associations with nutrient intakes, foods and food groups. Eur J Cancer B Oral Oncol. 1993;29B:45–55.

    Article  PubMed  CAS  Google Scholar 

  19. Franceschi S, Bidoli E, La Vecchia C, Talamini R, D’Avanzo B, Negri E. Tomatoes and risk of digestive-tract cancers. Int J Cancer. 1994;59:181–4.

    Article  PubMed  CAS  Google Scholar 

  20. Levi F, Pasche C, La Vecchia C, Lucchini F, Franceschi S, Monnier P. Food groups and risk of oral and pharyngeal cancer. Int J Cancer. 1998;77:705–9.

    Article  PubMed  CAS  Google Scholar 

  21. De Stefani E, Deneo-Pellegrini H, Mendilaharsu M, Ronco A. Diet and risk of cancer of the upper aerodigestive tract: 1. Foods. Oral Oncol. 1999;35:17–21.

    Article  PubMed  Google Scholar 

  22. Garrote LF, Herrero R, Reyes RM, et al. Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer. 2001;85:46–54.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  23. Kasum CM, Jacobs DR Jr, Nicodemus K, Folsom AR. Dietary risk factors for upper aerodigestive tract cancers. Int J Cancer. 2002;99:267–72.

    Article  PubMed  CAS  Google Scholar 

  24. Petridou E, Zavras AI, Lefatzis D, et al. The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer. 2002;94:2981–8.

    Article  PubMed  CAS  Google Scholar 

  25. Franceschi S, Favero A, Conti E, et al. Food groups, oils and butter, and cancer of the oral cavity and pharynx. Br J Cancer. 1999;80:614–20.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  26. Sanchez MJ, Martinez C, Nieto A, et al. Oral and oropharyngeal cancer in Spain: influence of dietary patterns. Eur J Cancer Prev. 2003;12:49–56.

    Article  PubMed  CAS  Google Scholar 

  27. Tavani A, Gallus S, La Vecchia C, et al. Diet and risk of oral and pharyngeal cancer: an Italian case-control study. Eur J Cancer Prev. 2001;10:191–5.

    Article  PubMed  CAS  Google Scholar 

  28. Pavia M, Pileggi C, Nobile C, Angelillo I. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83:1126–34.

    PubMed  CAS  Google Scholar 

  29. La Vecchia C, Negri E, D’Avanzo B, Boyle P, Franceschi S. Dietary indicators of oral and pharyngeal cancer. Int J Epidemiol. 1991;20:39–44.

    Article  PubMed  Google Scholar 

  30. Freedman N, Park Y, Subar A, Hollenbeck A, Leitzmann M, Schatzkin A, Abnet C. Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study. Int J Cancer. 2008;122:2330–6.

    Article  PubMed  CAS  Google Scholar 

  31. Kawakita D, Matsuo K, Sato F, Oze I, Hosono S, Ito H, Watanabe M, Yatabe Y, Hanai N, Hasegawa Y, Tajima K, Murakami S, Tanaka H. Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma. Ann Oncol. 2012;23(1):186.

    Article  PubMed  CAS  Google Scholar 

  32. Chatenoud L, Tavani A, La Vecchia C, et al. Whole grain food intake and cancer risk. Int J Cancer. 1998;77:24–8.

    Article  PubMed  CAS  Google Scholar 

  33. Levi F, Pasche C, Lucchini F, Chatenoud L, Jacobs DR Jr, La Vecchia C. Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer. Eur J Clin Nutr. 2000;54:487–9.

    Article  PubMed  CAS  Google Scholar 

  34. Lam T, Cross A, Freedman N, Park Y, HollenbeckA, Schatzkin A, Abnet C. Dietary fiber and grain consumption in relation to head and neck cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control. 2011;22(10):1405–1414.

    Google Scholar 

  35. Arthur A, Peterson K, Rozek L, Taylor J, Light E, Chepeha D, Hebert J, Terrell J, Wolf G, Duffy S, UM Head and Neck SPORE Program. Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosis. Am J Clin Nutr. 2012. doi:10:3945/ajcn.112.044859.

  36. De Stefani E, Oreggia F, Ronco A, Fierro L, Rivero S. Salted meat consumption as a risk factor for cancer of the oral cavity and pharynx: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev. 1994;3:381–5.

    PubMed  Google Scholar 

  37. Fernandez E, Chatenoud L, La Vecchia C, Negri E, Franceschi S. Fish consumption and cancer risk. Am J Clin Nutr. 1999;70:85–90.

    PubMed  CAS  Google Scholar 

  38. Bradshaw P, Siega-Riz A, Campbell M, Weissler M, Funkhouser W, Olshan A. Associations between dietary patterns and head and neck cancer: the Carolina head and neck cancer epidemiology study. Am J Epidemiol. 2012;175(12):1225–33.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Hildebrand J, Patel A, McCullough M, Gaudet M, Chen A, Hayes R, Gapstur S. Coffee, tea and fatal oral/pharyngeal cancer in a large prospective US cohort. Am J Epidem. 2013;177(1):50–58.

    Google Scholar 

  40. Galeone C, Tavani A, Pelucchi C, Turati F, Winn D, Levi F, et al. Coffee and tea intake and risk of head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 2010;19(7):1723–36.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  41. Chainani-Wu N, Epstein J, Tougher-Decker R. Diet and prevention of oral cancer: strategies for clinical practice. J Am Dent Assoc. 2011;142(2):166–9.

    Article  PubMed  Google Scholar 

  42. Marshall JR, Graham S, Haughey BP, et al. Smoking, alcohol, dentition and diet in the epidemiology of oral cancer. Eur J Cancer B Oral Oncol. 1992;28B:9–15.

    Article  PubMed  CAS  Google Scholar 

  43. Kune GA, Kune S, Field B, et al. Oral and pharyngeal cancer, diet, smoking, alcohol, and serum vitamin A and beta-carotene levels: a case-control study in men. Nutr Cancer. 1993;20:61–70.

    Article  PubMed  CAS  Google Scholar 

  44. Soler M, Bosetti C, Franceschi S, et al. Fiber intake and the risk of oral, pharyngeal and esophageal cancer. Int J Cancer. 2001;91:283–7.

    Article  PubMed  CAS  Google Scholar 

  45. Middleton B, Byers T, Marshall J, Graham S. Dietary vitamin A and cancer: a multisite case-control study. Nutr Cancer. 1986;8:107–16.

    Article  PubMed  CAS  Google Scholar 

  46. Marshall J, Graham S, Mettlin C, Shedd D, Swanson M. Diet in the epidemiology of oral cancer. Nutr Cancer. 1982;3:145–9.

    Article  PubMed  CAS  Google Scholar 

  47. Mayne ST, Graham S, Zheng TZ. Dietary retinol: prevention or promotion of carcinogenesis in humans? Cancer Causes Control. 1991;2:443–50.

    Article  PubMed  CAS  Google Scholar 

  48. Negri E, Franceschi S, Bosetti C, et al. Selected micronutrients and oral and pharyngeal cancer. Int J Cancer. 2000;86:122–7.

    Article  PubMed  CAS  Google Scholar 

  49. Rossing MA, Vaughan TL, McKnight B. Diet and pharyngeal cancer. Int J Cancer. 1989;44:593–7.

    Article  PubMed  CAS  Google Scholar 

  50. Shanmugham J, Zavras A, Rosner B, Giovannucci. Alcohol-folate interactions in women’s oral cancer risk: a prospective cohort study. Cancer Epidemiol biomarkers Prev. 2010;19(10):2516–4.

    Google Scholar 

  51. Kawakita, et al. Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma. Ann Oncol. 2012;23:186–92.

    Article  PubMed  CAS  Google Scholar 

  52. Shanmugham J, Zavras A, Rosner B, Giovannucci E. Alcohol-folate interactions in women’s oral cancer risk: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2516–24.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  53. Gridley G, McLaughlin JK, Block G, Blot WJ, Gluch M, Fraumeni JF Jr. Vitamin supplement use and reduced risk of oral and pharyngeal cancer. Am J Epidemiol. 1992;135:1083–92.

    PubMed  CAS  Google Scholar 

  54. Barone J, Taioli E, Hebert JR, Wynder EL. Vitamin supplement use and risk for oral and esophageal cancer. Nutr Cancer. 1992;18:31–41.

    Article  PubMed  CAS  Google Scholar 

  55. Knekt P, Aromaa A, Maatela J, et al. Serum micronutrients and risk of cancers of low incidence in Finland. Am J Epidemiol. 1991;134:356–61.

    PubMed  CAS  Google Scholar 

  56. Nomura AM, Ziegler RG, Stemmermann GN, Chyou PH, Craft NE. Serum micronutrients and upper aerodigestive tract cancer. Cancer Epidemiol Biomarkers Prev. 1997;6:407–12.

    PubMed  CAS  Google Scholar 

  57. Zheng W, Blot WJ, Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res. 1993;53:795–8.

    PubMed  CAS  Google Scholar 

  58. Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, et al. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst. 1996;88:1560–70.

    Article  PubMed  CAS  Google Scholar 

  59. Marshall JR, Boyle P. Nutrition and oral cancer. Cancer Causes Control. 1996;7:101–11.

    Article  PubMed  CAS  Google Scholar 

  60. Axell T, Pindborg JJ, Smith CJ, van der Waal I for the International Collaborative Group on Oral White Lesions. Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18–21, 1994. J Oral Pathol Med. 1996;25:49–54.

    Google Scholar 

  61. Gupta PC, Hebert JR, Bhonsle RB, Sinor PN, Mehta H, Mehta FS. Dietary factors in oral leukoplakia and sub mucous fibrosis in a population-based case control study in Gujarat India. Oral Dis. 1998;4:200–6.

    Article  PubMed  CAS  Google Scholar 

  62. Gupta PC, Hebert JR, Bhonsle RB, Murti PR, Mehta H, Mehta FS. Influence of dietary factors on oral precancerous lesions in a population-based case-control study in Kerala India. Cancer. 1999;85:1885–93.

    PubMed  CAS  Google Scholar 

  63. Morse DE, Pendrys DG, Katz RV, et al. Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes Control. 2000;11:713–20.

    Article  PubMed  CAS  Google Scholar 

  64. Hebert JR, Gupta PC, Bhonsle RB, et al. Dietary exposures and oral precancerous lesions in Srikakulam district, Andhra Pradesh India. Public Health Nutr. 2002;5:303–12.

    Article  PubMed  Google Scholar 

  65. Kaugars GE, Riley WT, Brandt RB, Burns JC, Svirsky JA. The prevalence of oral lesions in smokeless tobacco users and an evaluation of risk factors. Cancer. 1992;70:2579–85.

    Article  PubMed  CAS  Google Scholar 

  66. Kristal AR, Lippman SM. Nutritional prevention of cancer: new directions for an increasingly complex challenge. J Natl Cancer Inst. 2009;101(6):363–5.

    Google Scholar 

  67. Papadimitrakopoulou VA, Lee JJ, William WN Jr, Martin JW, Thomas M, et al. Randomized trial of 13-cis retinoic acid compared with retinyl palmitate with or without beta-carotene in oral premalignancy. J Clin Oncol. 2009;27(4):500–604.

    Google Scholar 

  68. Epstein JB, Gorsky M. Topical application of vitamin A to oral leukoplakia: a clinical case series. Cancer. 1999;86(6):921–7.

    Article  PubMed  CAS  Google Scholar 

  69. Silverman S, Renstrup G, Pindberg JJ. Studies in oral leukoplakias. 3. Effects of vitamin A comparing clinical, histopathologic, cytologic and hematologic responses. Acta Odont Scandinav. 1963;2:271–2.

    Google Scholar 

  70. Garewal HS, Meyskens FL Jr, Killen D, et al. Response of oral leukoplakia to beta-carotene. J Clin Oncol. 1990;8:1715–20.

    PubMed  CAS  Google Scholar 

  71. Garewal HS, Katz RV, Meyskens F, et al. Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial. Arch Otolaryngol Head Neck Surg. 1999;125:1305–10.

    Article  PubMed  CAS  Google Scholar 

  72. Stich HF, Hornby AP, Mathew B, Sankaranarayanan R, Nair MK. Response of oral leukoplakias to the administration of vitamin A. Cancer Lett. 1988;40:93–101.

    Article  PubMed  CAS  Google Scholar 

  73. Stich HF, Rosin MP, Hornby AP, Mathew B, Sankaranarayanan R, Nair MK. Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. Int J Cancer. 1988;42:195–9.

    Article  PubMed  CAS  Google Scholar 

  74. Sankaranarayanan R, Mathew B, Varghese C, et al. Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment. Oral Oncol. 1997;33:231–6.

    Article  PubMed  CAS  Google Scholar 

  75. Mayne ST, Cartmel B, Baum M, et al. Randomized trial of supplemental beta-carotene to prevent second head and neck cancer. Cancer Res. 2001;61:1457–63.

    PubMed  CAS  Google Scholar 

  76. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150–5.

    Article  PubMed  CAS  Google Scholar 

  77. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029–35.

    Article  Google Scholar 

  78. Kushi L, Doyle C, McCullough M, Rock C, Demark-Wahnefried W, et al. American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2012;62:30–67.

    Article  PubMed  Google Scholar 

  79. Rock C, Doyle C, Denmark-Wahnefried W, Meyerhardt J, Courneya K, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012;. doi:10.3322/caac.21142.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joel B. Epstein .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Epstein, J.B., Ganzer, H., Touger-Decker, R. (2014). Oral Pharyngeal Cancer Epidemiology and Prevention. In: Touger-Decker, R., Mobley, C., Epstein, J. (eds) Nutrition and Oral Medicine. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-60761-490-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-490-6_12

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-60761-489-0

  • Online ISBN: 978-1-60761-490-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics