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Behavioral Teratogenesis in Drosophila melanogaster

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Teratogenicity Testing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1797))

Abstract

Developmental biology is a fascinating branch of science which helps us to understand the mechanism of development, thus the findings are used in various therapeutic approach. Drosophila melanogaster served as a model to find the key molecules that initiate and regulate the mechanism of development. Various genes, transcription factors, and signaling pathways helping in development are identified in Drosophila. Many toxic compounds, which can affect the development, are also recognized using Drosophila model. These compounds, which can affect the development, are named as a teratogen. Many teratogens identified using Drosophila may also act as a teratogen for a human being since 75% of conservation exist between the disease genes present in Drosophila and human. There are certain teratogens, which do not cause developmental defect if exposed during pregnancy, however; behavioral defect appears in later part of development. Such compounds are named as a behavioral teratogen. Thus, it is worthy to identify the potential behavioral teratogen using Drosophila model. Drosophila behavior is well studied in various developmental stages. This chapter describes various methods which can be employed to test behavioral teratogenesis in Drosophila.

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Acknowledgments

We thank Mrs. Subhashree Priyadarshini for her help with the images presented in this chapter. Ms. Nibedita Nayak is gratefully acknowledged for her important comments on the larvae crawling experiment.

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Authors and Affiliations

  1. Neural Developmental Biology Lab, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India

    Monalisa Mishra & Bedanta Kumar Barik

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  1. Monalisa Mishra
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  2. Bedanta Kumar Barik
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Correspondence to Monalisa Mishra .

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Editors and Affiliations

  1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal

    Luís Félix

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Mishra, M., Barik, B.K. (2018). Behavioral Teratogenesis in Drosophila melanogaster . In: Félix, L. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 1797. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7883-0_14

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  • DOI: https://doi.org/10.1007/978-1-4939-7883-0_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7882-3

  • Online ISBN: 978-1-4939-7883-0

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