Abstract
CD95 (Fas-ligand) is a key mediator of cell death in multiple setting, thus its loss within the MRL-lpr (Faslpr) homozygote mice results in spontaneous autoimmunity. This is characterized by the development of arthritis and immune complex glomerulonephrosis making this strain a useful model for studying systemic lupus erythematosus. Herein we describe a method to exploit the heterozygote offspring of this strain in a model to study the effects of a CD95L blocking peptide on lupus-like disease in vivo.
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References
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Flynn, R.J. (2017). CD95 and the MRL-lpr Mouse Model. In: Legembre, P. (eds) CD95. Methods in Molecular Biology, vol 1557. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6780-3_21
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DOI: https://doi.org/10.1007/978-1-4939-6780-3_21
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-6778-0
Online ISBN: 978-1-4939-6780-3
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